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Select item 107213281.

Biallelic MAD2L1BP (p31^comet) mutation is associated with mosaic aneuploidy and juvenile granulosa cell tumors

Ghada M. H. Abdel-Salam, Susanne Hellmuth, Elise Gradhand, Stephan Käseberg, Jennifer Winter, Ann-Sophie Pabst, Maha M. Eid, Holger Thiele, Peter Nürnberg, Birgit S. Budde, Mohammad Reza Toliat, Ines B. Brecht, Christopher Schroeder, Axel Gschwind, Stephan Ossowski, Friederike Häuser, Heidi Rossmann, Mohamed S. Abdel-Hamid, Ibrahim Hegazy, Ahmed G. Mohamed, Dominik T. Schneider, Aida Bertoli-Avella, Peter Bauer, Jillian N. Pearring, Rolph Pfundt, Alexander Hoischen, Christian Gilissen, Dennis Strand, Ulrich Zechner, Soha A. Tashkandi, Eissa A. Faqeih, Olaf Stemmann, Susanne Strand, Hanno J. Bolz

JCI Insight. 2023 Nov 22; 8(22): e170079. Published online 2023 Nov 22. doi: 10.1172/jci.insight.170079

PMCID:: PMC10721328

Article PDF–17M

Select item 39050742.

Coordinated regulation of p31^Comet and Mad2 expression is required for cellular proliferation

Dipali A Date, Amy C Burrows, Monica Venere, Mark W Jackson, Matthew K Summers

Cell Cycle. 2013 Dec 15; 12(24): 3824–3832. Published online 2013 Oct 15. doi: 10.4161/cc.26811

PMCID:: PMC3905074

Article PDF–2.2M

Select item 33755773.

Depletion of p31^comet Protein Promotes Sensitivity to Antimitotic Drugs

Hoi Tang Ma, Yan Yan Chan, Xiao Chen, Kin Fan On, Randy Y. C. Poon

J Biol Chem. 2012 Jun 15; 287(25): 21561–21569. Published online 2012 Apr 27. doi: 10.1074/jbc.M112.364356

PMCID:: PMC3375577

Article PDF–1.6M

Select item 32166504.

p31^comet acts to ensure timely spindle checkpoint silencing subsequent to kinetochore attachment

Robert S. Hagan, Michael S. Manak, Håkon Kirkeby Buch, Michelle G. Meier, Patrick Meraldi, Jagesh V. Shah, Peter K. Sorger, Stephen J Doxsey

Mol Biol Cell. 2011 Nov 15; 22(22): 4236–4246. doi: 10.1091/mbc.E11-03-0216

PMCID:: PMC3216650

Article PDF–5.0M

Select item 103194345.

Biallelic variants in MAD2L1BP (p31^comet) cause female infertility characterized by oocyte maturation arrest

Lingli Huang, Wenqing Li, Xingxing Dai, Shuai Zhao, Bo Xu, Fengsong Wang, Ren-Tao Jin, Lihua Luo, Limin Wu, Xue Jiang, Yu Cheng, Jiaqi Zou, Caoling Xu, Xianhong Tong, Heng-Yu Fan, Han Zhao, Jianqiang Bao

eLife. 2023; 12: e85649. Published online 2023 Jun 19. doi: 10.7554/eLife.85649

PMCID:: PMC10319434

Article PDF–2.9M

Select item 70988896.

Mitotic slippage is determined by p31^comet and the weakening of the spindle-assembly checkpoint

Tsun Ming Lok, Yang Wang, Wendy Kaichun Xu, Siwei Xie, Hoi Tang Ma, Randy Y. C. Poon

Oncogene. 2020; 39(13): 2819–2834. Published online 2020 Feb 6. doi: 10.1038/s41388-020-1187-6

PMCID:: PMC7098889

Article PDF–3.5M

Select item 57171977.

Mechanistic insight into TRIP13-catalyzed Mad2 structural transition and spindle checkpoint silencing

Melissa L. Brulotte, Byung-Cheon Jeong, Faxiang Li, Bing Li, Eric B. Yu, Qiong Wu, Chad A. Brautigam, Hongtao Yu, Xuelian Luo

Nat Commun. 2017; 8: 1956. Published online 2017 Dec 5. doi: 10.1038/s41467-017-02012-2

PMCID:: PMC5717197

Article PDF–2.8M

Select item 40362738.

Phosphorylation Regulates the p31^Comet-Mitotic Arrest-deficient 2 (Mad2) Interaction to Promote Spindle Assembly Checkpoint (SAC) Activity

Dipali A. Date, Amy C. Burrows, Matthew K. Summers

J Biol Chem. 2014 Apr 18; 289(16): 11367–11373. Published online 2014 Mar 4. doi: 10.1074/jbc.M113.520841

PMCID:: PMC4036273

Article PDF–1.3M

Select item 76044619.

p31^comet promotes homologous recombination by inactivating REV7 through the TRIP13 ATPase

Prabha Sarangi, Connor S. Clairmont, Lucas D. Galli, Lisa A. Moreau, Alan D. D’Andrea

Proc Natl Acad Sci U S A. 2020 Oct 27; 117(43): 26795–26803. Published online 2020 Oct 13. doi: 10.1073/pnas.2008830117

PMCID:: PMC7604461

Article PDF–1.4M

Select item 555626510.

