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Volume 58(7);  July 2014

Articles from this journal are usually available in PMC after a 6-month delay (embargo). Some articles may be available sooner.

Editorial

In Memoriam: Robert C. Moellering, Jr.
Louis B. Rice, George M. Eliopoulos, George A. Jacoby
Antimicrob Agents Chemother. Jul 2014; 58(7): 3583–3584. doi: 10.1128/AAC.03199-14
PMCID:
PMC4068561

Mechanisms of Action: Physiological Effects

Michaël L. Cartron, Simon R. England, Alina Iulia Chiriac, Michaele Josten, Robert Turner, Yvonne Rauter, Alexander Hurd, Hans-Georg Sahl, Simon Jones, Simon J. Foster
Antimicrob Agents Chemother. Jul 2014; 58(7): 3599–3609. doi: 10.1128/AAC.01043-13
PMCID:
PMC4068517
Copper Complexation Screen Reveals Compounds with Potent Antibiotic Properties against Methicillin-Resistant Staphylococcus aureus
Mehri Haeili, Casey Moore, Christopher J. C. Davis, James B. Cochran, Santosh Shah, Tej B. Shrestha, Yaofang Zhang, Stefan H. Bossmann, William H. Benjamin, Olaf Kutsch, Frank Wolschendorf
Antimicrob Agents Chemother. Jul 2014; 58(7): 3727–3736. doi: 10.1128/AAC.02316-13
PMCID:
PMC4068557
The Broad-Spectrum Antiviral Compound ST-669 Restricts Chlamydial Inclusion Development and Bacterial Growth and Localizes to Host Cell Lipid Droplets within Treated Cells
Kelsi M. Sandoz, William G. Valiant, Steven G. Eriksen, Dennis E. Hruby, Robert D. Allen, III, Daniel D. Rockey
Antimicrob Agents Chemother. Jul 2014; 58(7): 3860–3866. doi: 10.1128/AAC.02064-13
PMCID:
PMC4068599
Structural Changes and Differentially Expressed Genes in Pseudomonas aeruginosa Exposed to Meropenem-Ciprofloxacin Combination
Vera Lúcia Dias Siqueira, Rosilene Fressatti Cardoso, Katiany Rizzieri Caleffi-Ferracioli, Regiane Bertin de Lima Scodro, Maria Aparecida Fernandez, Adriana Fiorini, Tania Ueda-Nakamura, Benedito Prado Dias-Filho, Celso Vataru Nakamura
Antimicrob Agents Chemother. Jul 2014; 58(7): 3957–3967. doi: 10.1128/AAC.02584-13
PMCID:
PMC4068605
Effects of Renal Impairment on the Pharmacokinetics of Morinidazole: Uptake Transporter-Mediated Renal Clearance of the Conjugated Metabolites
Kan Zhong, Xiuli Li, Cen Xie, Yifan Zhang, Dafang Zhong, Xiaoyan Chen
Antimicrob Agents Chemother. Jul 2014; 58(7): 4153–4161. doi: 10.1128/AAC.02414-14
PMCID:
PMC4068547

