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Volume 58(3);  March 2014

Articles from this journal are usually available in PMC after a 6-month delay (embargo). Some articles may be available sooner.

Epidemiology and Surveillance

Trends in Antibiotic Resistance in Coagulase-Negative Staphylococci in the United States, 1999 to 2012
Larissa May, Eili Y. Klein, Richard E. Rothman, Ramanan Laxminarayan
Antimicrob Agents Chemother. Mar 2014; 58(3): 1404–1409. doi: 10.1128/AAC.01908-13
PMCID:
PMC3957827
Antibiotic Utilization for Acute Respiratory Tract Infections in U.S. Emergency Departments
John P. Donnelly, John W. Baddley, Henry E. Wang
Antimicrob Agents Chemother. Mar 2014; 58(3): 1451–1457. doi: 10.1128/AAC.02039-13
PMCID:
PMC3957838
Molecular Identification and Antifungal Susceptibility of Yeast Isolates Causing Fungemia Collected in a Population-Based Study in Spain in 2010 and 2011
Jesús Guinea, Óscar Zaragoza, Pilar Escribano, Estrella Martín-Mazuelos, Javier Pemán, Ferrán Sánchez-Reus, Manuel Cuenca-Estrella
Antimicrob Agents Chemother. Mar 2014; 58(3): 1529–1537. doi: 10.1128/AAC.02155-13
PMCID:
PMC3957835
Antimicrobial Activity of Ceftazidime-Avibactam against Gram-Negative Organisms Collected from U.S. Medical Centers in 2012
Helio S. Sader, Mariana Castanheira, Robert K. Flamm, David J. Farrell, Ronald N. Jones
Antimicrob Agents Chemother. Mar 2014; 58(3): 1684–1692. doi: 10.1128/AAC.02429-13
PMCID:
PMC3957905
High Rate of Fecal Carriage of Extended-Spectrum-β-Lactamase-Producing Escherichia coli in Healthy Children in Gipuzkoa, Northern Spain
María Fernández-Reyes, Diego Vicente, María Gomariz, Olatz Esnal, Joseba Landa, Eider Oñate, Emilio Pérez-Trallero
Antimicrob Agents Chemother. Mar 2014; 58(3): 1822–1824. doi: 10.1128/AAC.01503-13
PMCID:
PMC3957886

Masthead

Editorial Board
Antimicrob Agents Chemother. Mar 2014; 58(3): A3. doi: 10.1128/AAC.masthead.58-3
PMCID:
PMC3957828

Minireview

Novel Composite Efficacy Measure To Demonstrate the Rationale and Efficacy of Combination Antiviral–Anti-Inflammatory Treatment for Recurrent Herpes Simplex Labialis
Christopher M. Hull, Myron J. Levin, Stephen K. Tyring, Spotswood L. Spruance
Antimicrob Agents Chemother. Mar 2014; 58(3): 1273–1278. doi: 10.1128/AAC.02150-13
PMCID:
PMC3957859

Chemistry; Biosynthesis

Federica Giordani, Manoj Munde, W. David Wilson, Mohamed A. Ismail, Arvind Kumar, David W. Boykin, Michael P. Barrett
Antimicrob Agents Chemother. Mar 2014; 58(3): 1793–1796. doi: 10.1128/AAC.02024-13
PMCID:
PMC3957857

Mechanisms of Action: Physiological Effects

Mechanism of Action of the Novel Aminomethylcycline Antibiotic Omadacycline
Michael P. Draper, S. Weir, A. Macone, J. Donatelli, C. A. Trieber, S. K. Tanaka, Stuart B. Levy
Antimicrob Agents Chemother. Mar 2014; 58(3): 1279–1283. doi: 10.1128/AAC.01066-13
PMCID:
PMC3957880
Savva Zorov, Yulia Yuzenkova, Vadim Nikiforov, Konstantin Severinov, Nikolay Zenkin
Antimicrob Agents Chemother. Mar 2014; 58(3): 1420–1424. doi: 10.1128/AAC.02248-13
PMCID:
PMC3957892
Synergistic Effect of the Flavonoid Catechin, Quercetin, or Epigallocatechin Gallate with Fluconazole Induces Apoptosis in Candida tropicalis Resistant to Fluconazole
Cecília Rocha da Silva, João Batista de Andrade Neto, Rosana de Sousa Campos, Narjara Silvestre Figueiredo, Letícia Serpa Sampaio, Hemerson Iury Ferreira Magalhães, Bruno Coêlho Cavalcanti, Danielle Macêdo Gaspar, Geanne Matos de Andrade, Iri Sandro Pampolha Lima, Glauce Socorro de Barros Viana, Manoel Odorico de Moraes, Marina Duarte Pinto Lobo, Thalles Barbosa Grangeiro, Hélio Vitoriano Nobre Júnior
Antimicrob Agents Chemother. Mar 2014; 58(3): 1468–1478. doi: 10.1128/AAC.00651-13
PMCID:
PMC3957875
Iron-Induced Virulence of Salmonella enterica Serovar Typhimurium at the Intestinal Epithelial Interface Can Be Suppressed by Carvacrol
Guus A. M. Kortman, Rian W. H. M. Roelofs, Dorine W. Swinkels, Marien I. de Jonge, Sara A. Burt, Harold Tjalsma
Antimicrob Agents Chemother. Mar 2014; 58(3): 1664–1670. doi: 10.1128/AAC.02060-13
PMCID:
PMC3957860
Evaluation of DNA Primase DnaG as a Potential Target for Antibiotics
Aneta Kuron, Malgorzata Korycka-Machala, Anna Brzostek, Marcin Nowosielski, Aidan Doherty, Bozena Dziadek, Jaroslaw Dziadek
Antimicrob Agents Chemother. Mar 2014; 58(3): 1699–1706. doi: 10.1128/AAC.01721-13
PMCID:
PMC3957862

