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Volume 59(4);  2015 Apr

Articles from this journal are usually available in PMC after a 6-month delay (embargo). Some articles may be available sooner.

Chemistry; Biosynthesis

In Vivo Efficacy of Anuran Trypsin Inhibitory Peptides against Staphylococcal Skin Infection and the Impact of Peptide Cyclization
U. Malik, O. N. Silva, I. C. M. Fensterseifer, L. Y. Chan, R. J. Clark, O. L. Franco, N. L. Daly, D. J. Craik
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2113–2121. Published online 2015 Jan 26. doi: 10.1128/AAC.04324-14
PMCID:
PMC4356830

Mechanisms of Action: Physiological Effects

Inhibition of Protein Synthesis and Malaria Parasite Development by Drug Targeting of Methionyl-tRNA Synthetases
Tahir Hussain, Manickam Yogavel, Amit Sharma
Antimicrob Agents Chemother. 2015 Apr; 59(4): 1856–1867. Published online 2015 Jan 12. doi: 10.1128/AAC.02220-13
PMCID:
PMC4356764
Mycobacterium tuberculosis Gyrase Inhibitors as a New Class of Antitubercular Drugs
Delia Blanco, Esther Perez-Herran, Mónica Cacho, Lluís Ballell, Julia Castro, Rubén González del Río, José Luis Lavandera, Modesto J. Remuiñán, Cindy Richards, Joaquin Rullas, María Jesús Vázquez-Muñiz, Ermias Woldu, María Cleofé Zapatero-González, Iñigo Angulo-Barturen, Alfonso Mendoza, David Barros
Antimicrob Agents Chemother. 2015 Apr; 59(4): 1868–1875. Published online 2015 Jan 12. doi: 10.1128/AAC.03913-14
PMCID:
PMC4356839
SQ109, a New Drug Lead for Chagas Disease
Phercyles Veiga-Santos, Kai Li, Lilianne Lameira, Tecia Maria Ulisses de Carvalho, Guozhong Huang, Melina Galizzi, Na Shang, Qian Li, Dolores Gonzalez-Pacanowska, Vanessa Hernandez-Rodriguez, Gustavo Benaim, Rey-Ting Guo, Julio A. Urbina, Roberto Docampo, Wanderley de Souza, Eric Oldfield
Antimicrob Agents Chemother. 2015 Apr; 59(4): 1950–1961. Published online 2015 Jan 12. doi: 10.1128/AAC.03972-14
PMCID:
PMC4356821
Subtle Changes in Endochin-Like Quinolone Structure Alter the Site of Inhibition within the Cytochrome bc1 Complex of Plasmodium falciparum
Allison M. Stickles, Mariana Justino de Almeida, Joanne M. Morrisey, Kayla A. Sheridan, Isaac P. Forquer, Aaron Nilsen, Rolf W. Winter, Jeremy N. Burrows, David A. Fidock, Akhil B. Vaidya, Michael K. Riscoe
Antimicrob Agents Chemother. 2015 Apr; 59(4): 1977–1982. Published online 2015 Jan 20. doi: 10.1128/AAC.04149-14
PMCID:
PMC4356778
Major Pathways of Polymyxin-Induced Apoptosis in Rat Kidney Proximal Tubular Cells
Mohammad A. K. Azad, Jesmin Akter, Kelly L. Rogers, Roger L. Nation, Tony Velkov, Jian Li
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2136–2143. Published online 2015 Jan 26. doi: 10.1128/AAC.04869-14
PMCID:
PMC4356794
Autophagy Regulates Colistin-Induced Apoptosis in PC-12 Cells
Ling Zhang, Yonghao Zhao, Wenjian Ding, Guozheng Jiang, Ziyin Lu, Li Li, Jinli Wang, Jian Li, Jichang Li
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2189–2197. Published online 2015 Feb 2. doi: 10.1128/AAC.04092-14
PMCID:
PMC4356802
Antipseudomonal Agents Exhibit Differential Pharmacodynamic Interactions with Human Polymorphonuclear Leukocytes against Established Biofilms of Pseudomonas aeruginosa
Athanasios Chatzimoschou, Maria Simitsopoulou, Charalampos Antachopoulos, Thomas J. Walsh, Emmanuel Roilides
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2198–2205. Published online 2015 Feb 2. doi: 10.1128/AAC.04934-14
PMCID:
PMC4356800
A Novel Antimycobacterial Compound Acts as an Intracellular Iron Chelator
Marte S. Dragset, Giovanna Poce, Salvatore Alfonso, Teresita Padilla-Benavides, Thomas R. Ioerger, Takushi Kaneko, James C. Sacchettini, Mariangela Biava, Tanya Parish, José M. Argüello, Magnus Steigedal, Eric J. Rubin
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2256–2264. Published online 2015 Feb 2. doi: 10.1128/AAC.05114-14
PMCID:
PMC4356758
Pyridodiazepine Amines Are Selective Therapeutic Agents for Helicobacter pylori by Suppressing Growth through Inhibition of Glutamate Racemase but Are Predicted To Require Continuous Elevated Levels in Plasma To Achieve Clinical Efficacy
Boudewijn L. M. de Jonge, Amy Kutschke, Joseph V. Newman, Michael T. Rooney, Wei Yang, Christer Cederberg
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2337–2342. Published online 2015 Feb 2. doi: 10.1128/AAC.04410-14
PMCID:
PMC4356811

