PMC

Distribution of Minor-Allele Frequency by Collection
Colors and line types for the densities of each collection are shown within the figure.

Genetic Structure Illustrated through Scatter Plots of Consecutive Principal Components
Subject scores are colored by continental and/or ethnic origin (see legend). East Asian populations are indicated by varying point types. Percent of variation explained by each component is given in parentheses on each axis label.

P-Plot Comparing Observed versus Expected Proportion of Associations over a Range of Significance Thresholds
Separate lines are presented for each of the four control matching strategies. Results of the allelic exact test are shown on the left and genotypic exact tests on the right. A light gray line corresponds to unity.

Distribution of Subject-Level Principal Component 5 Scores by Reported Ancestry
Each box and whisker indicates the median (heavy line), interquartile range (IQR, box), and minimum and maximum observations (whiskers). Whiskers are truncated at the last observation within 1.5 times the IQR from the edge of the box, with outliers shown individually. Plots for the remaining principal components are available in , available online.