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Volume 58(9);  September 2014

Articles from this journal are usually available in PMC after a 6-month delay (embargo). Some articles may be available sooner.

Minireview

A New Clone Sweeps Clean: the Enigmatic Emergence of Escherichia coli Sequence Type 131
Ritu Banerjee, James R. Johnson
Antimicrob Agents Chemother. Sep 2014; 58(9): 4997–5004. doi: 10.1128/AAC.02824-14
PMCID:
PMC4135879

Chemistry; Biosynthesis

Pyocyanin Production by Pseudomonas aeruginosa Confers Resistance to Ionic Silver
Michael Muller, Neil D. Merrett
Antimicrob Agents Chemother. Sep 2014; 58(9): 5492–5499. doi: 10.1128/AAC.03069-14
PMCID:
PMC4135871

Mechanisms of Action: Physiological Effects

Comparative Mechanistic Studies of Brilacidin, Daptomycin, and the Antimicrobial Peptide LL16
Bruk Mensa, Gabriella L. Howell, Richard Scott, William F. DeGrado
Antimicrob Agents Chemother. Sep 2014; 58(9): 5136–5145. doi: 10.1128/AAC.02955-14
PMCID:
PMC4135847
Fosmidomycin Decreases Membrane Hopanoids and Potentiates the Effects of Colistin on Burkholderia multivorans Clinical Isolates
Rebecca J. Malott, Chia-Hung Wu, Tracy D. Lee, Trevor J. Hird, Nathan F. Dalleska, James E. A. Zlosnik, Dianne K. Newman, David P. Speert
Antimicrob Agents Chemother. Sep 2014; 58(9): 5211–5219. doi: 10.1128/AAC.02705-14
PMCID:
PMC4135860
Synergy of Streptogramin Antibiotics Occurs Independently of Their Effects on Translation
Jonas Noeske, Jian Huang, Nelson B. Olivier, Robert A. Giacobbe, Mark Zambrowski, Jamie H. D. Cate
Antimicrob Agents Chemother. Sep 2014; 58(9): 5269–5279. doi: 10.1128/AAC.03389-14
PMCID:
PMC4135883
Cell-Based Assay To Identify Inhibitors of the Hfq-sRNA Regulatory Pathway
Shaima A. El-Mowafi, John N. Alumasa, Sarah E. Ades, Kenneth C. Keiler
Antimicrob Agents Chemother. Sep 2014; 58(9): 5500–5509. doi: 10.1128/AAC.03311-14
PMCID:
PMC4135888
Sharon Wein, Christophe Tran Van Ba, Marjorie Maynadier, Yann Bordat, Julie Perez, Suzanne Peyrottes, Laurent Fraisse, Henri J. Vial
Antimicrob Agents Chemother. Sep 2014; 58(9): 5519–5527. doi: 10.1128/AAC.00040-14
PMCID:
PMC4135818
Signaling of Chloroquine-Induced Stress in the Yeast Saccharomyces cerevisiae Requires the Hog1 and Slt2 Mitogen-Activated Protein Kinase Pathways
Shivani Baranwal, Gajendra Kumar Azad, Vikash Singh, Raghuvir S. Tomar
Antimicrob Agents Chemother. Sep 2014; 58(9): 5552–5566. doi: 10.1128/AAC.02393-13
PMCID:
PMC4135872
Pyochelin Potentiates the Inhibitory Activity of Gallium on Pseudomonas aeruginosa
Emanuela Frangipani, Carlo Bonchi, Fabrizia Minandri, Francesco Imperi, Paolo Visca
Antimicrob Agents Chemother. Sep 2014; 58(9): 5572–5575. doi: 10.1128/AAC.03154-14
PMCID:
PMC4135843

