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- Volume 56(5); May 2012
Volume 56(5); May 2012
Commentary
Early Endpoints for Acute Bacterial Skin and Skin Structure Infections
George L. Drusano
Antimicrob Agents Chemother. 2012 May; 56(5): 2221–2222. doi: 10.1128/AAC.00157-12
- PMCID:
- PMC3346651
Free in PMC on 2012/11/01
Epidemiology and Surveillance
Evolutionary Changes in Antimicrobial Resistance of Invasive Neisseria meningitidis Isolates in Belgium from 2000 to 2010: Increasing Prevalence of Penicillin Nonsusceptibility
Sophie Bertrand, Françoise Carion, René Wintjens, Vanessa Mathys, Raymond Vanhoof
Antimicrob Agents Chemother. 2012 May; 56(5): 2268–2272. doi: 10.1128/AAC.06310-11
- PMCID:
- PMC3346653
Free in PMC on 2012/11/01
Molecular Epidemiological Analysis of Escherichia coli Sequence Type ST131 (O25:H4) and blaCTX-M-15 among Extended-Spectrum-β-Lactamase-Producing E. coli from the United States, 2000 to 2009
James R. Johnson, Carl Urban, Scott J. Weissman, James H. Jorgensen, James S. Lewis, II, Glen Hansen, Paul H. Edelstein, Ari Robicsek, Timothy Cleary, Javier Adachi, David Paterson, John Quinn, Nancy D. Hanson, Brian D. Johnston, Connie Clabots, Michael A. Kuskowski, the AMERECUS Investigators
Antimicrob Agents Chemother. 2012 May; 56(5): 2364–2370. doi: 10.1128/AAC.05824-11
- PMCID:
- PMC3346636
Free in PMC on 2012/11/01
Microbiological Aetiology, Epidemiology, and Clinical Profile of Prosthetic Joint Infections: Are Current Antibiotic Prophylaxis Guidelines Effective?
Trisha N. Peel, Allen C. Cheng, Kirsty L. Buising, Peter F. M. Choong
Antimicrob Agents Chemother. 2012 May; 56(5): 2386–2391. doi: 10.1128/AAC.06246-11
- PMCID:
- PMC3346661
Free in PMC on 2012/11/01
Comparison of the Clinical Characteristics and Outcomes Associated with Vancomycin-Resistant Enterococcus faecalis and Vancomycin-Resistant E. faecium Bacteremia
Kayoko Hayakawa, Dror Marchaim, Emily T. Martin, Namita Tiwari, Adnan Yousuf, Bharath Sunkara, Harish Pulluru, Harikrishna Kotra, Asma Hasan, Suchitha Bheemreddy, Puja Sheth, Dae-Won Lee, Srinivasa Kamatam, Pradeep Bathina, Priyanka Nanjireddy, Indu K. Chalana, Satyam Patel, Sarwan Kumar, Amit Vahia, Kimberly Ku, Victoria Yee, Jessie Swan, Jason M. Pogue, Paul R. Lephart, Michael J. Rybak, Keith S. Kaye
Antimicrob Agents Chemother. 2012 May; 56(5): 2452–2458. doi: 10.1128/AAC.06299-11
- PMCID:
- PMC3346609
Free in PMC on 2012/11/01
Antibiotic Exposure as a Risk Factor for Fluconazole-Resistant Candida Bloodstream Infection
Ronen Ben-Ami, Keren Olshtain-Pops, Michal Krieger, Ilana Oren, Jihad Bishara, Michael Dan, Yonit Wiener-Well, Miriam Weinberger, Oren Zimhony, Michal Chowers, Gabriel Weber, Israel Potasman, Bibiana Chazan, Imad Kassis, Itamar Shalit, Colin Block, Nathan Keller, Dimitrios P. Kontoyiannis, Michael Giladi, for the Israeli Candidemia Study Group
Antimicrob Agents Chemother. 2012 May; 56(5): 2518–2523. doi: 10.1128/AAC.05947-11
- PMCID:
- PMC3346668
Free in PMC on 2012/11/01
Molecular Characterization of Extended-Spectrum-β-Lactamase-Producing and Plasmid-Mediated AmpC β-Lactamase-Producing Escherichia coli Isolated from Stray Dogs in South Korea
Migma Dorji Tamang, Hyang-Mi Nam, Geum-Chan Jang, Su-Ran Kim, Myung Hwa Chae, Suk-Chan Jung, Jae-Won Byun, Yong Ho Park, Suk-Kyung Lim
Antimicrob Agents Chemother. 2012 May; 56(5): 2705–2712. doi: 10.1128/AAC.05598-11
- PMCID:
- PMC3346616
Free in PMC on 2012/11/01
Minireview
Targeting Persisters for Tuberculosis Control
Ying Zhang, Wing Wai Yew, Michael R. Barer
Antimicrob Agents Chemother. 2012 May; 56(5): 2223–2230. doi: 10.1128/AAC.06288-11
- PMCID:
- PMC3346619
Free in PMC on 2012/11/01
Mechanisms of Action: Physiological Effects
Ajoene, a Sulfur-Rich Molecule from Garlic, Inhibits Genes Controlled by Quorum Sensing
Tim Holm Jakobsen, Maria van Gennip, Richard Kerry Phipps, Meenakshi Sundaram Shanmugham, Louise Dahl Christensen, Morten Alhede, Mette Eline Skindersoe, Thomas Bovbjerg Rasmussen, Karlheinz Friedrich, Friedrich Uthe, Peter Østrup Jensen, Claus Moser, Kristian Fog Nielsen, Leo Eberl, Thomas Ostenfeld Larsen, David Tanner, Niels Høiby, Thomas Bjarnsholt, Michael Givskov
Antimicrob Agents Chemother. 2012 May; 56(5): 2314–2325. doi: 10.1128/AAC.05919-11
- PMCID:
- PMC3346669
Free in PMC on 2012/11/01
Antimicrobial Action and Cell Agglutination by the Eosinophil Cationic Protein Are Modulated by the Cell Wall Lipopolysaccharide Structure
