PMC

Forest plots of the association between birth weight and genotype at each locus.
[A] Index SNP rs900400 at 3q25.
[B] Index SNP rs9883204 at 3q21.
If the index SNP was unavailable, a closely-correlated proxy (HapMap r²>0.9) was used.

Regional plots of two novel associations with birth weight. For each of the two regions, 3q25 [A] and 3q21 [B], directly genotyped and imputed SNPs are plotted using filled circles with their meta-analysis P values (as −log₁₀ values) as a function of genomic position (NCBI Build 35). In each plot, the discovery stage SNP taken forward to replication stage is represented by a blue diamond (defining a global meta-analysis P value), with its discovery meta-analysis P value denoted by a red diamond. Local LD structure is reflected by the plotted estimated recombination rates (taken from HapMap) in the region around the associated SNPs and their correlated proxies. Each analyzed SNP is represented by circle. The colour scheme of the circles respects LD patterns (HapMap CEU pair-wise r2 correlation coefficients) between top discovery SNP and surrounding variants: white r2<0.2, grey 0.5> r2 >= 0.2, orange 0.8> r2 >= 0.5, red r2 >= 0.8. Gene annotations were taken from the University of California Santa Cruz genome browser.