Mechanisms of Resistance

Genomic Analyses of DNA Transformation and Penicillin Resistance in Streptococcus pneumoniae Clinical Isolates
Fereshteh Fani, Philippe Leprohon, George G. Zhanel, Michel G. Bergeron, Marc Ouellette
Antimicrob Agents Chemother. Mar 2014; 58(3): 1397–1403. doi: 10.1128/AAC.01311-13
PMCID:
PMC3957846
Identification and Characterization of a Bacitracin Resistance Network in Enterococcus faecalis
Susanne Gebhard, Chong Fang, Aishath Shaaly, David J. Leslie, Marion R. Weimar, Falk Kalamorz, Alan Carne, Gregory M. Cook
Antimicrob Agents Chemother. Mar 2014; 58(3): 1425–1433. doi: 10.1128/AAC.02111-13
PMCID:
PMC3957847
Transcription Factor CCG-8 as a New Regulator in the Adaptation to Antifungal Azole Stress
Xianyun Sun, Kangji Wang, Xinxu Yu, Jie Liu, Hanxing Zhang, Fucai Zhou, Baogui Xie, Shaojie Li
Antimicrob Agents Chemother. Mar 2014; 58(3): 1434–1442. doi: 10.1128/AAC.02244-13
PMCID:
PMC3957830
Binding Pocket Alterations in Dihydrofolate Synthase Confer Resistance to para-Aminosalicylic Acid in Clinical Isolates of Mycobacterium tuberculosis
Fei Zhao, Xu-De Wang, Luke N. Erber, Ming Luo, Ai-zhen Guo, Shan-shan Yang, Jing Gu, Breanna J. Turman, Yun-rong Gao, Dong-fang Li, Zong-qiang Cui, Zhi-ping Zhang, Li-jun Bi, Anthony D. Baughn, Xian-En Zhang, Jiao-Yu Deng
Antimicrob Agents Chemother. Mar 2014; 58(3): 1479–1487. doi: 10.1128/AAC.01775-13
PMCID:
PMC3957869
Genetic Basis for Vancomycin-Enhanced Cephalosporin Susceptibility in Vancomycin-Resistant Enterococci Revealed Using Counterselection with Dominant-Negative Thymidylate Synthase
Christopher J. Kristich, Dušanka Djorić, Jaime L. Little
Antimicrob Agents Chemother. Mar 2014; 58(3): 1556–1564. doi: 10.1128/AAC.02001-13
PMCID:
PMC3957902
Reduced Antimony Accumulation in ARM58-Overexpressing Leishmania infantum
Carola Schäfer, Paloma Tejera Nevado, Dorothea Zander, Joachim Clos
Antimicrob Agents Chemother. Mar 2014; 58(3): 1565–1574. doi: 10.1128/AAC.01881-13
PMCID:
PMC3957878
Genomics of KPC-Producing Klebsiella pneumoniae Sequence Type 512 Clone Highlights the Role of RamR and Ribosomal S10 Protein Mutations in Conferring Tigecycline Resistance
Laura Villa, Claudia Feudi, Daniela Fortini, Aurora García-Fernández, Alessandra Carattoli
Antimicrob Agents Chemother. Mar 2014; 58(3): 1707–1712. doi: 10.1128/AAC.01803-13
PMCID:
PMC3957836
Peptidoglycan Cross-Linking in Glycopeptide-Resistant Actinomycetales
Jean-Emmanuel Hugonnet, Nabila Haddache, Carole Veckerlé, Lionel Dubost, Arul Marie, Noriyasu Shikura, Jean-Luc Mainardi, Louis B. Rice, Michel Arthur
Antimicrob Agents Chemother. Mar 2014; 58(3): 1749–1756. doi: 10.1128/AAC.02329-13
PMCID:
PMC3957865
vanO, a New Glycopeptide Resistance Operon in Environmental Rhodococcus equi Isolates
Dereje Dadi Gudeta, Arshnee Moodley, Valeria Bortolaia, Luca Guardabassi
Antimicrob Agents Chemother. Mar 2014; 58(3): 1768–1770. doi: 10.1128/AAC.01880-13
PMCID:
PMC3957834
Role of Acinetobacter baumannii UmuD Homologs in Antibiotic Resistance Acquired through DNA Damage-Induced Mutagenesis
Jesús Aranda, Mario López, Enoy Leiva, Andrés Magán, Ben Adler, Germán Bou, Jordi Barbé
Antimicrob Agents Chemother. Mar 2014; 58(3): 1771–1773. doi: 10.1128/AAC.02346-13
PMCID:
PMC3957856
Population Analysis of Escherichia coli Isolates with Discordant Resistance Levels by Piperacillin-Tazobactam Broth Microdilution and Agar Dilution Testing
Carole Shubert, Jen Slaughter, David Creely, Alex van Belkum, Jean Pierre Gayral, William Michael Dunne, Gilles Zambardi, Dee Shortridge
Antimicrob Agents Chemother. Mar 2014; 58(3): 1779–1781. doi: 10.1128/AAC.02181-13
PMCID:
PMC3957839
Induction of the Chlamydia muridarum Stress/Persistence Response Increases Azithromycin Treatment Failure in a Murine Model of Infection
R. Phillips-Campbell, J. Kintner, R. V. Schoborg
Antimicrob Agents Chemother. Mar 2014; 58(3): 1782–1784. doi: 10.1128/AAC.02097-13
PMCID:
PMC3957849
Identification of the Novel Lincosamide Resistance Gene lnu(E) Truncated by ISEnfa5-cfr-ISEnfa5 Insertion in Streptococcus suis: De Novo Synthesis and Confirmation of Functional Activity in Staphylococcus aureus
Qin Zhao, Sarah Wendlandt, Hui Li, Jun Li, Congming Wu, Jianzhong Shen, Stefan Schwarz, Yang Wang
Antimicrob Agents Chemother. Mar 2014; 58(3): 1785–1788. doi: 10.1128/AAC.02007-13
PMCID:
PMC3957883
Role of OmpA in the Multidrug Resistance Phenotype of Acinetobacter baumannii
Younes Smani, Anna Fàbrega, Ignasi Roca, Viviana Sánchez-Encinales, Jordi Vila, Jerónimo Pachón
Antimicrob Agents Chemother. Mar 2014; 58(3): 1806–1808. doi: 10.1128/AAC.02101-13
PMCID:
PMC3957889
The Complete Nucleotide Sequence of the Carbapenem Resistance-Conferring Conjugative Plasmid pLD209 from a Pseudomonas putida Clinical Strain Reveals a Chimeric Design Formed by Modules Derived from Both Environmental and Clinical Bacteria
Patricia M. Marchiaro, Luciano Brambilla, Jorgelina Morán-Barrio, Santiago Revale, Fernando Pasteran, Alejandro J. Vila, Alejandro M. Viale, Adriana S. Limansky
Antimicrob Agents Chemother. Mar 2014; 58(3): 1816–1821. doi: 10.1128/AAC.02494-13
PMCID:
PMC3957842