David Pulido, Mohammed Moussaoui, David Andreu, M. Victòria Nogués, Marc Torrent, Ester Boix
Antimicrob Agents Chemother. 2012 May; 56(5): 2378–2385. doi: 10.1128/AAC.06107-11
- PMCID:
- PMC3346588
Free in PMC on 2012/11/01
Induction of Oxidative Stress in Trypanosoma brucei by the Antitrypanosomal Dihydroquinoline OSU-40
Shanshan He, Alex Dayton, Periannan Kuppusamy, Karl A. Werbovetz, Mark E. Drew
Antimicrob Agents Chemother. 2012 May; 56(5): 2428–2434. doi: 10.1128/AAC.06386-11
- PMCID:
- PMC3346584
Free in PMC on 2012/11/01
Trudy H. Grossman, Agata L. Starosta, Corey Fyfe, William O'Brien, David M. Rothstein, Aleksandra Mikolajka, Daniel N. Wilson, Joyce A. Sutcliffe
Antimicrob Agents Chemother. 2012 May; 56(5): 2559–2564. doi: 10.1128/AAC.06187-11
- PMCID:
- PMC3346605
Efflux Pumps of Mycobacterium tuberculosis Play a Significant Role in Antituberculosis Activity of Potential Drug Candidates
Meenakshi Balganesh, Neela Dinesh, Sreevalli Sharma, Sanjana Kuruppath, Anju V. Nair, Umender Sharma
Antimicrob Agents Chemother. 2012 May; 56(5): 2643–2651. doi: 10.1128/AAC.06003-11
- PMCID:
- PMC3346595
Free in PMC on 2012/11/01
Novel N-Benzoyl-2-Hydroxybenzamide Disrupts Unique Parasite Secretory Pathway
Alina Fomovska, Qingqing Huang, Kamal El Bissati, Ernest J. Mui, William H. Witola, Gang Cheng, Ying Zhou, Caroline Sommerville, Craig W. Roberts, Sam Bettis, Sean T. Prigge, Gustavo A. Afanador, Mark R. Hickman, Patty J. Lee, Susan E. Leed, Jennifer M. Auschwitz, Marco Pieroni, Jozef Stec, Stephen P. Muench, David W. Rice, Alan P. Kozikowski, Rima McLeod
Antimicrob Agents Chemother. 2012 May; 56(5): 2666–2682. doi: 10.1128/AAC.06450-11
- PMCID:
- PMC3346615
Free in PMC on 2012/11/01
Mechanisms of Resistance
Genetic and Biochemical Characterization of a Novel Metallo-β-Lactamase, TMB-1, from an Achromobacter xylosoxidans Strain Isolated in Tripoli, Libya
Allaaeddin El Salabi, Pardha Saradhi Borra, Mark A. Toleman, Ørjan Samuelsen, Timothy R. Walsh
Antimicrob Agents Chemother. 2012 May; 56(5): 2241–2245. doi: 10.1128/AAC.05640-11
- PMCID:
- PMC3346670
Free in PMC on 2012/11/01
Emergence of Proteus mirabilis Harboring blaKPC-2 and qnrD in a Chinese Hospital
Yan-yan Hu, Jia-chang Cai, Rong Zhang, Hong-wei Zhou, Qian Sun, Gong-xiang Chen
Antimicrob Agents Chemother. 2012 May; 56(5): 2278–2282. doi: 10.1128/AAC.05519-11
- PMCID:
- PMC3346625
Free in PMC on 2012/11/01
Saquinavir Inhibits the Malaria Parasite's Chloroquine Resistance Transporter
Rowena E. Martin, Alice S. Butterworth, Donald L. Gardiner, Kiaran Kirk, James S. McCarthy, Tina S. Skinner-Adams
Antimicrob Agents Chemother. 2012 May; 56(5): 2283–2289. doi: 10.1128/AAC.00166-12
- PMCID:
- PMC3346596
Free in PMC on 2012/11/01
Phytosphingosine-1-Phosphate Is a Signaling Molecule Involved in Miconazole Resistance in Sessile Candida albicans Cells
Davy Vandenbosch, Anna Bink, Gilmer Govaert, Bruno P. A. Cammue, Hans J. Nelis, Karin Thevissen, Tom Coenye
Antimicrob Agents Chemother. 2012 May; 56(5): 2290–2294. doi: 10.1128/AAC.05106-11
- PMCID:
- PMC3346612
Free in PMC on 2012/11/01
New Mutations in the Mycobacterial ATP Synthase: New Insights into the Binding of the Diarylquinoline TMC207 to the ATP Synthase C-Ring Structure
Elena Segala, Wladimir Sougakoff, Aurelie Nevejans-Chauffour, Vincent Jarlier, Stephanie Petrella
Antimicrob Agents Chemother. 2012 May; 56(5): 2326–2334. doi: 10.1128/AAC.06154-11
- PMCID:
- PMC3346594
Free in PMC on 2012/11/01
Fitness Cost and Interference of Arm/Rmt Aminoglycoside Resistance with the RsmF Housekeeping Methyltransferases
Belen Gutierrez, Jose A. Escudero, Alvaro San Millan, Laura Hidalgo, Laura Carrilero, Cristina M. Ovejero, Alfonso Santos-Lopez, Daniel Thomas-Lopez, Bruno Gonzalez-Zorn
Antimicrob Agents Chemother. 2012 May; 56(5): 2335–2341. doi: 10.1128/AAC.06066-11
- PMCID:
- PMC3346654
Free in PMC on 2012/11/01
Mycobacterium tuberculosis Population Structure Determines the Outcome of Genetics-Based Second-Line Drug Resistance Testing
E. M. Streicher, I. Bergval, K. Dheda, E. C. Böttger, N. C. Gey van Pittius, M. Bosman, G. Coetzee, R. M. Anthony, P. D. van Helden, T. C. Victor, R. M. Warren
Antimicrob Agents Chemother. 2012 May; 56(5): 2420–2427. doi: 10.1128/AAC.05905-11
- PMCID:
- PMC3346650
Free in PMC on 2012/11/01
MurAA Is Required for Intrinsic Cephalosporin Resistance of Enterococcus faecalis
Dušanka Vesić, Christopher J. Kristich