Mechanisms of Resistance

Positions and Numbers of FKS Mutations in Candida albicans Selectively Influence In Vitro and In Vivo Susceptibilities to Echinocandin Treatment
M. Lackner, M. Tscherner, M. Schaller, K. Kuchler, C. Mair, B. Sartori, F. Istel, M. C. Arendrup, C. Lass-Flörl
Antimicrob Agents Chemother. Jul 2014; 58(7): 3626–3635. doi: 10.1128/AAC.00123-14
PMCID:
PMC4068606
Selection of Drug Resistance-Mediating Plasmodium falciparum Genetic Polymorphisms by Seasonal Malaria Chemoprevention in Burkina Faso
Anyirékun Fabrice Somé, Issaka Zongo, Yves-Daniel Compaoré, Souleymane Sakandé, François Nosten, Jean-Bosco Ouédraogo, Philip J. Rosenthal
Antimicrob Agents Chemother. Jul 2014; 58(7): 3660–3665. doi: 10.1128/AAC.02406-14
PMCID:
PMC4068591
IncH-Type Plasmid Harboring blaCTX-M-15, blaDHA-1, and qnrB4 Genes Recovered from Animal Isolates
Andreas Schlüter, Patrice Nordmann, Rémy A. Bonnin, Yves Millemann, Felix G. Eikmeyer, Daniel Wibberg, Alfred Pühler, Laurent Poirel
Antimicrob Agents Chemother. Jul 2014; 58(7): 3768–3773. doi: 10.1128/AAC.02695-14
PMCID:
PMC4068538
IS1R-Mediated Plasticity of IncL/M Plasmids Leads to the Insertion of blaOXA-48 into the Escherichia coli Chromosome
R. Beyrouthy, F. Robin, J. Delmas, L. Gibold, G. Dalmasso, F. Dabboussi, M. Hamzé, R. Bonnet
Antimicrob Agents Chemother. Jul 2014; 58(7): 3785–3790. doi: 10.1128/AAC.02669-14
PMCID:
PMC4068556
The mecA Homolog mecC Confers Resistance against β-Lactams in Staphylococcus aureus Irrespective of the Genetic Strain Background
Britta Ballhausen, André Kriegeskorte, Nina Schleimer, Georg Peters, Karsten Becker
Antimicrob Agents Chemother. Jul 2014; 58(7): 3791–3798. doi: 10.1128/AAC.02731-13
PMCID:
PMC4068569
Lack of Antimicrobial Bactericidal Activity in Mycobacterium abscessus
Florian P. Maurer, Vera L. Bruderer, Claudia Ritter, Claudio Castelberg, Guido V. Bloemberg, Erik C. Böttger
Antimicrob Agents Chemother. Jul 2014; 58(7): 3828–3836. doi: 10.1128/AAC.02448-14
PMCID:
PMC4068550
Metabolic Compensation of Fitness Costs Associated with Overexpression of the Multidrug Efflux Pump MexEF-OprN in Pseudomonas aeruginosa
Jorge Olivares, Carolina Álvarez-Ortega, José Luis Martinez
Antimicrob Agents Chemother. Jul 2014; 58(7): 3904–3913. doi: 10.1128/AAC.00121-14
PMCID:
PMC4068598
Crystal Structure of Mox-1, a Unique Plasmid-Mediated Class C β-Lactamase with Hydrolytic Activity towards Moxalactam
Takuma Oguri, Takamitsu Furuyama, Takashi Okuno, Yoshikazu Ishii, Kazuhiro Tateda, Robert A. Bonomo, Akiko Shimizu-Ibuka
Antimicrob Agents Chemother. Jul 2014; 58(7): 3914–3920. doi: 10.1128/AAC.02363-13
PMCID:
PMC4068568
A Low-Affinity Penicillin-Binding Protein 2x Variant Is Required for Heteroresistance in Streptococcus pneumoniae
Hansjürg Engel, Moana Mika, Dalia Denapaite, Regine Hakenbeck, Kathrin Mühlemann, Manfred Heller, Lucy J. Hathaway, Markus Hilty
Antimicrob Agents Chemother. Jul 2014; 58(7): 3934–3941. doi: 10.1128/AAC.02547-14
PMCID:
PMC4068597
Sheltering Effect and Indirect Pathogenesis of Carbapenem-Resistant Acinetobacter baumannii in Polymicrobial Infection
Yu-Ting Liao, Shu-Chen Kuo, Yi-Tzu Lee, Chien-Pei Chen, Shu-Wen Lin, Li-Jiuan Shen, Chang-Phone Fung, Wen-Long Cho, Te-Li Chen
Antimicrob Agents Chemother. Jul 2014; 58(7): 3983–3990. doi: 10.1128/AAC.02636-13
PMCID:
PMC4068520
Putrescine Reduces Antibiotic-Induced Oxidative Stress as a Mechanism of Modulation of Antibiotic Resistance in Burkholderia cenocepacia
Omar M. El-Halfawy, Miguel A. Valvano
Antimicrob Agents Chemother. Jul 2014; 58(7): 4162–4171. doi: 10.1128/AAC.02649-14
PMCID:
PMC4068564
Complete Nucleotide Sequence of Two Multidrug-Resistant IncR Plasmids from Klebsiella pneumoniae
Fabrice Compain, Lionel Frangeul, Laurence Drieux, Charlotte Verdet, Sylvain Brisse, Guillaume Arlet, Dominique Decré
Antimicrob Agents Chemother. Jul 2014; 58(7): 4207–4210. doi: 10.1128/AAC.02773-13
PMCID:
PMC4068571
Plasmid Carriage of blaNDM-1 in Clinical Acinetobacter baumannii Isolates from India
Lim S. Jones, Mark A. Toleman, Janis L. Weeks, Robin A. Howe, Timothy R. Walsh, Karthikeyan K. Kumarasamy
Antimicrob Agents Chemother. Jul 2014; 58(7): 4211–4213. doi: 10.1128/AAC.02500-14
PMCID:
PMC4068588
Phasevarions Mediate Epigenetic Regulation of Antimicrobial Susceptibility in Neisseria meningitidis
Freda E.-C. Jen, Kate L. Seib, Michael P. Jennings
Antimicrob Agents Chemother. Jul 2014; 58(7): 4219–4221. doi: 10.1128/AAC.00004-14
PMCID:
PMC4068601
Phase-Variable Expression of lptA Modulates the Resistance of Neisseria gonorrhoeae to Cationic Antimicrobial Peptides
Justin L. Kandler, Sandeep J. Joseph, Jacqueline T. Balthazar, Vijaya Dhulipala, Timothy D. Read, Ann E. Jerse, William M. Shafer
Antimicrob Agents Chemother. Jul 2014; 58(7): 4230–4233. doi: 10.1128/AAC.03108-14
PMCID:
PMC4068544
Inhibition of Aminoglycoside 6′-N-Acetyltransferase Type Ib by Zinc: Reversal of Amikacin Resistance in Acinetobacter baumannii and Escherichia coli by a Zinc Ionophore
David L. Lin, Tung Tran, Jamal Y. Alam, Steven R. Herron, Maria Soledad Ramirez, Marcelo E. Tolmasky
Antimicrob Agents Chemother. Jul 2014; 58(7): 4238–4241. doi: 10.1128/AAC.00129-14
PMCID:
PMC4068593

