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Volume 58(11);  November 2014

Articles from this journal are usually available in PMC after a 6-month delay (embargo). Some articles may be available sooner.

Mechanisms of Action: Physiological Effects

Pantothenic Acid Biosynthesis in the Parasite Toxoplasma gondii: a Target for Chemotherapy
Sarmad N. Mageed, Fraser Cunningham, Alvin Wei Hung, Hernani Leonardo Silvestre, Shijun Wen, Tom L. Blundell, Chris Abell, Glenn A. McConkey
Antimicrob Agents Chemother. Nov 2014; 58(11): 6345–6353. doi: 10.1128/AAC.02640-14
PMCID:
PMC4249369
Novel Insights into the Mechanism of Inhibition of MmpL3, a Target of Multiple Pharmacophores in Mycobacterium tuberculosis
Wei Li, Ashutosh Upadhyay, Fabio L. Fontes, E. Jeffrey North, Yuehong Wang, Debbie C. Crans, Anna E. Grzegorzewicz, Victoria Jones, Scott G. Franzblau, Richard E. Lee, Dean C. Crick, Mary Jackson
Antimicrob Agents Chemother. Nov 2014; 58(11): 6413–6423. doi: 10.1128/AAC.03229-14
PMCID:
PMC4249373
Role of PBPD1 in Stimulation of Listeria monocytogenes Biofilm Formation by Subminimal Inhibitory β-Lactam Concentrations
Uyen T. Nguyen, Hanjeong Harvey, Andrew J. Hogan, Alexandria C. F. Afonso, Gerard D. Wright, Lori L. Burrows
Antimicrob Agents Chemother. Nov 2014; 58(11): 6508–6517. doi: 10.1128/AAC.03671-14
PMCID:
PMC4249420
The Production of Reactive Oxygen Species Is a Universal Action Mechanism of Amphotericin B against Pathogenic Yeasts and Contributes to the Fungicidal Effect of This Drug
Ana Cecilia Mesa-Arango, Nuria Trevijano-Contador, Elvira Román, Ruth Sánchez-Fresneda, Celia Casas, Enrique Herrero, Juan Carlos Argüelles, Jesús Pla, Manuel Cuenca-Estrella, Oscar Zaragoza
Antimicrob Agents Chemother. Nov 2014; 58(11): 6627–6638. doi: 10.1128/AAC.03570-14
PMCID:
PMC4249417
Comparative Systems Biology Analysis To Study the Mode of Action of the Isothiocyanate Compound Iberin on Pseudomonas aeruginosa
Sean Yang-Yi Tan, Yang Liu, Song Lin Chua, Rebecca Munk Vejborg, Tim Holm Jakobsen, Su Chuen Chew, Yingying Li, Thomas E. Nielsen, Tim Tolker-Nielsen, Liang Yang, Michael Givskov
Antimicrob Agents Chemother. Nov 2014; 58(11): 6648–6659. doi: 10.1128/AAC.02620-13
PMCID:
PMC4249438
Ramoplanin at Bactericidal Concentrations Induces Bacterial Membrane Depolarization in Staphylococcus aureus
Mu Cheng, Johnny X. Huang, Soumya Ramu, Mark S. Butler, Matthew A. Cooper
Antimicrob Agents Chemother. Nov 2014; 58(11): 6819–6827. doi: 10.1128/AAC.00061-14
PMCID:
PMC4249368
Respiratory Flexibility in Response to Inhibition of Cytochrome c Oxidase in Mycobacterium tuberculosis
Kriti Arora, Bernardo Ochoa-Montaño, Patricia S. Tsang, Tom L. Blundell, Stephanie S. Dawes, Valerie Mizrahi, Tracy Bayliss, Claire J. Mackenzie, Laura A. T. Cleghorn, Peter C. Ray, Paul G. Wyatt, Eugene Uh, Jinwoo Lee, Clifton E. Barry, III, Helena I. Boshoff
Antimicrob Agents Chemother. Nov 2014; 58(11): 6962–6965. doi: 10.1128/AAC.03486-14
PMCID:
PMC4249445

