PMC

Kaplan-Meier survival curves for treatment failure during treatment with LTRA + LABA or ICS + LABA in the subjects eligible for the prespecified primary analysis (n = 110). p = 0.0008 (McNemar's test) for differential prolongation of time to failure between the treatments.

Timing of the assessments and disposition of all enrolled subjects during the (A) 4-week run-in and (B) the two 14-week randomized treatment periods. DSMB = Data and Safety Monitoring Board; ICS = inhaled corticosteroid; LABA = long-acting β-agonist; LTRA = leukotriene receptor antagonist; Mch = methacholine.