Structural modelling of wild-type, Thr92 and phospho-Thr92K protein isoforms. (A–C) model of the KH1 domain of the K protein, its A92T isoform and the A92T isoform phosphorylated at Thr92, respectively. The protein is shown in the space fill representation, with helices shown in orange, strands in green and loops in light grey. Residue 92 (Ala, Thr and phospho-Thr, respectively) is coloured according to the following scheme: C atoms: dark grey; O atoms: red; N atoms: blue; and P atoms: orange. (D–F) The Coulomb electrostatic potential mapped onto the surface of each variant of the KH1 domain and expressed as a colour range (from red, −6 kT, to blue, +6 kT). (G–I) Model of RNA interacting with KH1 domain of hnRNP K protein.