The AAA+ ATPase TRIP13 remodels HORMA domains through N‐terminal engagement and unfolding

Qiaozhen Ye, Dong Hyun Kim, Ihsan Dereli, Scott C Rosenberg, Goetz Hagemann, Franz Herzog, Attila Tóth, Don W Cleveland, Kevin D Corbett

EMBO J. 2017 Aug 15; 36(16): 2419–2434. Published online 2017 Jun 28. doi: 10.15252/embj.201797291

PMCID:: PMC5556265

Article PDF–2.0M

Select item 214474511.

p31^comet Blocks Mad2 Activation through Structural Mimicry

Maojun Yang, Bing Li, Diana R. Tomchick, Mischa Machius, Josep Rizo, Hongtao Yu, Xuelian Luo

Cell. Author manuscript; available in PMC 2007 Dec 18.

Published in final edited form as: Cell. 2007 Nov 16; 131(4): 744–755. doi: 10.1016/j.cell.2007.08.048

PMCID:: PMC2144745

Article PDF–2.8M

Select item 51493712.

Conformation-specific binding of p31^comet antagonizes the function of Mad2 in the spindle checkpoint

Guohong Xia, Xuelian Luo, Toshiyuki Habu, Josep Rizo, Tomohiro Matsumoto, Hongtao Yu

EMBO J. 2004 Aug 4; 23(15): 3133–3143. Published online 2004 Jul 15. doi: 10.1038/sj.emboj.7600322

PMCID:: PMC514937

Article PDF–558K

Select item 616826413.

The inositol 5-phosphatase INPP5K participates in the fine control of ER organization

Rui Dong, Ting Zhu, Lorena Benedetti, Swetha Gowrishankar, Huichao Deng, Yiying Cai, Xiangming Wang, Kang Shen, Pietro De Camilli

J Cell Biol. 2018 Oct 1; 217(10): 3577–3592. doi: 10.1083/jcb.201802125

PMCID:: PMC6168264

Article PDF–3.6M

Select item 463632114.

p31^comet-Induced Cell Death Is Mediated by Binding and Inactivation of Mad2

Hyun-Jin Shin, Eun-Ran Park, Sun-Hee Yun, Su-Hyeon Kim, Won-Hee Jung, Seon Rang Woo, Hyun-Yoo Joo, Su Hwa Jang, Hee Yong Chung, Sung Hee Hong, Myung-Haing Cho, Joong-Jean Park, Miyong Yun, Kee-Ho Lee

PLoS One. 2015; 10(11): e0141523. Published online 2015 Nov 6. doi: 10.1371/journal.pone.0141523

PMCID:: PMC4636321

Article PDF–911K

Select item 414299615.

Disassembly of mitotic checkpoint complexes by the joint action of the AAA-ATPase TRIP13 and p31^comet

Esther Eytan, Kexi Wang, Shirly Miniowitz-Shemtov, Danielle Sitry-Shevah, Sharon Kaisari, Tim J. Yen, Song-Tao Liu, Avram Hershko

Proc Natl Acad Sci U S A. 2014 Aug 19; 111(33): 12019–12024. Published online 2014 Aug 4. doi: 10.1073/pnas.1412901111

PMCID:: PMC4142996

Article PDF–888K

Select item 336140316.

Role of phosphorylation of Cdc20 in p31^comet-stimulated disassembly of the mitotic checkpoint complex

Shirly Miniowitz-Shemtov, Esther Eytan, Dvora Ganoth, Danielle Sitry-Shevah, Elena Dumin, Avram Hershko

Proc Natl Acad Sci U S A. 2012 May 22; 109(21): 8056–8060. Published online 2012 May 7. doi: 10.1073/pnas.1204081109

PMCID:: PMC3361403

Article PDF–338K

Select item 612674117.

Rev7 dimerization is important for assembly and function of the Rev1/Polζ translesion synthesis complex

Alessandro A. Rizzo, Faye-Marie Vassel, Nimrat Chatterjee, Sanjay D’Souza, Yunfeng Li, Bing Hao, Michael T. Hemann, Graham C. Walker, Dmitry M. Korzhnev

Proc Natl Acad Sci U S A. 2018 Aug 28; 115(35): E8191–E8200. Published online 2018 Aug 15. doi: 10.1073/pnas.1801149115

PMCID:: PMC6126741

Article PDF–1.7M

Select item 457713918.

Mode of interaction of TRIP13 AAA-ATPase with the Mad2-binding protein p31comet and with mitotic checkpoint complexes

Shirly Miniowitz-Shemtov, Ety Eytan, Sharon Kaisari, Danielle Sitry-Shevah, Avram Hershko

Proc Natl Acad Sci U S A. 2015 Sep 15; 112(37): 11536–11540. Published online 2015 Aug 31. doi: 10.1073/pnas.1515358112

PMCID:: PMC4577139

Article PDF–851K

Select item 304435719.

p31^comet promotes disassembly of the mitotic checkpoint complex in an ATP-dependent process

Adar Teichner, Esther Eytan, Danielle Sitry-Shevah, Shirly Miniowitz-Shemtov, Elena Dumin, Jonathan Gromis, Avram Hershko

Proc Natl Acad Sci U S A. 2011 Feb 22; 108(8): 3187–3192. Published online 2011 Feb 7. doi: 10.1073/pnas.1100023108

PMCID:: PMC3044357

Article PDF–767K

Select item 142216920.

Determinants of conformational dimerization of Mad2 and its inhibition by p31^comet

Marina Mapelli, Fabian V Filipp, Giulia Rancati, Lucia Massimiliano, Luigi Nezi, Gunter Stier, Robert S Hagan, Stefano Confalonieri, Simonetta Piatti, Michael Sattler, Andrea Musacchio

EMBO J. 2006 Mar 22; 25(6): 1273–1284. Published online 2006 Mar 9. doi: 10.1038/sj.emboj.7601033

PMCID:: PMC1422169

Article PDF–676K

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