Susceptibility

Double Recombinant Mycobacterium bovis BCG Strain for Screening of Primary and Rationale-Based Antimycobacterial Compounds
Vandana Singh, Rajesh Kumar Biswas, Bhupendra N. Singh
Antimicrob Agents Chemother. Mar 2014; 58(3): 1389–1396. doi: 10.1128/AAC.01301-13
PMCID:
PMC3957833
A Screen for and Validation of Prodrug Antimicrobials
Laura E. Fleck, E. Jeffrey North, Richard E. Lee, Lawrence R. Mulcahy, Gabriele Casadei, Kim Lewis
Antimicrob Agents Chemother. Mar 2014; 58(3): 1410–1419. doi: 10.1128/AAC.02136-13
PMCID:
PMC3957891
In Vitro Analyses of Mild Heat Stress in Combination with Antifungal Agents against Aspergillus fumigatus Biofilm
Rong Zeng, Min Li, Qing Chen, Le Wang, Ping Zhan, Chong Wang, Guixia Lv, Yongnian Shen, Weida Liu
Antimicrob Agents Chemother. Mar 2014; 58(3): 1443–1450. doi: 10.1128/AAC.01007-13
PMCID:
PMC3957873
In Vitro Efficacy of Corifungin against Acanthamoeba castellanii Trophozoites and Cysts
Anjan Debnath, Josefino B. Tunac, Angélica Silva-Olivares, Silvia Galindo-Gómez, Mineko Shibayama, James H. McKerrow
Antimicrob Agents Chemother. Mar 2014; 58(3): 1523–1528. doi: 10.1128/AAC.02254-13
PMCID:
PMC3957901
Phylogenetic Relationships Matter: Antifungal Susceptibility among Clinically Relevant Yeasts
A. F. Schmalreck, M. Lackner, K. Becker, W. Fegeler, V. Czaika, H. Ulmer, C. Lass-Flörl
Antimicrob Agents Chemother. Mar 2014; 58(3): 1575–1585. doi: 10.1128/AAC.01799-13
PMCID:
PMC3957855
In Vitro Activity of Solithromycin against Erythromycin-Resistant Streptococcus agalactiae
Giorgio Piccinelli, Prabhavathi Fernandes, Carlo Bonfanti, Francesca Caccuri, Arnaldo Caruso, Maria Antonia De Francesco
Antimicrob Agents Chemother. Mar 2014; 58(3): 1693–1698. doi: 10.1128/AAC.02210-13
PMCID:
PMC3957870
Activities of Tobramycin and Polymyxin E against Pseudomonas aeruginosa Biofilm-Coated Medical Grade Endotracheal Tubes
Keiko Tarquinio, Kelsey Confreda, James Shurko, Kerry LaPlante
Antimicrob Agents Chemother. Mar 2014; 58(3): 1723–1729. doi: 10.1128/AAC.01178-13
PMCID:
PMC3957908
Susceptibility of Multiresistant Gram-Negative Bacteria to Fosfomycin and Performance of Different Susceptibility Testing Methods
L. V. Perdigão-Neto, M. S. Oliveira, C. F. Rizek, C. M. D. M. Carrilho, S. F. Costa, A. S. Levin
Antimicrob Agents Chemother. Mar 2014; 58(3): 1763–1767. doi: 10.1128/AAC.02048-13
PMCID:
PMC3957874
In Vitro Activities of Ceftazidime-Avibactam and Aztreonam-Avibactam against 372 Gram-Negative Bacilli Collected in 2011 and 2012 from 11 Teaching Hospitals in China
Xiaojuan Wang, Feifei Zhang, Chunjiang Zhao, Zhanwei Wang, Wright W. Nichols, Raymond Testa, Henan Li, Hongbin Chen, Wenqiang He, Qi Wang, Hui Wang
Antimicrob Agents Chemother. Mar 2014; 58(3): 1774–1778. doi: 10.1128/AAC.02123-13
PMCID:
PMC3957831
In Vitro Activity of Nemonoxacin, a Novel Nonfluorinated Quinolone Antibiotic, against Chlamydia trachomatis and Chlamydia pneumoniae
Kobkul Chotikanatis, Stephan A. Kohlhoff, Margaret R. Hammerschlag
Antimicrob Agents Chemother. Mar 2014; 58(3): 1800–1801. doi: 10.1128/AAC.02263-13