Mechanisms of Resistance

Moraxella catarrhalis AcrAB-OprM Efflux Pump Contributes to Antimicrobial Resistance and Is Enhanced during Cold Shock Response
Violeta Spaniol, Sara Bernhard, Christoph Aebi
Antimicrob Agents Chemother. 2015 Apr; 59(4): 1886–1894. Published online 2015 Jan 12. doi: 10.1128/AAC.03727-14
PMCID:
PMC4356836
Missense Mutations in PBP2A Affecting Ceftaroline Susceptibility Detected in Epidemic Hospital-Acquired Methicillin-Resistant Staphylococcus aureus Clonotypes ST228 and ST247 in Western Switzerland Archived since 1998
William L. Kelley, Ambre Jousselin, Christine Barras, Emmanuelle Lelong, Adriana Renzoni
Antimicrob Agents Chemother. 2015 Apr; 59(4): 1922–1930. Published online 2015 Jan 12. doi: 10.1128/AAC.04068-14
PMCID:
PMC4356817
Dissemination of blaOXA-23 in Acinetobacter spp. in China: Main Roles of Conjugative Plasmid pAZJ221 and Transposon Tn2009
Li-Lin Liu, Shu-Juan Ji, Zhi Ruan, Ying Fu, Yi-Qi Fu, Yan-Fei Wang, Yun-Song Yu
Antimicrob Agents Chemother. 2015 Apr; 59(4): 1998–2005. Published online 2015 Jan 20. doi: 10.1128/AAC.04574-14
PMCID:
PMC4356780
Streptococcus gallolyticus subsp. gallolyticus from Human and Animal Origins: Genetic Diversity, Antimicrobial Susceptibility, and Characterization of a Vancomycin-Resistant Calf Isolate Carrying a vanA-Tn1546-Like Element
Beatriz Romero-Hernández, Ana P. Tedim, José Francisco Sánchez-Herrero, Pablo Librado, Julio Rozas, Gloria Muñoz, Fernando Baquero, Rafael Cantón, Rosa del Campo
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2006–2015. Published online 2015 Jan 20. doi: 10.1128/AAC.04083-14
PMCID:
PMC4356806
Analysis of embCAB Mutations Associated with Ethambutol Resistance in Multidrug-Resistant Mycobacterium tuberculosis Isolates from China
Li-li Zhao, Qing Sun, Hai-can Liu, Xiao-cui Wu, Tong-yang Xiao, Xiu-qin Zhao, Gui-lian Li, Yi Jiang, Chun-yan Zeng, Kang-lin Wan
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2045–2050. Published online 2015 Jan 20. doi: 10.1128/AAC.04933-14
PMCID:
PMC4356784
PmrD Is Required for Modifications to Escherichia coli Endotoxin That Promote Antimicrobial Resistance
Erica J. Rubin, Carmen M. Herrera, Alexander A. Crofts, M. Stephen Trent
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2051–2061. Published online 2015 Jan 20. doi: 10.1128/AAC.05052-14
PMCID:
PMC4356761
Characterization of High-Level Daptomycin Resistance in Viridans Group Streptococci Developed upon In Vitro Exposure to Daptomycin
Ronda L. Akins, Bradley D. Katz, Catherine Monahan, Dylan Alexander
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2102–2112. Published online 2015 Jan 26. doi: 10.1128/AAC.04219-14
PMCID:
PMC4356810
Staphylococcal Persistence Due to Biofilm Formation in Synovial Fluid Containing Prophylactic Cefazolin
Sana S. Dastgheyb, Sommer Hammoud, Constantinos Ketonis, Andrew Yongkun Liu, Keith Fitzgerald, Javad Parvizi, James Purtill, Michael Ciccotti, Irving M. Shapiro, Michael Otto, Noreen J. Hickok
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2122–2128. Published online 2015 Jan 26. doi: 10.1128/AAC.04579-14
PMCID:
PMC4356782
Experimental Resistance to Drug Combinations in Leishmania donovani: Metabolic and Phenotypic Adaptations
Maya Berg, Raquel García-Hernández, Bart Cuypers, Manu Vanaerschot, José I. Manzano, José A. Poveda, José A. Ferragut, Santiago Castanys, Jean-Claude Dujardin, Francisco Gamarro
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2242–2255. Published online 2015 Feb 2. doi: 10.1128/AAC.04231-14
PMCID:
PMC4356759
The Mycobacterium tuberculosis Outer Membrane Channel Protein CpnT Confers Susceptibility to Toxic Molecules
Olga Danilchanka, David Pires, Elsa Anes, Michael Niederweis
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2328–2336. Published online 2015 Feb 2. doi: 10.1128/AAC.04222-14
PMCID:
PMC4356772
Search for Novel Candidate Mutations for Metronidazole Resistance in Helicobacter pylori Using Next-Generation Sequencing
Tran Thanh Binh, Rumiko Suzuki, Tran Thi Huyen Trang, Dong Hyeon Kwon, Yoshio Yamaoka
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2343–2348. Published online 2015 Feb 2. doi: 10.1128/AAC.04852-14
PMCID:
PMC4356779
A Fluorescent Microplate Assay Quantifies Bacterial Efflux and Demonstrates Two Distinct Compound Binding Sites in AcrB
Ramkumar Iyer, Annette Ferrari, R. Rijnbrand, Alice L. Erwin
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2388–2397. Published online 2015 Feb 2. doi: 10.1128/AAC.05112-14
PMCID:
PMC4356777
Dissemination of High-Risk Clones of Extensively Drug-Resistant Pseudomonas aeruginosa in Colombia
Adriana Correa, Rosa del Campo, Marcela Perenguez, Victor M. Blanco, Mercedes Rodríguez-Baños, Federico Perez, Juan J. Maya, Laura Rojas, Rafael Cantón, Cesar A. Arias, Maria V. Villegas
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2421–2425. Published online 2015 Jan 20. doi: 10.1128/AAC.03926-14
PMCID:
PMC4356786
Potentiation of Antibacterial Activity of the MB-1 Siderophore-Monobactam Conjugate Using an Efflux Pump Inhibitor
Andrew P. Tomaras, Jared L. Crandon, Craig J. McPherson, David P. Nicolau
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2439–2442. Published online 2015 Jan 20. doi: 10.1128/AAC.04172-14
PMCID:
PMC4356814
A Novel New Delhi Metallo-β-Lactamase Variant, NDM-14, Isolated in a Chinese Hospital Possesses Increased Enzymatic Activity against Carbapenems
Dayang Zou, Yong Huang, Xiangna Zhao, Wei Liu, Derong Dong, Huan Li, Xuesong Wang, Simo Huang, Xiao Wei, Xiabei Yan, Zhan Yang, Yigang Tong, Liuyu Huang, Jing Yuan
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2450–2453. Published online 2015 Feb 2. doi: 10.1128/AAC.05168-14
PMCID:
PMC4356825
First Report of Macrolide Resistance Gene erm(T) Harbored by a Novel Small Plasmid from Erysipelothrix rhusiopathiae
Chang-Wen Xu, An-Yun Zhang, Chun-Mei Yang, Yun Pan, Zhong-Bin Guan, Chang-Wei Lei, Lin-Yao Peng, Qing-Zhou Li, Hong-Ning Wang
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2462–2465. Published online 2015 Feb 9. doi: 10.1128/AAC.00228-15
PMCID:
PMC4356795

