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Volume 54(1);  January 2010
Instructions to Authors
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY: 2010 INSTRUCTIONS TO AUTHORS
Antimicrob Agents Chemother. 2010 January; 54(1): 1–23. doi: 10.1128/AAC.01351-09.
PMCID: PMC2798546
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Minireview
Diversity, Epidemiology, and Genetics of Class D β-Lactamases
Laurent Poirel, Thierry Naas, and Patrice Nordmann
Antimicrob Agents Chemother. 2010 January; 54(1): 24–38. Published online 2009 August 31. doi: 10.1128/AAC.01512-08.
PMCID: PMC2798486
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Mechanisms of Action: Physiological Effects
Clindamycin-Induced CovS-Mediated Regulation of the Production of Virulent Exoproteins Streptolysin O, NAD Glycohydrolase, and Streptokinase in Streptococcus pyogenes
Masaaki Minami, Takuya Kamimura, Masanori Isaka, Ichiro Tatsuno, Michio Ohta, and Tadao Hasegawa
Antimicrob Agents Chemother. 2010 January; 54(1): 98–102. Published online 2009 October 5. doi: 10.1128/AAC.00804-09.
PMCID: PMC2798487
| Free in PMC on 2010/07/01 |
Mapping Simocyclinone D8 Interaction with DNA Gyrase: Evidence for a New Binding Site on GyrB
C. Sissi, E. Vazquez, A. Chemello, L. A. Mitchenall, A. Maxwell, and M. Palumbo
Antimicrob Agents Chemother. 2010 January; 54(1): 213–220. Published online 2009 October 26. doi: 10.1128/AAC.00972-09.
PMCID: PMC2798491
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Structure of the Heme Biosynthetic Pseudomonas aeruginosa Porphobilinogen Synthase in Complex with the Antibiotic Alaremycin
Ilka U. Heinemann, Claudia Schulz, Wolf-Dieter Schubert, Dirk W. Heinz, Yang-G. Wang, Yuichi Kobayashi, Yuuki Awa, Masaaki Wachi, Dieter Jahn, and Martina Jahn
Antimicrob Agents Chemother. 2010 January; 54(1): 267–272. Published online 2009 October 12. doi: 10.1128/AAC.00553-09.
PMCID: PMC2798535
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Isolation and Characterization of Two Members of the Siderophore-Microcin Family, Microcins M and H47
Gaëlle Vassiliadis, Delphine Destoumieux-Garzón, Carine Lombard, Sylvie Rebuffat, and Jean Peduzzi
Antimicrob Agents Chemother. 2010 January; 54(1): 288–297. Published online 2009 November 2. doi: 10.1128/AAC.00744-09.
PMCID: PMC2798501
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Influence of Tigecycline on Expression of Virulence Factors in Biofilm-Associated Cells of Methicillin-Resistant Staphylococcus aureus
Karen Smith, Katherine A. Gould, Gordon Ramage, Curtis G. Gemmell, Jason Hinds, and Sue Lang
Antimicrob Agents Chemother. 2010 January; 54(1): 380–387. Published online 2009 October 26. doi: 10.1128/AAC.00155-09.
PMCID: PMC2798542
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Pretreatment of Epithelial Cells with Rifaximin Alters Bacterial Attachment and Internalization Profiles
Eric L. Brown, Qiong Xue, Zhi-Dong Jiang, Yi Xu, and Herbert L. DuPont
Antimicrob Agents Chemother. 2010 January; 54(1): 388–396. Published online 2009 October 26. doi: 10.1128/AAC.00691-09.
PMCID: PMC2798526
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Structure-Microbicidal Activity Relationship of Synthetic Fragments Derived from the Antibacterial α-Helix of Human Lactoferrin
L. Håversen, N. Kondori, L. Baltzer, L. Å. Hanson, G. T. Dolphin, K. Dunér, and I. Mattsby-Baltzer
Antimicrob Agents Chemother. 2010 January; 54(1): 418–425. Published online 2009 November 16. doi: 10.1128/AAC.00908-09.
PMCID: PMC2798562
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Generic and Specific Adaptive Responses of Streptococcus pneumoniae to Challenge with Three Distinct Antimicrobial Peptides, Bacitracin, LL-37, and Nisin
Joanna A. Majchrzykiewicz, Oscar P. Kuipers, and Jetta J. E. Bijlsma
Antimicrob Agents Chemother. 2010 January; 54(1): 440–451. Published online 2009 November 16. doi: 10.1128/AAC.00769-09.
PMCID: PMC2798553
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Relative Contributions of Active Mediated Transport and Passive Diffusion of Fluoroquinolones with Various Lipophilicities in a Calu-3 Lung Epithelial Cell Model
Julien Brillault, Whocely Victor De Castro, and William Couet
Antimicrob Agents Chemother. 2010 January; 54(1): 543–545. Published online 2009 October 12. doi: 10.1128/AAC.00733-09.
PMCID: PMC2798514
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Mechanisms of Resistance
Patients with Long-Term Oral Carriage Harbor High-Persister Mutants of Candida albicans
Michael D. LaFleur, Qingguo Qi, and Kim Lewis
Antimicrob Agents Chemother. 2010 January; 54(1): 39–44. Published online 2009 October 19. doi: 10.1128/AAC.00860-09.
PMCID: PMC2798516
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Molecular and Biochemical Characterization of the Natural Chromosome-Encoded Class A β-Lactamase from Pseudomonas luteola
Benoît Doublet, Frédéric Robin, Isabelle Casin, Laëtitia Fabre, Anne Le Fleche, Richard Bonnet, and François-Xavier Weill
Antimicrob Agents Chemother. 2010 January; 54(1): 45–51. Published online 2009 November 2. doi: 10.1128/AAC.00427-09.
