Logo of aacJournal InfoAuthorsReviewersSubscribersPermissionsJournals.ASM.orgJournalAAC ArticleJournal InfoAuthorsReviewers

Volume 58(10);  October 2014

Articles from this journal are usually available in PMC after a 6-month delay (embargo). Some articles may be available sooner.

Minireview

Improving the Role and Contribution of Pharmacokinetic Analyses in Antimalarial Drug Clinical Trials
Katherine Kay, Eva Maria Hodel, Ian M. Hastings
Antimicrob Agents Chemother. Oct 2014; 58(10): 5643–5649. doi: 10.1128/AAC.02777-14
PMCID:
PMC4187976

Chemistry; Biosynthesis

Overproduction of Ristomycin A by Activation of a Silent Gene Cluster in Amycolatopsis japonicum MG417-CF17
Marius Spohn, Norbert Kirchner, Andreas Kulik, Angelika Jochim, Felix Wolf, Patrick Muenzer, Oliver Borst, Harald Gross, Wolfgang Wohlleben, Evi Stegmann
Antimicrob Agents Chemother. Oct 2014; 58(10): 6185–6196. doi: 10.1128/AAC.03512-14
PMCID:
PMC4187939

Mechanisms of Action: Physiological Effects

Microscopic and Spectroscopic Analyses of Chlorhexidine Tolerance in Delftia acidovorans Biofilms
Tara Rema, John R. Lawrence, James J. Dynes, Adam P. Hitchcock, Darren R. Korber
Antimicrob Agents Chemother. Oct 2014; 58(10): 5673–5686. doi: 10.1128/AAC.02984-14
PMCID:
PMC4187954
Statins Increase Rifampin Mycobactericidal Effect
Lívia Silva Lobato, Patrícia Sammarco Rosa, Jessica da Silva Ferreira, Arthur da Silva Neumann, Marlei Gomes da Silva, Dejair Caitano do Nascimento, Cleverson Teixeira Soares, Silvia Cristina Barbosa Pedrini, Diego Sá Leal de Oliveira, Cláudia Peres Monteiro, Geraldo Moura Batista Pereira, Marcelo Ribeiro-Alves, Mariana Andrea Hacker, Milton Ozório Moraes, Maria Cristina Vidal Pessolani, Rafael Silva Duarte, Flávio Alves Lara
Antimicrob Agents Chemother. Oct 2014; 58(10): 5766–5774. doi: 10.1128/AAC.01826-13
PMCID:
PMC4187984
Claudia M. Hemsley, Jamie X. Luo, Clio A. Andreae, Clive S. Butler, Orkun S. Soyer, Richard W. Titball
Antimicrob Agents Chemother. Oct 2014; 58(10): 5775–5783. doi: 10.1128/AAC.02793-14
PMCID:
PMC4187911
Induction of Mitochondrial Dysfunction and Oxidative Stress in Leishmania donovani by Orally Active Clerodane Diterpene
Manoj Kathuria, Arindam Bhattacharjee, Koneni V. Sashidhara, Suriya Pratap Singh, Kalyan Mitra
Antimicrob Agents Chemother. Oct 2014; 58(10): 5916–5928. doi: 10.1128/AAC.02459-14
PMCID:
PMC4187897
Interaction of Interferon Gamma-Induced Reactive Oxygen Species with Ceftazidime Leads to Synergistic Killing of Intracellular Burkholderia pseudomallei
Kara Mosovsky, Ediane Silva, Ryan Troyer, Katie Propst-Graham, Steven Dow
Antimicrob Agents Chemother. Oct 2014; 58(10): 5954–5963. doi: 10.1128/AAC.02781-14
PMCID:
PMC4187985
Pivotal Role for a Tail Subunit of the RNA Polymerase II Mediator Complex CgMed2 in Azole Tolerance and Adherence in Candida glabrata
Sapan Borah, Raju Shivarathri, Vivek Kumar Srivastava, Sélène Ferrari, Dominique Sanglard, Rupinder Kaur
Antimicrob Agents Chemother. Oct 2014; 58(10): 5976–5986. doi: 10.1128/AAC.02786-14
PMCID:
PMC4187919
UDP-N-Acetylmuramic Acid l-Alanine Ligase (MurC) Inhibition in a tolC Mutant Escherichia coli Strain Leads to Cell Death
Vaishali Humnabadkar, K. R. Prabhakar, Ashwini Narayan, Sreevalli Sharma, Supreeth Guptha, Praveena Manjrekar, Murugan Chinnapattu, Vasanthi Ramachandran, Shahul P. Hameed, Sudha Ravishankar, Monalisa Chatterji
Antimicrob Agents Chemother. Oct 2014; 58(10): 6165–6171. doi: 10.1128/AAC.02890-14
PMCID:
PMC4187968
Molecular Mechanism of MBX2319 Inhibition of Escherichia coli AcrB Multidrug Efflux Pump and Comparison with Other Inhibitors
Attilio V. Vargiu, Paolo Ruggerone, Timothy J. Opperman, Son T. Nguyen, Hiroshi Nikaido
Antimicrob Agents Chemother. Oct 2014; 58(10): 6224–6234. doi: 10.1128/AAC.03283-14
PMCID:
PMC4187987
Drug Target Identification Using a Trypanosome Overexpression Library
Daniela Begolo, Esteban Erben, Christine Clayton
Antimicrob Agents Chemother. Oct 2014; 58(10): 6260–6264. doi: 10.1128/AAC.03338-14
PMCID:
PMC4187942