Antimicrob Agents Chemother. 2012 May; 56(5): 2443–2451. doi: 10.1128/AAC.05984-11
- PMCID:
- PMC3346666
Free in PMC on 2012/11/01
Expression of the Resistance-Nodulation-Cell Division Pump AdeIJK in Acinetobacter baumannii Is Regulated by AdeN, a TetR-Type Regulator
Nicolas Rosenfeld, Christiane Bouchier, Patrice Courvalin, Bruno Périchon
Antimicrob Agents Chemother. 2012 May; 56(5): 2504–2510. doi: 10.1128/AAC.06422-11
- PMCID:
- PMC3346617
Free in PMC on 2012/11/01
Lack of Association of the S769N Mutation in Plasmodium falciparum SERCA (PfATP6) with Resistance to Artemisinins
Long Cui, Zenglei Wang, Hongying Jiang, Daniel Parker, Haiyan Wang, Xin-Zhuan Su, Liwang Cui
Antimicrob Agents Chemother. 2012 May; 56(5): 2546–2552. doi: 10.1128/AAC.05943-11
- PMCID:
- PMC3346631
Free in PMC on 2012/11/01
The T788G Mutation in the cyp51C Gene Confers Voriconazole Resistance in Aspergillus flavus Causing Aspergillosis
Wei Liu, Yi Sun, Wei Chen, Weixia Liu, Zhe Wan, Dingfang Bu, Ruoyu Li
Antimicrob Agents Chemother. 2012 May; 56(5): 2598–2603. doi: 10.1128/AAC.05477-11
- PMCID:
- PMC3346632
Free in PMC on 2012/11/01
Integrating Conjugative Elements as Vectors of Antibiotic, Mercury, and Quaternary Ammonium Compound Resistance in Marine Aquaculture Environments
Arturo Rodríguez-Blanco, Manuel L. Lemos, Carlos R. Osorio
Antimicrob Agents Chemother. 2012 May; 56(5): 2619–2626. doi: 10.1128/AAC.05997-11
- PMCID:
- PMC3346659
Free in PMC on 2012/11/01
Crystal Structures of KPC-2 β-Lactamase in Complex with 3-Nitrophenyl Boronic Acid and the Penam Sulfone PSR-3-226
Wei Ke, Christopher R. Bethel, Krisztina M. Papp-Wallace, Sundar Ram Reddy Pagadala, Micheal Nottingham, Daniel Fernandez, John D. Buynak, Robert A. Bonomo, Focco van den Akker
Antimicrob Agents Chemother. 2012 May; 56(5): 2713–2718. doi: 10.1128/AAC.06099-11
- PMCID:
- PMC3346646
Free in PMC on 2012/11/01
Diverse Sequence Types of Klebsiella pneumoniae Contribute to the Dissemination of blaNDM-1 in India, Sweden, and the United Kingdom
Christian G. Giske, Inga Fröding, Chowdhury Mehedi Hasan, Agata Turlej-Rogacka, Mark Toleman, David Livermore, Neil Woodford, Timothy R. Walsh
Antimicrob Agents Chemother. 2012 May; 56(5): 2735–2738. doi: 10.1128/AAC.06142-11
- PMCID:
- PMC3346639
Free in PMC on 2012/11/01
rplC T460C Identified as a Dominant Mutation in Linezolid-Resistant Mycobacterium tuberculosis Strains
Patrick Beckert, Doris Hillemann, Thomas A. Kohl, Jörn Kalinowski, Elvira Richter, Stefan Niemann, Silke Feuerriegel
Antimicrob Agents Chemother. 2012 May; 56(5): 2743–2745. doi: 10.1128/AAC.06227-11
- PMCID:
- PMC3346602
Free in PMC on 2012/11/01
Infrequent Finding of Metallo-β-Lactamase VIM-2 in Carbapenem-Resistant Pseudomonas aeruginosa Strains from Croatia
Sanda Sardelic, Branka Bedenic, Céline Colinon-Dupuich, Stjepan Orhanovic, Zrinka Bosnjak, Vanda Plecko, Benoit Cournoyer, Gian Maria Rossolini
Antimicrob Agents Chemother. 2012 May; 56(5): 2746–2749. doi: 10.1128/AAC.05212-11
- PMCID:
- PMC3346618
Free in PMC on 2012/11/01
The F423Y Mutation in the pfmdr2 Gene and Mutations N51I, C59R, and S108N in the pfdhfr Gene Are Independently Associated with Pyrimethamine Resistance in Plasmodium falciparum Isolates
Sébastien Briolant, Hervé Bogreau, Marine Gil, Housem Bouchiba, Eric Baret, Rémy Amalvict, Christophe Rogier, Bruno Pradines
Antimicrob Agents Chemother. 2012 May; 56(5): 2750–2752. doi: 10.1128/AAC.05618-11
- PMCID:
- PMC3346656
Free in PMC on 2012/11/01
No Decrease in Susceptibility to NVC-422 in Multiple-Passage Studies with Methicillin-Resistant Staphylococcus aureus, S. aureus, Pseudomonas aeruginosa, and Escherichia coli
Louisa D'Lima, Lisa Friedman, Lu Wang, Ping Xu, Mark Anderson, Dmitri Debabov
Antimicrob Agents Chemother. 2012 May; 56(5): 2753–2755. doi: 10.1128/AAC.05985-11
- PMCID:
- PMC3346591
Free in PMC on 2012/11/01
Wild Coastline Birds as Reservoirs of Broad-Spectrum-β-Lactamase-Producing Enterobacteriaceae in Miami Beach, Florida
Laurent Poirel, Anaïs Potron, Carolina De La Cuesta, Timothy Cleary, Patrice Nordmann, L. Silvia Munoz-Price
Antimicrob Agents Chemother. 2012 May; 56(5): 2756–2758. doi: 10.1128/AAC.05982-11
- PMCID:
- PMC3346599
Free in PMC on 2012/11/01
Kanika Deshpande Koirala, Duy Pham Thanh, Sudeep Dhoj Thapa, Amit Arjyal, Abhilasha Karkey, Sabina Dongol, Upendra Man Shrestha, Jeremy J. Farrar, Buddha Basnyat, Stephen Baker