Mechanisms of Resistance

Michie Saito, Yuki Katayama, Tomomi Hishinuma, Akira Iwamoto, Yoshifumi Aiba, Kyoko Kuwahara-Arai, Longzhu Cui, Miki Matsuo, Nanae Aritaka, Keiichi Hiramatsu
Antimicrob Agents Chemother. Sep 2014; 58(9): 5024–5035. doi: 10.1128/AAC.02470-13
PMCID:
PMC4135821
The Pseudomonas aeruginosa CreBC Two-Component System Plays a Major Role in the Response to β-Lactams, Fitness, Biofilm Growth, and Global Regulation
Laura Zamorano, Bartolomé Moyà, Carlos Juan, Xavier Mulet, Jesús Blázquez, Antonio Oliver
Antimicrob Agents Chemother. Sep 2014; 58(9): 5084–5095. doi: 10.1128/AAC.02556-14
PMCID:
PMC4135852
First Detection of TR46/Y121F/T289A and TR34/L98H Alterations in Aspergillus fumigatus Isolates from Azole-Naive Patients in Denmark despite Negative Findings in the Environment
K. M. T. Astvad, R. H. Jensen, T. M. Hassan, E. G. Mathiasen, G. M. Thomsen, U. G. Pedersen, M. Christensen, O. Hilberg, M. C. Arendrup
Antimicrob Agents Chemother. Sep 2014; 58(9): 5096–5101. doi: 10.1128/AAC.02855-14
PMCID:
PMC4135837
SAGA/ADA Complex Subunit Ada2 Is Required for Cap1- but Not Mrr1-Mediated Upregulation of the Candida albicans Multidrug Efflux Pump MDR1
Bernardo Ramírez-Zavala, Selene Mogavero, Eva Schöller, Christoph Sasse, P. David Rogers, Joachim Morschhäuser
Antimicrob Agents Chemother. Sep 2014; 58(9): 5102–5110. doi: 10.1128/AAC.03065-14
PMCID:
PMC4135829
Serratia marcescens arn, a PhoP-Regulated Locus Necessary for Polymyxin B Resistance
Quei Yen Lin, Yi-Lin Tsai, Ming-Che Liu, Wei-Cheng Lin, Po-Ren Hsueh, Shwu-Jen Liaw
Antimicrob Agents Chemother. Sep 2014; 58(9): 5181–5190. doi: 10.1128/AAC.00013-14
PMCID:
PMC4135846
Relationship between Glycopeptide Production and Resistance in the Actinomycete Nonomuraea sp. ATCC 39727
Giorgia Letizia Marcone, Elisa Binda, Lucia Carrano, Mervyn Bibb, Flavia Marinelli
Antimicrob Agents Chemother. Sep 2014; 58(9): 5191–5201. doi: 10.1128/AAC.02626-14
PMCID:
PMC4135873
Exposure of Staphylococcus aureus to Subinhibitory Concentrations of β-Lactam Antibiotics Induces Heterogeneous Vancomycin-Intermediate Staphylococcus aureus
Mélanie Roch, Perrine Clair, Adriana Renzoni, Marie-Elisabeth Reverdy, Olivier Dauwalder, Michèle Bes, Annie Martra, Anne-Marie Freydière, Frédéric Laurent, Philippe Reix, Oana Dumitrescu, François Vandenesch
Antimicrob Agents Chemother. Sep 2014; 58(9): 5306–5314. doi: 10.1128/AAC.02574-14
PMCID:
PMC4135816
Molecular Mechanisms of Substrate Recognition and Specificity of New Delhi Metallo-β-Lactamase
Jiachi Chiou, Thomas Yun-Chung Leung, Sheng Chen
Antimicrob Agents Chemother. Sep 2014; 58(9): 5372–5378. doi: 10.1128/AAC.01977-13
PMCID:
PMC4135836
Target Enzyme Mutations Confer Differential Echinocandin Susceptibilities in Candida kefyr
Janet F. Staab, Dionysios Neofytos, Peter Rhee, Cristina Jiménez-Ortigosa, Sean X. Zhang, David S. Perlin, Kieren A. Marr
Antimicrob Agents Chemother. Sep 2014; 58(9): 5421–5427. doi: 10.1128/AAC.00096-14
PMCID:
PMC4135851
Molecular Epidemiology of NDM-1-Producing Enterobacteriaceae and Acinetobacter baumannii Isolates from Pakistan
Anna L. Sartor, Muhammad W. Raza, Shahid A. Abbasi, Kathryn M. Day, John D. Perry, David L. Paterson, Hanna E. Sidjabat
Antimicrob Agents Chemother. Sep 2014; 58(9): 5589–5593. doi: 10.1128/AAC.02425-14
PMCID:
PMC4135889
Colistin Heteroresistance in Enterobacter cloacae Is Associated with Cross-Resistance to the Host Antimicrobial Lysozyme
Brooke A. Napier, Victor Band, Eileen M. Burd, David S. Weiss
Antimicrob Agents Chemother. Sep 2014; 58(9): 5594–5597. doi: 10.1128/AAC.02432-14
PMCID:
PMC4135841

