PMC

Change in AAT from baseline levels in sera of healthy men supplemented with plain yeast (placebo) and SY. The AAT levels in healthy men were significantly reduced following 9 months of SY-supplementation as compared to baseline and 3 months (p<0.05).

Figure 3A. AAT levels in AA and Caucasian men following SY supplementation. The AAT levels were significantly reduced (p<0.05) in SY-supplemented AA men at 3, 9 and 12 months compared to baseline. Levels of AAT in sera of caucasians were significantly reduced as compared to AA men at 3 months of SY supplementation.
Figure 3B. PSA levels of SY-supplemented AA and Caucasian men. PSA levels were equally reduced in AA and Caucasian men during SY supplementation.

2D-western blots for serum AAT and CLU. The 9 month (t = 9 Mo) time point was selected to confirm the presence of AAT and CLU proteins. (A) AAT isoforms (arrows) in sera of healthy men supplemented with plain yeast (placebo) or selenium-enriched yeast (SY) for 9 months. Western blots of three representative samples. (B) AAT level comparison between baseline and 9-months treatment, note AAT was decreased several fold in SY supplemented sample with no change in AAT for placebo sample. (C) Representative western blot for confirmation of CLU, note the higher expression in SY sample.