PMC

GxE effect on self-reported rumination. Scatterplots of self-reported rumination as a function of life stress for the S Group (n = 13) and L Group (n = 8), respectively.

aCBF in amygdala and hippocampus. (A Left Upper and Lower) Clusters represent voxels where aCBF (measured in ml·100 g⁻¹·min⁻¹) differed significantly between the S Group (n = 13) and L Group (n = 8). (A Right Upper and Lower) Bar graphs show level of activation in amygdala and hippocampus, with error bars depicting SEM. (B) Scatterplots from clusters within amygdala (Upper) and hippocampus (Lower) that showed a significant interaction of life stress and aCBF.

Amygdala and hippocampal activation as a function of 5-HTTLPR genotype and life stress. (Left) Clusters represent voxels in which amygdala (A) and hippocampus (H) activation to neutral faces-fixation varied significantly as an interaction of life stress and 5-HTTLPR genotype. (Center and Right) Columns show scatterplots of percent mean activation across the cluster shown in Left as a function of life stress for the “S Group” (n = 32) and “L Group” (n = 16), respectively.