Susceptibility

Levofloxacin-Ceftriaxone Combination Attenuates Lung Inflammation in a Mouse Model of Bacteremic Pneumonia Caused by Multidrug-Resistant Streptococcus pneumoniae via Inhibition of Cytolytic Activities of Pneumolysin and Autolysin
Arnab Majhi, Rana Adhikary, Aritra Bhattacharyya, Sayantika Mahanti, Biswadev Bishayi
Antimicrob Agents Chemother. Sep 2014; 58(9): 5164–5180. doi: 10.1128/AAC.03245-14
PMCID:
PMC4135890
Improved Plaque Assay Identifies a Novel Anti-Chlamydia Ceramide Derivative with Altered Intracellular Localization
Sebastian Banhart, Essa M. Saied, Andrea Martini, Sophia Koch, Lukas Aeberhard, Kazimierz Madela, Christoph Arenz, Dagmar Heuer
Antimicrob Agents Chemother. Sep 2014; 58(9): 5537–5546. doi: 10.1128/AAC.03457-14
PMCID:
PMC4135853
David J. Farrell, Rodrigo E. Mendes, Paul R. Rhomberg, Ronald N. Jones
Antimicrob Agents Chemother. Sep 2014; 58(9): 5547–5551. doi: 10.1128/AAC.03172-14
PMCID:
PMC4135820
Micafungin at Physiological Serum Concentrations Shows Antifungal Activity against Candida albicans and Candida parapsilosis Biofilms
M. Guembe, J. Guinea, L. J. Marcos-Zambrano, A. Fernández-Cruz, T. Peláez, P. Muñoz, E. Bouza
Antimicrob Agents Chemother. Sep 2014; 58(9): 5581–5584. doi: 10.1128/AAC.02738-14
PMCID:
PMC4135876
High In Vitro Activity of the Novel Spiropyrimidinetrione AZD0914, a DNA Gyrase Inhibitor, against Multidrug-Resistant Neisseria gonorrhoeae Isolates Suggests a New Effective Option for Oral Treatment of Gonorrhea
Susanne Jacobsson, Daniel Golparian, Richard A. Alm, Michael Huband, John Mueller, Jorgen Skov Jensen, Makoto Ohnishi, Magnus Unemo
Antimicrob Agents Chemother. Sep 2014; 58(9): 5585–5588. doi: 10.1128/AAC.03090-14
PMCID:
PMC4135813
In Vitro Activities of Nine Antifungal Drugs and Their Combinations against Phialophora verrucosa
Yali Li, Zhe Wan, Ruoyu Li
Antimicrob Agents Chemother. Sep 2014; 58(9): 5609–5612. doi: 10.1128/AAC.02875-14
PMCID:
PMC4135824
In Vitro Antifungal Susceptibility Profile and Correlation of Mycelial and Yeast Forms of Molecularly Characterized Histoplasma capsulatum Strains from India
Shallu Kathuria, Pradeep K. Singh, Jacques F. Meis, Anuradha Chowdhary
Antimicrob Agents Chemother. Sep 2014; 58(9): 5613–5616. doi: 10.1128/AAC.02973-14
PMCID:
PMC4135809
In Vitro Synergism Observed with Azithromycin, Clarithromycin, Minocycline, or Tigecycline in Association with Antifungal Agents against Pythium insidiosum
Francielli P. K. Jesus, Laerte Ferreiro, Érico S. Loreto, Maiara B. Pilotto, Aline Ludwig, Karine Bizzi, Juliana S. M. Tondolo, Régis A. Zanette, Sydney H. Alves, Janio M. Santurio
Antimicrob Agents Chemother. Sep 2014; 58(9): 5621–5625. doi: 10.1128/AAC.02349-14
PMCID:
PMC4135807
Cysticidal Activity of Antifungals against Different Genotypes of Acanthamoeba
Alfonso Iovieno, Darlene Miller, Dolena R. Ledee, Eduardo C. Alfonso
Antimicrob Agents Chemother. Sep 2014; 58(9): 5626–5628. doi: 10.1128/AAC.02635-14
PMCID:
PMC4135811
In Vitro Activities of Eight Antifungal Drugs against 104 Environmental and Clinical Isolates of Aureobasidium pullulans
M. Javad Najafzadeh, Deanna A. Sutton, M. Saradeghi Keisari, H. Zarrinfar, G. Sybren de Hoog, Anuradha Chowdhary, Jacques F. Meis
Antimicrob Agents Chemother. Sep 2014; 58(9): 5629–5631. doi: 10.1128/AAC.03095-14
PMCID:
PMC4135826
Comparison of Different Drug Susceptibility Test Methods To Detect Rifampin Heteroresistance in Mycobacterium tuberculosis
Zhijian Zhang, Yufeng Wang, Yu Pang, Changting Liu
Antimicrob Agents Chemother. Sep 2014; 58(9): 5632–5635. doi: 10.1128/AAC.02778-14
PMCID:
PMC4135805

Analytical Procedures

In Vitro and In Vivo Activities of Antimicrobial Peptides Developed Using an Amino Acid-Based Activity Prediction Method
Xiaozhe Wu, Zhenling Wang, Xiaolu Li, Yingzi Fan, Gu He, Yang Wan, Chaoheng Yu, Jianying Tang, Meng Li, Xian Zhang, Hailong Zhang, Rong Xiang, Ying Pan, Yan Liu, Lian Lu, Li Yang
Antimicrob Agents Chemother. Sep 2014; 58(9): 5342–5349. doi: 10.1128/AAC.02823-14
PMCID:
PMC4135812