PMCID: PMC2798517
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Metronidazole Resistance in Prevotella spp. and Description of a New nim Gene in Prevotella baroniae
C. Alauzet, F. Mory, C. Teyssier, H. Hallage, J. P. Carlier, G. Grollier, and A. Lozniewski
Antimicrob Agents Chemother. 2010 January; 54(1): 60–64. Published online 2009 October 5. doi: 10.1128/AAC.01003-09.
PMCID: PMC2798483
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Antimicrobial Resistance in Haemophilus influenzae Respiratory Tract Isolates in Korea: Results of a Nationwide Acute Respiratory Infections Surveillance
Songmee Bae, Jaehoon Lee, Jaehwa Lee, Eunah Kim, Sunhwa Lee, Jaeyon Yu, and Yeonho Kang
Antimicrob Agents Chemother. 2010 January; 54(1): 65–71. Published online 2009 November 2. doi: 10.1128/AAC.00966-09.
PMCID: PMC2798543
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Allelic Exchange and Mutant Selection Demonstrate that Common Clinical embCAB Gene Mutations Only Modestly Increase Resistance to Ethambutol in Mycobacterium tuberculosis
Hassan Safi, Robert D. Fleischmann, Scott N. Peterson, Marcus B. Jones, Behnam Jarrahi, and David Alland
Antimicrob Agents Chemother. 2010 January; 54(1): 103–108. Published online 2009 October 12. doi: 10.1128/AAC.01288-09.
PMCID: PMC2798522
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Novel Approach for Comparing the Abilities of Quinolones To Restrict the Emergence of Resistant Mutants during Quinolone Exposure
Muhammad Malik, Gerard Hoatam, Kalyan Chavda, Robert J. Kerns, and Karl Drlica
Antimicrob Agents Chemother. 2010 January; 54(1): 149–156. Published online 2009 October 5. doi: 10.1128/AAC.01035-09.
PMCID: PMC2798492
| Free in PMC on 2010/07/01 |
Transfer of Plasmid-Mediated CTX-M-9 from Salmonella enterica Serotype Virchow to Enterobacteriaceae in Human Flora-Associated Rats Treated with Cefixime
S. Faure, A. Perrin-Guyomard, J. M. Delmas, P. Chatre, and M. Laurentie
Antimicrob Agents Chemother. 2010 January; 54(1): 164–169. Published online 2009 November 9. doi: 10.1128/AAC.00310-09.
PMCID: PMC2798505
| Free in PMC on 2010/07/01 |
Klebsiella pneumoniae AcrAB Efflux Pump Contributes to Antimicrobial Resistance and Virulence
Emma Padilla, Enrique Llobet, Antonio Doménech-Sánchez, Luis Martínez-Martínez, José Antonio Bengoechea, and Sebastián Albertí
Antimicrob Agents Chemother. 2010 January; 54(1): 177–183. Published online 2009 October 26. doi: 10.1128/AAC.00715-09.
PMCID: PMC2798511
| Free in PMC on 2010/07/01 |
Φm46.1, the Main Streptococcus pyogenes Element Carrying mef(A) and tet(O) Genes
Andrea Brenciani, Alessandro Bacciaglia, Carla Vignaroli, Armanda Pugnaloni, Pietro E. Varaldo, and Eleonora Giovanetti
Antimicrob Agents Chemother. 2010 January; 54(1): 221–229. Published online 2009 October 26. doi: 10.1128/AAC.00499-09.
PMCID: PMC2798480
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A Single Mutation in Enzyme I of the Sugar Phosphotransferase System Confers Penicillin Tolerance to Streptococcus gordonii
A. Bizzini, J. M. Entenza, O. Michielin, I. Arnold, B. Erni, and P. Moreillon
Antimicrob Agents Chemother. 2010 January; 54(1): 259–266. Published online 2009 October 26. doi: 10.1128/AAC.00699-09.
PMCID: PMC2798540
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Dispersal of Carbapenemase blaVIM-1 Gene Associated with Different Tn402 Variants, Mercury Transposons, and Conjugative Plasmids in Enterobacteriaceae and Pseudomonas aeruginosa
Marta Tato, Teresa M. Coque, Fernando Baquero, and Rafael Cantón
Antimicrob Agents Chemother. 2010 January; 54(1): 320–327. Published online 2009 November 9. doi: 10.1128/AAC.00783-09.
PMCID: PMC2798558
| Free in PMC on 2010/07/01 |
Novel Ambler Class A Carbapenem-Hydrolyzing β-Lactamase from a Pseudomonas fluorescens Isolate from the Seine River, Paris, France
Delphine Girlich, Laurent Poirel, and Patrice Nordmann
Antimicrob Agents Chemother. 2010 January; 54(1): 328–332. Published online 2009 November 9. doi: 10.1128/AAC.00961-09.
PMCID: PMC2798510
| Free in PMC on 2010/07/01 |
Screening and Quantification of the Expression of Antibiotic Resistance Genes in Acinetobacter baumannii with a Microarray
Sébastien Coyne, Ghislaine Guigon, Patrice Courvalin, and Bruno Périchon
Antimicrob Agents Chemother. 2010 January; 54(1): 333–340. Published online 2009 November 2. doi: 10.1128/AAC.01037-09.
PMCID: PMC2798560
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Molecular Epidemiology of Metallo-β-Lactamase-Producing Pseudomonas aeruginosa Isolates from Norway and Sweden Shows Import of International Clones and Local Clonal Expansion
Ørjan Samuelsen, Mark A. Toleman, Arnfinn Sundsfjord, Johan Rydberg, Truls M. Leegaard, Mats Walder, Astrid Lia, Trond E. Ranheim, Yashas Rajendra, Nils O. Hermansen, Timothy R. Walsh, and Christian G. Giske
Antimicrob Agents Chemother. 2010 January; 54(1): 346–352. Published online 2009 November 2. doi: 10.1128/AAC.00824-09.