Mechanisms of Resistance

Triclosan Can Select for an AdeIJK-Overexpressing Mutant of Acinetobacter baumannii ATCC 17978 That Displays Reduced Susceptibility to Multiple Antibiotics
Dinesh M. Fernando, Wayne Xu, Peter C. Loewen, George G. Zhanel, Ayush Kumar
Antimicrob Agents Chemother. Nov 2014; 58(11): 6424–6431. doi: 10.1128/AAC.03074-14
PMCID:
PMC4249441
Synthesis of Metallo-β-Lactamase VIM-2 Is Associated with a Fitness Reduction in Salmonella enterica Serovar Typhimurium
Nicolás F. Cordeiro, José A. Chabalgoity, Lucía Yim, Rafael Vignoli
Antimicrob Agents Chemother. Nov 2014; 58(11): 6528–6535. doi: 10.1128/AAC.02847-14
PMCID:
PMC4249381
Distinct Roles of Major Peptidoglycan Recycling Enzymes in β-Lactamase Production in Shewanella oneidensis
Jianhua Yin, Yinting Mao, Lili Ju, Miao Jin, Yiyang Sun, Shouguang Jin, Haichun Gao
Antimicrob Agents Chemother. Nov 2014; 58(11): 6536–6543. doi: 10.1128/AAC.03238-14
PMCID:
PMC4249409
Genetic and Kinetic Characterization of the Novel AmpC β-Lactamases DHA-6 and DHA-7
Francisco José Pérez-Llarena, Laura Zamorano, Frédéric Kerff, Alejandro Beceiro, Patricia García, Elisenda Miró, Nieves Larrosa, Frederic Gómez-Bertomeu, José Antonio Méndez, Juan José González-López, Antonio Oliver, Moreno Galleni, Ferran Navarro, Germán Bou
Antimicrob Agents Chemother. Nov 2014; 58(11): 6544–6549. doi: 10.1128/AAC.03144-14
PMCID:
PMC4249421
Linezolid-Resistant Staphylococcus aureus Strain 1128105, the First Known Clinical Isolate Possessing the cfr Multidrug Resistance Gene
Jeffrey B. Locke, Douglas E. Zuill, Caitlyn R. Scharn, Jennifer Deane, Daniel F. Sahm, Gerald A. Denys, Richard V. Goering, Karen J. Shaw
Antimicrob Agents Chemother. Nov 2014; 58(11): 6592–6598. doi: 10.1128/AAC.03493-14
PMCID:
PMC4249393
PBP2a Mutations Causing High-Level Ceftaroline Resistance in Clinical Methicillin-Resistant Staphylococcus aureus Isolates
S. Wesley Long, Randall J. Olsen, Shrenik C. Mehta, Timothy Palzkill, Patricia L. Cernoch, Katherine K. Perez, William L. Musick, Adriana E. Rosato, James M. Musser
Antimicrob Agents Chemother. Nov 2014; 58(11): 6668–6674. doi: 10.1128/AAC.03622-14
PMCID:
PMC4249384
The msaABCR Operon Regulates Resistance in Vancomycin-Intermediate Staphylococcus aureus Strains
Dhritiman Samanta, Mohamed O. Elasri
Antimicrob Agents Chemother. Nov 2014; 58(11): 6685–6695. doi: 10.1128/AAC.03280-14
PMCID:
PMC4249426
Disruption of the Transcriptional Regulator Cas5 Results in Enhanced Killing of Candida albicans by Fluconazole
Erin M. Vasicek, Elizabeth L. Berkow, Vincent M. Bruno, Aaron P. Mitchell, Nathan P. Wiederhold, Katherine S. Barker, P. David Rogers
Antimicrob Agents Chemother. Nov 2014; 58(11): 6807–6818. doi: 10.1128/AAC.00064-14
PMCID:
PMC4249418
Mutations in the embC-embA Intergenic Region Contribute to Mycobacterium tuberculosis Resistance to Ethambutol
Zhenling Cui, Yuanyuan Li, Song Cheng, Hua Yang, Junmei Lu, Zhongyi Hu, Baoxue Ge
Antimicrob Agents Chemother. Nov 2014; 58(11): 6837–6843. doi: 10.1128/AAC.03285-14
PMCID:
PMC4249443
Mutation-Driven β-Lactam Resistance Mechanisms among Contemporary Ceftazidime-Nonsusceptible Pseudomonas aeruginosa Isolates from U.S. Hospitals
Mariana Castanheira, Janet C. Mills, David J. Farrell, Ronald N. Jones
Antimicrob Agents Chemother. Nov 2014; 58(11): 6844–6850. doi: 10.1128/AAC.03681-14
PMCID:
PMC4249397
Enhanced In Vitro Formation and Antibiotic Resistance of Nonattached Pseudomonas aeruginosa Aggregates through Incorporation of Neutrophil Products
Silvia M. Caceres, Kenneth C. Malcolm, Jennifer L. Taylor-Cousar, David P. Nichols, Milene T. Saavedra, Donna L. Bratton, Samuel M. Moskowitz, Jane L. Burns, Jerry A. Nick
Antimicrob Agents Chemother. Nov 2014; 58(11): 6851–6860. doi: 10.1128/AAC.03514-14
PMCID:
PMC4249413
Random Mutagenesis of the Multidrug Transporter AcrB from Escherichia coli for Identification of Putative Target Residues of Efflux Pump Inhibitors
Sabine Schuster, Samay Kohler, Annika Buck, Christine Dambacher, Armin König, Jürgen A. Bohnert, Winfried V. Kern
Antimicrob Agents Chemother. Nov 2014; 58(11): 6870–6878. doi: 10.1128/AAC.03775-14
PMCID:
PMC4249408
Identification of Genomic Binding Sites for Candida glabrata Pdr1 Transcription Factor in Wild-Type and ρ0 Cells
Sanjoy Paul, Thomas B. Bair, W. Scott Moye-Rowley
Antimicrob Agents Chemother. Nov 2014; 58(11): 6904–6912. doi: 10.1128/AAC.03921-14
PMCID:
PMC4249425
Molecular Characterization of Streptococcus agalactiae Isolates Harboring Small erm(T)-Carrying Plasmids
Fabrice Compain, Constantin Hays, Gérald Touak, Nicolas Dmytruk, Patrick Trieu-Cuot, Caroline Joubrel, Claire Poyart
Antimicrob Agents Chemother. Nov 2014; 58(11): 6928–6930. doi: 10.1128/AAC.03855-14
PMCID:
PMC4249376
Characterization of a Novel AmpC β-Lactamase Produced by a Carbapenem-Resistant Cedecea davisae Clinical Isolate
Nacim Ammenouche, Hervé Dupont, Hedi Mammeri
Antimicrob Agents Chemother. Nov 2014; 58(11): 6942–6945. doi: 10.1128/AAC.03237-14
PMCID:
PMC4249424
Identification and Characterization of Linezolid-Resistant cfr-Positive Staphylococcus aureus USA300 Isolates from a New York City Medical Center
Jeffrey B. Locke, Douglas E. Zuill, Caitlyn R. Scharn, Jennifer Deane, Daniel F. Sahm, Richard V. Goering, Stephen G. Jenkins, Karen J. Shaw
Antimicrob Agents Chemother. Nov 2014; 58(11): 6949–6952. doi: 10.1128/AAC.03380-14
PMCID:
PMC4249436
Integron-Borne Transmission of VEB-1 Extended-Spectrum β-Lactamase in Pseudomonas aeruginosa in a Tertiary Care Hospital in India
Anand Prakash Maurya, Anupam Das Talukdar, Debadatta Dhar Chanda, Atanu Chakravarty, Amitabha Bhattacharjee
Antimicrob Agents Chemother. Nov 2014; 58(11): 6966–6969. doi: 10.1128/AAC.02365-14
PMCID:
PMC4249423
Complete Sequence of a Conjugative IncN Plasmid Harboring blaKPC-2, blaSHV-12, and qnrS1 from an Escherichia coli Sequence Type 648 Strain
Jun-Jie Li, Chang-Seop Lee, Ji-Fang Sheng, Yohei Doi
Antimicrob Agents Chemother. Nov 2014; 58(11): 6974–6977. doi: 10.1128/AAC.03632-14
PMCID:
PMC4249370
Enterococcus faecium PBP5-S/R, the Missing Link between PBP5-S and PBP5-R
Ester Pietta, Maria Camila Montealegre, Jung Hyeob Roh, Pier Sandro Cocconcelli, Barbara E. Murray
Antimicrob Agents Chemother. Nov 2014; 58(11): 6978–6981. doi: 10.1128/AAC.03648-14
PMCID:
PMC4249377
Mechanisms of Tigecycline Resistance among Klebsiella pneumoniae Clinical Isolates
Zi-Ke Sheng, Fupin Hu, Weixia Wang, Qinglan Guo, Zhijun Chen, Xiaogang Xu, Demei Zhu, Minggui Wang
Antimicrob Agents Chemother. Nov 2014; 58(11): 6982–6985. doi: 10.1128/AAC.03808-14
PMCID:
PMC4249433
In Vitro Selection of Neisseria gonorrhoeae Mutants with Elevated MIC Values and Increased Resistance to Cephalosporins
Steven R. Johnson, Yonatan Grad, Satishkumar Ranganathan Ganakammal, Mark Burroughs, Mike Frace, Marc Lipsitch, Ryan Weil, David Trees
Antimicrob Agents Chemother. Nov 2014; 58(11): 6986–6989. doi: 10.1128/AAC.03082-14
PMCID:
PMC4249396