Antiviral Agents

Three Phase III Randomized Controlled Trials of Topical Resiquimod 0.01-Percent Gel To Reduce Anogenital Herpes Recurrences
Karen E. Mark, Spotswood Spruance, George R. Kinghorn, Stephen L. Sacks, Herbert B. Slade, Tze-Chiang Meng, Stacy Selke, Amalia Magaret, Anna Wald
Antimicrob Agents Chemother. Sep 2014; 58(9): 5016–5023. doi: 10.1128/AAC.00077-14
PMCID:
PMC4135828
Downregulation of Cellular c-Jun N-Terminal Protein Kinase and NF-κB Activation by Berberine May Result in Inhibition of Herpes Simplex Virus Replication
Siwei Song, Min Qiu, Ying Chu, Deyan Chen, Xiaohui Wang, Airong Su, Zhiwei Wu
Antimicrob Agents Chemother. Sep 2014; 58(9): 5068–5078. doi: 10.1128/AAC.02427-14
PMCID:
PMC4135844
Comparison of Daclatasvir Resistance Barriers on NS5A from Hepatitis C Virus Genotypes 1 to 6: Implications for Cross-Genotype Activity
Chunfu Wang, Lingling Jia, Donald R. O'Boyle, II, Jin-Hua Sun, Karen Rigat, Lourdes Valera, Peter Nower, Xin Huang, Bernadette Kienzle, Susan Roberts, Min Gao, Robert A. Fridell
Antimicrob Agents Chemother. Sep 2014; 58(9): 5155–5163. doi: 10.1128/AAC.02788-14
PMCID:
PMC4135806
Characterization of Drug-Resistant Influenza Virus A(H1N1) and A(H3N2) Variants Selected In Vitro with Laninamivir
Mélanie Samson, Yacine Abed, François-Marc Desrochers, Stephanie Hamilton, Angela Luttick, Simon P. Tucker, Melinda J. Pryor, Guy Boivin
Antimicrob Agents Chemother. Sep 2014; 58(9): 5220–5228. doi: 10.1128/AAC.03313-14
PMCID:
PMC4135884
Using Pharmacokinetic and Viral Kinetic Modeling To Estimate the Antiviral Effectiveness of Telaprevir, Boceprevir, and Pegylated Interferon during Triple Therapy in Treatment-Experienced Hepatitis C Virus-Infected Cirrhotic Patients
Cédric Laouénan, Patrick Marcellin, Martine Lapalus, Feryel Khelifa-Mouri, Nathalie Boyer, Fabien Zoulim, Lawrence Serfaty, Jean-Pierre Bronowicki, Michelle Martinot-Peignoux, Olivier Lada, Tarik Asselah, Céline Dorival, Christophe Hézode, Fabrice Carrat, Florence Nicot, Gilles Peytavin, France Mentré, Jeremie Guedj
Antimicrob Agents Chemother. Sep 2014; 58(9): 5332–5341. doi: 10.1128/AAC.02611-14
PMCID:
PMC4135822
Hepatitis C Virus Genotype 5a Subgenomic Replicons for Evaluation of Direct-Acting Antiviral Agents
Constance N. Wose Kinge, Christine Espiritu, Nishi Prabdial-Sing, Nomathamsaqa Patricia Sithebe, Mohsan Saeed, Charles M. Rice
Antimicrob Agents Chemother. Sep 2014; 58(9): 5386–5394. doi: 10.1128/AAC.03534-14
PMCID:
PMC4135880
Genotypic and Phenotypic Analyses of Hepatitis C Virus Variants Observed in Clinical Studies of VX-222, a Nonnucleoside NS5B Polymerase Inhibitor
Min Jiang, Eileen Z. Zhang, Andrzej Ardzinski, Ann Tigges, Andrew Davis, James C. Sullivan, Michelle Nelson, Joan Spanks, Jennifer Dorrian, Olivier Nicolas, Doug J. Bartels, B. Govinda Rao, Rene Rijnbrand, Tara L. Kieffer
Antimicrob Agents Chemother. Sep 2014; 58(9): 5456–5465. doi: 10.1128/AAC.03052-14
PMCID:
PMC4135882
Binding Mode Characterization of NBD Series CD4-Mimetic HIV-1 Entry Inhibitors by X-Ray Structure and Resistance Study
Francesca Curreli, Young Do Kwon, Hongtao Zhang, Yongping Yang, Daniel Scacalossi, Peter D. Kwong, Asim K. Debnath
Antimicrob Agents Chemother. Sep 2014; 58(9): 5478–5491. doi: 10.1128/AAC.03339-14
PMCID:
PMC4135886
In Vitro Efficacy of Brincidofovir against Variola Virus
Victoria A. Olson, Scott K. Smith, Scott Foster, Yu Li, E. Randall Lanier, Irina Gates, Lawrence C. Trost, Inger K. Damon
Antimicrob Agents Chemother. Sep 2014; 58(9): 5570–5571. doi: 10.1128/AAC.02814-14
PMCID:
PMC4135866
Placental Transfer of Darunavir in an Ex Vivo Human Cotyledon Perfusion Model
Laurent Mandelbrot, Dominique Duro, Emilie Belissa, Gilles Peytavin
Antimicrob Agents Chemother. Sep 2014; 58(9): 5617–5620. doi: 10.1128/AAC.03184-14
PMCID:
PMC4135808