PMCID: PMC2798561
| Free in PMC on 2010/07/01 |
An A643T Mutation in the Transcription Factor Upc2p Causes Constitutive ERG11 Upregulation and Increased Fluconazole Resistance in Candida albicans
Clemens J. Heilmann, Sabrina Schneider, Katherine S. Barker, P. David Rogers, and Joachim Morschhäuser
Antimicrob Agents Chemother. 2010 January; 54(1): 353–359. Published online 2009 November 2. doi: 10.1128/AAC.01102-09.
PMCID: PMC2798556
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Fitness Costs and Stability of a High-Level Ciprofloxacin Resistance Phenotype in Salmonella enterica Serotype Enteritidis: Reduced Infectivity Associated with Decreased Expression of Salmonella Pathogenicity Island 1 Genes
Edel O'Regan, Teresa Quinn, Jonathan G. Frye, Jean-Marie Pagès, Steffen Porwollik, Paula J. Fedorka-Cray, Michael McClelland, and Séamus Fanning
Antimicrob Agents Chemother. 2010 January; 54(1): 367–374. Published online 2009 November 16. doi: 10.1128/AAC.00801-09.
PMCID: PMC2798541
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Novel VIM Metallo-β-Lactamase Variant from Clinical Isolates of Enterobacteriaceae from Algeria
Frédéric Robin, Nadjet Aggoune-Khinache, Julien Delmas, Malek Naim, and Richard Bonnet
Antimicrob Agents Chemother. 2010 January; 54(1): 466–470. Published online 2009 November 9. doi: 10.1128/AAC.00017-09.
PMCID: PMC2798476
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VIM-19, a Metallo-β-Lactamase with Increased Carbapenemase Activity from Escherichia coli and Klebsiella pneumoniae
Jose-Manuel Rodriguez-Martinez, Patrice Nordmann, Nicolas Fortineau, and Laurent Poirel
Antimicrob Agents Chemother. 2010 January; 54(1): 471–476. Published online 2009 November 16. doi: 10.1128/AAC.00458-09.
PMCID: PMC2798500
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Molecular Correlates of High-Level Antifolate Resistance in Rwandan Children with Plasmodium falciparum Malaria
Corine Karema, Mallika Imwong, Caterina I. Fanello, Kasia Stepniewska, Aline Uwimana, Supatchara Nakeesathit, Arjen Dondorp, Nicholas P. Day, and Nicholas J. White
Antimicrob Agents Chemother. 2010 January; 54(1): 477–483. Published online 2009 October 19. doi: 10.1128/AAC.00498-09.
PMCID: PMC2798539
| Free in PMC on 2010/07/01 |
Biologic Activities of the TolC-Like Protein of Neisseria meningitidis as Assessed by Functional Complementation in Escherichia coli
Nazia Kamal and William M. Shafer
Antimicrob Agents Chemother. 2010 January; 54(1): 506–508. Published online 2009 November 2. doi: 10.1128/AAC.01168-09.
PMCID: PMC2798496
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Unusual Class 1 Integron Configuration Found in Salmonella Genomic Island 2 from Salmonella enterica Serovar Emek
Neil L. Wilson and Ruth M. Hall
Antimicrob Agents Chemother. 2010 January; 54(1): 513–516. Published online 2009 November 2. doi: 10.1128/AAC.00895-09.
PMCID: PMC2798563
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BEL-2, an Extended-Spectrum β-Lactamase with Increased Activity toward Expanded-Spectrum Cephalosporins in Pseudomonas aeruginosa
Laurent Poirel, Jean-Denis Docquier, Filomena De Luca, Annemie Verlinde, Louis Ide, Gian Maria Rossolini, and Patrice Nordmann
Antimicrob Agents Chemother. 2010 January; 54(1): 533–535. Published online 2009 November 2. doi: 10.1128/AAC.00859-09.
PMCID: PMC2798549
| Free in PMC on 2010/07/01 |
First Report of Extended-Spectrum-β-Lactamase-Producing Salmonella enterica Serovar Kentucky Isolated from Poultry in Ireland
F. Boyle, D. Morris, J. O'Connor, N. DeLappe, J. Ward, and M. Cormican
Antimicrob Agents Chemother. 2010 January; 54(1): 551–553. Published online 2009 November 2. doi: 10.1128/AAC.00916-09.
PMCID: PMC2798478
| Free in PMC on 2010/07/01 |
Characteristics and Population Dynamics of Mosaic penA Allele-Containing Neisseria gonorrhoeae Isolates Collected in Sydney, Australia, in 2007-2008
John W. Tapsall, Sanghamitra Ray, and Athena Limnios
Antimicrob Agents Chemother. 2010 January; 54(1): 554–556. Published online 2009 November 16. doi: 10.1128/AAC.01108-09.
PMCID: PMC2798529
| Free in PMC on 2010/07/01 |
Nonclonal Emergence of Colistin-Resistant Klebsiella pneumoniae Isolates from Blood Samples in South Korea
Ji-Yoeun Suh, Jun Seong Son, Doo Ryeon Chung, Kyong Ran Peck, Kwan Soo Ko, and Jae-Hoon Song
Antimicrob Agents Chemother. 2010 January; 54(1): 560–562. Published online 2009 September 14. doi: 10.1128/AAC.00762-09.