Susceptibility

In Vitro Antibiotic Susceptibilities of Yersinia pestis Determined by Broth Microdilution following CLSI Methods
Henry S. Heine, Jeremy Hershfield, Charles Marchand, Lynda Miller, Stephanie Halasohoris, Bret K. Purcell, Patricia L. Worsham
Antimicrob Agents Chemother. 2015 Apr; 59(4): 1919–1921. Published online 2015 Jan 12. doi: 10.1128/AAC.04548-14
PMCID:
PMC4356840
In Vitro Antibacterial Activity of the Ceftazidime-Avibactam Combination against Enterobacteriaceae, Including Strains with Well-Characterized β-Lactamases
Premavathy Levasseur, Anne-Marie Girard, Christine Miossec, John Pace, Ken Coleman
Antimicrob Agents Chemother. 2015 Apr; 59(4): 1931–1934. Published online 2015 Jan 12. doi: 10.1128/AAC.04218-14
PMCID:
PMC4356809
Identification of Metal Dithiocarbamates as a Novel Class of Antileishmanial Agents
Dhiman Sankar Pal, Dipon Kumar Mondal, Rupak Datta
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2144–2152. Published online 2015 Jan 26. doi: 10.1128/AAC.05146-14
PMCID:
PMC4356755
In Vitro Activity of RX-P873 against Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii
Robert K. Flamm, Paul R. Rhomberg, Ronald N. Jones, David J. Farrell
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2280–2285. Published online 2015 Feb 2. doi: 10.1128/AAC.04840-14
PMCID:
PMC4356824
In Vitro Activity of Five Quinolones and Analysis of the Quinolone Resistance-Determining Regions of gyrA, gyrB, parC, and parE in Ureaplasma parvum and Ureaplasma urealyticum Clinical Isolates from Perinatal Patients in Japan
Yasuhiro Kawai, Yukiko Nakura, Tetsu Wakimoto, Makoto Nomiyama, Tsugumichi Tokuda, Toshimitsu Takayanagi, Jun Shiraishi, Kenshi Wasada, Hiroyuki Kitajima, Tomio Fujita, Masahiro Nakayama, Nobuaki Mitsuda, Isao Nakanishi, Makoto Takeuchi, Itaru Yanagihara
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2358–2364. Published online 2015 Feb 2. doi: 10.1128/AAC.04262-14
PMCID:
PMC4356753
Ronald N. Jones, John D. Turnidge, Greg Moeck, Francis F. Arhin, Rodrigo E. Mendes
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2405–2409. Published online 2015 Feb 9. doi: 10.1128/AAC.05098-14
PMCID:
PMC4356816
Trafficking through the Late Endosome Significantly Impacts Candida albicans Tolerance of the Azole Antifungals
Arturo Luna-Tapia, Morgan E. Kerns, Karen E. Eberle, Branko S. Jursic, Glen E. Palmer
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2410–2420. Published online 2015 Feb 9. doi: 10.1128/AAC.04239-14
PMCID:
PMC4356793
In Vitro Susceptibility Testing of Eravacycline Is Unaffected by Medium Age and Nonstandard Assay Parameters
Trudy H. Grossman, Chris M. Pillar, Daniel F. Sahm, Joyce A. Sutcliffe
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2426–2427. Published online 2015 Jan 20. doi: 10.1128/AAC.04727-14
PMCID:
PMC4356796
Antimicrobial Activity of Solithromycin against Serotyped Macrolide-Resistant Streptococcus pneumoniae Isolates Collected from U.S. Medical Centers in 2012
D. J. Farrell, R. E. Mendes, R. N. Jones
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2432–2434. Published online 2015 Jan 20. doi: 10.1128/AAC.04568-14
PMCID:
PMC4356815
In Vitro Assessment of Dual Drug Combinations To Inhibit Growth of Neisseria gonorrhoeae
Kevin Pettus, Samera Sharpe, John R. Papp
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2443–2445. Published online 2015 Jan 26. doi: 10.1128/AAC.04127-14
PMCID:
PMC4356837
Eravacycline (TP-434) Is Active In Vitro against Biofilms Formed by Uropathogenic Escherichia coli
Trudy H. Grossman, William O'Brien, Kathryn O. Kerstein, Joyce A. Sutcliffe
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2446–2449. Published online 2015 Jan 26. doi: 10.1128/AAC.04967-14
PMCID:
PMC4356792