Mechanisms of Resistance

Antibiotic Resistance Mechanisms Inform Discovery: Identification and Characterization of a Novel Amycolatopsis Strain Producing Ristocetin
Andrew W. Truman, Min Jung Kwun, Jinhua Cheng, Seung Hwan Yang, Joo-Won Suh, Hee-Jeon Hong
Antimicrob Agents Chemother. Oct 2014; 58(10): 5687–5695. doi: 10.1128/AAC.03349-14
PMCID:
PMC4187901
MgrB Inactivation Is a Common Mechanism of Colistin Resistance in KPC-Producing Klebsiella pneumoniae of Clinical Origin
Antonio Cannatelli, Tommaso Giani, Marco Maria D'Andrea, Vincenzo Di Pilato, Fabio Arena, Viola Conte, Kyriaki Tryfinopoulou, Alkiviadis Vatopoulos, Gian Maria Rossolini
Antimicrob Agents Chemother. Oct 2014; 58(10): 5696–5703. doi: 10.1128/AAC.03110-14
PMCID:
PMC4187966
Ceftaroline Is Active against Heteroresistant Methicillin-Resistant Staphylococcus aureus Clinical Strains despite Associated Mutational Mechanisms and Intermediate Levels of Resistance
Regina Fernandez, Liliana I. Paz, Roberto R. Rosato, Adriana E. Rosato
Antimicrob Agents Chemother. Oct 2014; 58(10): 5736–5746. doi: 10.1128/AAC.03019-14
PMCID:
PMC4187932
Mutations in mmpL and in the Cell Wall Stress Stimulon Contribute to Resistance to Oxadiazole Antibiotics in Methicillin-Resistant Staphylococcus aureus
Qiaobin Xiao, Sergei Vakulenko, Mayland Chang, Shahriar Mobashery
Antimicrob Agents Chemother. Oct 2014; 58(10): 5841–5847. doi: 10.1128/AAC.03501-14
PMCID:
PMC4187926
Tn5253 Family Integrative and Conjugative Elements Carrying mef(I) and catQ Determinants in Streptococcus pneumoniae and Streptococcus pyogenes
Marina Mingoia, Eleonora Morici, Gianluca Morroni, Eleonora Giovanetti, Maria Del Grosso, Annalisa Pantosti, Pietro E. Varaldo
Antimicrob Agents Chemother. Oct 2014; 58(10): 5886–5893. doi: 10.1128/AAC.03638-14
PMCID:
PMC4187955
Reduced In Vitro Doxycycline Susceptibility in Plasmodium falciparum Field Isolates from Kenya Is Associated with PfTetQ KYNNNN Sequence Polymorphism
Angela O. Achieng, Luiser A. Ingasia, Dennis W. Juma, Agnes C. Cheruiyot, Charles A. Okudo, Redemptah A. Yeda, Jelagat Cheruiyot, Hoseah M. Akala, Jacob Johnson, Ben Andangalu, Fredrick Eyase, Walter G. Z. O. Jura, Edwin Kamau
Antimicrob Agents Chemother. Oct 2014; 58(10): 5894–5899. doi: 10.1128/AAC.02788-13
PMCID:
PMC4187988
Double Mutation in the pfmdr1 Gene Is Associated with Emergence of Chloroquine-Resistant Plasmodium falciparum Malaria in Eastern India
Sabyasachi Das, Santanu Kar Mahapatra, Satyajit Tripathy, Sourav Chattopadhyay, Sandeep Kumar Dash, Debasis Mandal, Balaram Das, Amiya Kumar Hati, Somenath Roy
Antimicrob Agents Chemother. Oct 2014; 58(10): 5909–5915. doi: 10.1128/AAC.02762-14
PMCID:
PMC4187921
Extensively Drug-Resistant Pseudomonas aeruginosa Isolates Containing blaVIM-2 and Elements of Salmonella Genomic Island 2: a New Genetic Resistance Determinant in Northeast Ohio
Federico Perez, Andrea M. Hujer, Steven H. Marshall, Amy J. Ray, Philip N. Rather, Nuntra Suwantarat, Donald Dumford, III, Patrick O'Shea, T. Nicholas J. Domitrovic, Robert A. Salata, Kalyan D. Chavda, Liang Chen, Barry N. Kreiswirth, Alejandro J. Vila, Susanne Haussler, Michael R. Jacobs, Robert A. Bonomo
Antimicrob Agents Chemother. Oct 2014; 58(10): 5929–5935. doi: 10.1128/AAC.02372-14
PMCID:
PMC4187935
Whole-Genome Assembly of Klebsiella pneumoniae Coproducing NDM-1 and OXA-232 Carbapenemases Using Single-Molecule, Real-Time Sequencing
Yohei Doi, Tracy H. Hazen, Matthew Boitano, Yu-Chih Tsai, Tyson A. Clark, Jonas Korlach, David A. Rasko
Antimicrob Agents Chemother. Oct 2014; 58(10): 5947–5953. doi: 10.1128/AAC.03180-14
PMCID:
PMC4187971
Sigma S-Dependent Antioxidant Defense Protects Stationary-Phase Escherichia coli against the Bactericidal Antibiotic Gentamicin
Jing-Hung Wang, Rachna Singh, Michael Benoit, Mimi Keyhan, Matthew Sylvester, Michael Hsieh, Anuradha Thathireddy, Yi-Ju Hsieh, A. C. Matin
Antimicrob Agents Chemother. Oct 2014; 58(10): 5964–5975. doi: 10.1128/AAC.03683-14
PMCID:
PMC4187989
Crystal Structure of the Extended-Spectrum β-Lactamase PER-2 and Insights into the Role of Specific Residues in the Interaction with β-Lactams and β-Lactamase Inhibitors