Antimicrob Agents Chemother. 2012 May; 56(5): 2761–2762. doi: 10.1128/AAC.06414-11
- PMCID:
- PMC3346606
Contribution of IncFII and Broad-Host IncA/C and IncN Plasmids to the Local Expansion and Diversification of Phylogroup B2 Escherichia coli ST131 Clones Carrying blaCTX-M-15 and qnrS1 Genes
Ângela Novais, Diana Viana, Fernando Baquero, Javier Martínez-Botas, Rafael Cantón, Teresa M. Coque
Antimicrob Agents Chemother. 2012 May; 56(5): 2763–2766. doi: 10.1128/AAC.06001-11
- PMCID:
- PMC3346627
Free in PMC on 2012/11/01
Genomewide Overexpression Screen for Fosfomycin Resistance in Escherichia coli: MurA Confers Clinical Resistance at Low Fitness Cost
Alejandro Couce, Alejandra Briales, Alexandro Rodríguez-Rojas, Coloma Costas, Álvaro Pascual, Jesús Blázquez
Antimicrob Agents Chemother. 2012 May; 56(5): 2767–2769. doi: 10.1128/AAC.06122-11
- PMCID:
- PMC3346583
Free in PMC on 2012/11/01
blaNDM-1 Is a Chimera Likely Constructed in Acinetobacter baumannii
M. A. Toleman, J. Spencer, L. Jones, T. R. Walsh
Antimicrob Agents Chemother. 2012 May; 56(5): 2773–2776. doi: 10.1128/AAC.06297-11
- PMCID:
- PMC3346620
Free in PMC on 2012/11/01
Chromosomal Mutations Responsible for Fluoroquinolone Resistance in Ureaplasma Species in the United States
Li Xiao, Donna M. Crabb, Lynn B. Duffy, Vanya Paralanov, John I. Glass, Ken B. Waites
Antimicrob Agents Chemother. 2012 May; 56(5): 2780–2783. doi: 10.1128/AAC.06342-11
- PMCID:
- PMC3346621
Free in PMC on 2012/11/01
Susceptibility
An Isoniazid Analogue Promotes Mycobacterium tuberculosis-Nanoparticle Interactions and Enhances Bacterial Killing by Macrophages
Tatiany J. de Faria, Mariane Roman, Nicole M. de Souza, Rodrigo De Vecchi, João Vitor de Assis, Ana Lúcia Gomes dos Santos, Ivan H. Bechtold, Nathalie Winter, Maurilio José Soares, Luciano Paulino Silva, Mauro V. De Almeida, André Báfica
Antimicrob Agents Chemother. 2012 May; 56(5): 2259–2267. doi: 10.1128/AAC.05993-11
- PMCID:
- PMC3346657
Free in PMC on 2012/11/01
Differential In Vivo Activities of Anidulafungin, Caspofungin, and Micafungin against Candida glabrata Isolates with and without FKS Resistance Mutations
Maiken Cavling Arendrup, David S. Perlin, Rasmus Hare Jensen, Susan Julie Howard, Joanne Goodwin, William Hope
Antimicrob Agents Chemother. 2012 May; 56(5): 2435–2442. doi: 10.1128/AAC.06369-11
- PMCID:
- PMC3346593
Free in PMC on 2012/11/01
Comparative In Vitro Activities of LFF571 against Clostridium difficile and 630 Other Intestinal Strains of Aerobic and Anaerobic Bacteria
Diane M. Citron, Kerin L. Tyrrell, C. Vreni Merriam, Ellie J. C. Goldstein
Antimicrob Agents Chemother. 2012 May; 56(5): 2493–2503. doi: 10.1128/AAC.06305-11
- PMCID:
- PMC3346664
Free in PMC on 2012/11/01
Epidemiological Cutoff Values for Azoles and Aspergillus fumigatus Based on a Novel Mathematical Approach Incorporating cyp51A Sequence Analysis
J. Meletiadis, E. Mavridou, W. J. G. Melchers, J. W. Mouton, P. E. Verweij
Antimicrob Agents Chemother. 2012 May; 56(5): 2524–2529. doi: 10.1128/AAC.05959-11
- PMCID:
- PMC3346643
Free in PMC on 2012/11/01
Evaluation of the Morphological Effects of TDT 067 (Terbinafine in Transfersome) and Conventional Terbinafine on Dermatophyte Hyphae In Vitro and In Vivo
M. Ghannoum, N. Isham, W. Henry, H.-A. Kroon, S. Yurdakul
Antimicrob Agents Chemother. 2012 May; 56(5): 2530–2534. doi: 10.1128/AAC.05998-11
- PMCID:
- PMC3346586
Free in PMC on 2012/11/01
Dynamic Interaction between Fluconazole and Amphotericin B against Cryptococcus gattii
Julliana Ribeiro Alves Santos, Ludmila Ferreira Gouveia, Erika Linzi Silva Taylor, Maria Aparecida Resende-Stoianoff, Gerson Antônio Pianetti, Isabela Costa César, Daniel Assis Santos
Antimicrob Agents Chemother. 2012 May; 56(5): 2553–2558. doi: 10.1128/AAC.06098-11
- PMCID:
- PMC3346628
Free in PMC on 2012/11/01
Species-Specific Antifungal Susceptibility Patterns of Scedosporium and Pseudallescheria Species
Michaela Lackner, G. Sybren de Hoog, Paul E. Verweij, Mohammad J. Najafzadeh, Ilse Curfs-Breuker, Corné H. Klaassen, Jacques F. Meis
Antimicrob Agents Chemother. 2012 May; 56(5): 2635–2642. doi: 10.1128/AAC.05910-11
- PMCID:
- PMC3346635
Free in PMC on 2012/11/01
In Vitro Activity of the New Fluoroketolide Solithromycin (CEM-101) against a Large Collection of Clinical Neisseria gonorrhoeae Isolates and International Reference Strains, Including Those with High-Level Antimicrobial Resistance: Potential Treatment Option for Gonorrhea?