Biologic Response Modifiers

Epoxy-α-Lapachone Has In Vitro and In Vivo Anti-Leishmania (Leishmania) amazonensis Effects and Inhibits Serine Proteinase Activity in This Parasite
Franklin Souza-Silva, Saulo Cabral Bourguignon, Bernardo Acácio Santini Pereira, Luzia Monteiro de Castro Côrtes, Luiz Filipe Gonçalves de Oliveira, Andrea Henriques-Pons, Lea Cysne Finkelstein, Vitor Francisco Ferreira, Paula Fernandes Carneiro, Rosa Teixeira de Pinho, Ernesto Raul Caffarena, Carlos Roberto Alves
Antimicrob Agents Chemother. 2015 Apr; 59(4): 1910–1918. Published online 2015 Jan 12. doi: 10.1128/AAC.04742-14
PMCID:
PMC4356828

Antiviral Agents

Biochemical Characterization of Recombinant Enterovirus 71 3C Protease with Fluorogenic Model Peptide Substrates and Development of a Biochemical Assay
Luqing Shang, Shumei Zhang, Xi Yang, Jixue Sun, Linfeng Li, Zhengjie Cui, Qiuhong He, Yu Guo, Yuna Sun, Zheng Yin
Antimicrob Agents Chemother. 2015 Apr; 59(4): 1827–1836. Published online 2014 Nov 24. doi: 10.1128/AAC.04698-14
PMCID:
PMC4356770
Insights into the Mechanism of Inhibition of CXCR4: Identification of Piperidinylethanamine Analogs as Anti-HIV-1 Inhibitors
Debananda Das, Kenji Maeda, Yasuhiro Hayashi, Navnath Gavande, Darshan V. Desai, Simon B. Chang, Arun K. Ghosh, Hiroaki Mitsuya
Antimicrob Agents Chemother. 2015 Apr; 59(4): 1895–1904. Published online 2015 Jan 12. doi: 10.1128/AAC.04654-14
PMCID:
PMC4356787
Simian-Tropic HIV as a Model To Study Drug Resistance against Integrase Inhibitors
Melissa Wares, Said Hassounah, Thibault Mesplède, Paul A. Sandstrom, Mark A. Wainberg
Antimicrob Agents Chemother. 2015 Apr; 59(4): 1942–1949. Published online 2015 Jan 12. doi: 10.1128/AAC.04829-14
PMCID:
PMC4356797
A Novel CDK7 Inhibitor of the Pyrazolotriazine Class Exerts Broad-Spectrum Antiviral Activity at Nanomolar Concentrations
Corina Hutterer, Jan Eickhoff, Jens Milbradt, Klaus Korn, Isabel Zeitträger, Hanife Bahsi, Sabrina Wagner, Gunther Zischinsky, Alexander Wolf, Carsten Degenhart, Anke Unger, Matthias Baumann, Bert Klebl, Manfred Marschall
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2062–2071. Published online 2015 Jan 26. doi: 10.1128/AAC.04534-14
PMCID:
PMC4356785
Synergistic Suppression of Dengue Virus Replication Using a Combination of Nucleoside Analogs and Nucleoside Synthesis Inhibitors
Kim Long Yeo, Yen-Liang Chen, Hao Ying Xu, Hongping Dong, Qing-Yin Wang, Fumiaki Yokokawa, Pei-Yong Shi
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2086–2093. Published online 2015 Jan 26. doi: 10.1128/AAC.04779-14
PMCID:
PMC4356831
Depot Medroxyprogesterone Acetate in Combination with a Twice-Daily Lopinavir-Ritonavir-Based Regimen in HIV-Infected Women Showed Effective Contraception and a Lack of Clinically Significant Interactions, with Good Safety and Tolerability: Results of the ACTG 5283 Study
Amneris E. Luque, Susan E. Cohn, Jeong-Gun Park, Yoninah Cramer, Adriana Weinberg, Elizabeth Livingston, Karin L. Klingman, Francesca Aweeka, D. Heather Watts
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2094–2101. Published online 2015 Jan 26. doi: 10.1128/AAC.04701-14
PMCID:
PMC4356823
Thermosensitive and Mucoadhesive Pluronic-Hydroxypropylmethylcellulose Hydrogel Containing the Mini-CD4 M48U1 Is a Promising Efficient Barrier against HIV Diffusion through Macaque Cervicovaginal Mucus
Kawthar Bouchemal, Armelle Aka-Any-Grah, Nathalie Dereuddre-Bosquet, Loïc Martin, Vanessa Lievin-Le-Moal, Roger Le Grand, Valérie Nicolas, Davide Gibellini, David Lembo, Christian Poüs, Armand Koffi, Gilles Ponchel
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2215–2222. Published online 2015 Feb 2. doi: 10.1128/AAC.03503-14
PMCID:
PMC4356805
Application of a Seven-Target Pyrosequencing Assay To Improve the Detection of Neuraminidase Inhibitor-Resistant Influenza A(H3N2) Viruses
Daisuke Tamura, Margaret Okomo-Adhiambo, Vasiliy P. Mishin, Zhu Guo, Xiyan Xu, Julie Villanueva, Alicia M. Fry, James Stevens, Larisa V. Gubareva
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2374–2379. Published online 2015 Feb 2. doi: 10.1128/AAC.04939-14
PMCID:
PMC4356763