Melina Ruggiero, Frédéric Kerff, Raphaël Herman, Frédéric Sapunaric, Moreno Galleni, Gabriel Gutkind, Paulette Charlier, Eric Sauvage, Pablo Power
Antimicrob Agents Chemother. Oct 2014; 58(10): 5994–6002. doi: 10.1128/AAC.00089-14
PMCID:
PMC4187900
An Upstream Truncation of the furA-katG Operon Confers High-Level Isoniazid Resistance in a Mycobacterium tuberculosis Clinical Isolate with No Known Resistance-Associated Mutations
Gilman Kit Hang Siu, Wing Cheong Yam, Ying Zhang, Richard Y. T. Kao
Antimicrob Agents Chemother. Oct 2014; 58(10): 6093–6100. doi: 10.1128/AAC.03277-14
PMCID:
PMC4187958
The Novel Macrolide-Lincosamide-Streptogramin B Resistance Gene erm(44) Is Associated with a Prophage in Staphylococcus xylosus
Juliette R. K. Wipf, Sybille Schwendener, Vincent Perreten
Antimicrob Agents Chemother. Oct 2014; 58(10): 6133–6138. doi: 10.1128/AAC.02949-14
PMCID:
PMC4187952
IS5 Element Integration, a Novel Mechanism for Rapid In Vivo Emergence of Tigecycline Nonsusceptibility in Klebsiella pneumoniae
Lindsey E. Nielsen, Erik C. Snesrud, Fatma Onmus-Leone, Yoon I. Kwak, Ricardo Avilés, Eric D. Steele, Deena E. Sutter, Paige E. Waterman, Emil P. Lesho
Antimicrob Agents Chemother. Oct 2014; 58(10): 6151–6156. doi: 10.1128/AAC.03053-14
PMCID:
PMC4187979
Inhibition of Cyclooxygenase-1 and Cyclooxygenase-2 Impairs Trypanosoma cruzi Entry into Cardiac Cells and Promotes Differential Modulation of the Inflammatory Response
Aparecida D. Malvezi, Carolina Panis, Rosiane V. da Silva, Rafael Carvalho de Freitas, Maria I. Lovo-Martins, Vera L. H. Tatakihara, Nágela G. Zanluqui, Edecio Cunha Neto, Samuel Goldenberg, Juliano Bordignon, Sueli F. Yamada-Ogatta, Marli C. Martins-Pinge, Rubens Cecchini, Phileno Pinge-Filho
Antimicrob Agents Chemother. Oct 2014; 58(10): 6157–6164. doi: 10.1128/AAC.02752-14
PMCID:
PMC4187892
Ascorbate Peroxidase, a Key Molecule Regulating Amphotericin B Resistance in Clinical Isolates of Leishmania donovani
Ashish Kumar, Sushmita Das, Bidyut Purkait, Abul Hasan Sardar, Ayan Kumar Ghosh, Manas Ranjan Dikhit, Kumar Abhishek, Pradeep Das
Antimicrob Agents Chemother. Oct 2014; 58(10): 6172–6184. doi: 10.1128/AAC.02834-14
PMCID:
PMC4187981
Deletion Mutations Conferring Substrate Spectrum Extension in the Class A β-Lactamase
Junghyun Hwang, Kwang-Hwi Cho, Han Song, Hyojeong Yi, Heenam Stanley Kim
Antimicrob Agents Chemother. Oct 2014; 58(10): 6265–6269. doi: 10.1128/AAC.02648-14
PMCID:
PMC4187959
Kinetic Study of the Effect of Histidines 240 and 164 on TEM-149 Enzyme Probed by β-Lactam Inhibitors
Mariagrazia Perilli, Alisia Mancini, Giuseppe Celenza, Carlo Bottoni, Pierangelo Bellio, Alessia Sabatini, Letizia Di Pietro, Fabrizia Brisdelli, Bernardetta Segatore, Gianfranco Amicosante
Antimicrob Agents Chemother. Oct 2014; 58(10): 6294–6296. doi: 10.1128/AAC.02950-14
PMCID:
PMC4187899
NDM-12, a Novel New Delhi Metallo-β-Lactamase Variant from a Carbapenem-Resistant Escherichia coli Clinical Isolate in Nepal
Tatsuya Tada, Basudha Shrestha, Tohru Miyoshi-Akiyama, Kayo Shimada, Hiroshi Ohara, Teruo Kirikae, Bharat M. Pokhrel
Antimicrob Agents Chemother. Oct 2014; 58(10): 6302–6305. doi: 10.1128/AAC.03355-14
PMCID:
PMC4187903
The Activity of Glycopeptide Antibiotics against Resistant Bacteria Correlates with Their Ability To Induce the Resistance System
Min Jung Kwun, Hee-Jeon Hong
Antimicrob Agents Chemother. Oct 2014; 58(10): 6306–6310. doi: 10.1128/AAC.03668-14
PMCID:
PMC4187914
Identification of a Novel 6′-N-Aminoglycoside Acetyltransferase, AAC(6′)-Iak, from a Multidrug-Resistant Clinical Isolate of Stenotrophomonas maltophilia
Tatsuya Tada, Tohru Miyoshi-Akiyama, Rajan K. Dahal, Shyam K. Mishra, Kayo Shimada, Hiroshi Ohara, Teruo Kirikae, Bharat M. Pokhrel
Antimicrob Agents Chemother. Oct 2014; 58(10): 6324–6327. doi: 10.1128/AAC.03354-14
PMCID:
PMC4187913
Resistome Analysis of Enterobacter cloacae CY01, an Extensively Drug-Resistant Strain Producing VIM-1 Metallo-β-Lactamase from China
Ling Yang, Ai-Wu Wu, Dan-Hong Su, Yong-Ping Lin, Ding-Qiang Chen, Yu-Rong Qiu
Antimicrob Agents Chemother. Oct 2014; 58(10): 6328–6330. doi: 10.1128/AAC.03060-14
PMCID:
PMC4187898