PMCID: PMC2798536
| Free in PMC on 2010/07/01 |
Hydrolysis and Inhibition Profiles of β-Lactamases from Molecular Classes A to D with Doripenem, Imipenem, and Meropenem
Anne Marie Queenan, Wenchi Shang, Robert Flamm, and Karen Bush
Antimicrob Agents Chemother. 2010 January; 54(1): 565–569. Published online 2009 November 2. doi: 10.1128/AAC.01004-09.
PMCID: PMC2798497
| Free in PMC on 2010/07/01 |
Phenotypic and Genotypic Characterization of Enterobacteriaceae with Decreased Susceptibility to Carbapenems: Results from Large Hospital-Based Surveillance Studies in China
Qiwen Yang, Hui Wang, Hongli Sun, Hongbin Chen, Yingchun Xu, and Minjun Chen
Antimicrob Agents Chemother. 2010 January; 54(1): 573–577. Published online 2009 October 5. doi: 10.1128/AAC.01099-09.
PMCID: PMC2798477
| Free in PMC on 2010/07/01 |
Susceptibility
Prevalence and Clonal Characterization of Streptococcus pyogenes Clinical Isolates with Reduced Fluoroquinolone Susceptibility in Spain
Milagrosa Montes, Esther Tamayo, Beatriz Orden, Julián Larruskain, and Emilio Perez-Trallero
Antimicrob Agents Chemother. 2010 January; 54(1): 93–97. Published online 2009 October 5. doi: 10.1128/AAC.00780-09.
PMCID: PMC2798512
| Free in PMC on 2010/07/01 |
In Vitro Activity of Gallium Maltolate against Staphylococci in Logarithmic, Stationary, and Biofilm Growth Phases: Comparison of Conventional and Calorimetric Susceptibility Testing Methods
Daniela Baldoni, Andrea Steinhuber, Werner Zimmerli, and Andrej Trampuz
Antimicrob Agents Chemother. 2010 January; 54(1): 157–163. Published online 2009 October 5. doi: 10.1128/AAC.00700-09.
PMCID: PMC2798479
| Free in PMC on 2010/07/01 |
In Vitro Activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with Defined Macrolide Resistance Mechanisms
Pamela McGhee, Catherine Clark, Klaudia M. Kosowska-Shick, Kensuke Nagai, Bonifacio Dewasse, Linda Beachel, and Peter C. Appelbaum
Antimicrob Agents Chemother. 2010 January; 54(1): 230–238. Published online 2009 November 2. doi: 10.1128/AAC.01123-09.
PMCID: PMC2798494
| Free in PMC on 2010/07/01 |
Echinocandin Susceptibility Testing of Candida Species: Comparison of EUCAST EDef 7.1, CLSI M27-A3, Etest, Disk Diffusion, and Agar Dilution Methods with RPMI and IsoSensitest Media
Maiken Cavling Arendrup, Guillermo Garcia-Effron, Cornelia Lass-Flörl, Alicia Gomez Lopez, Juan-Luis Rodriguez-Tudela, Manuel Cuenca-Estrella, and David S. Perlin
Antimicrob Agents Chemother. 2010 January; 54(1): 426–439. Published online 2009 November 2. doi: 10.1128/AAC.01256-09.
PMCID: PMC2798528
| Free in PMC on 2010/07/01 |
Assessment of the In Vitro Kinetic Activity of Caspofungin against Candida glabrata
V. Nagappan, D. Boikov, and J. A. Vazquez
Antimicrob Agents Chemother. 2010 January; 54(1): 522–525. Published online 2009 October 19. doi: 10.1128/AAC.01339-08.
PMCID: PMC2798515
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In Vitro Activity of Fosfomycin against blaKPC-Containing Klebsiella pneumoniae Isolates, Including Those Nonsusceptible to Tigecycline and/or Colistin
Andrea Endimiani, Gopi Patel, Kristine M. Hujer, Mahesh Swaminathan, Federico Perez, Louis B. Rice, Michael R. Jacobs, and Robert A. Bonomo
Antimicrob Agents Chemother. 2010 January; 54(1): 526–529. Published online 2009 November 9. doi: 10.1128/AAC.01235-09.
PMCID: PMC2798518
| Free in PMC on 2010/07/01 |
In Vitro Activity of Thimerosal against Ocular Pathogenic Fungi
Yan Xu, Guangren Pang, Dongqing Zhao, Chuanwen Gao, Lutan Zhou, Shengtao Sun, and Bingliang Wang
Antimicrob Agents Chemother. 2010 January; 54(1): 536–539. Published online 2009 October 19. doi: 10.1128/AAC.00714-09.
PMCID: PMC2798525
| Free in PMC on 2010/07/01 |
In Vitro Activity of Mirincamycin (U24729A) against Plasmodium falciparum Isolates from Gabon
Jana Held, Richard Westerman, Peter G. Kremsner, and Benjamin Mordmüller
Antimicrob Agents Chemother. 2010 January; 54(1): 540–542. Published online 2009 October 19. doi: 10.1128/AAC.01090-09.
PMCID: PMC2798552
| Free in PMC on 2010/07/01 |
Escherichia coli Sequence Type ST131 as an Emerging Fluoroquinolone-Resistant Uropathogen among Renal Transplant Recipients
James R. Johnson, Brian Johnston, Connie Clabots, Michael A. Kuskowski, Swaroop Pendyala, Chitrita DebRoy, Bogdan Nowicki, and James Rice
Antimicrob Agents Chemother. 2010 January; 54(1): 546–550. Published online 2009 November 16. doi: 10.1128/AAC.01089-09.
PMCID: PMC2798475
| Free in PMC on 2010/07/01 |
In Vitro Potency of CXA-101, a Novel Cephalosporin, against Pseudomonas aeruginosa Displaying Various Resistance Phenotypes, Including Multidrug Resistance
Catharine C. Bulik, Henry Christensen, and David P. Nicolau
Antimicrob Agents Chemother. 2010 January; 54(1): 557–559. Published online 2009 November 16. doi: 10.1128/AAC.00912-09.