Epidemiology and Surveillance

Tuberculous Spondylitis in Russia and Prominent Role of Multidrug-Resistant Clone Mycobacterium tuberculosis Beijing B0/W148
Anna Vyazovaya, Igor Mokrousov, Natalia Solovieva, Alexander Mushkin, Olga Manicheva, Boris Vishnevsky, Viacheslav Zhuravlev, Olga Narvskaya
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2349–2357. Published online 2015 Feb 2. doi: 10.1128/AAC.04221-14
PMCID:
PMC4356832
Update on Linezolid In Vitro Activity through the Zyvox Annual Appraisal of Potency and Spectrum Program, 2013
Rodrigo E. Mendes, Patricia A. Hogan, Jennifer M. Streit, Ronald N. Jones, Robert K. Flamm
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2454–2457. Published online 2015 Feb 2. doi: 10.1128/AAC.04784-14
PMCID:
PMC4356783
Ceftaroline Activity against Bacterial Pathogens Frequently Isolated in U.S. Medical Centers: Results from Five Years of the AWARE Surveillance Program
Helio S. Sader, Robert K. Flamm, Jennifer M. Streit, David J. Farrell, Ronald N. Jones
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2458–2461. Published online 2015 Feb 2. doi: 10.1128/AAC.04614-14
PMCID:
PMC4356765
Emergence of the First Levofloxacin-Resistant Strains of Streptococcus agalactiae Isolated in Italy
G. Piccinelli, F. Gargiulo, S. Corbellini, G. Ravizzola, C. Bonfanti, A. Caruso, M. A. De Francesco
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2466–2469. Published online 2015 Feb 9. doi: 10.1128/AAC.05127-14
PMCID:
PMC4356756

