A, MicroRNA expression profiling of various human tissues identify the myomiRs (miR-1, -133a and -206) and show miR-206 expression is restricted to skeletal muscle. Image is reproduced from Baskerville and Bartel (2005) with permission granted from Cold Spring Harbor Laboratory Press [].
B. RNase protection assay of different human tissues clearly shows that miR-206 is skeletal muscle specific, confirming microarray analysis presented in A; Co, colon; Kd, kidney; Ht, heart; Lv, liver; Bs, breast; Lu, lung; Si, small intestine; Sm, skeletal muscle; Ut, uterus; At, atrium; Sp, spleen; Te, testis; Ov, ovary; Bm, bone marrow; Br, brain; Cv, cervix; Pt, prostate tumor; Pe, prostate epithelium. The image is reproduced from Kim et al (2006) with permission from Rockefeller University Press [].