Susceptibility

Amikacin-Fosfomycin at a Five-to-Two Ratio: Characterization of Mutation Rates in Microbial Strains Causing Ventilator-Associated Pneumonia and Interactions with Commonly Used Antibiotics
A. Bruce Montgomery, Paul R. Rhomberg, Tammy Abuan, Kathie-Anne Walters, Robert K. Flamm
Antimicrob Agents Chemother. Jul 2014; 58(7): 3708–3713. doi: 10.1128/AAC.02779-13
PMCID:
PMC4068581
Unacceptably High Error Rates in Vitek 2 Testing of Cefepime Susceptibility in Extended-Spectrum-β-Lactamase-Producing Escherichia coli
Nathaniel J. Rhodes, Chad L. Richardson, Ryan Heraty, Jiajun Liu, Michael Malczynski, Chao Qi, Marc H. Scheetz
Antimicrob Agents Chemother. Jul 2014; 58(7): 3757–3761. doi: 10.1128/AAC.00041-14
PMCID:
PMC4068587
Antifungal Susceptibilities of Candida Isolates Causing Bloodstream Infections at a Medical Center in Taiwan, 2009-2010
Yu-Tsung Huang, Chia-Ying Liu, Chun-Hsing Liao, Kuei-Pin Chung, Wang-Huei Sheng, Po-Ren Hsueh
Antimicrob Agents Chemother. Jul 2014; 58(7): 3814–3819. doi: 10.1128/AAC.01035-13
PMCID:
PMC4068559
Validation of Antibiotic Susceptibility Testing Guidelines in a Routine Clinical Microbiology Laboratory Exemplifies General Key Challenges in Setting Clinical Breakpoints
Michael Hombach, Patrice Courvalin, Erik C. Böttger
Antimicrob Agents Chemother. Jul 2014; 58(7): 3921–3926. doi: 10.1128/AAC.02489-13
PMCID:
PMC4068562
In Vivo Assessment of Drug Efficacy against Mycobacterium abscessus Using the Embryonic Zebrafish Test System
Audrey Bernut, Vincent Le Moigne, Tiffany Lesne, Georges Lutfalla, Jean-Louis Herrmann, Laurent Kremer
Antimicrob Agents Chemother. Jul 2014; 58(7): 4054–4063. doi: 10.1128/AAC.00142-14
PMCID:
PMC4068527
4-Amino Bis-Pyridinium Derivatives as Novel Antileishmanial Agents
Verónica Gómez-Pérez, José Ignacio Manzano, Raquel García-Hernández, Santiago Castanys, Joaquín M. Campos Rosa, Francisco Gamarro
Antimicrob Agents Chemother. Jul 2014; 58(7): 4103–4112. doi: 10.1128/AAC.02481-13
PMCID:
PMC4068582
In Vitro Amphotericin B Susceptibility of Malassezia pachydermatis Determined by the CLSI Broth Microdilution Method and Etest Using Lipid-Enriched Media
Sergio Álvarez-Pérez, José L. Blanco, Teresa Peláez, Maite Cutuli, Marta E. García
Antimicrob Agents Chemother. Jul 2014; 58(7): 4203–4206. doi: 10.1128/AAC.00091-14
PMCID:
PMC4068533
In Vitro Activity of AZD5847 against Geographically Diverse Clinical Isolates of Mycobacterium tuberculosis
Jim Werngren, Maria Wijkander, Nasrin Perskvist, V. Balasubramanian, Vasan K. Sambandamurthy, Camilla Rodrigues, Sven Hoffner
Antimicrob Agents Chemother. Jul 2014; 58(7): 4222–4223. doi: 10.1128/AAC.02718-14
PMCID:
PMC4068592
Anti-Candida Activity of Fluoxetine Alone and Combined with Fluconazole: a Synergistic Action against Fluconazole-Resistant Strains
Ana S. Oliveira, Carlos A. Gaspar, Rita Palmeira-de-Oliveira, José Martinez-de-Oliveira, Ana Palmeira-de-Oliveira
Antimicrob Agents Chemother. Jul 2014; 58(7): 4224–4226. doi: 10.1128/AAC.02623-13
PMCID:
PMC4068595

Antiviral Agents

Significance and Clinical Management of Persistent Low-Level Viremia and Very-Low-Level Viremia in HIV-1-Infected Patients
Patrick Ryscavage, Sean Kelly, Jonathan Z. Li, P. Richard Harrigan, Babafemi Taiwo
Antimicrob Agents Chemother. Jul 2014; 58(7): 3585–3598. doi: 10.1128/AAC.00076-14
PMCID:
PMC4068602
Efficiency of Incorporation and Chain Termination Determines the Inhibition Potency of 2′-Modified Nucleotide Analogs against Hepatitis C Virus Polymerase
Amy Fung, Zhinan Jin, Natalia Dyatkina, Guangyi Wang, Leo Beigelman, Jerome Deval
Antimicrob Agents Chemother. Jul 2014; 58(7): 3636–3645. doi: 10.1128/AAC.02666-14
PMCID:
PMC4068585
A Conserved Hydrogen-Bonding Network of P2 bis-Tetrahydrofuran-Containing HIV-1 Protease Inhibitors (PIs) with a Protease Active-Site Amino Acid Backbone Aids in Their Activity against PI-Resistant HIV
Ravikiran S. Yedidi, Harisha Garimella, Manabu Aoki, Hiromi Aoki-Ogata, Darshan V. Desai, Simon B. Chang, David A. Davis, W. Sean Fyvie, Joshua D. Kaufman, David W. Smith, Debananda Das, Paul T. Wingfield, Kenji Maeda, Arun K. Ghosh, Hiroaki Mitsuya
Antimicrob Agents Chemother. Jul 2014; 58(7): 3679–3688. doi: 10.1128/AAC.00107-14
PMCID:
PMC4068604
Akt Inhibitor MK2206 Prevents Influenza pH1N1 Virus Infection In Vitro
Oxana V. Denisova, Sandra Söderholm, Salla Virtanen, Carina Von Schantz, Dmitrii Bychkov, Elena Vashchinkina, Jens Desloovere, Janne Tynell, Niina Ikonen, Linda L. Theisen, Tuula A. Nyman, Sampsa Matikainen, Olli Kallioniemi, Ilkka Julkunen, Claude P. Muller, Xavier Saelens, Vladislav V. Verkhusha, Denis E. Kainov
Antimicrob Agents Chemother. Jul 2014; 58(7): 3689–3696. doi: 10.1128/AAC.02798-13
PMCID:
PMC4068572
Pharmacokinetics-Pharmacodynamics of the Helicase-Primase Inhibitor Pritelivir following Treatment of Wild-Type or Pritelivir-Resistant Virus Infection in a Murine Herpes Simplex Virus 1 Infection Model
Subhajit Biswas, Soumi Sukla, Thomas Goldner, Hugh J. Field, Dirk Kropeit, Daniela Paulsen, André Welbers, Helga Ruebsamen-Schaeff, Holger Zimmermann, Alexander Birkmann
Antimicrob Agents Chemother. Jul 2014; 58(7): 3843–3852. doi: 10.1128/AAC.02641-14
PMCID:
PMC4068558
Characterization of a Respiratory Syncytial Virus L Protein Inhibitor
Choi-Lai Tiong-Yip, Lisa Aschenbrenner, Kenneth D. Johnson, Robert E. McLaughlin, Jun Fan, SreeRupa Challa, Hui Xiong, Qin Yu
Antimicrob Agents Chemother. Jul 2014; 58(7): 3867–3873. doi: 10.1128/AAC.02540-14
PMCID:
PMC4068518
Enhanced Antiretroviral Therapy in Rhesus Macaques Improves RT-SHIV Viral Decay Kinetics
Thomas W. North, Andradi Villalobos, Selwyn J. Hurwitz, Jesse D. Deere, Joanne Higgins, Payel Chatterjee, Sijia Tao, Robert C. Kauffman, Paul A. Luciw, James J. Kohler, Raymond F. Schinazi
Antimicrob Agents Chemother. Jul 2014; 58(7): 3927–3933. doi: 10.1128/AAC.02522-14
PMCID:
PMC4068512
Intracellular Antiviral Activity of Low-Dose Ritonavir in Boosted Protease Inhibitor Regimens
Amedeo De Nicolò, Marco Simiele, Andrea Calcagno, Adnan Mohamed Abdi, Stefano Bonora, Giovanni Di Perri, Antonio D'Avolio
Antimicrob Agents Chemother. Jul 2014; 58(7): 4042–4047. doi: 10.1128/AAC.00104-14
PMCID:
PMC4068548
Inhibition of Foamy Virus Reverse Transcriptase by Human Immunodeficiency Virus Type 1 RNase H Inhibitors
Angela Corona, Anna Schneider, Kristian Schweimer, Paul Rösch, Birgitta M. Wöhrl, Enzo Tramontano
Antimicrob Agents Chemother. Jul 2014; 58(7): 4086–4093. doi: 10.1128/AAC.00056-14
PMCID:
PMC4068541