PMCID:
PMC3957896
In Vitro Screening Test Using Leishmania Promastigotes Stably Expressing mCherry Protein
Paola Vacchina, Miguel A. Morales
Antimicrob Agents Chemother. Mar 2014; 58(3): 1825–1828. doi: 10.1128/AAC.02224-13
PMCID:
PMC3957829

Analytical Procedures

Phenotypic Profiling of Antibiotic Response Signatures in Escherichia coli Using Raman Spectroscopy
A. I. M. Athamneh, R. A. Alajlouni, R. S. Wallace, M. N. Seleem, R. S. Senger
Antimicrob Agents Chemother. Mar 2014; 58(3): 1302–1314. doi: 10.1128/AAC.02098-13
PMCID:
PMC3957840

Antiviral Agents

Raltegravir Has a Low Propensity To Cause Clinical Drug Interactions through Inhibition of Major Drug Transporters: an In Vitro Evaluation
Matthew L. Rizk, Robert Houle, Grace Hoyee Chan, Mike Hafey, Elizabeth G. Rhee, Xiaoyan Chu
Antimicrob Agents Chemother. Mar 2014; 58(3): 1294–1301. doi: 10.1128/AAC.02049-13
PMCID:
PMC3957841
Multiple Classes of Antiviral Agents Exhibit In Vitro Activity against Human Rhinovirus Type C
Chris Mello, Esmeralda Aguayo, Madeleine Rodriguez, Gary Lee, Robert Jordan, Tomas Cihlar, Gabriel Birkus
Antimicrob Agents Chemother. Mar 2014; 58(3): 1546–1555. doi: 10.1128/AAC.01746-13
PMCID:
PMC3957863
A Conformational Restriction in the Influenza A Virus Neuraminidase Binding Site by R152 Results in a Combinational Effect of I222T and H274Y on Oseltamivir Resistance
Lan Huang, Yang Cao, Jianfang Zhou, Kun Qin, Wenfei Zhu, Yun Zhu, Lei Yang, Dayan Wang, Hong Wei, Yuelong Shu
Antimicrob Agents Chemother. Mar 2014; 58(3): 1639–1645. doi: 10.1128/AAC.01848-13
PMCID:
PMC3957868
In Vitro Characterization of MK-1439, a Novel HIV-1 Nonnucleoside Reverse Transcriptase Inhibitor
Ming-Tain Lai, Meizhen Feng, Jean-Pierre Falgueyret, Paul Tawa, Marc Witmer, Daniel DiStefano, Yuan Li, Jason Burch, Nancy Sachs, Meiqing Lu, Elizabeth Cauchon, Louis-Charles Campeau, Jay Grobler, Youwei Yan, Yves Ducharme, Bernard Côté, Ernest Asante-Appiah, Daria J. Hazuda, Michael D. Miller
Antimicrob Agents Chemother. Mar 2014; 58(3): 1652–1663. doi: 10.1128/AAC.02403-13
PMCID:
PMC3957832
Prior Exposure to Lamivudine Increases Entecavir Resistance Risk in Chronic Hepatitis B Patients without Detectable Lamivudine Resistance
Jeong-Hoon Lee, Yuri Cho, Dong Hyeon Lee, Minjong Lee, Jeong-ju Yoo, Won-mook Choi, Young Youn Cho, Yun Bin Lee, Su Jong Yu, Jung-Hwan Yoon, Hyo-Suk Lee, Yoon Jun Kim
Antimicrob Agents Chemother. Mar 2014; 58(3): 1730–1737. doi: 10.1128/AAC.02483-13
PMCID:
PMC3957876
In Vitro Characterization of a Sustained-Release Formulation for Enfuvirtide
Sam N. Rothstein, Kelly D. Huber, Nicolas Sluis-Cremer, Steven R. Little
Antimicrob Agents Chemother. Mar 2014; 58(3): 1797–1799. doi: 10.1128/AAC.02440-13
PMCID:
PMC3957899
Cytomegalovirus Mutants Resistant to Ganciclovir and Cidofovir Differ in Susceptibilities to Synguanol and Its 6-Ether and 6-Thioether Derivatives
Sunwen Chou, Gloria Komazin-Meredith, John D. Williams, Terry L. Bowlin
Antimicrob Agents Chemother. Mar 2014; 58(3): 1809–1812. doi: 10.1128/AAC.02544-13
PMCID:
PMC3957852