Susceptibility

Synergistic Effects of Antimicrobial Peptides and Antibiotics against Clostridium difficile
Sabine Nuding, Tina Frasch, Martin Schaller, Eduard F. Stange, Lutz T. Zabel
Antimicrob Agents Chemother. Oct 2014; 58(10): 5719–5725. doi: 10.1128/AAC.02542-14
PMCID:
PMC4187972
Time-Kill Assay and Etest Evaluation for Synergy with Polymyxin B and Fluconazole against Candida glabrata
George Pankey, Deborah Ashcraft, Heather Kahn, Abdulrahim Ismail
Antimicrob Agents Chemother. Oct 2014; 58(10): 5795–5800. doi: 10.1128/AAC.03035-14
PMCID:
PMC4187950
Simple and Rapid Method To Determine Antimycobacterial Potency of Compounds by Using Autoluminescent Mycobacterium tuberculosis
Sreevalli Sharma, Ekaterina Gelman, Chandan Narayan, Deepa Bhattacharjee, Vijayashree Achar, Vaishali Humnabadkar, V. Balasubramanian, Vasanthi Ramachandran, Neeraj Dhar, Neela Dinesh
Antimicrob Agents Chemother. Oct 2014; 58(10): 5801–5808. doi: 10.1128/AAC.03205-14
PMCID:
PMC4187967
Sarah Forbes, Curtis B. Dobson, Gavin J. Humphreys, Andrew J. McBain
Antimicrob Agents Chemother. Oct 2014; 58(10): 5809–5817. doi: 10.1128/AAC.03364-14
PMCID:
PMC4187928
Synergy of Silver Nanoparticles and Aztreonam against Pseudomonas aeruginosa PAO1 Biofilms
Marc B. Habash, Amber J. Park, Emily C. Vis, Robert J. Harris, Cezar M. Khursigara
Antimicrob Agents Chemother. Oct 2014; 58(10): 5818–5830. doi: 10.1128/AAC.03170-14
PMCID:
PMC4187931
Charlotte A. Lanteri, Suwanna Chaorattanakawee, Chanthap Lon, David L. Saunders, Wiriya Rutvisuttinunt, Kritsanai Yingyuen, Ian Bathurst, Xavier C. Ding, Stuart D. Tyner
Antimicrob Agents Chemother. Oct 2014; 58(10): 5831–5840. doi: 10.1128/AAC.02462-14
PMCID:
PMC4187925
Repurposing the Open Access Malaria Box To Discover Potent Inhibitors of Toxoplasma gondii and Entamoeba histolytica
Fabrice F. Boyom, Patrick V. T. Fokou, Lauve R. Y. Tchokouaha, Thomas Spangenberg, Alvine N. Mfopa, Ruffin M. T. Kouipou, Cedric J. Mbouna, Valerie F. Donkeng Donfack, Paul H. A. Zollo
Antimicrob Agents Chemother. Oct 2014; 58(10): 5848–5854. doi: 10.1128/AAC.02541-14
PMCID:
PMC4187973
In Vitro Analysis of Finasteride Activity against Candida albicans Urinary Biofilm Formation and Filamentation
Alba A. Chavez-Dozal, Livia Lown, Maximillian Jahng, Carla J. Walraven, Samuel A. Lee
Antimicrob Agents Chemother. Oct 2014; 58(10): 5855–5862. doi: 10.1128/AAC.03137-14
PMCID:
PMC4187923
Susceptibility and Diversity in the Therapy-Refractory Genus Scedosporium
M. Lackner, F. Hagen, J. F. Meis, A. H. G. Gerrits van den Ende, D. Vu, V. Robert, J. Fritz, T. A. A. Moussa, G. S. de Hoog
Antimicrob Agents Chemother. Oct 2014; 58(10): 5877–5885. doi: 10.1128/AAC.03211-14
PMCID:
PMC4187929
Redefining Multidrug-Resistant Tuberculosis Based on Clinical Response to Combination Therapy
Tawanda Gumbo, Jotam G. Pasipanodya, Peter Wash, André Burger, Helen McIlleron
Antimicrob Agents Chemother. Oct 2014; 58(10): 6111–6115. doi: 10.1128/AAC.03549-14
PMCID:
PMC4187940
Chloroquine Has a Cytotoxic Effect on Acanthamoeba Encystation through Modulation of Autophagy
Bijay Kumar Jha, Hui-Jung Jung, Incheol Seo, Hyun Ah Kim, Seong-Il Suh, Min-Ho Suh, Won-Ki Baek
Antimicrob Agents Chemother. Oct 2014; 58(10): 6235–6241. doi: 10.1128/AAC.03164-14
PMCID:
PMC4187977
Antistaphylococcal Activity of Oritavancin and Its Synergistic Effect in Combination with Other Antimicrobial Agents
Gengrong Lin, Glenn Pankuch, Peter C. Appelbaum, Klaudia Kosowska-Shick
Antimicrob Agents Chemother. Oct 2014; 58(10): 6251–6254. doi: 10.1128/AAC.02932-14
PMCID:
PMC4187905
Transmission Potential of Antimony-Resistant Leishmania Field Isolates
Veronika Seblova, Bruno Oury, Naouel Eddaikra, Khatima Aït-Oudhia, Francine Pratlong, Elodie Gazanion, Carla Maia, Petr Volf, Denis Sereno
Antimicrob Agents Chemother. Oct 2014; 58(10): 6273–6276. doi: 10.1128/AAC.02406-13
PMCID:
PMC4187949

Antiviral Agents

Hepatitis C Virus (HCV) NS3 Sequence Diversity and Antiviral Resistance-Associated Variant Frequency in HCV/HIV Coinfection
Cassandra B. Jabara, Fengyu Hu, Katie R. Mollan, Sara E. Williford, Prema Menezes, Yan Yang, Joseph J. Eron, Michael W. Fried, Michael G. Hudgens, Corbin D. Jones, Ronald Swanstrom, Stanley M. Lemon
Antimicrob Agents Chemother. Oct 2014; 58(10): 6079–6092. doi: 10.1128/AAC.03466-14
PMCID:
PMC4187920
Identification of Highly Conserved Residues Involved in Inhibition of HIV-1 RNase H Function by Diketo Acid Derivatives
Angela Corona, Francesco Saverio Di Leva, Sylvain Thierry, Luca Pescatori, Giuliana Cuzzucoli Crucitti, Frederic Subra, Olivier Delelis, Francesca Esposito, Giuseppe Rigogliuso, Roberta Costi, Sandro Cosconati, Ettore Novellino, Roberto Di Santo, Enzo Tramontano
Antimicrob Agents Chemother. Oct 2014; 58(10): 6101–6110. doi: 10.1128/AAC.03605-14
PMCID:
PMC4187941
The Combined Anti-HIV-1 Activities of Emtricitabine and Tenofovir plus the Integrase Inhibitor Elvitegravir or Raltegravir Show High Levels of Synergy In Vitro
Rima Kulkarni, Rebecca Hluhanich, Damian M. McColl, Michael D. Miller, Kirsten L. White
Antimicrob Agents Chemother. Oct 2014; 58(10): 6145–6150. doi: 10.1128/AAC.03591-14
PMCID:
PMC4187912
Combination of the CCL5-Derived Peptide R4.0 with Different HIV-1 Blockers Reveals Wide Target Compatibility and Synergic Cobinding to CCR5
Massimiliano Secchi, Lia Vassena, Sébastien Morin, Dominique Schols, Luca Vangelista
Antimicrob Agents Chemother. Oct 2014; 58(10): 6215–6223. doi: 10.1128/AAC.03559-14
PMCID:
PMC4187945
Agmatine-Containing Poly(amidoamine)s as a Novel Class of Antiviral Macromolecules: Structural Properties and In Vitro Evaluation of Infectivity Inhibition
Manuela Donalisio, Elisabetta Ranucci, Valeria Cagno, Andrea Civra, Amedea Manfredi, Roberta Cavalli, Paolo Ferruti, David Lembo
Antimicrob Agents Chemother. Oct 2014; 58(10): 6315–6319. doi: 10.1128/AAC.03420-14
PMCID:
PMC4187951