Susceptibility

In Vitro Susceptibility of Plasmodium vivax to Antimalarials in Colombia
Diana Fernández, César Segura, Margarita Arboleda, Giovanny Garavito, Silvia Blair, Adriana Pabón
Antimicrob Agents Chemother. Nov 2014; 58(11): 6354–6359. doi: 10.1128/AAC.03191-14
PMCID:
PMC4249416
Antimalarial Activity of the Myxobacterial Macrolide Chlorotonil A
Jana Held, Tamirat Gebru, Markus Kalesse, Rolf Jansen, Klaus Gerth, Rolf Müller, Benjamin Mordmüller
Antimicrob Agents Chemother. Nov 2014; 58(11): 6378–6384. doi: 10.1128/AAC.03326-14
PMCID:
PMC4249382
EUCAST Testing of Isavuconazole Susceptibility in Aspergillus: Comparison of Results for Inoculum Standardization Using Conidium Counting versus Optical Density
Maiken Cavling Arendrup, Susan Howard, Cornelia Lass-Flörl, Johan W. Mouton, Joseph Meletiadis, Manuel Cuenca-Estrella
Antimicrob Agents Chemother. Nov 2014; 58(11): 6432–6436. doi: 10.1128/AAC.03779-14
PMCID:
PMC4249446
Antibacterial Synergy of Glycerol Monolaurate and Aminoglycosides in Staphylococcus aureus Biofilms
Donavon J. Hess, Michelle J. Henry-Stanley, Carol L. Wells
Antimicrob Agents Chemother. Nov 2014; 58(11): 6970–6973. doi: 10.1128/AAC.03672-14
PMCID:
PMC4249351
In Vitro Combination of Voriconazole and Miltefosine against Clinically Relevant Molds
S. Imbert, M. Palous, I. Meyer, E. Dannaoui, D. Mazier, A. Datry, A. Fekkar
Antimicrob Agents Chemother. Nov 2014; 58(11): 6996–6998. doi: 10.1128/AAC.03212-14
PMCID:
PMC4249431
In Vitro Potential of Lycosin-I as an Alternative Antimicrobial Drug for Treatment of Multidrug-Resistant Acinetobacter baumannii Infections
Ling Wang, Yong-Jun Wang, Yin-Yin Liu, Hui Li, Ling-Xia Guo, Zhong-Hua Liu, Xiao-Liu Shi, Min Hu
Antimicrob Agents Chemother. Nov 2014; 58(11): 6999–7002. doi: 10.1128/AAC.03279-14
PMCID:
PMC4249444
In Vitro Susceptibility of Mycobacterium tuberculosis Isolates to an Oral Carbapenem Alone or in Combination with β-Lactamase Inhibitors
Yasuhiro Horita, Shinji Maeda, Yuko Kazumi, Norio Doi
Antimicrob Agents Chemother. Nov 2014; 58(11): 7010–7014. doi: 10.1128/AAC.03539-14
PMCID:
PMC4249422