Experimental Therapeutics

Activities of Fosfomycin and Rifampin on Planktonic and Adherent Enterococcus faecalis Strains in an Experimental Foreign-Body Infection Model
Alessandra Oliva, Ulrika Furustrand Tafin, Elena Maryka Maiolo, Safaa Jeddari, Bertrand Bétrisey, Andrej Trampuz
Antimicrob Agents Chemother. Mar 2014; 58(3): 1284–1293. doi: 10.1128/AAC.02583-12
PMCID:
PMC3957906
Mitchell G. Thompson, Chad C. Black, Rebecca L. Pavlicek, Cary L. Honnold, Matthew C. Wise, Yonas A. Alamneh, Jay K. Moon, Jennifer L. Kessler, Yuanzheng Si, Robert Williams, Suleyman Yildirim, Benjamin C. Kirkup, Jr., Romanza K. Green, Eric R. Hall, Thomas J. Palys, Daniel V. Zurawski
Antimicrob Agents Chemother. Mar 2014; 58(3): 1332–1342. doi: 10.1128/AAC.01944-13
PMCID:
PMC3957858
New Dosing Strategies for an Old Antibiotic: Pharmacodynamics of Front-Loaded Regimens of Colistin at Simulated Pharmacokinetics in Patients with Kidney or Liver Disease
Gauri G. Rao, Neang S. Ly, Curtis E. Haas, Samira Garonzik, Alan Forrest, Jurgen B. Bulitta, Pamela A. Kelchlin, Patricia N. Holden, Roger L. Nation, Jian Li, Brian T. Tsuji
Antimicrob Agents Chemother. Mar 2014; 58(3): 1381–1388. doi: 10.1128/AAC.00327-13
PMCID:
PMC3957851
A Structural Biology Approach Enables the Development of Antimicrobials Targeting Bacterial Immunophilins
Darren W. Begley, David Fox, III, Dominic Jenner, Christina Juli, Phillip G. Pierce, Jan Abendroth, Muigai Muruthi, Kris Safford, Vanessa Anderson, Kateri Atkins, Steve R. Barnes, Spencer O. Moen, Amy C. Raymond, Robin Stacy, Peter J. Myler, Bart L. Staker, Nicholas J. Harmer, Isobel H. Norville, Ulrike Holzgrabe, Mitali Sarkar-Tyson, Thomas E. Edwards, Donald D. Lorimer
Antimicrob Agents Chemother. Mar 2014; 58(3): 1458–1467. doi: 10.1128/AAC.01875-13
PMCID:
PMC3957879
Ceftaroline Restores Daptomycin Activity against Daptomycin-Nonsusceptible Vancomycin-Resistant Enterococcus faecium
George Sakoulas, Warren Rose, Poochit Nonejuie, Joshua Olson, Joseph Pogliano, Romney Humphries, Victor Nizet
Antimicrob Agents Chemother. Mar 2014; 58(3): 1494–1500. doi: 10.1128/AAC.02274-13
PMCID:
PMC3957885
Pharmacological Assessment Defines Leishmania donovani Casein Kinase 1 as a Drug Target and Reveals Important Functions in Parasite Viability and Intracellular Infection
Najma Rachidi, Jean François Taly, Emilie Durieu, Olivier Leclercq, Nathalie Aulner, Eric Prina, Pascale Pescher, Cedric Notredame, Laurent Meijer, Gerald F. Späth
Antimicrob Agents Chemother. Mar 2014; 58(3): 1501–1515. doi: 10.1128/AAC.02022-13
PMCID:
PMC3957854
Dihydroquinazolinone Inhibitors of Proliferation of Blood and Liver Stage Malaria Parasites
Emily R. Derbyshire, Jaeki Min, W. Armand Guiguemde, Julie A. Clark, Michele C. Connelly, Andreia D. Magalhães, R. Kiplin Guy, Jon Clardy
Antimicrob Agents Chemother. Mar 2014; 58(3): 1516–1522. doi: 10.1128/AAC.02148-13
PMCID:
PMC3957893
Use of the Antimicrobial Peptide Pardaxin (GE33) To Protect against Methicillin-Resistant Staphylococcus aureus Infection in Mice with Skin Injuries
Han-Ning Huang, Chieh-Yu Pan, Yi-Lin Chan, Jyh-Yih Chen, Chang-Jer Wu
Antimicrob Agents Chemother. Mar 2014; 58(3): 1538–1545. doi: 10.1128/AAC.02427-13
PMCID:
PMC3957904
Anne-Marie Zeeman, Sandra M. van Amsterdam, Case W. McNamara, Annemarie Voorberg-van der Wel, Els J. Klooster, Alexander van den Berg, Edmond J. Remarque, David M. Plouffe, Geert-Jan van Gemert, Adrian Luty, Robert Sauerwein, Kerstin Gagaring, Rachel Borboa, Zhong Chen, Kelli Kuhen, Richard J. Glynne, Arnab K. Chatterjee, Advait Nagle, Jason Roland, Elizabeth A. Winzeler, Didier Leroy, Brice Campo, Thierry T. Diagana, Bryan K. S. Yeung, Alan W. Thomas, Clemens H. M. Kocken
Antimicrob Agents Chemother. Mar 2014; 58(3): 1586–1595. doi: 10.1128/AAC.01927-13
PMCID:
PMC3957848
In Vitro Synergistic Effect of Amphotericin B and Allicin on Leishmania donovani and L. infantum