Epidemiology and Surveillance

Decreasing Clostridium difficile Infections by an Antimicrobial Stewardship Program That Reduces Moxifloxacin Use
Judith Maria Wenisch, Susanne Equiluz-Bruck, Marta Fudel, Ingun Reiter, Andrea Schmid, Erna Singer, Andreas Chott
Antimicrob Agents Chemother. Sep 2014; 58(9): 5079–5083. doi: 10.1128/AAC.03006-14
PMCID:
PMC4135825
Long-Term Dissemination of CTX-M-5-Producing Hypermutable Salmonella enterica Serovar Typhimurium Sequence Type 328 Strains in Russia, Belarus, and Kazakhstan
Varvara K. Kozyreva, Elena N. Ilina, Maja V. Malakhova, Alessandra Carattoli, Ilya S. Azizov, Dmitry V. Tapalski, Roman S. Kozlov, Mikhail V. Edelstein
Antimicrob Agents Chemother. Sep 2014; 58(9): 5202–5210. doi: 10.1128/AAC.02506-14
PMCID:
PMC4135874
Mathematical Model To Quantify the Effects of Risk Factors on Carbapenem-Resistant Acinetobacter baumannii
Michelle W. Tan, David C. Lye, Tat-Ming Ng, Michael Nikolaou, Vincent H. Tam
Antimicrob Agents Chemother. Sep 2014; 58(9): 5239–5244. doi: 10.1128/AAC.02791-14
PMCID:
PMC4135838
High Prevalence of blaCTX-M-1/IncI1/ST3 and blaCMY-2/IncI1/ST2 Plasmids in Healthy Urban Dogs in France
Marisa Haenni, Estelle Saras, Véronique Métayer, Christine Médaille, Jean-Yves Madec
Antimicrob Agents Chemother. Sep 2014; 58(9): 5358–5362. doi: 10.1128/AAC.02545-14
PMCID:
PMC4135814
Clinical and Molecular Characteristics of Emerging Hypervirulent Klebsiella pneumoniae Bloodstream Infections in Mainland China
Ying Mei Liu, Bin Bin Li, Yu Yu Zhang, Wu Zhang, Hong Shen, Hui Li, Bin Cao
Antimicrob Agents Chemother. Sep 2014; 58(9): 5379–5385. doi: 10.1128/AAC.02523-14
PMCID:
PMC4135864
Emergence of Multidrug-Resistant Campylobacter Species Isolates with a Horizontally Acquired rRNA Methylase
Yang Wang, Maojun Zhang, Fengru Deng, Zhangqi Shen, Congming Wu, Jianzhong Zhang, Qijing Zhang, Jianzhong Shen
Antimicrob Agents Chemother. Sep 2014; 58(9): 5405–5412. doi: 10.1128/AAC.03039-14
PMCID:
PMC4135855
Impact of Third-Generation-Cephalosporin Administration in Hatcheries on Fecal Escherichia coli Antimicrobial Resistance in Broilers and Layers
Sandrine Baron, Eric Jouy, Emeline Larvor, Florent Eono, Stéphanie Bougeard, Isabelle Kempf
Antimicrob Agents Chemother. Sep 2014; 58(9): 5428–5434. doi: 10.1128/AAC.03106-14
PMCID:
PMC4135878
Frequency of Outpatient Antibiotic Prescription on Discharge to Hospice Care
Jon P. Furuno, Brie N. Noble, Kristi N. Horne, Jessina C. McGregor, Miriam R. Elman, David T. Bearden, Eric W. Walsh, Erik K. Fromme
Antimicrob Agents Chemother. Sep 2014; 58(9): 5473–5477. doi: 10.1128/AAC.02873-14
PMCID:
PMC4135830
NDM-5 Carbapenemase-Encoding Gene in Multidrug-Resistant Clinical Isolates of Escherichia coli from Algeria
Asma Sassi, Lotfi Loucif, Sushim Kumar Gupta, Mazouz Dekhil, Houria Chettibi, Jean-Marc Rolain
Antimicrob Agents Chemother. Sep 2014; 58(9): 5606–5608. doi: 10.1128/AAC.02818-13
PMCID:
PMC4135848