Epidemiology and Surveillance

Jelagat Cheruiyot, Luicer A. Ingasia, Angela A. Omondi, Dennis W. Juma, Benjamin H. Opot, Joseph M. Ndegwa, Joan Mativo, Agnes C. Cheruiyot, Redemptah Yeda, Charles Okudo, Peninah Muiruri, Ngalah S. Bidii, Lorna J. Chebon, Paul O. Angienda, Fredrick L. Eyase, Jacob D. Johnson, Wallace D. Bulimo, Ben Andagalu, Hoseah M. Akala, Edwin Kamau
Antimicrob Agents Chemother. Jul 2014; 58(7): 3737–3743. doi: 10.1128/AAC.02472-14
PMCID:
PMC4068580
Emergence of Clinical Salmonella enterica Serovar Typhimurium Isolates with Concurrent Resistance to Ciprofloxacin, Ceftriaxone, and Azithromycin
Marcus Ho Yin Wong, Meiying Yan, Edward Wai Chi Chan, Kan Biao, Sheng Chen
Antimicrob Agents Chemother. Jul 2014; 58(7): 3752–3756. doi: 10.1128/AAC.02770-13
PMCID:
PMC4068579
Characteristics of Escherichia coli Sequence Type 131 Isolates That Produce Extended-Spectrum β-Lactamases: Global Distribution of the H30-Rx Sublineage
Gisele Peirano, Akke K. van der Bij, Joshua L. Freeman, Laurent Poirel, Patrice Nordmann, Michael Costello, Veronika L. Tchesnokova, Johann D. D. Pitout
Antimicrob Agents Chemother. Jul 2014; 58(7): 3762–3767. doi: 10.1128/AAC.02428-14
PMCID:
PMC4068522
The T2 Mycobacterium tuberculosis Genotype, Predominant in Kampala, Uganda, Shows Negative Correlation with Antituberculosis Drug Resistance
Deus Lukoye, Fred A. Katabazi, Kenneth Musisi, David P. Kateete, Benon B. Asiimwe, Moses Okee, Moses L. Joloba, Frank G. J. Cobelens
Antimicrob Agents Chemother. Jul 2014; 58(7): 3853–3859. doi: 10.1128/AAC.02338-13
PMCID:
PMC4068514
Inhibitor-Resistant TEM- and OXA-1-Producing Escherichia coli Isolates Resistant to Amoxicillin-Clavulanate Are More Clonal and Possess Lower Virulence Gene Content than Susceptible Clinical Isolates
Jesús Oteo, Juan José González-López, Adriana Ortega, J. Natalia Quintero-Zárate, Germán Bou, Emilia Cercenado, María Carmen Conejo, Luis Martínez-Martínez, Ferran Navarro, Antonio Oliver, Rosa M. Bartolomé, José Campos
Antimicrob Agents Chemother. Jul 2014; 58(7): 3874–3881. doi: 10.1128/AAC.02738-13
PMCID:
PMC4068566
Ceftobiprole Activity against over 60,000 Clinical Bacterial Pathogens Isolated in Europe, Turkey, and Israel from 2005 to 2010
David J. Farrell, Robert K. Flamm, Helio S. Sader, Ronald N. Jones
Antimicrob Agents Chemother. Jul 2014; 58(7): 3882–3888. doi: 10.1128/AAC.02465-14
PMCID:
PMC4068590
Alessandra Carattoli, Ea Zankari, Aurora García-Fernández, Mette Voldby Larsen, Ole Lund, Laura Villa, Frank Møller Aarestrup, Henrik Hasman
Antimicrob Agents Chemother. Jul 2014; 58(7): 3895–3903. doi: 10.1128/AAC.02412-14
PMCID:
PMC4068535
Pediatric Infection and Intestinal Carriage Due to Extended-Spectrum-Cephalosporin-Resistant Enterobacteriaceae
Danielle M. Zerr, Xuan Qin, Assaf P. Oron, Amanda L. Adler, Daniel J. Wolter, Jessica E. Berry, Lucas Hoffman, Scott J. Weissman
Antimicrob Agents Chemother. Jul 2014; 58(7): 3997–4004. doi: 10.1128/AAC.02558-14
PMCID:
PMC4068567
Surveillance of Carbapenem-Resistant Klebsiella pneumoniae: Tracking Molecular Epidemiology and Outcomes through a Regional Network
David van Duin, Federico Perez, Susan D. Rudin, Eric Cober, Jennifer Hanrahan, Julie Ziegler, Raymond Webber, Jacqueline Fox, Pamela Mason, Sandra S. Richter, Marianne Cline, Geraldine S. Hall, Keith S. Kaye, Michael R. Jacobs, Robert C. Kalayjian, Robert A. Salata, Julia A. Segre, Sean Conlan, Scott Evans, Vance G. Fowler, Jr., Robert A. Bonomo
Antimicrob Agents Chemother. Jul 2014; 58(7): 4035–4041. doi: 10.1128/AAC.02636-14
PMCID:
PMC4068524
Clinical Outcomes of Hospital-Acquired Infection with Acinetobacter nosocomialis and Acinetobacter pittii
Sarunyou Chusri, Virasakdi Chongsuvivatwong, Jesabel I. Rivera, Kachornsakdi Silpapojakul, Kamonnut Singkhamanan, Edward McNeil, Yohei Doi
Antimicrob Agents Chemother. Jul 2014; 58(7): 4172–4179. doi: 10.1128/AAC.02992-14
PMCID:
PMC4068534
Multiplex PCR for Identification of Two Capsular Types in Epidemic KPC-Producing Klebsiella pneumoniae Sequence Type 258 Strains
Liang Chen, Kalyan D. Chavda, Jacqueline Findlay, Gisele Peirano, Katie Hopkins, Johann D. D. Pitout, Robert A. Bonomo, Neil Woodford, Frank R. DeLeo, Barry N. Kreiswirth
Antimicrob Agents Chemother. Jul 2014; 58(7): 4196–4199. doi: 10.1128/AAC.02673-14
PMCID:
PMC4068549
Strain Types and Antimicrobial Resistance Patterns of Clostridium difficile Isolates from the United States, 2011 to 2013
Isabella A. Tickler, Richard V. Goering, Joseph D. Whitmore, Ashley N. W. Lynn, David H. Persing, Fred C. Tenover
Antimicrob Agents Chemother. Jul 2014; 58(7): 4214–4218. doi: 10.1128/AAC.02775-13
PMCID:
PMC4068552
Molecular Epidemiology of KPC-Producing Escherichia coli: Occurrence of ST131-fimH30 Subclone Harboring pKpQIL-Like IncFIIk Plasmid
Jessica A. O'Hara, Fupin Hu, Chulsoo Ahn, Jeremy Nelson, Jesabel I. Rivera, Anthony W. Pasculle, Yohei Doi
Antimicrob Agents Chemother. Jul 2014; 58(7): 4234–4237. doi: 10.1128/AAC.02182-13
PMCID:
PMC4068586

