PMC

Overall survival according to IDH1 mutation status. The hazard ratio for death among patients with wild-type IDH1 (n = 79), as compared to those with mutant IDH1 (n = 11), was 3.7 (95 percent confidence interval, 2.1 to 6.5; P < 0.001). The median survival was 3.8 years for patients with mutated IDH1, as compared to 1.1 years for patients with wild-type IDH1.

Structure of the active site of IDH1. The crystal structure of the human cytosolic NADP(+)–dependent IDH is shown in ribbon format (PDBID: 1T0L) (). The active cleft of IDH1 consists of a NADP-binding site and the isocitrate-metal ion-binding site. The alpha-carboxylate oxygen and the hydroxyl group of isocitrate chelate the Ca²⁺ ion. NADP is colored in orange, isocitrate in purple and Ca²⁺ in blue. The Arg¹³² residue, displayed in yellow, forms hydrophilic interactions, shown in red, with the alpha-carboxylate of isocitrate. Displayed image was created with UCSF Chimera software version 1.2422 ().