M. J. Corral, E. González-Sánchez, M. Cuquerella, J. M. Alunda
Antimicrob Agents Chemother. Mar 2014; 58(3): 1596–1602. doi: 10.1128/AAC.00710-13
PMCID:
PMC3957907
Validation of IMP Dehydrogenase Inhibitors in a Mouse Model of Cryptosporidiosis
Suresh Kumar Gorla, Nina N. McNair, Guangyi Yang, Song Gao, Ming Hu, Venkatakrishna R. Jala, Bodduluri Haribabu, Boris Striepen, Gregory D. Cuny, Jan R. Mead, Lizbeth Hedstrom
Antimicrob Agents Chemother. Mar 2014; 58(3): 1603–1614. doi: 10.1128/AAC.02075-13
PMCID:
PMC3957894
Bioluminescence and 19F Magnetic Resonance Imaging Visualize the Efficacy of Lysostaphin Alone and in Combination with Oxacillin against Staphylococcus aureus in Murine Thigh and Catheter-Associated Infection Models
Tobias Hertlein, Volker Sturm, Udo Lorenz, K. Sumathy, Peter Jakob, Knut Ohlsen
Antimicrob Agents Chemother. Mar 2014; 58(3): 1630–1638. doi: 10.1128/AAC.01422-13
PMCID:
PMC3957871
Substituted Diphenyl Ethers as a Novel Chemotherapeutic Platform against Burkholderia pseudomallei
Jason E. Cummings, Adam J. Beaupre, Susan E. Knudson, Nina Liu, Weixuan Yu, Carla Neckles, Hui Wang, Avinash Khanna, Gopal R. Bommineni, Lily A. Trunck, Herbert P. Schweizer, Peter J. Tonge, Richard A. Slayden
Antimicrob Agents Chemother. Mar 2014; 58(3): 1646–1651. doi: 10.1128/AAC.02296-13
PMCID:
PMC3957837
In Vivo Efficacy of Human Simulated Regimens of Carbapenems and Comparator Agents against NDM-1-Producing Enterobacteriaceae
Dora E. Wiskirchen, Patrice Nordmann, Jared L. Crandon, David P. Nicolau
Antimicrob Agents Chemother. Mar 2014; 58(3): 1671–1677. doi: 10.1128/AAC.01946-13
PMCID:
PMC3957895
Efficacy of Humanized Carbapenem and Ceftazidime Regimens against Enterobacteriaceae Producing OXA-48 Carbapenemase in a Murine Infection Model
Dora E. Wiskirchen, Patrice Nordmann, Jared L. Crandon, David P. Nicolau
Antimicrob Agents Chemother. Mar 2014; 58(3): 1678–1683. doi: 10.1128/AAC.01947-13
PMCID:
PMC3957853
Macrophage Reporter Cell Assay for Screening Immunopharmacological Activity of Cell Wall-Active Antifungals
Russell E. Lewis, Guangling Liao, Katherine Young, Cameron Douglas, Dimitrios P. Kontoyiannis
Antimicrob Agents Chemother. Mar 2014; 58(3): 1738–1743. doi: 10.1128/AAC.02408-13
PMCID:
PMC3957890
Low or High Doses of Cefquinome Targeting Low or High Bacterial Inocula Cure Klebsiella pneumoniae Lung Infections but Differentially Impact the Levels of Antibiotic Resistance in Fecal Flora
Maleck V. Vasseur, Michel Laurentie, Jean-Guy Rolland, Agnès Perrin-Guyomard, Jérôme Henri, Aude A. Ferran, Pierre-Louis Toutain, Alain Bousquet-Mélou
Antimicrob Agents Chemother. Mar 2014; 58(3): 1744–1748. doi: 10.1128/AAC.02135-13
PMCID:
PMC3957826
Evaluation of Double- and Triple-Antibiotic Combinations for VIM- and NDM-Producing Klebsiella pneumoniae by In Vitro Time-Kill Experiments
T. Tängdén, R. A. Hickman, P. Forsberg, P. Lagerbäck, C. G. Giske, O. Cars
Antimicrob Agents Chemother. Mar 2014; 58(3): 1757–1762. doi: 10.1128/AAC.00741-13
PMCID:
PMC3957864
Spiroindolone That Inhibits PfATPase4 Is a Potent, Cidal Inhibitor of Toxoplasma gondii Tachyzoites In Vitro and In Vivo
Ying Zhou, Alina Fomovska, Stephen Muench, Bo-Shiun Lai, Ernest Mui, Rima McLeod
Antimicrob Agents Chemother. Mar 2014; 58(3): 1789–1792. doi: 10.1128/AAC.02225-13
PMCID:
PMC3957861
Disruption of Biofilm Formation by the Human Pathogen Acinetobacter baumannii Using Engineered Quorum-Quenching Lactonases
Jeng Yeong Chow, Yuanyong Yang, Song Buck Tay, Kim Lee Chua, Wen Shan Yew
Antimicrob Agents Chemother. Mar 2014; 58(3): 1802–1805. doi: 10.1128/AAC.02410-13
PMCID:
PMC3957888
Microbicidal Power of Alpha Radiation in Sterilizing Germinating Bacillus anthracis Spores
Johanna Rivera, Alfred Morgenstern, Frank Bruchertseifer, John F. Kearney, Charles L. Turnbough, Jr., Ekaterina Dadachova, Arturo Casadevall
Antimicrob Agents Chemother. Mar 2014; 58(3): 1813–1815. doi: 10.1128/AAC.01266-13
PMCID:
PMC3957843