Experimental Therapeutics

Efficacy and Safety of AVP-21D9, an Anthrax Monoclonal Antibody, in Animal Models and Humans
Nina V. Malkevich, Robert J. Hopkins, Edward Bernton, Gabriel T. Meister, Eric M. Vela, George Atiee, Virginia Johnson, Gary S. Nabors, Ronald T. Aimes, Boris Ionin, Mario H. Skiadopoulos
Antimicrob Agents Chemother. Jul 2014; 58(7): 3618–3625. doi: 10.1128/AAC.02295-13
PMCID:
PMC4068543
In Vitro Antifungal Susceptibility of Candida glabrata to Caspofungin and the Presence of FKS Mutations Correlate with Treatment Response in an Immunocompromised Murine Model of Invasive Infection
Fabiola Fernández-Silva, Michaela Lackner, Javier Capilla, Emilio Mayayo, Deanna Sutton, Mariana Castanheira, Annette W. Fothergill, Cornelia Lass-Flörl, Josep Guarro
Antimicrob Agents Chemother. Jul 2014; 58(7): 3646–3649. doi: 10.1128/AAC.02666-13
PMCID:
PMC4068555
Pneumocystis jirovecii Rtt109, a Novel Drug Target for Pneumocystis Pneumonia in Immunosuppressed Humans
Jayme L. Dahlin, Theodore Kottom, Junhong Han, Hui Zhou, Michael A. Walters, Zhiguo Zhang, Andrew H. Limper
Antimicrob Agents Chemother. Jul 2014; 58(7): 3650–3659. doi: 10.1128/AAC.02637-14
PMCID:
PMC4068529
Lysine Acetylation in Sexual Stage Malaria Parasites Is a Target for Antimalarial Small Molecules
Katharine Trenholme, Linda Marek, Sandra Duffy, Gabriele Pradel, Gillian Fisher, Finn K. Hansen, Tina S. Skinner-Adams, Alice Butterworth, Che Julius Ngwa, Jonas Moecking, Christopher D. Goodman, Geoffrey I. McFadden, Subathdrage D. M. Sumanadasa, David P. Fairlie, Vicky M. Avery, Thomas Kurz, Katherine T. Andrews
Antimicrob Agents Chemother. Jul 2014; 58(7): 3666–3678. doi: 10.1128/AAC.02721-13
PMCID:
PMC4068603
Synergistic Activity of the Tyrocidines, Antimicrobial Cyclodecapeptides from Bacillus aneurinolyticus, with Amphotericin B and Caspofungin against Candida albicans Biofilms
Anscha Mari Troskie, Marina Rautenbach, Nicolas Delattin, Johan Arnold Vosloo, Margitta Dathe, Bruno P. A. Cammue, Karin Thevissen
Antimicrob Agents Chemother. Jul 2014; 58(7): 3697–3707. doi: 10.1128/AAC.02381-14
PMCID:
PMC4068576
Potentiation Effects of Amikacin and Fosfomycin against Selected Amikacin-Nonsusceptible Gram-Negative Respiratory Tract Pathogens
A. Bruce Montgomery, Paul R. Rhomberg, Tammy Abuan, Kathie-Anne Walters, Robert K. Flamm
Antimicrob Agents Chemother. Jul 2014; 58(7): 3714–3719. doi: 10.1128/AAC.02780-13
PMCID:
PMC4068521
In Vitro and In Vivo Biological Effects of Novel Arylimidamide Derivatives against Trypanosoma cruzi
Bruno Lisboa Timm, Patrícia Bernadino da Silva, Marcos Meuser Batista, Francisca Hildemagna Guedes da Silva, Cristiane França da Silva, Richard R. Tidwell, Donald A. Patrick, Susan Kilgore Jones, Stanislav A. Bakunov, Svetlana M. Bakunova, Maria de Nazaré C. Soeiro
Antimicrob Agents Chemother. Jul 2014; 58(7): 3720–3726. doi: 10.1128/AAC.02353-14
PMCID:
PMC4068584
Art-175 Is a Highly Efficient Antibacterial against Multidrug-Resistant Strains and Persisters of Pseudomonas aeruginosa
Yves Briers, Maarten Walmagh, Barbara Grymonprez, Manfred Biebl, Jean-Paul Pirnay, Valerie Defraine, Jan Michiels, William Cenens, Abram Aertsen, Stefan Miller, Rob Lavigne
Antimicrob Agents Chemother. Jul 2014; 58(7): 3774–3784. doi: 10.1128/AAC.02668-14
PMCID:
PMC4068523
Activity of Potent and Selective Host Defense Peptide Mimetics in Mouse Models of Oral Candidiasis
Lisa K. Ryan, Katie B. Freeman, Jorge A. Masso-Silva, Klaudia Falkovsky, Ashwag Aloyouny, Kenneth Markowitz, Amy G. Hise, Mahnaz Fatahzadeh, Richard W. Scott, Gill Diamond
Antimicrob Agents Chemother. Jul 2014; 58(7): 3820–3827. doi: 10.1128/AAC.02649-13
PMCID:
PMC4068575
The Low Keratin Affinity of Efinaconazole Contributes to Its Nail Penetration and Fungicidal Activity in Topical Onychomycosis Treatment