Experimental Therapeutics

Development and Validation of an In Vitro Pharmacokinetic/Pharmacodynamic Model To Test the Antibacterial Efficacy of Antibiotic Polymer Conjugates
Ernest A. Azzopardi, Elaine L. Ferguson, David W. Thomas
Antimicrob Agents Chemother. 2015 Apr; 59(4): 1837–1843. Published online 2014 Dec 15. doi: 10.1128/AAC.03708-14
PMCID:
PMC4356820
Ability of Hydroxypropyl Chitosan Nail Lacquer To Protect against Dermatophyte Nail Infection
M. A. Ghannoum, L. Long, N. Isham, A. Bulgheroni, M. Setaro, M. Caserini, R. Palmieri, F. Mailland
Antimicrob Agents Chemother. 2015 Apr; 59(4): 1844–1848. Published online 2014 Dec 29. doi: 10.1128/AAC.04842-14
PMCID:
PMC4356771
Characterization of a Novel Small Molecule That Potentiates β-Lactam Activity against Gram-Positive and Gram-Negative Pathogens
Dhanalakshmi R. Nair, João M. Monteiro, Guido Memmi, Jane Thanassi, Michael Pucci, Joseph Schwartzman, Mariana G. Pinho, Ambrose L. Cheung
Antimicrob Agents Chemother. 2015 Apr; 59(4): 1876–1885. Published online 2015 Jan 12. doi: 10.1128/AAC.04164-14
PMCID:
PMC4356822
Activities of N,N′-Diarylurea MMV665852 Analogs against Schistosoma mansoni
Noemi Cowan, Philipp Dätwyler, Beat Ernst, Chunkai Wang, Jonathan L. Vennerstrom, Thomas Spangenberg, Jennifer Keiser
Antimicrob Agents Chemother. 2015 Apr; 59(4): 1935–1941. Published online 2015 Jan 12. doi: 10.1128/AAC.04463-14
PMCID:
PMC4356791
Novel Phage Lysin Capable of Killing the Multidrug-Resistant Gram-Negative Bacterium Acinetobacter baumannii in a Mouse Bacteremia Model
Rolf Lood, Benjamin Y. Winer, Adam J. Pelzek, Roberto Diez-Martinez, Mya Thandar, Chad W. Euler, Raymond Schuch, Vincent A. Fischetti
Antimicrob Agents Chemother. 2015 Apr; 59(4): 1983–1991. Published online 2015 Jan 20. doi: 10.1128/AAC.04641-14
PMCID:
PMC4356752
VT-1161 Dosed Once Daily or Once Weekly Exhibits Potent Efficacy in Treatment of Dermatophytosis in a Guinea Pig Model
E. P. Garvey, W. J. Hoekstra, W. R. Moore, R. J. Schotzinger, L. Long, M. A. Ghannoum
Antimicrob Agents Chemother. 2015 Apr; 59(4): 1992–1997. Published online 2015 Jan 20. doi: 10.1128/AAC.04902-14
PMCID:
PMC4356789
Small-Molecule Inhibitors of Staphylococcus aureus RnpA-Mediated RNA Turnover and tRNA Processing
Tess M. Eidem, Nicole Lounsbury, John F. Emery, Jeffrey Bulger, Andrew Smith, Magid Abou-Gharbia, Wayne Childers, Paul M. Dunman
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2016–2028. Published online 2015 Jan 20. doi: 10.1128/AAC.04352-14
PMCID:
PMC4356807
Antimicrobial Activity against Intraosteoblastic Staphylococcus aureus
Florent Valour, Sophie Trouillet-Assant, Natacha Riffard, Jason Tasse, Sacha Flammier, Jean-Philippe Rasigade, Christian Chidiac, François Vandenesch, Tristan Ferry, Frédéric Laurent
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2029–2036. Published online 2015 Jan 20. doi: 10.1128/AAC.04359-14
PMCID:
PMC4356812
Bis-Benzimidazole Hits against Naegleria fowleri Discovered with New High-Throughput Screens
Christopher A. Rice, Beatrice L. Colon, Mehmet Alp, Hakan Göker, David W. Boykin, Dennis E. Kyle
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2037–2044. Published online 2015 Jan 20. doi: 10.1128/AAC.05122-14
PMCID:
PMC4356813
Neutralization of Staphylococcal Enterotoxin B by an Aptamer Antagonist
Kaiyu Wang, Longjie Gan, Li Jiang, Xianhui Zhang, Xiangyue Yang, Min Chen, Xiaopeng Lan
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2072–2077. Published online 2015 Jan 26. doi: 10.1128/AAC.04414-14
PMCID:
PMC4356834
Characterization of Mouse Models of Mycobacterium avium Complex Infection and Evaluation of Drug Combinations
Claire Andréjak, Deepak V. Almeida, Sandeep Tyagi, Paul J. Converse, Nicole C. Ammerman, Jacques H. Grosset
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2129–2135. Published online 2015 Jan 26. doi: 10.1128/AAC.04841-14
PMCID:
PMC4356827
Quercetin Sensitizes Fluconazole-Resistant Candida albicans To Induce Apoptotic Cell Death by Modulating Quorum Sensing
B. N. Singh, D. K. Upreti, B. R. Singh, G. Pandey, S. Verma, S. Roy, A. H. Naqvi, A. K. S. Rawat
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2153–2168. Published online 2015 Feb 2. doi: 10.1128/AAC.03599-14
PMCID:
PMC4356769
Colostrum Hexasaccharide, a Novel Staphylococcus aureus Quorum-Sensing Inhibitor
A. Srivastava, B. N. Singh, D. Deepak, A. K. S. Rawat, B. R. Singh
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2169–2178. Published online 2015 Feb 2. doi: 10.1128/AAC.03722-14
PMCID:
PMC4356819
Efficacy of ETI-204 Monoclonal Antibody as an Adjunct Therapy in a New Zealand White Rabbit Partial Survival Model for Inhalational Anthrax
Bethany Biron, Katie Beck, David Dyer, Marc Mattix, Nancy Twenhafel, Aysegul Nalca
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2206–2214. Published online 2015 Feb 2. doi: 10.1128/AAC.04593-14
PMCID:
PMC4356799
ω-Hydroxyemodin Limits Staphylococcus aureus Quorum Sensing-Mediated Pathogenesis and Inflammation
Seth M. Daly, Bradley O. Elmore, Jeffrey S. Kavanaugh, Kathleen D. Triplett, Mario Figueroa, Huzefa A. Raja, Tamam El-Elimat, Heidi A. Crosby, Jon K. Femling, Nadja B. Cech, Alexander R. Horswill, Nicholas H. Oberlies, Pamela R. Hall
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2223–2235. Published online 2015 Feb 2. doi: 10.1128/AAC.04564-14
PMCID:
PMC4356798
Sustained Release of a Novel Anti-Quorum-Sensing Agent against Oral Fungal Biofilms
Mark Feldman, Julia Shenderovich, Abed Al Aziz Al-Quntar, Michael Friedman, Doron Steinberg
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2265–2272. Published online 2015 Feb 2. doi: 10.1128/AAC.04212-14
PMCID:
PMC4356767
Rapid Drug Tolerance and Dramatic Sterilizing Effect of Moxifloxacin Monotherapy in a Novel Hollow-Fiber Model of Intracellular Mycobacterium kansasii Disease
Shashikant Srivastava, Jotam Pasipanodya, Carleton M. Sherman, Claudia Meek, Richard Leff, Tawanda Gumbo
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2273–2279. Published online 2015 Feb 2. doi: 10.1128/AAC.04441-14
PMCID:
PMC4356829
In Vivo Effect of Flucloxacillin in Experimental Endocarditis Caused by mecC-positive Staphylococcus aureus Showing Temperature-Dependent Susceptibility In Vitro
Stefano Mancini, Frédéric Laurent, Tiago R. Veloso, Marlyse Giddey, Jacques Vouillamoz, François Vandenesch, Philippe Moreillon, José M. Entenza
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2435–2438. Published online 2015 Jan 20. doi: 10.1128/AAC.04733-14
PMCID:
PMC4356768