Experimental Therapeutics

Kelli L. Kuhen, Arnab K. Chatterjee, Matthias Rottmann, Kerstin Gagaring, Rachel Borboa, Jennifer Buenviaje, Zhong Chen, Carolyn Francek, Tao Wu, Advait Nagle, S. Whitney Barnes, David Plouffe, Marcus C. S. Lee, David A. Fidock, Wouter Graumans, Marga van de Vegte-Bolmer, Geert J. van Gemert, Grennady Wirjanata, Boni Sebayang, Jutta Marfurt, Bruce Russell, Rossarin Suwanarusk, Ric N. Price, Francois Nosten, Anchalee Tungtaeng, Montip Gettayacamin, Jetsumon Sattabongkot, Jennifer Taylor, John R. Walker, David Tully, Kailash P. Patra, Erika L. Flannery, Joseph M. Vinetz, Laurent Renia, Robert W. Sauerwein, Elizabeth A. Winzeler, Richard J. Glynne, Thierry T. Diagana
Antimicrob Agents Chemother. Sep 2014; 58(9): 5060–5067. doi: 10.1128/AAC.02727-13
PMCID:
PMC4135840
Efficacy of Fosfomycin Compared to Vancomycin in Treatment of Implant-Associated Chronic Methicillin-Resistant Staphylococcus aureus Osteomyelitis in Rats
Wolfgang Poeppl, Tilman Lingscheid, Dominik Bernitzky, Uwe Y. Schwarze, Oliver Donath, Thomas Perkmann, Nicolas Kozakowski, Roberto Plasenzotti, Gottfried Reznicek, Heinz Burgmann
Antimicrob Agents Chemother. Sep 2014; 58(9): 5111–5116. doi: 10.1128/AAC.02720-13
PMCID:
PMC4135863
In Vitro and In Vivo Effects of Tamoxifen against Larval Stage Echinococcus granulosus
María Celeste Nicolao, María Celina Elissondo, Guillermo M. Denegri, Alejandra B. Goya, Andrea C. Cumino
Antimicrob Agents Chemother. Sep 2014; 58(9): 5146–5154. doi: 10.1128/AAC.02113-13
PMCID:
PMC4135819
Xiao Wei Tan, Tze Wei Goh, P. Saraswathi, Chan Lwin Nyein, Melina Setiawan, Andri Riau, R. Lakshminarayanan, Shouping Liu, Donald Tan, Roger W. Beuerman, Jodhbir S. Mehta
Antimicrob Agents Chemother. Sep 2014; 58(9): 5229–5238. doi: 10.1128/AAC.02859-14
PMCID:
PMC4135834
Structural Insights into and Activity Analysis of the Antimicrobial Peptide Myxinidin
Marco Cantisani, Emiliana Finamore, Eleonora Mignogna, Annarita Falanga, Giovanni Francesco Nicoletti, Carlo Pedone, Giancarlo Morelli, Marilisa Leone, Massimiliano Galdiero, Stefania Galdiero
Antimicrob Agents Chemother. Sep 2014; 58(9): 5280–5290. doi: 10.1128/AAC.02395-14
PMCID:
PMC4135842
Bactericidal Activity, Absence of Serum Effect, and Time-Kill Kinetics of Ceftazidime-Avibactam against β-Lactamase-Producing Enterobacteriaceae and Pseudomonas aeruginosa
Tiffany R. Keepers, Marcela Gomez, Chris Celeri, Wright W. Nichols, Kevin M. Krause
Antimicrob Agents Chemother. Sep 2014; 58(9): 5297–5305. doi: 10.1128/AAC.02894-14
PMCID:
PMC4135815
Monalisa Chatterji, Radha Shandil, M. R. Manjunatha, Suresh Solapure, Vasanthi Ramachandran, Naveen Kumar, Ramanatha Saralaya, Vijender Panduga, Jitendar Reddy, Prabhakar KR, Sreevalli Sharma, Claire Sadler, Christopher B. Cooper, Khisi Mdluli, Pravin S. Iyer, Shridhar Narayanan, Pravin S. Shirude
Antimicrob Agents Chemother. Sep 2014; 58(9): 5325–5331. doi: 10.1128/AAC.03233-14
PMCID:
PMC4135869
A Broad-Spectrum Antibiofilm Peptide Enhances Antibiotic Action against Bacterial Biofilms
Fany Reffuveille, César de la Fuente-Núñez, Sarah Mansour, Robert E. W. Hancock
Antimicrob Agents Chemother. Sep 2014; 58(9): 5363–5371. doi: 10.1128/AAC.03163-14
PMCID:
PMC4135845
Derivatives of the Mouse Cathelicidin-Related Antimicrobial Peptide (CRAMP) Inhibit Fungal and Bacterial Biofilm Formation
Katrijn De Brucker, Nicolas Delattin, Stijn Robijns, Hans Steenackers, Natalie Verstraeten, Bart Landuyt, Walter Luyten, Liliane Schoofs, Barbara Dovgan, Mirjam Fröhlich, Jan Michiels, Jos Vanderleyden, Bruno P. A. Cammue, Karin Thevissen
Antimicrob Agents Chemother. Sep 2014; 58(9): 5395–5404. doi: 10.1128/AAC.03045-14
PMCID:
PMC4135870
Maternal Intravenous Treatment with either Azithromycin or Solithromycin Clears Ureaplasma parvum from the Amniotic Fluid in an Ovine Model of Intrauterine Infection
Yuichiro Miura, Matthew S. Payne, Jeffrey A. Keelan, Andres Noe, Sean Carter, Rory Watts, Owen B. Spiller, Alan H. Jobe, Suhas G. Kallapur, Masatoshi Saito, Sarah J. Stock, John P. Newnham, Matthew W. Kemp
Antimicrob Agents Chemother. Sep 2014; 58(9): 5413–5420. doi: 10.1128/AAC.03187-14
PMCID:
PMC4135857
N-Terminally Modified Linear and Branched Spermine Backbone Dipeptidomimetics against Planktonic and Sessile Methicillin-Resistant Staphylococcus aureus
Rikeshwer Prasad Dewangan, Seema Joshi, Shalini Kumari, Hemlata Gautam, Mohammed Shahar Yar, Santosh Pasha
Antimicrob Agents Chemother. Sep 2014; 58(9): 5435–5447. doi: 10.1128/AAC.03391-14
PMCID:
PMC4135887
Activity of Praziquantel Enantiomers and Main Metabolites against Schistosoma mansoni
Isabel Meister, Katrin Ingram-Sieber, Noemi Cowan, Matthew Todd, Murray N. Robertson, Claudia Meli, Malay Patra, Gilles Gasser, Jennifer Keiser
Antimicrob Agents Chemother. Sep 2014; 58(9): 5466–5472. doi: 10.1128/AAC.02741-14
PMCID:
PMC4135865
Efficacy of Liposome-Encapsulated Ciprofloxacin in a Murine Model of Q Fever
I. H. Norville, G. J. Hatch, K. R. Bewley, D. J. Atkinson, K. A. Hamblin, J. D. Blanchard, S. J. Armstrong, J. K. Pitman, E. Rayner, G. Hall, J. Vipond, T. P. Atkins
Antimicrob Agents Chemother. Sep 2014; 58(9): 5510–5518. doi: 10.1128/AAC.03443-14
PMCID:
PMC4135868
Sterilizing Activity of Thioridazine in Combination with the First-Line Regimen against Acute Murine Tuberculosis
Noton K. Dutta, Michael L. Pinn, Petros C. Karakousis
Antimicrob Agents Chemother. Sep 2014; 58(9): 5567–5569. doi: 10.1128/AAC.03408-14
PMCID:
PMC4135856
Comparative Efficacies of Cloxacillin-Daptomycin and the Standard Cloxacillin-Rifampin Therapies against an Experimental Foreign-Body Infection by Methicillin-Susceptible Staphylococcus aureus
Cristina El Haj, Oscar Murillo, Alba Ribera, Mireia Vivas, Dolors Garcia-Somoza, Fe Tubau, Javier Cabo, Javier Ariza
Antimicrob Agents Chemother. Sep 2014; 58(9): 5576–5580. doi: 10.1128/AAC.02681-14
PMCID:
PMC4135877

