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Figure 4. SLX4 associates with structure-specific endonuclease activity. From: Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.
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Figure 5. SLX4-dependent cleavage of HJs maps to the C-terminal MUS81-EME1 and SLX1 binding domain (SBD). From: Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.
Figure 6. Cleavage specificity of SLX4 and SLX1-SLX4SBD complexes. From: Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.
Figure 2. Structural anatomy of the human SLX4 complex. From: Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.
Figure 3. Reduction in components of the SLX4 complex sensitizes cells to DNA damaging agents. From: Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.
Figure 1. Human SLX4 associates with structure-specific endonucleases, telomere recognition proteins, miss-match repair proteins, and PLK1. From: Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.
Figure 7. SLX1-SLX4 complexes resolve HJs through an ordered pathway in vitro and are required for efficient homology-directed repair of DSBs in vivo. From: Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.
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