Epidemiology and Surveillance

Case-Case-Control Study of Patients with Carbapenem-Resistant and Third-Generation-Cephalosporin-Resistant Klebsiella pneumoniae Bloodstream Infections
Jason C. Gallagher, Safia Kuriakose, Kevin Haynes, Peter Axelrod
Antimicrob Agents Chemother. Oct 2014; 58(10): 5732–5735. doi: 10.1128/AAC.03564-14
PMCID:
PMC4187915
Antibiotic Pressure Is a Major Risk Factor for Rectal Colonization by Multidrug-Resistant Pseudomonas aeruginosa in Critically Ill Patients
Silvia Gómez-Zorrilla, Mariana Camoez, Fe Tubau, Elisabet Periche, Rosario Cañizares, M. Angeles Dominguez, Javier Ariza, Carmen Peña
Antimicrob Agents Chemother. Oct 2014; 58(10): 5863–5870. doi: 10.1128/AAC.03419-14
PMCID:
PMC4187938
Changing Antimicrobial Resistance Profiles among Neisseria gonorrhoeae Isolates in Italy, 2003 to 2012
Anna Carannante, Giovanna Renna, Ivano Dal Conte, Valeria Ghisetti, Alberto Matteelli, Grazia Prignano, Giampaolo Impara, Marco Cusini, Antonietta D'Antuono, Caterina Vocale, Raffaele Antonetti, Marina Gaino, Marina Busetti, Maria Agnese Latino, Antonella Mencacci, Carmen Bonanno, Maria Carmela Cava, Cristina Giraldi, Paola Stefanelli
Antimicrob Agents Chemother. Oct 2014; 58(10): 5871–5876. doi: 10.1128/AAC.00103-14
PMCID:
PMC4187924
First Identification of a Chromosomally Located Penicillinase Gene in Kingella kingae Species Isolated in Continental Europe
Romain Basmaci, Philippe Bidet, Béatrice Berçot, Christelle Jost, Thérésa Kwon, Elodie Gaumetou, Stéphane Bonacorsi
Antimicrob Agents Chemother. Oct 2014; 58(10): 6258–6259. doi: 10.1128/AAC.03562-14
PMCID:
PMC4187927
Sequence Types 235, 111, and 132 Predominate among Multidrug-Resistant Pseudomonas aeruginosa Clinical Isolates in Croatia
Marija Guzvinec, Radosław Izdebski, Iva Butic, Marko Jelic, Maja Abram, Iva Koscak, Anna Baraniak, Waleria Hryniewicz, Marek Gniadkowski, Arjana Tambic Andrasevic
Antimicrob Agents Chemother. Oct 2014; 58(10): 6277–6283. doi: 10.1128/AAC.03116-14
PMCID:
PMC4187922
High Prevalence of Extended-Spectrum β-Lactamase, Plasmid-Mediated AmpC, and Carbapenemase Genes in Pet Food
Salome N. Seiffert, Alessandra Carattoli, Regula Tinguely, Agnese Lupo, Vincent Perreten, Andrea Endimiani
Antimicrob Agents Chemother. Oct 2014; 58(10): 6320–6323. doi: 10.1128/AAC.03185-14
PMCID:
PMC4187980