Clinical Therapeutics

Antibiotics for Treatment of Clostridium difficile Infection in Hospitalized Patients with Inflammatory Bowel Disease
Henry A. Horton, Seper Dezfoli, Dror Berel, Julianna Hirsch, Andrew Ippoliti, Dermot McGovern, Manreet Kaur, David Shih, Marla Dubinsky, Stephan R. Targan, Phillip Fleshner, Eric A. Vasiliauskas, Jonathan Grein, Rekha Murthy, Gil Y. Melmed
Antimicrob Agents Chemother. Sep 2014; 58(9): 5054–5059. doi: 10.1128/AAC.02606-13
PMCID:
PMC4135854
Comparison of Cefazolin versus Oxacillin for Treatment of Complicated Bacteremia Caused by Methicillin-Susceptible Staphylococcus aureus
Julius Li, Kelly L. Echevarria, Darrel W. Hughes, Jose A. Cadena, Jason E. Bowling, James S. Lewis, II
Antimicrob Agents Chemother. Sep 2014; 58(9): 5117–5124. doi: 10.1128/AAC.02800-14
PMCID:
PMC4135867
Epidemiology and Predictors of Multidrug-Resistant Community-Acquired and Health Care-Associated Pneumonia
Alan E. Gross, Trevor C. Van Schooneveld, Keith M. Olsen, Mark E. Rupp, Thu Hong Bui, Elsie Forsung, Andre C. Kalil
Antimicrob Agents Chemother. Sep 2014; 58(9): 5262–5268. doi: 10.1128/AAC.02582-14
PMCID:
PMC4135885
Prevention of Transmission of Multidrug-Resistant Organisms during Catheter Exchange using Antimicrobial Catheters
Mohamed A. Jamal, Joel Rosenblatt, Ying Jiang, Ray Hachem, Ann-Marie Chaftari, Issam I. Raad
Antimicrob Agents Chemother. Sep 2014; 58(9): 5291–5296. doi: 10.1128/AAC.02886-14
PMCID:
PMC4135861
Population Pharmacokinetics of Bedaquiline (TMC207), a Novel Antituberculosis Drug
Sarah C. McLeay, Peter Vis, Rolf P. G. van Heeswijk, Bruce Green
Antimicrob Agents Chemother. Sep 2014; 58(9): 5315–5324. doi: 10.1128/AAC.01418-13
PMCID:
PMC4135833
Multicenter, Double-Blind, Randomized, Phase II Trial To Assess the Safety and Efficacy of Ceftolozane-Tazobactam plus Metronidazole Compared with Meropenem in Adult Patients with Complicated Intra-Abdominal Infections
Christopher Lucasti, Ellie Hershberger, Benjamin Miller, Sara Yankelev, Judith Steenbergen, Ian Friedland, Joseph Solomkin
Antimicrob Agents Chemother. Sep 2014; 58(9): 5350–5357. doi: 10.1128/AAC.00049-14
PMCID:
PMC4135839
M. A. Onyamboko, C. I. Fanello, K. Wongsaen, J. Tarning, P. Y. Cheah, K. A. Tshefu, A. M. Dondorp, F. Nosten, N. J. White, N. P. J. Day
Antimicrob Agents Chemother. Sep 2014; 58(9): 5528–5536. doi: 10.1128/AAC.02682-14
PMCID:
PMC4135835
Preliminary Study of Colistin versus Colistin plus Fosfomycin for Treatment of Carbapenem-Resistant Acinetobacter baumannii Infections
Rujipas Sirijatuphat, Visanu Thamlikitkul
Antimicrob Agents Chemother. Sep 2014; 58(9): 5598–5601. doi: 10.1128/AAC.02435-13
PMCID:
PMC4135862
Monitoring of Trough Plasma Ganciclovir Levels and Peripheral Blood Cytomegalovirus (CMV)-Specific CD8+ T Cells To Predict CMV DNAemia Clearance in Preemptively Treated Allogeneic Stem Cell Transplant Recipients
Estela Giménez, Carlos Solano, José Ramón Azanza, Paula Amat, David Navarro
Antimicrob Agents Chemother. Sep 2014; 58(9): 5602–5605. doi: 10.1128/AAC.02953-14
PMCID:
PMC4135831