Biologic Response Modifiers

Effective Control of Salmonella Infections by Employing Combinations of Recombinant Antimicrobial Human β-Defensins hBD-1 and hBD-2
Soumitra Maiti, Sunita Patro, Sukumar Purohit, Sumeet Jain, Shantibhusan Senapati, Nrisingha Dey
Antimicrob Agents Chemother. Nov 2014; 58(11): 6896–6903. doi: 10.1128/AAC.03628-14
PMCID:
PMC4249419

Analytical Procedures

In Vivo Monitoring of Staphylococcus aureus Biofilm Infections and Antimicrobial Therapy by [18F]Fluoro-Deoxyglucose–MicroPET in a Mouse Model
Victoria Garrido, María Collantes, Montserrat Barberán, Iván Peñuelas, Javier Arbizu, Beatriz Amorena, María-Jesús Grilló
Antimicrob Agents Chemother. Nov 2014; 58(11): 6660–6667. doi: 10.1128/AAC.03138-14
PMCID:
PMC4249392
Clinical Validation of the Analysis of Fluconazole in Oral Fluid in Hospitalized Children
Kim C. M. van der Elst, Manouche van Alst, Marjolijn N. Lub-de Hooge, Kai van Hateren, Jos G. W. Kosterink, Jan-Willem C. Alffenaar, Elisabeth H. Schölvinck
Antimicrob Agents Chemother. Nov 2014; 58(11): 6742–6746. doi: 10.1128/AAC.03636-14
PMCID:
PMC4249449
Quantification of Rifapentine, a Potent Antituberculosis Drug, from Dried Blood Spot Samples Using Liquid Chromatographic-Tandem Mass Spectrometric Analysis
Teresa L. Parsons, Mark A. Marzinke, Thuy Hoang, Erin Bliven-Sizemore, Marc Weiner, William R. Mac Kenzie, Susan E. Dorman, Kelly E. Dooley
Antimicrob Agents Chemother. Nov 2014; 58(11): 6747–6757. doi: 10.1128/AAC.03607-14
PMCID:
PMC4249427