Clinical Therapeutics

Pharmacokinetics of Ertapenem in Critically Ill Patients Receiving Continuous Venovenous Hemodialysis or Hemodiafiltration
Rachel F. Eyler, A. Mary Vilay, Ahmed M. Nader, Michael Heung, Melissa Pleva, Kevin M. Sowinski, Daryl D. DePestel, Fritz Sörgel, Martina Kinzig, Bruce A. Mueller
Antimicrob Agents Chemother. Mar 2014; 58(3): 1320–1326. doi: 10.1128/AAC.02090-12
PMCID:
PMC3957850
Failure of Clindamycin To Eradicate Infection with Beta-Hemolytic Streptococci Inducibly Resistant to Clindamycin in an Animal Model and in Human Infections
James S. Lewis, II, Alex J. Lepak, George R. Thompson, III, William A. Craig, David R. Andes, Kathryn E. Sabol-Dzintars, James H. Jorgensen
Antimicrob Agents Chemother. Mar 2014; 58(3): 1327–1331. doi: 10.1128/AAC.01877-13
PMCID:
PMC3957897
Retrospective Analysis of the Efficacies of Two Different Regimens of Aqueous Penicillin G Administered to Children with Pneumonia
Alyson Brandão, Raquel Simbalista, Igor C. Borges, Dafne C. Andrade, Marcelo Araújo, Cristiana M. Nascimento-Carvalho
Antimicrob Agents Chemother. Mar 2014; 58(3): 1343–1347. doi: 10.1128/AAC.01951-13
PMCID:
PMC3957887
Imipenem, Meropenem, or Doripenem To Treat Patients with Pseudomonas aeruginosa Ventilator-Associated Pneumonia
Charles-Edouard Luyt, Alexandra Aubry, Qin Lu, Maïté Micaelo, Nicolas Bréchot, Florence Brossier, Hélène Brisson, Jean-Jacques Rouby, Jean-Louis Trouillet, Alain Combes, Vincent Jarlier, Jean Chastre
Antimicrob Agents Chemother. Mar 2014; 58(3): 1372–1380. doi: 10.1128/AAC.02109-13
PMCID:
PMC3957866
Outcome of Intravenous Azithromycin Therapy in Patients with Complicated Scrub Typhus Compared with That of Doxycycline Therapy Using Propensity-Matched Analysis
Mi-Ok Jang, Hee-Chang Jang, Uh Jin Kim, Joon Hwan Ahn, Seung-Ji Kang, Sook-In Jung, Hee-Young Shin, Kyung-Hwa Park
Antimicrob Agents Chemother. Mar 2014; 58(3): 1488–1493. doi: 10.1128/AAC.01996-13
PMCID:
PMC3957884
Synergistic Effects and Antibiofilm Properties of Chimeric Peptides against Multidrug-Resistant Acinetobacter baumannii Strains
Ramamourthy Gopal, Young Gwon Kim, Jun Ho Lee, Seog Ki Lee, Jeong Don Chae, Byoung Kwan Son, Chang Ho Seo, Yoonkyung Park
Antimicrob Agents Chemother. Mar 2014; 58(3): 1622–1629. doi: 10.1128/AAC.02473-13
PMCID:
PMC3957903

