PMC

LOD scores for a genome scan of sibships with CaP. Marker locations are indicated by tick marks above the lower axis. Five models are included: the baseline one-parameter model (black) and four models with one covariate each, including Gleason score (blue), age at onset (red), male-to-male transmission (green), and number of affected relatives (yellow). Horizontal lines correspond to LOD score cutpoints at α = .001 for baseline LOD score (cutpoint 2.07) and models including a single covariate (cutpoint 2.78).