PMCID: PMC2798502
| Free in PMC on 2010/07/01 |
Analytical Procedures
Method for Screening Compounds That Influence Virulence Gene Expression in Staphylococcus aureus
Anita Nielsen, Kristian F. Nielsen, Dorte Frees, Thomas O. Larsen, and Hanne Ingmer
Antimicrob Agents Chemother. 2010 January; 54(1): 509–512. Published online 2009 November 16. doi: 10.1128/AAC.00940-09.
PMCID: PMC2798519
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Antiviral Agents
Factors Associated with Virological Response to Etravirine in Nonnucleoside Reverse Transcriptase Inhibitor-Experienced HIV-1-Infected Patients
Anne-Genevieve Marcelin, Philippe Flandre, Diane Descamps, Laurence Morand-Joubert, Charlotte Charpentier, Jacques Izopet, Mary-Anne Trabaud, Henia Saoudin, Constance Delaugerre, Catherine Tamalet, Jacqueline Cottalorda, Magali Bouvier-Alias, Dominique Bettinger, Georges Dos Santos, Annick Ruffault, Chakib Alloui, Cecile Henquell, Sylvie Rogez, Francis Barin, Anne Signori-Schmuck, Sophie Vallet, Bernard Masquelier, Vincent Calvez, and and the ANRS AC11 Resistance Study Group
Antimicrob Agents Chemother. 2010 January; 54(1): 72–77. Published online 2009 November 9. doi: 10.1128/AAC.01051-09.
PMCID: PMC2798499
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Inducible APOBEC3G-Vif Double Stable Cell Line as a High-Throughput Screening Platform To Identify Antiviral Compounds
Boris Nowotny, Thomas Schneider, Gabriele Pradel, Tanja Schirmeister, Axel Rethwilm, and Marc Kirschner
Antimicrob Agents Chemother. 2010 January; 54(1): 78–87. Published online 2009 October 19. doi: 10.1128/AAC.00775-09.
PMCID: PMC2798503
| Free in PMC on 2010/07/01 |
Effects of the Combination of Favipiravir (T-705) and Oseltamivir on Influenza A Virus Infections in Mice
Donald F. Smee, Brett L. Hurst, Min-Hui Wong, Kevin W. Bailey, E. Bart Tarbet, John D. Morrey, and Yousuke Furuta
Antimicrob Agents Chemother. 2010 January; 54(1): 126–133. Published online 2009 November 9. doi: 10.1128/AAC.00933-09.
PMCID: PMC2798555
| Free in PMC on 2010/07/01 |
Long-Lasting Enfuvirtide Carrier Pentasaccharide Conjugates with Potent Anti-Human Immunodeficiency Virus Type 1 Activity
Thierry Huet, Olivier Kerbarh, Dominique Schols, Pascal Clayette, Cécile Gauchet, Guy Dubreucq, Loïc Vincent, Heidi Bompais, Romain Mazinghien, Olivier Querolle, Arnaud Salvador, Jérôme Lemoine, Bruno Lucidi, Jan Balzarini, and Maurice Petitou
Antimicrob Agents Chemother. 2010 January; 54(1): 134–142. Published online 2009 October 5. doi: 10.1128/AAC.00827-09.
PMCID: PMC2798524
| Free in PMC on 2010/07/01 |
An Albumin-Conjugated Peptide Exhibits Potent Anti-HIV Activity and Long In Vivo Half-Life
Dong Xie, Cheng Yao, Li Wang, Wenjie Min, Jiahong Xu, Jiahai Xiao, Mingxian Huang, Bo Chen, Bin Liu, Xiaolin Li, and He Jiang
Antimicrob Agents Chemother. 2010 January; 54(1): 191–196. Published online 2009 October 26. doi: 10.1128/AAC.00976-09.
PMCID: PMC2798538
| Free in PMC on 2010/07/01 |
A Novel Class of meso-Tetrakis-Porphyrin Derivatives Exhibits Potent Activities against Hepatitis C Virus Genotype 1b Replicons In Vitro
Yao Cheng, Lun K. Tsou, Jianfeng Cai, Toshihiro Aya, Ginger E. Dutschman, Elizabeth A. Gullen, Susan P. Grill, Annie Pei-Chun Chen, Brett D. Lindenbach, Andrew D. Hamilton, and Yung-chi Cheng
Antimicrob Agents Chemother. 2010 January; 54(1): 197–206. Published online 2009 November 9. doi: 10.1128/AAC.01206-09.
PMCID: PMC2798527
| Free in PMC on 2010/07/01 |
Mitochondrial DNA Depletion and Respiratory Chain Activity in Primary Human Subcutaneous Adipocytes Treated with Nucleoside Analogue Reverse Transcriptase Inhibitors
Metodi V. Stankov, Thomas Lücke, Anibh M. Das, Reinhold E. Schmidt, and Georg M. N. Behrens
Antimicrob Agents Chemother. 2010 January; 54(1): 280–287. Published online 2009 October 5. doi: 10.1128/AAC.00914-09.
PMCID: PMC2798495
| Free in PMC on 2010/07/01 |
MK-7009, a Potent and Selective Inhibitor of Hepatitis C Virus NS3/4A Protease
Nigel J. Liverton, Steven S. Carroll, Jillian DiMuzio, Christine Fandozzi, Donald J. Graham, Daria Hazuda, M. Katherine Holloway, Steven W. Ludmerer, John A. McCauley, Charles J. McIntyre, David B. Olsen, Michael T. Rudd, Mark Stahlhut, and Joseph P. Vacca
Antimicrob Agents Chemother. 2010 January; 54(1): 305–311. Published online 2009 October 19. doi: 10.1128/AAC.00677-09.