Antiviral Agents

Evolution of Oseltamivir Resistance Mutations in Influenza A(H1N1) and A(H3N2) Viruses during Selection in Experimentally Infected Mice
Andrés Pizzorno, Yacine Abed, Pier-Luc Plante, Julie Carbonneau, Mariana Baz, Marie-Ève Hamelin, Jacques Corbeil, Guy Boivin
Antimicrob Agents Chemother. Nov 2014; 58(11): 6398–6405. doi: 10.1128/AAC.02956-14
PMCID:
PMC4249448
Effects of Tenofovir on Cytokines and Nucleotidases in HIV-1 Target Cells and the Mucosal Tissue Environment in the Female Reproductive Tract
Nabanita Biswas, Marta Rodriguez-Garcia, Zheng Shen, Sarah G. Crist, Jack E. Bodwell, John V. Fahey, Charles R. Wira
Antimicrob Agents Chemother. Nov 2014; 58(11): 6444–6453. doi: 10.1128/AAC.03270-14
PMCID:
PMC4249387
Phenyl-1-Pyridin-2yl-Ethanone-Based Iron Chelators Increase IκB-α Expression, Modulate CDK2 and CDK9 Activities, and Inhibit HIV-1 Transcription
Namita Kumari, Sergey Iordanskiy, Dmytro Kovalskyy, Denitra Breuer, Xiaomei Niu, Xionghao Lin, Min Xu, Konstantin Gavrilenko, Fatah Kashanchi, Subhash Dhawan, Sergei Nekhai
Antimicrob Agents Chemother. Nov 2014; 58(11): 6558–6571. doi: 10.1128/AAC.02918-14
PMCID:
PMC4249367
Clinical and In Vitro Resistance to GS-9669, a Thumb Site II Nonnucleoside Inhibitor of the Hepatitis C Virus NS5B Polymerase
Hadas Dvory-Sobol, Christian Voitenleitner, Eric Mabery, Taylor Skurnac, Eric J. Lawitz, John McHutchison, Evguenia S. Svarovskaia, William Delaney, Michael D. Miller, Hongmei Mo
Antimicrob Agents Chemother. Nov 2014; 58(11): 6599–6606. doi: 10.1128/AAC.02815-14
PMCID:
PMC4249356
BCX4430, a Novel Nucleoside Analog, Effectively Treats Yellow Fever in a Hamster Model
Justin G. Julander, Shanta Bantia, Brian R. Taubenheim, Dena M. Minning, Pravin Kotian, John D. Morrey, Donald F. Smee, William P. Sheridan, Yarlagadda S. Babu
Antimicrob Agents Chemother. Nov 2014; 58(11): 6607–6614. doi: 10.1128/AAC.03368-14
PMCID:
PMC4249364
The 6-Aminoquinolone WC5 Inhibits Different Functions of the Immediate-Early 2 (IE2) Protein of Human Cytomegalovirus That Are Essential for Viral Replication
Beatrice Mercorelli, Anna Luganini, Giulia Muratore, Serena Massari, Maria Elena Terlizzi, Oriana Tabarrini, Giorgio Gribaudo, Giorgio Palù, Arianna Loregian
Antimicrob Agents Chemother. Nov 2014; 58(11): 6615–6626. doi: 10.1128/AAC.03309-14
PMCID:
PMC4249379
Safety and Pharmacokinetic Profiles of Phosphorodiamidate Morpholino Oligomers with Activity against Ebola Virus and Marburg Virus: Results of Two Single-Ascending-Dose Studies
Alison E. Heald, Patrick L. Iversen, Jay B. Saoud, Peter Sazani, Jay S. Charleston, Tim Axtelle, Michael Wong, William B. Smith, Apinya Vutikullird, Edward Kaye
Antimicrob Agents Chemother. Nov 2014; 58(11): 6639–6647. doi: 10.1128/AAC.03442-14
PMCID:
PMC4249403
Effect of Fosamprenavir-Ritonavir on the Pharmacokinetics of Dolutegravir in Healthy Subjects
Ivy Song, Julie Borland, Shuguang Chen, Amanda Peppercorn, Toshihiro Wajima, Stephen C. Piscitelli
Antimicrob Agents Chemother. Nov 2014; 58(11): 6696–6700. doi: 10.1128/AAC.03282-14
PMCID:
PMC4249430
Lack of Clinically Significant Pharmacokinetic Interaction between the Thrombopoietin Receptor Agonist Eltrombopag and Hepatitis C Virus Protease Inhibitors Boceprevir and Telaprevir
Mary Beth Wire, Lei Fang, Azra Hussaini, Joseph F. Kleha, Dickens Theodore
Antimicrob Agents Chemother. Nov 2014; 58(11): 6704–6709. doi: 10.1128/AAC.03091-14
PMCID:
PMC4249398
Efficacy of Entecavir-Tenofovir Combination Therapy for Chronic Hepatitis B Patients with Multidrug-Resistant Strains
Yun Bin Lee, Jeong-Hoon Lee, Dong Hyeon Lee, Hyeki Cho, Hongkeun Ahn, Won-Mook Choi, Young Youn Cho, Minjong Lee, Jeong-Ju Yoo, Yuri Cho, Eun Ju Cho, Su Jong Yu, Yoon Jun Kim, Jung-Hwan Yoon, Chung Yong Kim, Hyo-Suk Lee
Antimicrob Agents Chemother. Nov 2014; 58(11): 6710–6716. doi: 10.1128/AAC.03845-14
PMCID:
PMC4249402
Differential Subcutaneous Adipose Tissue Gene Expression Patterns in a Randomized Clinical Trial of Efavirenz or Lopinavir-Ritonavir in Antiretroviral-Naive Patients
L. Egaña-Gorroño, E. Martínez, P. Domingo, M. Loncà, T. Escribà, J. Fontdevila, F. Vidal, E. Negredo, J. M. Gatell, M. Arnedo
Antimicrob Agents Chemother. Nov 2014; 58(11): 6717–6723. doi: 10.1128/AAC.03481-14
PMCID:
PMC4249432
Antiviral Effects of Artesunate on JC Polyomavirus Replication in COS-7 Cells
Biswa Nath Sharma, Manfred Marschall, Christine Hanssen Rinaldo
Antimicrob Agents Chemother. Nov 2014; 58(11): 6724–6734. doi: 10.1128/AAC.03714-14
PMCID:
PMC4249435
Zidovudine Induces Downregulation of Mitochondrial Deoxynucleoside Kinases: Implications for Mitochondrial Toxicity of Antiviral Nucleoside Analogs
Ren Sun, Staffan Eriksson, Liya Wang
Antimicrob Agents Chemother. Nov 2014; 58(11): 6758–6766. doi: 10.1128/AAC.03613-14
PMCID:
PMC4249380
Effect of Suberoylanilide Hydroxamic Acid (SAHA) Administration on the Residual Virus Pool in a Model of Combination Antiretroviral Therapy-Mediated Suppression in SIVmac239-Infected Indian Rhesus Macaques
Gregory Q. Del Prete, Rebecca Shoemaker, Kelli Oswald, Abigail Lara, Charles M. Trubey, Randy Fast, Douglas K. Schneider, Rebecca Kiser, Vicky Coalter, Adam Wiles, Rodney Wiles, Brandi Freemire, Brandon F. Keele, Jacob D. Estes, Octavio A. Quiñones, Jeremy Smedley, Rhonda Macallister, Rosa I. Sanchez, John S. Wai, Christopher M. Tan, W. Gregory Alvord, Daria J. Hazuda, Michael Piatak, Jr., Jeffrey D. Lifson
Antimicrob Agents Chemother. Nov 2014; 58(11): 6790–6806. doi: 10.1128/AAC.03746-14
PMCID:
PMC4249371
Molecular and Structural Basis for the Roles of Hepatitis C Virus Polymerase NS5B Amino Acids 15, 223, and 321 in Viral Replication and Drug Resistance
Angela M. Lam, Thomas E. Edwards, Ralph T. Mosley, Eisuke Murakami, Shalini Bansal, Christopher Lugo, Haiying Bao, Michael J. Otto, Michael J. Sofia, Phillip A. Furman
Antimicrob Agents Chemother. Nov 2014; 58(11): 6861–6869. doi: 10.1128/AAC.03847-14
PMCID:
PMC4249362
The Capsid Binder Vapendavir and the Novel Protease Inhibitor SG85 Inhibit Enterovirus 71 Replication
Aloys Tijsma, David Franco, Simon Tucker, Rolf Hilgenfeld, Mathy Froeyen, Pieter Leyssen, Johan Neyts
Antimicrob Agents Chemother. Nov 2014; 58(11): 6990–6992. doi: 10.1128/AAC.03328-14
PMCID:
PMC4249361