Keita Sugiura, Noriaki Sugimoto, Shinya Hosaka, Maria Katafuchi-Nagashima, Yoshio Arakawa, Yoshiyuki Tatsumi, William Jo Siu, Radhakrishnan Pillai
Antimicrob Agents Chemother. Jul 2014; 58(7): 3837–3842. doi: 10.1128/AAC.00111-14
PMCID:
PMC4068573
Surotomycin Demonstrates Low In Vitro Frequency of Resistance and Rapid Bactericidal Activity in Clostridium difficile, Enterococcus faecalis, and Enterococcus faecium
Carmela T. M. Mascio, Laurent Chesnel, Grace Thorne, Jared A. Silverman
Antimicrob Agents Chemother. Jul 2014; 58(7): 3976–3982. doi: 10.1128/AAC.00124-14
PMCID:
PMC4068600
Aerosol Phage Therapy Efficacy in Burkholderia cepacia Complex Respiratory Infections
Diana D. Semler, Amanda D. Goudie, Warren H. Finlay, Jonathan J. Dennis
Antimicrob Agents Chemother. Jul 2014; 58(7): 4005–4013. doi: 10.1128/AAC.02388-13
PMCID:
PMC4068594
Limited Activity of Clofazimine as a Single Drug in a Mouse Model of Tuberculosis Exhibiting Caseous Necrotic Granulomas
Scott M. Irwin, Veronica Gruppo, Elizabeth Brooks, Janet Gilliland, Michael Scherman, Matthew J. Reichlen, Rachel Leistikow, Igor Kramnik, Eric L. Nuermberger, Martin I. Voskuil, Anne J. Lenaerts
Antimicrob Agents Chemother. Jul 2014; 58(7): 4026–4034. doi: 10.1128/AAC.02565-14
PMCID:
PMC4068578
Targeting Methicillin-Resistant Staphylococcus aureus with Short Salt-Resistant Synthetic Peptides
Mohamed F. Mohamed, Maha I. Hamed, Alyssa Panitch, Mohamed N. Seleem
Antimicrob Agents Chemother. Jul 2014; 58(7): 4113–4122. doi: 10.1128/AAC.02578-14
PMCID:
PMC4068565
Screening for Inhibition of Vibrio cholerae VipA-VipB Interaction Identifies Small-Molecule Compounds Active against Type VI Secretion
Kun Sun, Jeanette Bröms, Moa Lavander, Bharat Kumar Gurram, Per-Anders Enquist, C. David Andersson, Mikael Elofsson, Anders Sjöstedt
Antimicrob Agents Chemother. Jul 2014; 58(7): 4123–4130. doi: 10.1128/AAC.02819-13
PMCID:
PMC4068513
Immunomodulatory Effect of Linezolid on Methicillin-Resistant Staphylococcus aureus Supernatant-Induced MUC5AC Overexpression in Human Airway Epithelial Cells
Norihito Kaku, Katsunori Yanagihara, Yoshitomo Morinaga, Koichi Yamada, Yosuke Harada, Yohei Migiyama, Kentaro Nagaoka, Shigeki Nakamura, Koichi Izumikawa, Shigeru Kohno
Antimicrob Agents Chemother. Jul 2014; 58(7): 4131–4137. doi: 10.1128/AAC.02811-13
PMCID:
PMC4068536
Hsp90 Inhibitors as New Leads To Target Parasitic Diarrheal Diseases
Anjan Debnath, Dea Shahinas, Clifford Bryant, Ken Hirata, Yukiko Miyamoto, Grace Hwang, Jiri Gut, Adam R. Renslo, Dylan R. Pillai, Lars Eckmann, Sharon L. Reed, James H. McKerrow
Antimicrob Agents Chemother. Jul 2014; 58(7): 4138–4144. doi: 10.1128/AAC.02576-14
PMCID:
PMC4068574
Pharmacokinetic and Pharmacodynamic Evaluation of AZD5847 in a Mouse Model of Tuberculosis
V. Balasubramanian, Suresh Solapure, Radha Shandil, Sheshagiri Gaonkar, K. N. Mahesh, Jitender Reddy, Abhijeet Deshpande, Sowmya Bharath, Naveen Kumar, Lindsay Wright, David Melnick, Scott L. Butler
Antimicrob Agents Chemother. Jul 2014; 58(7): 4185–4190. doi: 10.1128/AAC.00137-14
PMCID:
PMC4068583
In Vitro and In Vivo Studies of the Biological Activity of Novel Arylimidamides against Trypanosoma cruzi
J. S. De Araújo, C. F. Da Silva, D. G. J. Batista, P. B. Da Silva, M. B. Meuser, C. A. F. Aiub, M. F. V. da Silva, C. F. Araújo-Lima, M. Banerjee, A. A. Farahat, C. E. Stephens, A. Kumar, D. W. Boykin, M. N. C. Soeiro
Antimicrob Agents Chemother. Jul 2014; 58(7): 4191–4195. doi: 10.1128/AAC.01403-13
PMCID:
PMC4068551
New Insights into the Bacterial RNA Polymerase Inhibitor CBR703 as a Starting Point for Optimization as an Anti-Infective Agent
Weixing Zhu, Jörg Haupenthal, Matthias Groh, Michelle Fountain, Rolf W. Hartmann
Antimicrob Agents Chemother. Jul 2014; 58(7): 4242–4245. doi: 10.1128/AAC.02600-14
PMCID:
PMC4068539