PMCID: PMC2798506
| Free in PMC on 2010/07/01 |
Cellular Pharmacology of the Anti-Hepatitis B Virus Agent β-l-2′,3′-Didehydro-2′,3′-Dideoxy-N4-Hydroxycytidine: Relevance for Activation in HepG2 Cells
E. Matthes and H. Bünger
Antimicrob Agents Chemother. 2010 January; 54(1): 341–345. Published online 2009 November 16. doi: 10.1128/AAC.01176-09.
PMCID: PMC2798482
| Free in PMC on 2010/07/01 |
Inhibition of B Virus (Macacine herpesvirus 1) by Conventional and Experimental Antiviral Compounds
P. W. Krug, R. F. Schinazi, and J. K. Hilliard
Antimicrob Agents Chemother. 2010 January; 54(1): 452–459. Published online 2009 October 26. doi: 10.1128/AAC.01435-08.
PMCID: PMC2798509
| Free in PMC on 2010/07/01 |
Impact of Y143 HIV-1 Integrase Mutations on Resistance to Raltegravir In Vitro and In Vivo
Olivier Delelis, Sylvain Thierry, Frédéric Subra, Françoise Simon, Isabelle Malet, Chakib Alloui, Sophie Sayon, Vincent Calvez, Eric Deprez, Anne-Geneviève Marcelin, Luba Tchertanov, and Jean-François Mouscadet
Antimicrob Agents Chemother. 2010 January; 54(1): 491–501. Published online 2009 November 9. doi: 10.1128/AAC.01075-09.
PMCID: PMC2798554
| Free in PMC on 2010/07/01 |
Experimental Therapeutics
In Vivo Activity of Ceftobiprole in Murine Skin Infections Due to Staphylococcus aureus and Pseudomonas aeruginosa
Jeffrey Fernandez, Jamese J. Hilliard, Darren Abbanat, Wenyan Zhang, John L. Melton, Colleen M. Santoro, Robert K. Flamm, and Karen Bush
Antimicrob Agents Chemother. 2010 January; 54(1): 116–125. Published online 2009 November 2. doi: 10.1128/AAC.00642-09.
PMCID: PMC2798551
| Free in PMC on 2010/07/01 |
In Vitro Pharmacodynamics of Levofloxacin and Other Aerosolized Antibiotics under Multiple Conditions Relevant to Chronic Pulmonary Infection in Cystic Fibrosis
Paula King, Olga Lomovskaya, David C. Griffith, Jane L. Burns, and Michael N. Dudley
Antimicrob Agents Chemother. 2010 January; 54(1): 143–148. Published online 2009 October 5. doi: 10.1128/AAC.00248-09.
PMCID: PMC2798504
| Free in PMC on 2010/07/01 |
In Vitro and In Vivo Efficacies of Teicoplanin-Loaded Calcium Sulfate for Treatment of Chronic Methicillin-Resistant Staphylococcus aureus Osteomyelitis
Wei-Tao Jia, Shi-Hua Luo, Chang-Qing Zhang, and Jian-Qiang Wang
Antimicrob Agents Chemother. 2010 January; 54(1): 170–176. Published online 2009 November 16. doi: 10.1128/AAC.01122-09.
PMCID: PMC2798490
| Free in PMC on 2010/07/01 |
Gallium Disrupts Iron Uptake by Intracellular and Extracellular Francisella Strains and Exhibits Therapeutic Efficacy in a Murine Pulmonary Infection Model
Oyebode Olakanmi, John S. Gunn, Shengchang Su, Shilpa Soni, Daniel J. Hassett, and Bradley E. Britigan
Antimicrob Agents Chemother. 2010 January; 54(1): 244–253. Published online 2009 November 16. doi: 10.1128/AAC.00655-09.
PMCID: PMC2798485
| Free in PMC on 2010/07/01 |
Slow Release of Nitric Oxide from Charged Catheters and Its Effect on Biofilm Formation by Escherichia coli
Gilly Regev-Shoshani, Mary Ko, Chris Miller, and Yossef Av-Gay
Antimicrob Agents Chemother. 2010 January; 54(1): 273–279. Published online 2009 November 2. doi: 10.1128/AAC.00511-09.
PMCID: PMC2798533
| Free in PMC on 2010/07/01 |
Prevention and Treatment of Staphylococcus aureus Pneumonia with a β-Cyclodextrin Derivative
Brook E. Ragle, Vladimir A. Karginov, and Juliane Bubeck Wardenburg
Antimicrob Agents Chemother. 2010 January; 54(1): 298–304. Published online 2009 October 5. doi: 10.1128/AAC.00973-09.
PMCID: PMC2798498
| Free in PMC on 2010/07/01 |
Chip Calorimetry for Fast and Reliable Evaluation of Bactericidal and Bacteriostatic Treatments of Biofilms
F. Buchholz, A. Wolf, J. Lerchner, F. Mertens, H. Harms, and T. Maskow
Antimicrob Agents Chemother. 2010 January; 54(1): 312–319. Published online 2009 October 12. doi: 10.1128/AAC.00583-09.
PMCID: PMC2798513
| Free in PMC on 2010/07/01 |
Bacteriophage Cocktail for the Prevention of Biofilm Formation by Pseudomonas aeruginosa on Catheters in an In Vitro Model System
Weiling Fu, Terri Forster, Oren Mayer, John J. Curtin, Susan M. Lehman, and Rodney M. Donlan
Antimicrob Agents Chemother. 2010 January; 54(1): 397–404. Published online 2009 October 12. doi: 10.1128/AAC.00669-09.