Epidemiology and Surveillance

Changes in Pneumococcal Serotypes and Antimicrobial Resistance after Introduction of the 13-Valent Conjugate Vaccine in the United States
Sandra S. Richter, Daniel J. Diekema, Kristopher P. Heilmann, Cassie L. Dohrn, Fathollah Riahi, Gary V. Doern
Antimicrob Agents Chemother. Nov 2014; 58(11): 6484–6489. doi: 10.1128/AAC.03344-14
PMCID:
PMC4249410
Antimicrobial Resistance in Salmonella enterica Serovar Typhi Isolates from Bangladesh, Indonesia, Taiwan, and Vietnam
Chien-Shun Chiou, Tsai-Ling Lauderdale, Dac Cam Phung, Haruo Watanabe, Jung-Che Kuo, Pei-Jen Wang, Yen-Yi Liu, Shiu-Yun Liang, Pei-Chen Chen
Antimicrob Agents Chemother. Nov 2014; 58(11): 6501–6507. doi: 10.1128/AAC.03608-14
PMCID:
PMC4249406
Characterization of a P1-Like Bacteriophage Carrying an SHV-2 Extended-Spectrum β-Lactamase from an Escherichia coli Strain
Typhaine Billard-Pomares, Stéphanie Fouteau, Marie Elise Jacquet, David Roche, Valérie Barbe, Miguel Castellanos, Jean Yves Bouet, Stéphane Cruveiller, Claudine Médigue, Jorge Blanco, Olivier Clermont, Erick Denamur, Catherine Branger
Antimicrob Agents Chemother. Nov 2014; 58(11): 6550–6557. doi: 10.1128/AAC.03183-14
PMCID:
PMC4249366
Temporal Trends in Antimicrobial Resistance and Virulence-Associated Traits within the Escherichia coli Sequence Type 131 Clonal Group and Its H30 and H30-Rx Subclones, 1968 to 2012
Bente Olesen, Jakob Frimodt-Møller, Rikke Fleron Leihof, Carsten Struve, Brian Johnston, Dennis S. Hansen, Flemming Scheutz, Karen A. Krogfelt, Michael A. Kuskowski, Connie Clabots, James R. Johnson
Antimicrob Agents Chemother. Nov 2014; 58(11): 6886–6895. doi: 10.1128/AAC.03679-14
PMCID:
PMC4249411
Molecular Features of Community-Associated Extended-Spectrum-β-Lactamase-Producing Escherichia coli Strains in the United States
Fupin Hu, Jessica A. O'Hara, Jesabel I. Rivera, Yohei Doi
Antimicrob Agents Chemother. Nov 2014; 58(11): 6953–6957. doi: 10.1128/AAC.03321-14
PMCID:
PMC4249407
Plasmodium falciparum and Plasmodium vivax Genotypes and Efficacy of Intermittent Preventive Treatment in Papua New Guinea
Celine Barnadas, Nicolas Senn, Jonah Iga, Lincoln Timinao, Sarah Javati, Elisheba Malau, Patricia Rarau, John C. Reeder, Peter Siba, Harin Karunajeewa, Peter A. Zimmerman, Timothy M. Davis, Ivo Mueller
Antimicrob Agents Chemother. Nov 2014; 58(11): 6958–6961. doi: 10.1128/AAC.03323-14
PMCID:
PMC4249390
Clinical and Molecular Epidemiology of Escherichia coli Sequence Type 131 among Hospitalized Patients Colonized Intestinally with Fluoroquinolone-Resistant E. coli
Jennifer H. Han, Brian Johnston, Irving Nachamkin, Pam Tolomeo, Warren B. Bilker, Xiangqun Mao, Connie Clabots, Ebbing Lautenbach, James R. Johnson
Antimicrob Agents Chemother. Nov 2014; 58(11): 7003–7006. doi: 10.1128/AAC.03256-14
PMCID:
PMC4249391