Pharmacology

Moxifloxacin Pharmacokinetics and Pleural Fluid Penetration in Patients with Pleural Effusion
Kalliopi Chatzika, Katerina Manika, Paschalina Kontou, Georgia Pitsiou, Despina Papakosta, Konstantinos Zarogoulidis, Ioannis Kioumis
Antimicrob Agents Chemother. Mar 2014; 58(3): 1315–1319. doi: 10.1128/AAC.02291-13
PMCID:
PMC3957872
Antibiotic Activity against Naive and Induced Streptococcus pneumoniae Biofilms in an In Vitro Pharmacodynamic Model
Nathalie M. Vandevelde, Paul M. Tulkens, Françoise Van Bambeke
Antimicrob Agents Chemother. Mar 2014; 58(3): 1348–1358. doi: 10.1128/AAC.01858-13
PMCID:
PMC3957900
Clinical Pharmacodynamics of Antipseudomonal Cephalosporins in Patients with Ventilator-Associated Pneumonia
Shawn H. MacVane, Joseph L. Kuti, David P. Nicolau
Antimicrob Agents Chemother. Mar 2014; 58(3): 1359–1364. doi: 10.1128/AAC.01463-13
PMCID:
PMC3957877
Efficacies of Ceftazidime-Avibactam and Ceftazidime against Pseudomonas aeruginosa in a Murine Lung Infection Model
Seth T. Housman, Jared L. Crandon, Wright W. Nichols, David P. Nicolau
Antimicrob Agents Chemother. Mar 2014; 58(3): 1365–1371. doi: 10.1128/AAC.02161-13
PMCID:
PMC3957844
Podjanee Jittamala, Sasithon Pukrittayakamee, Joel Tarning, Niklas Lindegardh, Warunee Hanpithakpong, Walter Robert John Taylor, Saranath Lawpoolsri, Prakaykaew Charunwattana, Salwaluk Panapipat, Nicholas J. White, Nicholas P. J. Day
Antimicrob Agents Chemother. Mar 2014; 58(3): 1615–1621. doi: 10.1128/AAC.01786-13
PMCID:
PMC3957867
Role of P-Glycoprotein in the Distribution of the HIV Protease Inhibitor Atazanavir in the Brain and Male Genital Tract
Kevin R. Robillard, Gary N. Y. Chan, Guijin Zhang, Charles la Porte, William Cameron, Reina Bendayan
Antimicrob Agents Chemother. Mar 2014; 58(3): 1713–1722. doi: 10.1128/AAC.02031-13
PMCID:
PMC3957845

Letters to the Editor

Highly Rifampin-Resistant Listeria monocytogenes Isolated from a Patient with Prosthetic Bone Infection
Viviane Chenal-Francisque, Caroline Charlier, Saleem Mehvish, Hélène Dieye, Alexandre Leclercq, Patrice Courvalin, Marc Lecuit
Antimicrob Agents Chemother. Mar 2014; 58(3): 1829–1830. doi: 10.1128/AAC.02449-13
PMCID:
PMC3957898
Detection of PER-2-Producing Enterobacter cloacae in a Brazilian Liver Transplantation Unit
Lorena Cristina Corrêa Fehlberg, Keite da Silva Nogueira, Rodrigo Cayô da Silva, Adriana Gianinni Nicoletti, Jussara Kasuko Palmeiro, Ana Cristina Gales, Libera Maria Dalla-Costa
Antimicrob Agents Chemother. Mar 2014; 58(3): 1831–1832. doi: 10.1128/AAC.01260-13
PMCID:
PMC3957881

Erratum

Multiple Mutations Lead to MexXY-OprM-Dependent Aminoglycoside Resistance in Clinical Strains of Pseudomonas aeruginosa
Sophie Guénard, Cédric Muller, Laura Monlezun, Philippe Benas, Isabelle Broutin, Katy Jeannot, Patrick Plésiat
Antimicrob Agents Chemother. Mar 2014; 58(3): 1833. doi: 10.1128/AAC.00033-14
PMCID:
PMC3957882

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)