Clinical Therapeutics

Cohort Study of the Impact of Time to Antibiotic Administration on Mortality in Patients with Febrile Neutropenia
Regis G. Rosa, Luciano Z. Goldani
Antimicrob Agents Chemother. Jul 2014; 58(7): 3799–3803. doi: 10.1128/AAC.02561-14
PMCID:
PMC4068526
Relationship between Time to Clinical Response and Outcomes among Pneumonia Outcomes Research Team (PORT) Risk Class III and IV Hospitalized Patients with Community-Acquired Pneumonia Who Received Ceftriaxone and Azithromycin
Evan Zasowski, Jill M. Butterfield, Louise-Ann McNutt, Jason Cohen, Leon Cosler, Manjunath P. Pai, Joseph Gottwald, Wen Zhen Chen, Thomas P. Lodise
Antimicrob Agents Chemother. Jul 2014; 58(7): 3804–3813. doi: 10.1128/AAC.02632-13
PMCID:
PMC4068528
Impact of Different Antimicrobial Therapies on Clinical and Fiscal Outcomes of Patients with Bacteremia Due to Vancomycin-Resistant Enterococci
Kayoko Hayakawa, Emily T. Martin, Uma Mahesh Gudur, Dror Marchaim, Dalia Dalle, Khaled Alshabani, Kalyan Srinivas Muppavarapu, Fnu Jaydev, Pradeep Bathina, Pranathi Rao Sundaragiri, Shashi Dhar Rajuri, Jaikumar Khatri, Jason M. Pogue, Paul R. Lephart, Michael J. Rybak, Keith S. Kaye
Antimicrob Agents Chemother. Jul 2014; 58(7): 3968–3975. doi: 10.1128/AAC.02943-14
PMCID:
PMC4068570
Randomized, Double-Blind, Multicenter Safety and Efficacy Study of Rifalazil Compared with Azithromycin for Treatment of Uncomplicated Genital Chlamydia trachomatis Infection in Women
William M. Geisler, Maria Luz G. Pascual, Judy Mathew, William D. Koltun, Franklin Morgan, Byron E. Batteiger, Annette Mayes, Sijia Tao, Selwyn J. Hurwitz, Chalom Sayada, Raymond F. Schinazi
Antimicrob Agents Chemother. Jul 2014; 58(7): 4014–4019. doi: 10.1128/AAC.02521-14
PMCID:
PMC4068607
Posaconazole Tablet Pharmacokinetics: Lack of Effect of Concomitant Medications Altering Gastric pH and Gastric Motility in Healthy Subjects
Walter K. Kraft, Peter S. Chang, Marlou L. P. S. van Iersel, Hetty Waskin, Gopal Krishna, Wendy M. Kersemaekers
Antimicrob Agents Chemother. Jul 2014; 58(7): 4020–4025. doi: 10.1128/AAC.02448-13
PMCID:
PMC4068532
Reduced Emergence of Isoniazid Resistance with Concurrent Use of Thioridazine against Acute Murine Tuberculosis
Noton K. Dutta, Michael L. Pinn, Petros C. Karakousis
Antimicrob Agents Chemother. Jul 2014; 58(7): 4048–4053. doi: 10.1128/AAC.02981-14
PMCID:
PMC4068531
T. W. Felton, J. A. Roberts, T. P. Lodise, M. Van Guilder, E. Boselli, M. N. Neely, W. W. Hope
Antimicrob Agents Chemother. Jul 2014; 58(7): 4094–4102. doi: 10.1128/AAC.02664-14
PMCID:
PMC4068511
Tunneled Catheters with Taurolidine-Citrate-Heparin Lock Solution Significantly Improve the Inflammatory Profile of Hemodialysis Patients
Néstor Fontseré, Celia Cardozo, Javier Donate, Alex Soriano, Mercedes Muros, Mercedes Pons, Josep Mensa, Josep M. Campistol, Juan F. Navarro-González, Francisco Maduell
Antimicrob Agents Chemother. Jul 2014; 58(7): 4180–4184. doi: 10.1128/AAC.02421-14
PMCID:
PMC4068545
Linezolid-Induced Lactic Acidosis in Two Liver Transplant Patients with the Mitochondrial DNA A2706G Polymorphism
J. L. Del Pozo, N. Fernández-Ros, E. Sáez, J. I. Herrero, J. R. Yuste, J. M. Banales
Antimicrob Agents Chemother. Jul 2014; 58(7): 4227–4229. doi: 10.1128/AAC.02856-14
PMCID:
PMC4068560