Daniel Golparian, Prabhavathi Fernandes, Makoto Ohnishi, Jörgen S. Jensen, Magnus Unemo
Antimicrob Agents Chemother. 2012 May; 56(5): 2739–2742. doi: 10.1128/AAC.00036-12
- PMCID:
- PMC3346660
Free in PMC on 2012/11/01
Analytical Procedures
Expression Turnover Profiling To Monitor the Antifungal Activities of Amphotericin B, Voriconazole, and Micafungin against Aspergillus fumigatus
Yanan Zhao, Padmaja Paderu, Steven Park, Aleksandra Dukhan, Meredith Senter, David S. Perlin
Antimicrob Agents Chemother. 2012 May; 56(5): 2770–2772. doi: 10.1128/AAC.06163-11
- PMCID:
- PMC3346633
Free in PMC on 2012/11/01
Antiviral Agents
George L. Melikian, Soo-Yon Rhee, Jonathan Taylor, W. Jeffrey Fessel, David Kaufman, William Towner, Paolo V. Troia-Cancio, Andrew Zolopa, Gregory K. Robbins, Ron Kagan, Dennis Israelski, Robert W. Shafer
Antimicrob Agents Chemother. 2012 May; 56(5): 2305–2313. doi: 10.1128/AAC.05487-11
- PMCID:
- PMC3346663
Preclinical Evaluation of the HIV-1 Fusion Inhibitor L'644 as a Potential Candidate Microbicide
Sarah Harman, Carolina Herrera, Naomi Armanasco, Jeremy Nuttall, Robin J. Shattock
Antimicrob Agents Chemother. 2012 May; 56(5): 2347–2356. doi: 10.1128/AAC.06108-11
- PMCID:
- PMC3346626
Free in PMC on 2012/11/01
Safety and Efficacy of GSK2248761, a Next-Generation Nonnucleoside Reverse Transcriptase Inhibitor, in Treatment-Naive HIV-1-Infected Subjects
Carlos Zala, Marty St. Clair, Kathleen Dudas, Joseph Kim, Yu Lou, Scott White, Steve Piscitelli, Etienne Dumont, Keith Pietropaolo, Xiao-Jian Zhou, Douglas Mayers
Antimicrob Agents Chemother. 2012 May; 56(5): 2570–2575. doi: 10.1128/AAC.05597-11
- PMCID:
- PMC3346662
Free in PMC on 2012/11/01
Anti-Human Immunodeficiency Virus Type 1 Activity of Novel 6-Substituted 1-Benzyl-3-(3,5-Dimethylbenzyl)Uracil Derivatives
Paula Ordonez, Takayuki Hamasaki, Yohei Isono, Norikazu Sakakibara, Masahiro Ikejiri, Tokumi Maruyama, Masanori Baba
Antimicrob Agents Chemother. 2012 May; 56(5): 2581–2589. doi: 10.1128/AAC.06307-11
- PMCID:
- PMC3346622
Free in PMC on 2012/11/01
Exploiting the Anti-HIV-1 Activity of Acyclovir: Suppression of Primary and Drug-Resistant HIV Isolates and Potentiation of the Activity by Ribavirin
Christophe Vanpouille, Andrea Lisco, Andrea Introini, Jean-Charles Grivel, Arshi Munawwar, Melanie Merbah, Raymond F. Schinazi, Marco Derudas, Christopher McGuigan, Jan Balzarini, Leonid Margolis
Antimicrob Agents Chemother. 2012 May; 56(5): 2604–2611. doi: 10.1128/AAC.05986-11
- PMCID:
- PMC3346610
Free in PMC on 2012/11/01
Effect of Natural Polymorphisms in the HIV-1 CRF02_AG Protease on Protease Inhibitor Hypersusceptibility
André F. A. Santos, Denis M. Tebit, Matthew S. Lalonde, Ana B. Abecasis, Annette Ratcliff, Ricardo J. Camacho, Ricardo S. Diaz, Ottmar Herchenröder, Marcelo A. Soares, Eric J. Arts
Antimicrob Agents Chemother. 2012 May; 56(5): 2719–2725. doi: 10.1128/AAC.06079-11
- PMCID:
- PMC3346603
Free in PMC on 2012/11/01
First Pharmacokinetic and Safety Study in Humans of the Novel Lipid Antiviral Conjugate CMX001, a Broad-Spectrum Oral Drug Active against Double-Stranded DNA Viruses
Wendy Painter, Alice Robertson, Lawrence C. Trost, Susan Godkin, Bernhard Lampert, George Painter
Antimicrob Agents Chemother. 2012 May; 56(5): 2726–2734. doi: 10.1128/AAC.05983-11
- PMCID:
- PMC3346600
Free in PMC on 2012/11/01
Experimental Therapeutics
In Vitro and In Vivo Activities of Posaconazole and Amphotericin B in a Murine Invasive Infection by Mucor circinelloides: Poor Efficacy of Posaconazole
Valentina Salas, F. Javier Pastor, Enrique Calvo, Eduardo Alvarez, Deanna A. Sutton, Emilio Mayayo, Anette W. Fothergill, Michael G. Rinaldi, Josep Guarro
Antimicrob Agents Chemother. 2012 May; 56(5): 2246–2250. doi: 10.1128/AAC.05956-11
- PMCID:
- PMC3346623
Free in PMC on 2012/11/01
Sustained Release of the CCR5 Inhibitors CMPD167 and Maraviroc from Vaginal Rings in Rhesus Macaques
R. Karl Malcolm, Ronald S. Veazey, Leslie Geer, Deborah Lowry, Susan M. Fetherston, Diarmaid J. Murphy, Peter Boyd, Ian Major, Robin J. Shattock, Per Johan Klasse, Lara A. Doyle, Kelsi K. Rasmussen, Laurie Goldman, Thomas J. Ketas, John P. Moore
Antimicrob Agents Chemother. 2012 May; 56(5): 2251–2258. doi: 10.1128/AAC.05810-11
- PMCID:
- PMC3346641
Free in PMC on 2012/11/01