Pharmacology

Evaluation of the Pharmacokinetics and Pharmacodynamics of Liposomal Amikacin for Inhalation in Cystic Fibrosis Patients with Chronic Pseudomonal Infections Using Data from Two Phase 2 Clinical Studies
Olanrewaju O. Okusanya, Sujata M. Bhavnani, Jeffrey P. Hammel, Alan Forrest, Catharine C. Bulik, Paul G. Ambrose, Renu Gupta
Antimicrob Agents Chemother. Sep 2014; 58(9): 5005–5015. doi: 10.1128/AAC.02421-13
PMCID:
PMC4135881
Metabolic Drug-Drug Interaction Potential of Macrolactin A and 7-O-Succinyl Macrolactin A Assessed by Evaluating Cytochrome P450 Inhibition and Induction and UDP-Glucuronosyltransferase Inhibition In Vitro
Soo Hyeon Bae, Min Jo Kwon, Jung Bae Park, Doyun Kim, Dong-Hee Kim, Jae-Seon Kang, Chun-Gyu Kim, Euichaul Oh, Soo Kyung Bae
Antimicrob Agents Chemother. Sep 2014; 58(9): 5036–5046. doi: 10.1128/AAC.00018-14
PMCID:
PMC4135859
Safety and Pharmacokinetics of XOMA 3AB, a Novel Mixture of Three Monoclonal Antibodies against Botulinum Toxin A
S. U. Nayak, J. M. Griffiss, R. McKenzie, E. J. Fuchs, R. A. Jurao, A. T. An, A. Ahene, M. Tomic, C. W. Hendrix, J. M. Zenilman
Antimicrob Agents Chemother. Sep 2014; 58(9): 5047–5053. doi: 10.1128/AAC.02830-14
PMCID:
PMC4135817
Pharmacokinetics and Preliminary Safety Study of Pod-Intravaginal Rings Delivering Antiretroviral Combinations for HIV Prophylaxis in a Macaque Model
John A. Moss, Priya Srinivasan, Thomas J. Smith, Irina Butkyavichene, Gilbert Lopez, Amanda A. Brooks, Amy Martin, Chuong T. Dinh, James M. Smith, Marc M. Baum
Antimicrob Agents Chemother. Sep 2014; 58(9): 5125–5135. doi: 10.1128/AAC.02871-14
PMCID:
PMC4135875
Phase I Safety, Pharmacokinetics, and Pharmacogenetics Study of the Antituberculosis Drug PA-824 with Concomitant Lopinavir-Ritonavir, Efavirenz, or Rifampin
Kelly E. Dooley, Anne F. Luetkemeyer, Jeong-Gun Park, Reena Allen, Yoninah Cramer, Stephen Murray, Deborah Sutherland, Francesca Aweeka, Susan L. Koletar, Florence Marzan, Jing Bao, Rada Savic, David W. Haas
Antimicrob Agents Chemother. Sep 2014; 58(9): 5245–5252. doi: 10.1128/AAC.03332-14
PMCID:
PMC4135849
Defining Daptomycin Resistance Prevention Exposures in Vancomycin-Resistant Enterococcus faecium and E. faecalis
B. J. Werth, M. E. Steed, C. E. Ireland, T. T. Tran, P. Nonejuie, B. E. Murray, W. E. Rose, G. Sakoulas, J. Pogliano, C. A. Arias, M. J. Rybak
Antimicrob Agents Chemother. Sep 2014; 58(9): 5253–5261. doi: 10.1128/AAC.00098-14
PMCID:
PMC4135850
High-Dose Continuous Oxacillin Infusion Results in Achievement of Pharmacokinetics Targets in Critically Ill Patients with Deep Sternal Wound Infections following Cardiac Surgery
Nicolas Nesseler, Marie-Clémence Verdier, Yoann Launey, Alexandre Malherbe, Marine Dermu, Caroline Piau, Erwan Flécher, Olivier Tribut, Yannick Mallédant, Philippe Seguin
Antimicrob Agents Chemother. Sep 2014; 58(9): 5448–5455. doi: 10.1128/AAC.02624-14
PMCID:
PMC4135832

Letters to the Editor

Genetic Environment of the lnu(B) Gene in a Streptococcus agalactiae Clinical Isolate
A. Montilla, A. Zavala, R. Cáceres Cáceres, R. Cittadini, C. Vay, G. Gutkind, A. Famiglietti, L. Bonofiglio, M. Mollerach
Antimicrob Agents Chemother. Sep 2014; 58(9): 5636–5637. doi: 10.1128/AAC.02630-14
PMCID:
PMC4135823
Clonal Diversity of Escherichia coli Isolates Carrying Plasmid-Mediated Fosfomycin Resistance Gene fosA3 from Livestock and Other Animals
Jane Chan, Wai-U Lo, Kin-Hung Chow, Eileen L. Lai, Pierra Y. Law, Pak-Leung Ho
Antimicrob Agents Chemother. Sep 2014; 58(9): 5638–5639. doi: 10.1128/AAC.02700-14
PMCID:
PMC4135827
HIV-1 Clinical Isolates with the E138A Substitution in Reverse Transcriptase Show Full Susceptibility to Emtricitabine and Other Nucleoside Reverse Transcriptase Inhibitors
Danielle P. Porter, Rima Kulkarni, Kirsten L. White
Antimicrob Agents Chemother. Sep 2014; 58(9): 5640–5641. doi: 10.1128/AAC.03173-14
PMCID:
PMC4135858

Masthead

Editorial Board
Antimicrob Agents Chemother. Sep 2014; 58(9): A3. doi: 10.1128/AAC.masthead.58-9
PMCID:
PMC4135810

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)