Pharmacology

Phase 1B Study of the Pharmacokinetics and Safety of Posaconazole Intravenous Solution in Patients at Risk for Invasive Fungal Disease
Johan Maertens, Oliver A. Cornely, Andrew J. Ullmann, Werner J. Heinz, Gopal Krishna, Hernando Patino, Maria Caceres, Nicholas Kartsonis, Hetty Waskin, Michael N. Robertson
Antimicrob Agents Chemother. Jul 2014; 58(7): 3610–3617. doi: 10.1128/AAC.02686-13
PMCID:
PMC4068540
Population Pharmacokinetic Analysis of Piperacillin in Burn Patients
Sangil Jeon, Seunghoon Han, Jongtae Lee, Taegon Hong, Jeongki Paek, Heungjeong Woo, Dong-Seok Yim
Antimicrob Agents Chemother. Jul 2014; 58(7): 3744–3751. doi: 10.1128/AAC.02089-13
PMCID:
PMC4068553
Chris Lourens, Niklas Lindegardh, Karen I. Barnes, Philippe J. Guerin, Carol H. Sibley, Nicholas J. White, Joel Tarning
Antimicrob Agents Chemother. Jul 2014; 58(7): 3889–3894. doi: 10.1128/AAC.02362-14
PMCID:
PMC4068537
Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats: 1. Ciprofloxacin, Moxifloxacin, and Grepafloxacin
Aline Vidal Lacerda Gontijo, Julien Brillault, Nicolas Grégoire, Isabelle Lamarche, Patrice Gobin, William Couet, Sandrine Marchand
Antimicrob Agents Chemother. Jul 2014; 58(7): 3942–3949. doi: 10.1128/AAC.02818-14
PMCID:
PMC4068515
Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats: 2. Colistin
Aline Vidal Lacerda Gontijo, Nicolas Grégoire, Isabelle Lamarche, Patrice Gobin, William Couet, Sandrine Marchand
Antimicrob Agents Chemother. Jul 2014; 58(7): 3950–3956. doi: 10.1128/AAC.02819-14
PMCID:
PMC4068596
Penetration of Daptomycin into Bone and Synovial Fluid in Joint Replacement
D. Montange, F. Berthier, G. Leclerc, A. Serre, L. Jeunet, M. Berard, P. Muret, L. Vettoretti, J. Leroy, B. Hoen, C. Chirouze
Antimicrob Agents Chemother. Jul 2014; 58(7): 3991–3996. doi: 10.1128/AAC.02344-14
PMCID:
PMC4068525
Pharmacokinetic Comparison To Determine the Mechanisms Underlying the Differential Efficacies of Cationic Diamidines against First- and Second-Stage Human African Trypanosomiasis
Sihyung Yang, Tanja Wenzler, Patrik N. Miller, Huali Wu, David W. Boykin, Reto Brun, Michael Zhuo Wang
Antimicrob Agents Chemother. Jul 2014; 58(7): 4064–4074. doi: 10.1128/AAC.02605-14
PMCID:
PMC4068519
Colistin-Induced Nephrotoxicity in Mice Involves the Mitochondrial, Death Receptor, and Endoplasmic Reticulum Pathways
Chongshan Dai, Jichang Li, Shusheng Tang, Jian Li, Xilong Xiao
Antimicrob Agents Chemother. Jul 2014; 58(7): 4075–4085. doi: 10.1128/AAC.00070-14
PMCID:
PMC4068542
Isoniazid Mediates the CYP2B6*6 Genotype-Dependent Interaction between Efavirenz and Antituberculosis Drug Therapy through Mechanism-Based Inactivation of CYP2A6
Michael H. Court, Fawziah E. Almutairi, David J. Greenblatt, Suwagmani Hazarika, Hongyan Sheng, Kathrin Klein, Ulrich M. Zanger, Joanne Bourgea, Christopher J. Patten, Awewura Kwara
Antimicrob Agents Chemother. Jul 2014; 58(7): 4145–4152. doi: 10.1128/AAC.02532-14
PMCID:
PMC4068589
Uptake of Polymyxin B into Renal Cells
Kamilia Abdelraouf, Kai-Tai Chang, Taijun Yin, Ming Hu, Vincent H. Tam
Antimicrob Agents Chemother. Jul 2014; 58(7): 4200–4202. doi: 10.1128/AAC.02557-14
PMCID:
PMC4068554

Letters to the Editor

Escherichia coli Sequence Type 354 Coproducing CMY-2 Cephalosporinase and RmtE 16S rRNA Methyltransferase
Chang-Seop Lee, Fupin Hu, Jesabel I. Rivera, Yohei Doi
Antimicrob Agents Chemother. Jul 2014; 58(7): 4246–4247. doi: 10.1128/AAC.02627-14
PMCID:
PMC4068577
Emergence of High-Level Azithromycin Resistance in Campylobacter jejuni Isolates from Pediatric Diarrhea Patients in Kolkata, India
Piyali Mukherjee, T. Ramamurthy, Utpala Mitra, Asish K. Mukhopadhyay
Antimicrob Agents Chemother. Jul 2014; 58(7): 4248. doi: 10.1128/AAC.02931-14
PMCID:
PMC4068546

Masthead

Editorial Board
Antimicrob Agents Chemother. Jul 2014; 58(7): A3. doi: 10.1128/AAC.masthead.58-7
PMCID:
PMC4068516

Errata

Mark Contarino, Arangassery R. Bastian, Ramalingam Venkat Kalyana Sundaram, Karyn McFadden, Caitlin Duffy, Vamshi Gangupomu, Michelle Baker, Cameron Abrams, Irwin Chaiken
Antimicrob Agents Chemother. Jul 2014; 58(7): 4249. doi: 10.1128/AAC.03093-14
PMCID:
PMC4068563
NBTI 5463 Is a Novel Bacterial Type II Topoisomerase Inhibitor with Activity against Gram-Negative Bacteria and In Vivo Efficacy
Thomas J. Dougherty, Asha Nayar, Joseph V. Newman, Sussie Hopkins, Gregory G. Stone, Michele Johnstone, Adam B. Shapiro, Mark Cronin, Folkert Reck, David E. Ehmann
Antimicrob Agents Chemother. Jul 2014; 58(7): 4250. doi: 10.1128/AAC.03222-14
PMCID:
PMC4068530

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)