PMC

Strategies for stem cell-based antibody therapy of cancer. Models of potential strategies for the use of stem cells in antibody therapy. Delivery of antibodies or antibody-like molecules directly to tumor by tumor-tropic stem cells expressing either secreted antibody (A) or cell surface-bound antibody (B). Use of stem cells as “biological pumps” to secrete antibodies or antibody-like molecules into the bloodstream (C). All strategies utilize unique properties of stem cells to overcome limitations of traditional antibody therapy.