Clinical Therapeutics

Lung Concentrations of Ceftazidime Administered by Continuous versus Intermittent Infusion in Patients with Ventilator-Associated Pneumonia
Joël Cousson, Thierry Floch, Thomas Guillard, Véronique Vernet, Pascal Raclot, Aurore Wolak-Thierry, Damien Jolly
Antimicrob Agents Chemother. 2015 Apr; 59(4): 1905–1909. Published online 2015 Jan 12. doi: 10.1128/AAC.04232-14
PMCID:
PMC4356804
Impact of Extended-Spectrum β-Lactamase Production on Treatment Outcomes of Acute Pyelonephritis Caused by Escherichia coli in Patients without Health Care-Associated Risk Factors
Sun Hee Park, Su-Mi Choi, Dong-Gun Lee, Sung-Yeon Cho, Hyo-Jin Lee, Jae-ki Choi, Jung-Hyun Choi, Jin-Hong Yoo
Antimicrob Agents Chemother. 2015 Apr; 59(4): 1962–1968. Published online 2015 Jan 12. doi: 10.1128/AAC.04821-14
PMCID:
PMC4356776
Oliver A. Cornely, Angelika Böhme, Anne Schmitt-Hoffmann, Andrew J. Ullmann
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2078–2085. Published online 2015 Jan 26. doi: 10.1128/AAC.04569-14
PMCID:
PMC4356760
Efficacy of Postexposure Therapy against Glanders in Mice
David M. Waag
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2236–2241. Published online 2015 Feb 2. doi: 10.1128/AAC.04801-14
PMCID:
PMC4356808
Candida Infective Endocarditis: an Observational Cohort Study with a Focus on Therapy
Christopher J. Arnold, Melissa Johnson, Arnold S. Bayer, Suzanne Bradley, Efthymia Giannitsioti, José M. Miró, Pilar Tornos, Pierre Tattevin, Jacob Strahilevitz, Denis Spelman, Eugene Athan, Francisco Nacinovich, Claudio Q. Fortes, Cristiane Lamas, Bruno Barsic, Nuria Fernández-Hidalgo, Patricia Muñoz, Vivian H. Chu
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2365–2373. Published online 2015 Feb 2. doi: 10.1128/AAC.04867-14
PMCID:
PMC4356766
Moxifloxacin Pharmacokinetic Profile and Efficacy Evaluation in Empiric Treatment of Community-Acquired Pneumonia
Kristina Öbrink-Hansen, Tore Forsingdal Hardlei, Birgitte Brock, Søren Jensen-Fangel, Marianne Kragh Thomsen, Eskild Petersen, Mads Kreilgaard
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2398–2404. Published online 2015 Feb 9. doi: 10.1128/AAC.04659-14
PMCID:
PMC4356773
Examining the Use of Ceftaroline in the Treatment of Streptococcus pneumoniae Meningitis with Reference to Human Cathelicidin LL-37
George Sakoulas, Poochit Nonejuie, Ravina Kullar, Joseph Pogliano, Michael J. Rybak, Victor Nizet
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2428–2431. Published online 2015 Jan 20. doi: 10.1128/AAC.04965-14
PMCID:
PMC4356754
Factors Influencing Culture Positivity in Pyogenic Vertebral Osteomyelitis Patients with Prior Antibiotic Exposure
Chung-Jong Kim, Seung-Ji Kang, Doran Yoon, Myung Jin Lee, Moonsuk Kim, Kyoung-Ho Song, Hee-Chang Jang, Sook-In Jung, Eu Suk Kim, Hong Bin Kim, Myoung-don Oh, Kyung-Hwa Park, Nam Joong Kim
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2470–2473. Published online 2015 Feb 9. doi: 10.1128/AAC.04949-14
PMCID:
PMC4356833

