PMC

Effect of OLIG2 genotype (SNP rs1059004) on OLIG2 mRNA expression in the dorsolateral prefrontal cortex white matter. Individuals homozygous and for an A allele and heterozygotes had significantly lower OLIG2 mRNA expression than subjects homozygous for the C allele, “C/C” n = 37, “A/C” n = 40, “A/A” n = 14. (mean ± SE), * p<0.01.

Expression of normalized MOBP mRNA levels in schizophrenic patients and controls in the dorsolateral prefrontal cortex (DLPFC) white matter (WM) in 70 controls and 32 patients with schizophrenia and in the DLPFC grey matter (GM) in 64 controls and 30 patients with schizophrenia. Values are expressed as percentage of controls (MOBP % Controls, mean ± SE). *statistically significant from controls, p<0.05

Effect of a history of substance abuse on normalized MOBP mRNA expression in the dorsolateral prefrontal cortex A. white matter (WM) in 70 controls (Controls), 17 patients with schizophrenia without history of substance abuse (Sch without SubAb), and 15 patients with schizophrenia with history of substance abuse (Sch with SubAb) and in B. grey matter (GM), controls n = 64, schizophrenia without substance abuse n = 16, schizophrenia with substance abuse n = 14. None of the controls had a history of substance abuse. * statistically significant from schizophrenia patients without substance abuse, p<0.05.

MOBP and CNP protein immunoreactivity in DLPFC white matter in controls (n=47) and in patients with schizophrenia (n=26). Immunobloting was performed using antibodies against MOBP and a loading control Actin as well as CNP and a loading control GAPDH. MOBP and CNP immunoreactivity in controls and patients with schizophrenia were normalized to control proteins (Actin and GAPDH, respectively) and expressed as a percentage of controls (mean ± SE). There were no differences in immunoreactivity between the diagnostic groups.

Effect of race and CNP genotype (rs2070106) on normalized CNP mRNA expression in the dorsolateral prefrontal cortex grey matter (“African American G/G” n = 39, “African American A-carriers” n = 11, “Caucasian G/G” n = 15, “Caucasian A-carriers” n = 13). Caucasian individuals carrying a high risk A allele showed significantly lower levels of CNP expression compared to Caucasian subjects homozygous for the G allele. (mean ± SE) * statistically significant from Caucasian G/G, p< 0.05.