Efficacy of Posaconazole in Murine Experimental Sporotrichosis
Fabiola Fernández-Silva, Javier Capilla, Emilio Mayayo, Josep Guarro
Antimicrob Agents Chemother. 2012 May; 56(5): 2273–2277. doi: 10.1128/AAC.05376-11
- PMCID:
- PMC3346655
Free in PMC on 2012/11/01
Peroral Ciprofloxacin Therapy Impairs the Generation of a Protective Immune Response in a Mouse Model for Salmonella enterica Serovar Typhimurium Diarrhea, while Parenteral Ceftriaxone Therapy Does Not
Kathrin Endt, Lisa Maier, Rina Käppeli, Manja Barthel, Benjamin Misselwitz, Marcus Kremer, Wolf-Dietrich Hardt
Antimicrob Agents Chemother. 2012 May; 56(5): 2295–2304. doi: 10.1128/AAC.05819-11
- PMCID:
- PMC3346637
Free in PMC on 2012/11/01
Pamela R. Tessier, Rebecca A. Keel, Mao Hagihara, Jared L. Crandon, David P. Nicolau
Antimicrob Agents Chemother. 2012 May; 56(5): 2342–2346. doi: 10.1128/AAC.06427-11
- PMCID:
- PMC3346598
In Vitro Efficacy of Diallyl Sulfides against the Periodontopathogen Aggregatibacter actinomycetemcomitans
Kabilan Velliyagounder, Krishnaraj Ganeshnarayan, Senthil Kumar Velusamy, Daniel H. Fine
Antimicrob Agents Chemother. 2012 May; 56(5): 2397–2407. doi: 10.1128/AAC.00020-12
- PMCID:
- PMC3346624
Free in PMC on 2012/11/01
MK-4815, a Potential New Oral Agent for Treatment of Malaria
Mary Ann Powles, John Allocco, Lai Yeung, Bakela Nare, Paul Liberator, Dennis Schmatz
Antimicrob Agents Chemother. 2012 May; 56(5): 2414–2419. doi: 10.1128/AAC.05326-11
- PMCID:
- PMC3346645
Free in PMC on 2012/11/01
Three-Dimensional Human Skin Equivalent as a Tool To Study Acinetobacter baumannii Colonization
Anna de Breij, Elisabeth M. Haisma, Marion Rietveld, Abdelouahab El Ghalbzouri, Peterhans J. van den Broek, Lenie Dijkshoorn, Peter H. Nibbering
Antimicrob Agents Chemother. 2012 May; 56(5): 2459–2464. doi: 10.1128/AAC.05975-11
- PMCID:
- PMC3346587
Free in PMC on 2012/11/01
Daptomycin versus Vancomycin in a Methicillin-Resistant Staphylococcus aureus Endophthalmitis Rabbit Model: Bactericidal Effect, Safety, and Ocular Pharmacokinetics
Sophie Lefèvre, Maher Saleh, Luc Marcellin, Audrey Subilia, Tristan Bourcier, Gilles Prévost, François Jehl
Antimicrob Agents Chemother. 2012 May; 56(5): 2485–2492. doi: 10.1128/AAC.05745-11
- PMCID:
- PMC3346597
Free in PMC on 2012/11/01
Targeted Intracellular Delivery of Antituberculosis Drugs to Mycobacterium tuberculosis-Infected Macrophages via Functionalized Mesoporous Silica Nanoparticles
Daniel L. Clemens, Bai-Yu Lee, Min Xue, Courtney R. Thomas, Huan Meng, Daniel Ferris, Andre E. Nel, Jeffrey I. Zink, Marcus A. Horwitz
Antimicrob Agents Chemother. 2012 May; 56(5): 2535–2545. doi: 10.1128/AAC.06049-11
- PMCID:
- PMC3346638
Free in PMC on 2012/11/01
Daptomycin and Tigecycline Have Broader Effective Dose Ranges than Vancomycin as Prophylaxis against a Staphylococcus aureus Surgical Implant Infection in Mice
Jared A. Niska, Jonathan H. Shahbazian, Romela Irene Ramos, Jonathan R. Pribaz, Fabrizio Billi, Kevin P. Francis, Lloyd S. Miller
Antimicrob Agents Chemother. 2012 May; 56(5): 2590–2597. doi: 10.1128/AAC.06291-11
- PMCID:
- PMC3346658
Free in PMC on 2012/11/01
Pharmacokinetics of Sequential Doses of Capreomycin Powder for Inhalation in Guinea Pigs
L. Garcia-Contreras, Pavan Muttil, John K. Fallon, Mohan Kabadi, Robert Gerety, Anthony J. Hickey
Antimicrob Agents Chemother. 2012 May; 56(5): 2612–2618. doi: 10.1128/AAC.06145-11
- PMCID:
- PMC3346614
Free in PMC on 2012/11/01
Inhibition of Bacterial Biofilm Formation and Swarming Motility by a Small Synthetic Cationic Peptide
César de la Fuente-Núñez, Victoria Korolik, Manjeet Bains, Uyen Nguyen, Elena B. M. Breidenstein, Shawn Horsman, Shawn Lewenza, Lori Burrows, Robert E. W. Hancock
Antimicrob Agents Chemother. 2012 May; 56(5): 2696–2704. doi: 10.1128/AAC.00064-12
- PMCID:
- PMC3346644
Free in PMC on 2012/11/01
Broad-Spectrum β-Lactam Antibiotics for Treating Experimental Peritonitis in Mice Due to Klebsiella pneumoniae Producing the Carbapenemase OXA-48
Olivier Mimoz, Nicolas Grégoire, Laurent Poirel, Manuella Marliat, William Couet, Patrice Nordmann
Antimicrob Agents Chemother. 2012 May; 56(5): 2759–2760. doi: 10.1128/AAC.06069-11
- PMCID:
- PMC3346608
Free in PMC on 2012/11/01
Clinical Therapeutics
