PMC

Scatter-plot in which final severity is on the x-axis and pupillary motility at 11.78 seconds is on the y-axis for high-initial-severity participants. Responders were defined as participants with final BDI < 10. The threshold of maximal discrimination between responders and non-responders (−0.07mm) is plotted as a blue line.

CONSORT diagram of patient flow through the study. The box on the middle right displays the experimental protocol showing the time-course for the digit-sorting and alternating task. Only the alternating task was analyzed in this manuscript.

Pupillary responses to negative words followed by digit-sorting on the alternating task for controls, and both responders and non-responders with high-initial-severity (BDI-II> 20). Significant differences between responders and non-responders are highlighted below the x-axis; yellow=p<.1, red=p<.05. Black lines show regions with enough consecutive tests to be considered significant.

Association in 20 treated depressed patients of BOLD activity in five a priori regions with pupil dilation at 11.78 seconds – the point which maximally discriminated depressed responders from non-responders. In the second column, the Y axis represents correlation and the X axis is seconds. Scans with significant correlations are highlighted as yellow: p<.1, red: p<.05. In the third column, each participant’s data on both activity at the maximally predictive scan (X axis) and pupil dilation at 11.78 seconds (Y axis) are plotted.