PMC

Mean radixin staining intensity by Gleason score. Mean radixin staining intensity by Gleason score. No significant differences were seen in this classification (p = 0.938).

Mean radixin staining intensity by carcinoma stage. No significant differences were seen in this classification (p = 0.737).

Mean moesin staining intensity by Gleason score. No significant differences were seen in this classification (p = 0.719).

Mean moesin staining intensity by prostatic tissue type. No significant differences were seen in this classification (p = 0.152).

Mean moesin staining intensity by carcinoma stage. A significant decrease between Stage 2 and Stage 4 staining was observed (p = 0.003).

Mean radixin staining intensity by prostatic tissue type. Significant differences are seen between prostatic intraepithelial neoplasia and prostatic adenocarcinoma (p = < 0.001) and normal tissue adjacent to prostatic adenocarcinoma (p = 0.001). The asterisk (*) and the dagger (†) are used to signify the tissue types that are significantly different.

Photomicrographs of radixin TMA cores. Representative immunohistochemical staining for radixin in A) normal donor prostate B) high-grade prostatic intraepithelial neoplasia and C) prostatic adenocarcinoma. Radixin staining was diffuse and cytoplasmic. High-grade prostatic intraepithelial neoplasia had a significantly higher staining score than prostatic adenocarcinoma (p < 0.001).

Photomicrographs of moesin TMA cores. Representative immunohistochemical staining for moesin is featured in A) normal tissue adjacent to prostatic adenocarcinoma B) high-grade prostatic intraepithelial neoplasia and C) prostatic adenocarcinoma. Moesin staining was also diffuse and cytoplasmic, but was more granular in appearance than radixin. There were no significant differences in staining among the tissue types (p = 0.0152).