CANVAS 1 and 2: Analysis of Clinical Response at Day 3 in Two Phase 3 Trials of Ceftaroline Fosamil versus Vancomycin plus Aztreonam in Treatment of Acute Bacterial Skin and Skin Structure Infections
H. David Friedland, Tanya O'Neal, Donald Biek, Paul B. Eckburg, Douglas R. Rank, Lily Llorens, Alex Smith, Gary W. Witherell, Joseph B. Laudano, Dirk Thye
Antimicrob Agents Chemother. 2012 May; 56(5): 2231–2236. doi: 10.1128/AAC.05738-11
- PMCID:
- PMC3346585
Free in PMC on 2012/11/01
Prospective, Observational Study of Voriconazole Therapeutic Drug Monitoring among Lung Transplant Recipients Receiving Prophylaxis: Factors Impacting Levels of and Associations between Serum Troughs, Efficacy, and Toxicity
Dimitra Mitsani, M. Hong Nguyen, Ryan K. Shields, Yoshiya Toyoda, Eun J. Kwak, Fernanda P. Silveira, Joseph M. Pilewski, Maria M. Crespo, Christian Bermudez, Jay K. Bhama, Cornelius J. Clancy
Antimicrob Agents Chemother. 2012 May; 56(5): 2371–2377. doi: 10.1128/AAC.05219-11
- PMCID:
- PMC3346665
Free in PMC on 2012/11/01
Incidence and Predictors of Nephrotoxicity Associated with Intravenous Colistin in Overweight and Obese Patients
Timothy P. Gauthier, William R. Wolowich, Arathi Reddy, Ennie Cano, Lilian Abbo, Laura B. Smith
Antimicrob Agents Chemother. 2012 May; 56(5): 2392–2396. doi: 10.1128/AAC.00028-12
- PMCID:
- PMC3346640
Free in PMC on 2012/11/01
No Effect of a Single Supratherapeutic Dose of Lersivirine, a Next-Generation Nonnucleoside Reverse Transcriptase Inhibitor, on Corrected QT Interval in Healthy Subjects
Manoli Vourvahis, Rong Wang, Marie-Noella Ndongo, Melissa O'Gorman, Margaret Tawadrous
Antimicrob Agents Chemother. 2012 May; 56(5): 2408–2413. doi: 10.1128/AAC.05194-11
- PMCID:
- PMC3346613
Free in PMC on 2012/11/01
Artemisinin-Naphthoquine Combination Therapy for Uncomplicated Pediatric Malaria: a Tolerability, Safety, and Preliminary Efficacy Study
John Benjamin, Brioni Moore, Sook Ting Lee, Michèle Senn, Susan Griffin, Dulci Lautu, Sam Salman, Peter Siba, Ivo Mueller, Timothy M. E. Davis
Antimicrob Agents Chemother. 2012 May; 56(5): 2465–2471. doi: 10.1128/AAC.06248-11
- PMCID:
- PMC3346652
Free in PMC on 2012/11/01
Artemisinin-Naphthoquine Combination Therapy for Uncomplicated Pediatric Malaria: a Pharmacokinetic Study
Kevin T. Batty, Sam Salman, Brioni R. Moore, John Benjamin, Sook Ting Lee, Madhu Page-Sharp, Nolene Pitus, Kenneth F. Ilett, Ivo Mueller, Francis W. Hombhanje, Peter Siba, Timothy M. E. Davis
Antimicrob Agents Chemother. 2012 May; 56(5): 2472–2484. doi: 10.1128/AAC.06250-11
- PMCID:
- PMC3346649
Free in PMC on 2012/11/01
Comparative Efficacies of Artemisinin Combination Therapies in Plasmodium falciparum Malaria and Polymorphism of pfATPase6, pfcrt, pfdhfr, and pfdhps Genes in Tea Gardens of Jalpaiguri District, India
Pabitra Saha, Subhasish K. Guha, Sonali Das, Shrabanee Mullick, Swagata Ganguly, Asit Biswas, Dilip K. Bera, Gaurangadeb Chattopadhyay, Madhusudan Das, Pratip K. Kundu, Krishnangshu Ray, Ardhendu K. Maji
Antimicrob Agents Chemother. 2012 May; 56(5): 2511–2517. doi: 10.1128/AAC.05388-11
- PMCID:
- PMC3346630
Free in PMC on 2012/11/01
Microbiological Analysis of a Prospective, Randomized, Double-Blind Trial Comparing Moxifloxacin and Clindamycin in the Treatment of Odontogenic Infiltrates and Abscesses
Ingo Sobottka, Karl Wegscheider, Ludwig Balzer, Rainer H. Böger, Olaf Hallier, Ina Giersdorf, Thomas Streichert, Munif Haddad, Ursula Platzer, Georg Cachovan
Antimicrob Agents Chemother. 2012 May; 56(5): 2565–2569. doi: 10.1128/AAC.06428-11
- PMCID:
- PMC3346634
Free in PMC on 2012/11/01
Efficacy of Human Simulated Exposures of Ceftaroline against Phenotypically Diverse Enterobacteriaceae Isolates
Seth T. Housman, Rebecca A. Keel, Jared L. Crandon, Gregory Williams, David P. Nicolau
Antimicrob Agents Chemother. 2012 May; 56(5): 2576–2580. doi: 10.1128/AAC.06416-11
- PMCID:
- PMC3346611
Free in PMC on 2012/11/01
Pharmacokinetics of Different Dosing Strategies of Oral Posaconazole in Patients with Compromised Gastrointestinal Function and Who Are at High Risk for Invasive Fungal Infection
Oliver A. Cornely, David Helfgott, Amelia Langston, Werner Heinz, Jörg-Janne Vehreschild, Maria J. G. T. Vehreschild, Gopal Krishna, Lei Ma, Susan Huyck, Michael C. McCarthy
Antimicrob Agents Chemother. 2012 May; 56(5): 2652–2658. doi: 10.1128/AAC.05937-11