Experimental Therapeutics

Efficacy of a Ceftazidime-Avibactam Combination in a Murine Model of Septicemia Caused by Enterobacteriaceae Species Producing AmpC or Extended-Spectrum β-Lactamases
Premavathy Levasseur, Anne-Marie Girard, Ludovic Lavallade, Christine Miossec, John Pace, Kenneth Coleman
Antimicrob Agents Chemother. Nov 2014; 58(11): 6490–6495. doi: 10.1128/AAC.03579-14
PMCID:
PMC4249388
Ceftaroline-Fosamil Efficacy against Methicillin-Resistant Staphylococcus aureus in a Rabbit Prosthetic Joint Infection Model
Laure Gatin, Azzam Saleh-Mghir, Jason Tasse, Idir Ghout, Frédéric Laurent, Anne-Claude Crémieux
Antimicrob Agents Chemother. Nov 2014; 58(11): 6496–6500. doi: 10.1128/AAC.03600-14
PMCID:
PMC4249363
Maternal Intravenous Administration of Azithromycin Results in Significant Fetal Uptake in a Sheep Model of Second Trimester Pregnancy
Matthew W. Kemp, Yuichiro Miura, Matthew S. Payne, Alan H. Jobe, Suhas G. Kallapur, Masatoshi Saito, Sarah J. Stock, O. Brad Spiller, Demelza J. Ireland, Nobuo Yaegashi, Michael Clarke, Dorothee Hahne, Jennifer Rodger, Jeffrey A. Keelan, John P. Newnham
Antimicrob Agents Chemother. Nov 2014; 58(11): 6581–6591. doi: 10.1128/AAC.03721-14
PMCID:
PMC4249365
Comparative Pharmacodynamics of Posaconazole in Neutropenic Murine Models of Invasive Pulmonary Aspergillosis and Mucormycosis
Russell E. Lewis, Nathaniel D. Albert, Dimitrios P. Kontoyiannis
Antimicrob Agents Chemother. Nov 2014; 58(11): 6767–6772. doi: 10.1128/AAC.03569-14
PMCID:
PMC4249415
Evaluation of Meropenem Regimens Suppressing Emergence of Resistance in Acinetobacter baumannii with Human Simulated Exposure in an In Vitro Intravenous-Infusion Hollow-Fiber Infection Model
Xin Li, Lin Wang, Xian-Jia Zhang, Yang Yang, Wei-Tao Gong, Bin Xu, Ying-Qun Zhu, Wei Liu
Antimicrob Agents Chemother. Nov 2014; 58(11): 6773–6781. doi: 10.1128/AAC.03505-14
PMCID:
PMC4249358
Nitrotriazole- and Imidazole-Based Amides and Sulfonamides as Antitubercular Agents
Maria V. Papadopoulou, William D. Bloomer, Howard S. Rosenzweig, Alexander Arena, Francisco Arrieta, Joseph C. J. Rebolledo, Diane K. Smith
Antimicrob Agents Chemother. Nov 2014; 58(11): 6828–6836. doi: 10.1128/AAC.03644-14
PMCID:
PMC4249394
In Vivo Efficacy of Apramycin in Murine Infection Models
Martin Meyer, Pietro Freihofer, Michael Scherman, Joanne Teague, Anne Lenaerts, Erik C. Böttger
Antimicrob Agents Chemother. Nov 2014; 58(11): 6938–6941. doi: 10.1128/AAC.03239-14
PMCID:
PMC4249428

