PMC

TORC1 integrates intra- and extracellular environmental cues through discrete signaling modules that sense and relay diverse inputs to a central “signaling core” (in green). This figure summarizes biochemical evidence from various studies that have identified the inputs and outputs of TORC1. Various outputs (in grey) that keep cellular growth in balance with the environment are regulated by TORC1. See main text for details.

The diagram represents the genetic interactions in the TOR signaling network that execute lifespan extension in yeast, worms, flies and mice. The diagram summarizes the lifespan data for genes in the TOR signaling pathway or those that demonstrate a genetic interaction with mutants in the TOR pathway. The shaded area refers to components of the TOR pathway that show conserved effects on lifespan extension in different species. See main text for details.