Experimental Therapeutics

Enhanced Antimalarial Activity by a Novel Artemether-Lumefantrine Lipid Emulsion for Parenteral Administration
Yufan Ma, Tingli Lu, Wen Zhao, Ying Wang, Ting Chen, Qibing Mei, Tao Chen
Antimicrob Agents Chemother. Oct 2014; 58(10): 5658–5665. doi: 10.1128/AAC.01428-13
PMCID:
PMC4187974
William Weiss, Mark Pulse, Richard Vickers
Antimicrob Agents Chemother. Oct 2014; 58(10): 5714–5718. doi: 10.1128/AAC.02903-14
PMCID:
PMC4187990
Characterization of a Melamino Nitroheterocycle as a Potential Lead for the Treatment of Human African Trypanosomiasis
Federica Giordani, Annamaria Buschini, Alessandro Baliani, Marcel Kaiser, Reto Brun, Michael P. Barrett, Claudia Pellacani, Paola Poli, Ian H. Gilbert
Antimicrob Agents Chemother. Oct 2014; 58(10): 5747–5757. doi: 10.1128/AAC.01449-13
PMCID:
PMC4187918
In Vivo Study of the Efficacy of the Aromatic Water of Zataria multiflora on Hydatid Cysts
Mohammad Moazeni, Sara Larki, Mohammad Jamal Saharkhiz, Ahmad Oryan, Maryam Ansary Lari, Amir Mootabi Alavi
Antimicrob Agents Chemother. Oct 2014; 58(10): 6003–6008. doi: 10.1128/AAC.02963-14
PMCID:
PMC4187908
In Vivo Effect of Quaternized Chitosan-Loaded Polymethylmethacrylate Bone Cement on Methicillin-Resistant Staphylococcus epidermidis Infection of the Tibial Metaphysis in a Rabbit Model
Hong-lue Tan, Hai-yong Ao, Rui Ma, Wen-tao Lin, Ting-ting Tang
Antimicrob Agents Chemother. Oct 2014; 58(10): 6016–6023. doi: 10.1128/AAC.03489-14
PMCID:
PMC4187961
Keith H. Ansell, Hayley M. Jones, David Whalley, Alisdair Hearn, Debra L. Taylor, Emmanuel C. Patin, Timothy M. Chapman, Simon A. Osborne, Claire Wallace, Kristian Birchall, Jonathan Large, Nathalie Bouloc, Ela Smiljanic-Hurley, Barbara Clough, Robert W. Moon, Judith L. Green, Anthony A. Holder
Antimicrob Agents Chemother. Oct 2014; 58(10): 6032–6043. doi: 10.1128/AAC.02959-14
PMCID:
PMC4187893
Nitro/Nitrosyl-Ruthenium Complexes Are Potent and Selective Anti-Trypanosoma cruzi Agents Causing Autophagy and Necrotic Parasite Death
Tanira M. Bastos, Marília I. F. Barbosa, Monize M. da Silva, José W. da C. Júnior, Cássio S. Meira, Elisalva T. Guimaraes, Javier Ellena, Diogo R. M. Moreira, Alzir A. Batista, Milena B. P. Soares
Antimicrob Agents Chemother. Oct 2014; 58(10): 6044–6055. doi: 10.1128/AAC.02765-14
PMCID:
PMC4187982
Antibiotic Selection of Escherichia coli Sequence Type 131 in a Mouse Intestinal Colonization Model
Frederik Boetius Hertz, Anders Løbner-Olesen, Niels Frimodt-Møller
Antimicrob Agents Chemother. Oct 2014; 58(10): 6139–6144. doi: 10.1128/AAC.03021-14
PMCID:
PMC4187947
Resveratrol Is Active against Leishmania amazonensis: In Vitro Effect of Its Association with Amphotericin B
Christian Ferreira, Deivid Costa Soares, Michelle Tanny Cunha do Nascimento, Lucia Helena Pinto-da-Silva, Carolina Galvão Sarzedas, Luzineide Wanderley Tinoco, Elvira Maria Saraiva
Antimicrob Agents Chemother. Oct 2014; 58(10): 6197–6208. doi: 10.1128/AAC.00093-14
PMCID:
PMC4187957
Experimental Therapy with Azoles against Candida guilliermondii
Marta Sanchis, Francisco Javier Pastor, Javier Capilla, Deanna A. Sutton, Annette W. Fothergill, Josep Guarro
Antimicrob Agents Chemother. Oct 2014; 58(10): 6255–6257. doi: 10.1128/AAC.03051-14
PMCID:
PMC4187986
Emanuele Marra, Vitor L. Sousa, Roberta Gaziano, M. Lucrezia Pacello, Brunilde Arseni, Luigi Aurisicchio, Rita De Santis, Giovanni Salvatori
Antimicrob Agents Chemother. Oct 2014; 58(10): 6284–6286. doi: 10.1128/AAC.03038-14
PMCID:
PMC4187902
The New Pyrazolyltetrazole Derivative MSN20 Is Effective via Oral Delivery against Cutaneous Leishmaniasis
Viviane dos Santos Faiões, Maurício Silva dos Santos, Alice Maria Rolim Bernardino, Edézio Ferreira Cunha-Júnior, Marilene Marcuzzo do Canto Cavalheiro, Eduardo Caio Torres-Santos
Antimicrob Agents Chemother. Oct 2014; 58(10): 6290–6293. doi: 10.1128/AAC.02874-14
PMCID:
PMC4187983