PMCID: PMC2798481
| Free in PMC on 2010/07/01 |
Antifungal Activity of Colistin against Mucorales Species In Vitro and in a Murine Model of Rhizopus oryzae Pulmonary Infection
Ronen Ben-Ami, Russell E. Lewis, Jeffrey Tarrand, Konstantinos Leventakos, and Dimitrios P. Kontoyiannis
Antimicrob Agents Chemother. 2010 January; 54(1): 484–490. Published online 2009 October 26. doi: 10.1128/AAC.00956-09.
PMCID: PMC2798530
| Free in PMC on 2010/07/01 |
Comparative Efficacies of Two Antimony Regimens To Treat Leishmania braziliensis-Induced Cutaneous Leishmaniasis in Rhesus Macaques (Macaca mulatta)
G. Grimaldi, Jr., R. Porrozzi, K. Friedrich, A. Teva, R. S. Marchevsky, F. Vieira, N. Miekeley, and F. J. R. Paumgartten
Antimicrob Agents Chemother. 2010 January; 54(1): 502–505. Published online 2009 October 12. doi: 10.1128/AAC.00858-09.
PMCID: PMC2798537
| Free in PMC on 2010/07/01 |
In Vitro and In Vivo Activities of 1-Hydroxy-2-Alkyl-4(1H)Quinolone Derivatives against Toxoplasma gondii
Lara Liv Bajohr, Ling Ma, Christian Platte, Oliver Liesenfeld, Lutz F. Tietze, Uwe Groß, and Wolfgang Bohne
Antimicrob Agents Chemother. 2010 January; 54(1): 517–521. Published online 2009 November 2. doi: 10.1128/AAC.01001-09.
PMCID: PMC2798484
| Free in PMC on 2010/07/01 |
Efficacy of Posaconazole in a Murine Disseminated Infection by Candida tropicalis
Marçal Mariné, F. Javier Pastor, and Josep Guarro
Antimicrob Agents Chemother. 2010 January; 54(1): 530–532. Published online 2009 October 19. doi: 10.1128/AAC.01136-09.
PMCID: PMC2798508
| Free in PMC on 2010/07/01 |
In Vivo Activities of Recombinant Divercin V41 and Its Structural Variants against Listeria monocytogenes
Jitka Rihakova, Jean-Michel Cappelier, Isabelle Hue, Katerina Demnerova, Michel Fédérighi, Hervé Prévost, and Djamel Drider
Antimicrob Agents Chemother. 2010 January; 54(1): 563–564. Published online 2009 October 19. doi: 10.1128/AAC.00765-09.
PMCID: PMC2798489
| Free in PMC on 2010/07/01 |
Clinical Therapeutics
Continuous Clindamycin Infusion, an Innovative Approach to Treating Bone and Joint Infections
Valérie Zeller, Arnaud Dzeing-Ella, Marie-Dominique Kitzis, Jean-Marc Ziza, Patrick Mamoudy, and Nicole Desplaces
Antimicrob Agents Chemother. 2010 January; 54(1): 88–92. Published online 2009 October 19. doi: 10.1128/AAC.01081-09.
PMCID: PMC2798520
| Free in PMC on 2010/07/01 |
Attributable Hospital Cost and Length of Stay Associated with Health Care-Associated Infections Caused by Antibiotic-Resistant Gram-Negative Bacteria
Patrick D. Mauldin, Cassandra D. Salgado, Ida Solhøj Hansen, Darshana T. Durup, and John A. Bosso
Antimicrob Agents Chemother. 2010 January; 54(1): 109–115. Published online 2009 October 19. doi: 10.1128/AAC.01041-09.
PMCID: PMC2798544
| Free in PMC on 2010/07/01 |
Effect of Antifungal Therapy Timing on Mortality in Cancer Patients with Candidemia
Ying Taur, Nina Cohen, Sarah Dubnow, Alla Paskovaty, and Susan K. Seo
Antimicrob Agents Chemother. 2010 January; 54(1): 184–190. Published online 2009 November 2. doi: 10.1128/AAC.00945-09.
PMCID: PMC2798557
| Free in PMC on 2010/07/01 |
Pharmacology
Pharmacokinetics of Artemether-Lumefantrine and Artesunate-Amodiaquine in Children in Kampala, Uganda
Julia Mwesigwa, Sunil Parikh, Bryan McGee, Polina German, Troy Drysdale, Joan N. Kalyango, Tamara D. Clark, Grant Dorsey, Niklas Lindegardh, Anna Annerberg, Philip J. Rosenthal, Moses R. Kamya, and Francesca Aweeka
Antimicrob Agents Chemother. 2010 January; 54(1): 52–59. Published online 2009 October 19. doi: 10.1128/AAC.00679-09.
PMCID: PMC2798532
| Free in PMC on 2010/07/01 |
Factors Influencing Pharmacokinetics of Prophylactic Posaconazole in Patients Undergoing Allogeneic Stem Cell Transplantation
V. Kohl, C. Müller, O. A. Cornely, K. Abduljalil, U. Fuhr, J. J. Vehreschild, C. Scheid, M. Hallek, and M. J. G. T. Rüping
Antimicrob Agents Chemother. 2010 January; 54(1): 207–212. Published online 2009 October 26. doi: 10.1128/AAC.01027-09.
