PMC

Distribution of PZAse missense mutations in Peruvian and worldwide Mycobacterium tuberculosis PZA-resistant strains. The amino acid sequence of the PZAse and its secondary structure is considered. 4 alpha helix (α1 – α4), 6 beta strands (β1 – β6) and 10 loops (L1 – L10). The AS is included within the secondary structure domains L2 and L7, while the MCS is included within L4.
(†) Peruvian mutations reported by Escalante et al.