Clinical Therapeutics

Quasi-Experimental Study of Sodium Citrate Locks and the Risk of Acute Hemodialysis Catheter Infection among Critically Ill Patients
Jean-Jacques Parienti, Stéphanie Deryckère, Bruno Mégarbane, Xavier Valette, Amélie Seguin, Bertrand Sauneuf, Jean-Paul Mira, Bertrand Souweine, Vincent Cattoir, Cédric Daubin, Damien du Cheyron
Antimicrob Agents Chemother. Oct 2014; 58(10): 5666–5672. doi: 10.1128/AAC.03079-14
PMCID:
PMC4187910
Avibactam and Class C β-Lactamases: Mechanism of Inhibition, Conservation of the Binding Pocket, and Implications for Resistance
S. D. Lahiri, M. R. Johnstone, P. L. Ross, R. E. McLaughlin, N. B. Olivier, R. A. Alm
Antimicrob Agents Chemother. Oct 2014; 58(10): 5704–5713. doi: 10.1128/AAC.03057-14
PMCID:
PMC4187909
Musculoskeletal Safety Outcomes of Patients Receiving Daptomycin with HMG-CoA Reductase Inhibitors
Christopher M. Bland, P. Brandon Bookstaver, Z. Kevin Lu, Brianne L. Dunn, Kathey Fulton Rumley
Antimicrob Agents Chemother. Oct 2014; 58(10): 5726–5731. doi: 10.1128/AAC.02910-14
PMCID:
PMC4187944
Phase 1b Study of New Posaconazole Tablet for Prevention of Invasive Fungal Infections in High-Risk Patients with Neutropenia
Rafael F. Duarte, Javier López-Jiménez, Oliver A. Cornely, Michel Laverdiere, David Helfgott, Shariq Haider, Pranatharthi Chandrasekar, Amelia Langston, John Perfect, Lei Ma, Marlou L. P. S. van Iersel, Nancy Connelly, Nicholas Kartsonis, Hetty Waskin
Antimicrob Agents Chemother. Oct 2014; 58(10): 5758–5765. doi: 10.1128/AAC.03050-14
PMCID:
PMC4187965
Effect of Coadministered Fat on the Tolerability, Safety, and Pharmacokinetic Properties of Dihydroartemisinin-Piperaquine in Papua New Guinean Children with Uncomplicated Malaria
B. R. Moore, J. M. Benjamin, S. Salman, S. Griffin, E. Ginny, M. Page-Sharp, L. J. Robinson, P. Siba, K. T. Batty, I. Mueller, T. M. E. Davis
Antimicrob Agents Chemother. Oct 2014; 58(10): 5784–5794. doi: 10.1128/AAC.03314-14
PMCID:
PMC4187992
Randomized Controlled Trial Comparing 7-Day Triple, 10-Day Sequential, and 7-Day Concomitant Therapies for Helicobacter pylori Infection
Ping-I Hsu, Deng-Chyang Wu, Wen-Chi Chen, Hui-Hwa Tseng, Hsien-Chung Yu, Huay-Min Wang, Sung-Shuo Kao, Kwok-Hung Lai, Angela Chen, Feng-Woei Tsay
Antimicrob Agents Chemother. Oct 2014; 58(10): 5936–5942. doi: 10.1128/AAC.02922-14
PMCID:
PMC4187978
Effects of Rifampin and Ketoconazole on Pharmacokinetics of Morinidazole in Healthy Chinese Subjects
Xiaoyan Pang, Yifan Zhang, Ruina Gao, Kan Zhong, Dafang Zhong, Xiaoyan Chen
Antimicrob Agents Chemother. Oct 2014; 58(10): 5987–5993. doi: 10.1128/AAC.03382-14
PMCID:
PMC4187946
A Replicate Designed Bioequivalence Study To Compare Two Fixed-Dose Combination Products of Artesunate and Amodiaquine in Healthy Chinese Volunteers
Yun Liu, Chaoying Hu, Gangyi Liu, Jingying Jia, Chen Yu, Jianmin Zhu, Qingsi Zheng, Kanyin E. Zhang
Antimicrob Agents Chemother. Oct 2014; 58(10): 6009–6015. doi: 10.1128/AAC.02617-14
PMCID:
PMC4187933
Randomized, Double-Blind, Placebo-Controlled Clinical Trial of a Two-Day Regimen of Dihydroartemisinin-Piperaquine for Malaria Prevention Halted for Concern over Prolonged Corrected QT Interval
Jessica Manning, Pattaraporn Vanachayangkul, Chanthap Lon, Michele Spring, Mary So, Darapiseth Sea, Youry Se, Sok Somethy, Sut-Thang Phann, Soklyda Chann, Sabaithip Sriwichai, Nillawan Buathong, Worachet Kuntawunginn, Mashamon Mitprasat, Raveewan Siripokasupkul, Paktiya Teja-Isavadharm, Eugene Soh, Ans Timmermans, Charlotte Lanteri, Jaranit Kaewkungwal, Montida Auayporn, Douglas Tang, Char Meng Chour, Satharath Prom, Mark Haigney, Louis Cantilena, David Saunders
Antimicrob Agents Chemother. Oct 2014; 58(10): 6056–6067. doi: 10.1128/AAC.02667-14
PMCID:
PMC4187937
Safety, Tolerability, and Pharmacokinetics of Intravenous Nemonoxacin in Healthy Chinese Volunteers
Guo-ying Cao, Jing Zhang, Ying-yuan Zhang, Bei-ning Guo, Ji-cheng Yu, Xiao-jie Wu, Yuan-cheng Chen, Ju-Fang Wu, Yao-guo Shi
Antimicrob Agents Chemother. Oct 2014; 58(10): 6116–6121. doi: 10.1128/AAC.02972-14
PMCID:
PMC4187916
F. Joel Leong, Ruobing Li, Jay Prakash Jain, Gilbert Lefèvre, Baldur Magnusson, Thierry T. Diagana, Peter Pertel
Antimicrob Agents Chemother. Oct 2014; 58(10): 6209–6214. doi: 10.1128/AAC.03393-14
PMCID:
PMC4187895
Pharmacokinetics of para-Aminosalicylic Acid in HIV-Uninfected and HIV-Coinfected Tuberculosis Patients Receiving Antiretroviral Therapy, Managed for Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis
Lizanne de Kock, Sherwin K. B. Sy, Bernd Rosenkranz, Andreas H. Diacon, Kim Prescott, Kenneth R. Hernandez, Mingming Yu, Hartmut Derendorf, Peter R. Donald
Antimicrob Agents Chemother. Oct 2014; 58(10): 6242–6250. doi: 10.1128/AAC.03073-14
PMCID:
PMC4187930
Chloroquine Remains Effective for Treating Plasmodium vivax Malaria in Pursat Province, Western Cambodia
Chanaki Amaratunga, Sokunthea Sreng, Sivanna Mao, Gregory S. Tullo, Jennifer M. Anderson, Char Meng Chuor, Seila Suon, Rick M. Fairhurst
Antimicrob Agents Chemother. Oct 2014; 58(10): 6270–6272. doi: 10.1128/AAC.03026-14
PMCID:
PMC4187907
Linezolid Manifests a Rapid and Dramatic Therapeutic Effect for Patients with Life-Threatening Tuberculous Meningitis
Feng Sun, Qiaoling Ruan, Jiali Wang, Shu Chen, Jialin Jin, Lingyun Shao, Ying Zhang, Wenhong Zhang
Antimicrob Agents Chemother. Oct 2014; 58(10): 6297–6301. doi: 10.1128/AAC.02784-14
PMCID:
PMC4187991