PMCID: PMC2798545
| Free in PMC on 2010/07/01 |
Safety and Pharmacokinetics of Urtoxazumab, a Humanized Monoclonal Antibody, against Shiga-Like Toxin 2 in Healthy Adults and in Pediatric Patients Infected with Shiga-Like Toxin-Producing Escherichia coli
Eduardo L. López, Maria M. Contrini, Eduardo Glatstein, Silvia González Ayala, Roberto Santoro, Daniel Allende, Gustavo Ezcurra, Eduardo Teplitz, Tamotsu Koyama, Yoichi Matsumoto, Hiroaki Sato, Kazuaki Sakai, Satoru Hoshide, Keiji Komoriya, Takuya Morita, Ronald Harning, and Sheldon Brookman
Antimicrob Agents Chemother. 2010 January; 54(1): 239–243. Published online 2009 October 12. doi: 10.1128/AAC.00343-09.
PMCID: PMC2798559
| Free in PMC on 2010/07/01 |
Pharmacokinetics and Safety of S/GSK1349572, a Next-Generation HIV Integrase Inhibitor, in Healthy Volunteers
Sherene Min, Ivy Song, Julie Borland, Shuguang Chen, Yu Lou, Tamio Fujiwara, and Stephen C. Piscitelli
Antimicrob Agents Chemother. 2010 January; 54(1): 254–258. Published online 2009 November 2. doi: 10.1128/AAC.00842-09.
PMCID: PMC2798521
Pharmacokinetic Properties of Azithromycin in Pregnancy
Sam Salman, Stephen J. Rogerson, Kay Kose, Susan Griffin, Servina Gomorai, Francesca Baiwog, Josephine Winmai, Josin Kandai, Harin A. Karunajeewa, Sean J. O'Halloran, Peter Siba, Kenneth F. Ilett, Ivo Mueller, and Timothy M. E. Davis
Antimicrob Agents Chemother. 2010 January; 54(1): 360–366. Published online 2009 October 26. doi: 10.1128/AAC.00771-09.
PMCID: PMC2798488
| Free in PMC on 2010/07/01 |
Pharmacometrics-Based Dose Selection of Levofloxacin as a Treatment for Postexposure Inhalational Anthrax in Children
Fang Li, Partha Nandy, Shuchean Chien, Gary J. Noel, and Christoffer W. Tornoe
Antimicrob Agents Chemother. 2010 January; 54(1): 375–379. Published online 2009 October 26. doi: 10.1128/AAC.00667-09.
PMCID: PMC2798547
| Free in PMC on 2010/07/01 |
Dose Escalation Study of the Safety, Tolerability, and Pharmacokinetics of Nemonoxacin (TG-873870), a Novel Potent Broad-Spectrum Nonfluorinated Quinolone, in Healthy Volunteers
Luke Lin, Li-Wen Chang, Cheng-Yuan Tsai, Ching-Hung Hsu, David T. Chung, William S. Aronstein, Funmi Ajayi, Barbara Kuzmak, and Robert A. Lyon
Antimicrob Agents Chemother. 2010 January; 54(1): 405–410. Published online 2009 November 2. doi: 10.1128/AAC.00682-09.
PMCID: PMC2798534
| Free in PMC on 2010/07/01 |
Multiple-Dose Safety, Tolerability, and Pharmacokinetics of Oral Nemonoxacin (TG-873870) in Healthy Volunteers
David T. Chung, Cheng-Yuan Tsai, Shu-Jen Chen, Li-Wen Chang, Chi-Hsin R. King, Ching-Hung Hsu, Kit-Mui Chiu, Hao-Chen Tan, Yu-Ting Chang, and Ming-Chu Hsu
Antimicrob Agents Chemother. 2010 January; 54(1): 411–417. Published online 2009 November 2. doi: 10.1128/AAC.00683-09.
PMCID: PMC2798523
| Free in PMC on 2010/07/01 |
Identification of Optimal Renal Dosage Adjustments for Traditional and Extended-Infusion Piperacillin-Tazobactam Dosing Regimens in Hospitalized Patients
N. Patel, M. H. Scheetz, G. L. Drusano, and T. P. Lodise
Antimicrob Agents Chemother. 2010 January; 54(1): 460–465. Published online 2009 October 26. doi: 10.1128/AAC.00296-09.
PMCID: PMC2798531
| Free in PMC on 2010/07/01 |
Absorption, Pharmacokinetics, and Safety of Triclosan after Dermal Administration
Christian Queckenberg, Jürgen Meins, Bertil Wachall, Oxana Doroshyenko, Dorota Tomalik-Scharte, Bärbel Bastian, Mona Abdel-Tawab, and Uwe Fuhr
Antimicrob Agents Chemother. 2010 January; 54(1): 570–572. Published online 2009 October 12. doi: 10.1128/AAC.00615-09.
PMCID: PMC2798550
| Free in PMC on 2010/07/01 |
Letters to the Editor
First Isolation of the blaOXA-23 Carbapenemase Gene from an Environmental Acinetobacter baumannii Isolate
Delphine Girlich, Laurent Poirel, and Patrice Nordmann
Antimicrob Agents Chemother. 2010 January; 54(1): 578–579. Published online 2009 November 2. doi: 10.1128/AAC.00861-09.
PMCID: PMC2798507
| Free in PMC on 2010/07/01 |
SmQnr Contributes to Intrinsic Resistance to Quinolones in Stenotrophomonas maltophilia
María B. Sánchez and José L. Martínez
Antimicrob Agents Chemother. 2010 January; 54(1): 580–581. Published online 2009 October 19. doi: 10.1128/AAC.00496-09.
PMCID: PMC2798493
| Free in PMC on 2010/07/01 |
First Report of the Metallo-β-Lactamase SPM-1 in Europe
Allaaeddin El Salabi, Mark A. Toleman, Janis Weeks, Thomas Bruderer, Reno Frei, and Timothy R. Walsh
Antimicrob Agents Chemother. 2010 January; 54(1): 582. Published online 2009 October 26. doi: 10.1128/AAC.00719-09.
PMCID: PMC2798548
| Free in PMC on 2010/07/01 |
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