- PMCID:
- PMC3346642
Free in PMC on 2012/11/01
Acyclovir Achieves a Lower Concentration in African HIV-Seronegative, Herpes Simplex Virus 2-Seropositive Women than in Non-African Populations
Yanhui Lu, Connie Celum, Anna Wald, Jared M. Baeten, Frances Cowan, Sinead Delany-Moretlwe, Stewart E. Reid, James P. Hughes, Ellen Wilcox, Lawrence Corey, Craig W. Hendrix
Antimicrob Agents Chemother. 2012 May; 56(5): 2777–2779. doi: 10.1128/AAC.06160-11
- PMCID:
- PMC3346629
Free in PMC on 2012/11/01
Pharmacology
Novel Modeling Framework To Guide Design of Optimal Dosing Strategies for β-Lactamase Inhibitors
Pratik Bhagunde, Kai-Tai Chang, Elizabeth B. Hirsch, Kimberly R. Ledesma, Michael Nikolaou, Vincent H. Tam
Antimicrob Agents Chemother. 2012 May; 56(5): 2237–2240. doi: 10.1128/AAC.06113-11
- PMCID:
- PMC3346582
Free in PMC on 2012/11/01
Pharmacokinetics of Rifampin in Peruvian Tuberculosis Patients with and without Comorbid Diabetes or HIV
Ana Requena-Méndez, Geraint Davies, Alison Ardrey, Oswaldo Jave, Sonia L. López-Romero, Stephen A. Ward, David A. J. Moore
Antimicrob Agents Chemother. 2012 May; 56(5): 2357–2363. doi: 10.1128/AAC.06059-11
- PMCID:
- PMC3346648
Free in PMC on 2012/11/01
Seth T. Housman, J. Samuel Pope, John Russomanno, Edward Salerno, Eric Shore, Joseph L. Kuti, David P. Nicolau
Antimicrob Agents Chemother. 2012 May; 56(5): 2627–2634. doi: 10.1128/AAC.05354-11
- PMCID:
- PMC3346604
Therapeutic Equivalence Requires Pharmaceutical, Pharmacokinetic, and Pharmacodynamic Identities: True Bioequivalence of a Generic Product of Intravenous Metronidazole
M. Agudelo, O. Vesga
Antimicrob Agents Chemother. 2012 May; 56(5): 2659–2665. doi: 10.1128/AAC.06012-11
- PMCID:
- PMC3346647
Free in PMC on 2012/11/01
In Vivo Pharmacokinetics/Pharmacodynamics of Colistin and Imipenem in Pseudomonas aeruginosa Biofilm Infection
Wang Hengzhuang, Hong Wu, Oana Ciofu, Zhijun Song, Niels Høiby
Antimicrob Agents Chemother. 2012 May; 56(5): 2683–2690. doi: 10.1128/AAC.06486-11
- PMCID:
- PMC3346607
Free in PMC on 2012/11/01
Evaluation of Ceftaroline Activity versus Ceftriaxone against Clinical Isolates of Streptococcus pneumoniae with Various Susceptibilities to Cephalosporins in an In Vitro Pharmacokinetic/Pharmacodynamic Model
Molly E. Steed, Céline Vidaillac, Patricia Winterfield, Donald Biek, Michael J. Rybak
Antimicrob Agents Chemother. 2012 May; 56(5): 2691–2695. doi: 10.1128/AAC.06185-11
- PMCID:
- PMC3346590
Free in PMC on 2012/11/01
Letters to the Editor
NDM-1-Producing Klebsiella pneumoniae Now in Turkey
Laurent Poirel, Melda Özdamar, Alain A. Ocampo-Sosa, Salih Türkoglu, Ufuk Guney Ozer, Patrice Nordmann
Antimicrob Agents Chemother. 2012 May; 56(5): 2784–2785. doi: 10.1128/AAC.00150-12
- PMCID:
- PMC3346671
Free in PMC on 2012/11/01
First Carbapenem-Resistant Isolates of Acinetobacter soli in Japan
Shiro Endo, Mina Sasano, Hisakazu Yano, Kazuaki Arai, Tetsuji Aoyagi, Masumitsu Hatta, Yoshiaki Gu, Mitsuhiro Yamada, Koichi Tokuda, Miho Ogawa, Masahiro Shimojima, Miho Kitagawa, Hiroyuki Kunishima, Yoichi Hirakata, Mitsuo Kaku
Antimicrob Agents Chemother. 2012 May; 56(5): 2786–2787. doi: 10.1128/AAC.00021-12
- PMCID:
- PMC3346589
Free in PMC on 2012/11/01
In Vivo Selection of Moxifloxacin-Resistant Clostridium difficile
Ana Mena, Elena Riera, Carla López-Causapé, Irene Weber, José L. Pérez, Antonio Oliver
Antimicrob Agents Chemother. 2012 May; 56(5): 2788–2789. doi: 10.1128/AAC.06433-11
- PMCID:
- PMC3346592
Free in PMC on 2012/11/01
A Case of New Delhi Metallo-β-Lactamase 1 (NDM-1)-Producing Klebsiella pneumoniae with Putative Secondary Transmission from the Balkan Region in the Netherlands
Teysir Halaby, Ascelijn E. Reuland, Nashwan al Naiemi, Anais Potron, Paul H. M. Savelkoul, Christina M. J. E. Vandenbroucke-Grauls, Patrice Nordmann
Antimicrob Agents Chemother. 2012 May; 56(5): 2790–2791. doi: 10.1128/AAC.00111-12
- PMCID:
- PMC3346667
Free in PMC on 2012/11/01
Clonal Dissemination of Linezolid-Resistant Staphylococcus haemolyticus Exhibiting the G2576T Mutation in the 23S rRNA Gene in a Tertiary Care Hospital in Brazil
Lara M. de Almeida, Nilton Lincopan, Maria Rita E. de Araújo, Elsa M. Mamizuka
Antimicrob Agents Chemother. 2012 May; 56(5): 2792–2793. doi: 10.1128/AAC.06089-11
- PMCID:
- PMC3346601
Free in PMC on 2012/11/01