Pharmacology

Renal Handling of Amphotericin B and Amphotericin B-Deoxycholate and Potential Renal Drug-Drug Interactions with Selected Antivirals
František Trejtnar, Jana Mandíková, Jana Kočíncová, Marie Volková
Antimicrob Agents Chemother. Oct 2014; 58(10): 5650–5657. doi: 10.1128/AAC.02829-14
PMCID:
PMC4187917
Carrie A. Morris, Rolf Pokorny, Luis Lopez-Lazaro, Robert M. Miller, Sarah Arbe-Barnes, Stephan Duparc, Isabelle Borghini-Fuhrer, Jang-Sik Shin, Lawrence Fleckenstein
Antimicrob Agents Chemother. Oct 2014; 58(10): 5900–5908. doi: 10.1128/AAC.02716-14
PMCID:
PMC4187956
In Vivo Activity of Cefquinome against Escherichia coli in the Thighs of Neutropenic Mice
Qi Shan, Chaoping Liang, Jing Wang, Jufeng Li, Zhenling Zeng
Antimicrob Agents Chemother. Oct 2014; 58(10): 5943–5946. doi: 10.1128/AAC.03446-14
PMCID:
PMC4187953
Relationship between Ceftolozane-Tazobactam Exposure and Selection for Pseudomonas aeruginosa Resistance in a Hollow-Fiber Infection Model
Brian D. VanScoy, Rodrigo E. Mendes, Mariana Castanheira, Jennifer McCauley, Sujata M. Bhavnani, Ronald N. Jones, Lawrence V. Friedrich, Judith N. Steenbergen, Paul G. Ambrose
Antimicrob Agents Chemother. Oct 2014; 58(10): 6024–6031. doi: 10.1128/AAC.02310-13
PMCID:
PMC4187943
Interspecies Allometric Scaling of Antimalarial Drugs and Potential Application to Pediatric Dosing
S. M. D. K. Ganga Senarathna, Kevin T. Batty
Antimicrob Agents Chemother. Oct 2014; 58(10): 6068–6078. doi: 10.1128/AAC.02538-14
PMCID:
PMC4187962
Structure, Activity, and Inhibition of the Carboxyltransferase β-Subunit of Acetyl Coenzyme A Carboxylase (AccD6) from Mycobacterium tuberculosis
Manchi C. M. Reddy, Ardala Breda, John B. Bruning, Mukul Sherekar, Spandana Valluru, Cory Thurman, Hannah Ehrenfeld, James C. Sacchettini
Antimicrob Agents Chemother. Oct 2014; 58(10): 6122–6132. doi: 10.1128/AAC.02574-13
PMCID:
PMC4187906
Population Pharmacokinetics of Abacavir in Pregnant Women
Floris Fauchet, Jean-Marc Treluyer, Laure-Helene Préta, Elodie Valade, Emmanuelle Pannier, Saik Urien, Déborah Hirt
Antimicrob Agents Chemother. Oct 2014; 58(10): 6287–6289. doi: 10.1128/AAC.03469-14
PMCID:
PMC4187964
Impact of MIC Range for Pseudomonas aeruginosa and Streptococcus pneumoniae on the Ceftolozane In Vivo Pharmacokinetic/Pharmacodynamic Target
A. J. Lepak, A. Reda, K. Marchillo, J. Van Hecker, W. A. Craig, D. Andes
Antimicrob Agents Chemother. Oct 2014; 58(10): 6311–6314. doi: 10.1128/AAC.03572-14
PMCID:
PMC4187960

Letters to the Editor

First Description of a blaVIM-2-Carrying Citrobacter freundii Isolate in Spain
Nerea Porres-Osante, Vanesa Estepa, Cristina Seral, Beatriz Rojo-Bezares, Soledad Salvo, Sonia Algarate, Carmen Torres, Francisco Javier Castillo, Yolanda Sáenz
Antimicrob Agents Chemother. Oct 2014; 58(10): 6331–6332. doi: 10.1128/AAC.03168-14
PMCID:
PMC4187894
Characterization of Environmental CTX-M-15-Producing Stenotrophomonas maltophilia
Ana Maravić, Mirjana Skočibušić, Željana Fredotović, Svjetlana Cvjetan, Ivica Šamanić, Jasna Puizina
Antimicrob Agents Chemother. Oct 2014; 58(10): 6333–6334. doi: 10.1128/AAC.03601-14
PMCID:
PMC4187975
Emergence of KPC-2-Producing Salmonella enterica Serotype Schwarzengrund in Argentina
M. A. Jure, M. Duprilot, H. E. Musa, C. López, Marta C. de Castillo, F. X. Weill, G. Arlet, D. Decré
Antimicrob Agents Chemother. Oct 2014; 58(10): 6335–6336. doi: 10.1128/AAC.03322-14
PMCID:
PMC4187970
Measuring Polymyxin Uptake by Renal Tubular Cells: Is BODIPY-Polymyxin B an Appropriate Probe?
Mohammad A. K. Azad, Bo Yun, Kade D. Roberts, Roger L. Nation, Philip E. Thompson, Tony Velkov, Jian Li
Antimicrob Agents Chemother. Oct 2014; 58(10): 6337–6338. doi: 10.1128/AAC.03733-14
PMCID:
PMC4187948
Reply to “Measuring Polymyxin Uptake by Renal Tubular Cells: Is BODIPY-Polymyxin B an Appropriate Probe?”
Kamilia Abdelraouf, Vincent H. Tam
Antimicrob Agents Chemother. Oct 2014; 58(10): 6339. doi: 10.1128/AAC.03784-14
PMCID:
PMC4187904
Compliance with Antimicrobial Therapy for Buruli Ulcer
S. Klis, R. Kingma, W. Tuah, Y. Stienstra, T. S. van der Werf
Antimicrob Agents Chemother. Oct 2014; 58(10): 6340. doi: 10.1128/AAC.03763-14
PMCID:
PMC4187936
Reply to “Compliance with Antimicrobial Therapy for Buruli Ulcer”
Richard O. Phillips, Fred S. Sarfo, Mohammed K. Abass, Michael Frimpong, Edwin Ampadu, Mark Forson, Yaw A. Amoako, William Thompson, Kingsley Asiedu, Mark Wansbrough-Jones
Antimicrob Agents Chemother. Oct 2014; 58(10): 6341. doi: 10.1128/AAC.03874-14
PMCID:
PMC4187934

Masthead

Editorial Board
Antimicrob Agents Chemother. Oct 2014; 58(10): A3. doi: 10.1128/AAC.masthead.58-10
PMCID:
PMC4187896

Errata

Erratum for Gross et al., Epidemiology and Predictors of Multidrug-Resistant Community-Acquired and Health Care-Associated Pneumonia
Alan E. Gross, Trevor C. Van Schooneveld, Keith M. Olsen, Mark E. Rupp, Thu Hong Bui, Elsie Forsung, Andre C. Kalil
Antimicrob Agents Chemother. Oct 2014; 58(10): 6342. doi: 10.1128/AAC.04097-14
PMCID:
PMC4187963
Erratum for Wright et al., Population Structure of KPC-Producing Klebsiella pneumoniae Isolates from Midwestern U.S. Hospitals
Meredith S. Wright, Federico Perez, Lauren Brinkac, Michael R. Jacobs, Keith Kaye, Eric Cober, David van Duin, Steven H. Marshall, Andrea M. Hujer, Susan D. Rudin, Kristine M. Hujer, Robert A. Bonomo, Mark D. Adams
Antimicrob Agents Chemother. Oct 2014; 58(10): 6343. doi: 10.1128/AAC.04128-14
PMCID:
PMC4187969

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)