Pharmacology

Michael W. Dunne, Sailaja Puttagunta, Craig R. Sprenger, Chris Rubino, Scott Van Wart, James Baldassarre
Antimicrob Agents Chemother. 2015 Apr; 59(4): 1849–1855. Published online 2015 Jan 5. doi: 10.1128/AAC.04550-14
PMCID:
PMC4356775
Impact of the Combination of Daptomycin and Trimethoprim-Sulfamethoxazole on Clinical Outcomes in Methicillin-Resistant Staphylococcus aureus Infections
Kimberly C. Claeys, Jordan R. Smith, Anthony M. Casapao, Ryan P. Mynatt, Lisa Avery, Anjali Shroff, Deborah Yamamura, Susan L. Davis, Michael J. Rybak
Antimicrob Agents Chemother. 2015 Apr; 59(4): 1969–1976. Published online 2015 Jan 20. doi: 10.1128/AAC.04141-14
PMCID:
PMC4356801
Population Pharmacokinetic Modeling of Plasma and Intracellular Ribavirin Concentrations in Patients with Chronic Hepatitis C Virus Infection
Liviawati S. Wu, Joseph E. Rower, James R. Burton, Jr., Peter L. Anderson, Kyle P. Hammond, Fafa Baouchi-Mokrane, Gregory T. Everson, Thomas J. Urban, David Z. D'Argenio, Jennifer J. Kiser
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2179–2188. Published online 2015 Feb 2. doi: 10.1128/AAC.04618-14
PMCID:
PMC4356818
Novel Approach To Optimize Synergistic Carbapenem-Aminoglycoside Combinations against Carbapenem-Resistant Acinetobacter baumannii
Rajbharan Yadav, Cornelia B. Landersdorfer, Roger L. Nation, John D. Boyce, Jürgen B. Bulitta
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2286–2298. Published online 2015 Feb 2. doi: 10.1128/AAC.04379-14
PMCID:
PMC4356774
Pharmacokinetics and Penetration of Ceftazidime and Avibactam into Epithelial Lining Fluid in Thigh- and Lung-Infected Mice
Johanna Berkhout, Maria J. Melchers, Anita C. van Mil, Seyedmojtaba Seyedmousavi, Claudia M. Lagarde, Wright W. Nichols, Johan W. Mouton
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2299–2304. Published online 2015 Feb 2. doi: 10.1128/AAC.04627-14
PMCID:
PMC4356781
Variability of Voriconazole Plasma Concentrations after Allogeneic Hematopoietic Stem Cell Transplantation: Impact of Cytochrome P450 Polymorphisms and Comedications on Initial and Subsequent Trough Levels
Elodie Gautier-Veyret, Xavier Fonrose, Julia Tonini, Anne Thiebaut-Bertrand, Mireille Bartoli, Jean-Louis Quesada, Claude-Eric Bulabois, Jean-Yves Cahn, Françoise Stanke-Labesque
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2305–2314. Published online 2015 Feb 2. doi: 10.1128/AAC.04838-14
PMCID:
PMC4356835
Two Mechanisms of Killing of Pseudomonas aeruginosa by Tobramycin Assessed at Multiple Inocula via Mechanism-Based Modeling
Jürgen B. Bulitta, Neang S. Ly, Cornelia B. Landersdorfer, Nicholin A. Wanigaratne, Tony Velkov, Rajbharan Yadav, Antonio Oliver, Lisandra Martin, Beom Soo Shin, Alan Forrest, Brian T. Tsuji
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2315–2327. Published online 2015 Feb 2. doi: 10.1128/AAC.04099-14
PMCID:
PMC4356757
Differential CYP 2D6 Metabolism Alters Primaquine Pharmacokinetics
Brittney M. J. Potter, Lisa H. Xie, Chau Vuong, Jing Zhang, Ping Zhang, Dehui Duan, Thu-Lan T. Luong, H. M. T. Bandara Herath, N. P. Dhammika Nanayakkara, Babu L. Tekwani, Larry A. Walker, Christina K. Nolan, Richard J. Sciotti, Victor E. Zottig, Philip L. Smith, Robert M. Paris, Lisa T. Read, Qigui Li, Brandon S. Pybus, Jason C. Sousa, Gregory A. Reichard, Sean R. Marcsisin
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2380–2387. Published online 2015 Feb 2. doi: 10.1128/AAC.00015-15
PMCID:
PMC4356838

Letters to the Editor

Adequate Design of Pharmacokinetic-Pharmacodynamic Studies Will Help Optimize Tuberculosis Treatment for the Future
Marieke G. G. Sturkenboom, Onno W. Akkerman, Mathieu S. Bolhuis, Wiel C. M. de Lange, Tjip S. van der Werf, Jan-Willem C. Alffenaar
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2474. Published online 2015 Mar 11. doi: 10.1128/AAC.05173-14
PMCID:
PMC4356826
Reply to “Adequate Design of Pharmacokinetic-Pharmacodynamic Studies Will Help Optimize Tuberculosis Treatment for the Future”
Ana Requena-Méndez, Geraint Davies, David A. J. Moore
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2475. Published online 2015 Mar 11. doi: 10.1128/AAC.05182-14
PMCID:
PMC4356803
Nomenclature and Functionality of the So-Called cfr Gene from Clostridium difficile
Stefan Schwarz, Yang Wang
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2476–2477. Published online 2015 Mar 11. doi: 10.1128/AAC.04893-14
PMCID:
PMC4356762

Masthead

Editorial Board
Antimicrob Agents Chemother. 2015 Apr; 59(4): A1. Published online 2015 Mar 11. doi: 10.1128/AAC.masthead.59-4
PMCID:
PMC4356788

Erratum

Erratum for Kim et al., Inappropriate Continued Empirical Vancomycin Use in a Hospital with a High Prevalence of Methicillin-Resistant Staphylococcus aureus
Nak-Hyun Kim, Hei Lim Koo, Pyoeng Gyun Choe, Shinhye Cheon, Moonsuk Kim, Myung Jin Lee, Younghee Jung, Wan Beom Park, Kyoung-Ho Song, Eu Suk Kim, Ji Hwan Bang, Hong Bin Kim, Sang Won Park, Nam Joong Kim, Myoung-don Oh, Eui Chong Kim
Antimicrob Agents Chemother. 2015 Apr; 59(4): 2478. Published online 2015 Mar 11. doi: 10.1128/AAC.00241-15
PMCID:
PMC4356790

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)