PMC

 Plasma levels of C reactive protein (CRP) (A), interleukin 6 (IL-6) (B), soluble IL-1 receptor II (sIL-1RII) (C), and soluble IL-1 receptor I (sIL-1RI) (D) in nine Crohn’s disease patients with active disease after corticosteroid administration. Results are expressed as mean (SEM) and statistical comparisons were performed using the Wilcoxon signed rank test. *p<0.05.

 Correlations between soluble interleukin 1 receptor II (sIL-1RII), sgp130, and C reactive protein (CRP) levels in active Crohn’s disease patients before treatment (infliximab or corticosteroids), in Crohn’s disease patients in remission, and in healthy subjects. (A) sIL-1RII and CRP levels. (B) sgp130 and CRP levels. ρ, Spearman’s correlation coefficient; p, significance.

 Plasma levels of C reactive protein (CRP) (A), interleukin 6 (IL-6) (B), soluble IL-6 receptor (sIL-6R) (C), and soluble tumour necrosis factor receptor II (sTNFRII) of Crohn’s disease patients with active disease after infliximab administration. Results are expressed as mean (SEM) and statistical comparisons were performed using the Wilcoxon signed rank test. *p<0.05, **p<0.01.

 Circulating soluble interleukin 1 receptor II (sIL-1RII) (A) and sgp130 (B) levels in 15 healthy subjects (HS), in 11 patients with ulcerative colitis in clinical remission (rUC), and in 13 patients with active UC (aUC). aCD v HS: *p<0.05; aCD v rCD: †p<0.05. Results are shown as box plots; the line within the box represents the median value with the outer limits of the box representing the 25th and 75th percentile values; whiskers above and below the box indicate the 90th and 10th percentile values. Statistical comparisons were performed using the Kruskal-Wallis test.

 Interleukin 1β (IL-1β) (A), IL-6 (B), soluble interleukin 1 receptor II (sIL-1RII) (C), and sgp130 (D) levels in 18 hour culture media of colonic biopsies of healthy (HCM, n = 8), non-inflamed Crohn’s disease (CDnon-inf, n = 7), and inflamed Crohn’s disease mucosa (CDinf, n = 8). CDinf v HCM: **p<0.01; CDinf v CDnon-inf: †p<0.05, ††p<0.01; CDnon-inf v HCM: ‡p<0.05. Results are shown as box plots; the line within the box represents the median value with the outer limits of the box representing the 25th and 75th percentile values; whiskers above and below the box indicate the 90th and 10th percentile values. Statistical comparisons were performed using the Kruskal-Wallis test.

 Circulating soluble cytokine receptor levels in 15 healthy subjects (HS), 20 patients in Crohn’s disease remission (rCD), and 30 active Crohn’s disease patients (aCD). (A) Soluble tumour necrosis factor receptor I (sTNFRI) and receptor II (sTNFRII) levels. (B) Soluble interleukin 1 receptor I (sIL-1RI) and receptor II (sIL-1RII) levels. (C) Interleukin 6 (IL-6), soluble IL-6 receptor (sIL-6R), and sgp130 levels. aCD v HS: *p<0.05, **p<0.01; aCD v rCD: †p<0.05, ††p<0.01; rCD v HS: ‡p<0.05. Results are shown as box plots; the line within the box represents the median value with the outer limits of the box representing the 25th and 75th percentile values; whiskers above and below the box indicate the 90th and 10th percentile values. Statistical comparisons were performed using the Kruskal-Wallis test.