Clinical Therapeutics

Identification of Acinetobacter baumannii Serum-Associated Antibiotic Efflux Pump Inhibitors
Catlyn Blanchard, Pamela Barnett, Jessamyn Perlmutter, Paul M. Dunman
Antimicrob Agents Chemother. Nov 2014; 58(11): 6360–6370. doi: 10.1128/AAC.03535-14
PMCID:
PMC4249429
A First-in-Human Randomized, Double-Blind, Placebo-Controlled, Single- and Multiple-Ascending Oral Dose Study of Novel Imidazolopiperazine KAF156 To Assess Its Safety, Tolerability, and Pharmacokinetics in Healthy Adult Volunteers
F. Joel Leong, Rong Zhao, Shuqi Zeng, Baldur Magnusson, Thierry T. Diagana, Peter Pertel
Antimicrob Agents Chemother. Nov 2014; 58(11): 6437–6443. doi: 10.1128/AAC.03478-14
PMCID:
PMC4249437
Safety, Tolerability, and Efficacy of GSK1322322 in the Treatment of Acute Bacterial Skin and Skin Structure Infections
Ralph Corey, Odin J. Naderer, William D. O'Riordan, Etienne Dumont, Lori S. Jones, Milena Kurtinecz, John Z. Zhu
Antimicrob Agents Chemother. Nov 2014; 58(11): 6518–6527. doi: 10.1128/AAC.03360-14
PMCID:
PMC4249383
Culture of the Entire Mouse To Determine whether Cultivable Borrelia burgdorferi Persists in Infected Mice Treated with a Five-Day Course of Ceftriaxone
Charles S. Pavia, Gary P. Wormser
Antimicrob Agents Chemother. Nov 2014; 58(11): 6701–6703. doi: 10.1128/AAC.03751-14
PMCID:
PMC4249442
Population Pharmacokinetics of Teicoplanin in Children
V. Ramos-Martín, S. Paulus, S. Siner, E. Scott, K. Padmore, P. Newland, R. J. Drew, T. W. Felton, F. Docobo-Pérez, B. Pizer, F. Pea, M. Peak, M. A. Turner, M. W. Beresford, W. W. Hope
Antimicrob Agents Chemother. Nov 2014; 58(11): 6920–6927. doi: 10.1128/AAC.03685-14
PMCID:
PMC4249354
Validation of a Model To Predict the Risk of Nephrotoxicity in Patients Receiving Colistin
Kady Phe, Michael L. Johnson, Hannah R. Palmer, Vincent H. Tam
Antimicrob Agents Chemother. Nov 2014; 58(11): 6946–6948. doi: 10.1128/AAC.03776-14
PMCID:
PMC4249357
Switching from Posaconazole Suspension to Tablets Increases Serum Drug Levels in Leukemia Patients without Clinically Relevant Hepatotoxicity
Dong Sik Jung, Frank P. Tverdek, Dimitrios P. Kontoyiannis
Antimicrob Agents Chemother. Nov 2014; 58(11): 6993–6995. doi: 10.1128/AAC.04035-14
PMCID:
PMC4249440

Pharmacology

A Clinical Adverse Drug Reaction Prediction Model for Patients with Chagas Disease Treated with Benznidazole
Gilberto Marcelo Sperandio da Silva, Mauro Felippe Felix Mediano, Pedro Emmanuel Alvarenga Americano do Brasil, Mayara da Costa Chambela, Joyce Almeida da Silva, Andrea Silvestre de Sousa, Sergio Salles Xavier, Andrea Rodrigues da Costa, Roberto Magalhães Saraiva, Alejandro Marcel Hasslocher-Moreno
Antimicrob Agents Chemother. Nov 2014; 58(11): 6371–6377. doi: 10.1128/AAC.02842-14
PMCID:
PMC4249401
Comparison of the Antibiotic Activities of Daptomycin, Vancomycin, and the Investigational Fluoroquinolone Delafloxacin against Biofilms from Staphylococcus aureus Clinical Isolates
Wafi Siala, Marie-Paule Mingeot-Leclercq, Paul M. Tulkens, Marie Hallin, Olivier Denis, Françoise Van Bambeke
Antimicrob Agents Chemother. Nov 2014; 58(11): 6385–6397. doi: 10.1128/AAC.03482-14
PMCID:
PMC4249400
Impact of Lopinavir-Ritonavir or Nevirapine on Bedaquiline Exposures and Potential Implications for Patients with Tuberculosis-HIV Coinfection
Elin M. Svensson, Kelly E. Dooley, Mats O. Karlsson
Antimicrob Agents Chemother. Nov 2014; 58(11): 6406–6412. doi: 10.1128/AAC.03246-14
PMCID:
PMC4249405
Association between Vancomycin Trough Concentration and Area under the Concentration-Time Curve in Neonates
Adam Frymoyer, Adam L. Hersh, Mohammed H. El-Komy, Shabnam Gaskari, Felice Su, David R. Drover, Krisa Van Meurs
Antimicrob Agents Chemother. Nov 2014; 58(11): 6454–6461. doi: 10.1128/AAC.03620-14
PMCID:
PMC4249374
Tedizolid Population Pharmacokinetics, Exposure Response, and Target Attainment
S. Flanagan, J. Passarell, Q. Lu, J. Fiedler-Kelly, E. Ludwig, P. Prokocimer
Antimicrob Agents Chemother. Nov 2014; 58(11): 6462–6470. doi: 10.1128/AAC.03423-14
PMCID:
PMC4249359
Pharmacokinetics of Tedizolid in Subjects with Renal or Hepatic Impairment
S. Flanagan, S. L. Minassian, D. Morris, R. Ponnuraj, T. C. Marbury, H. W. Alcorn, E. Fang, P. Prokocimer
Antimicrob Agents Chemother. Nov 2014; 58(11): 6471–6476. doi: 10.1128/AAC.03431-14
PMCID:
PMC4249404
Use of Microdosing and Accelerator Mass Spectrometry To Evaluate the Pharmacokinetic Linearity of a Novel Tricyclic GyrB/ParE Inhibitor in Rats
Michael A. Malfatti, Victoria Lao, Courtney L. Ramos, Voon S. Ong, Kenneth W. Turteltaub
Antimicrob Agents Chemother. Nov 2014; 58(11): 6477–6483. doi: 10.1128/AAC.03300-14
PMCID:
PMC4249412
Population Pharmacokinetics of Ciprofloxacin in Neonates and Young Infants Less than Three Months of Age
Wei Zhao, Helen Hill, Chantal Le Guellec, Tim Neal, Sarah Mahoney, Stephane Paulus, Charlotte Castellan, Behrouz Kassai, Johannes N. van den Anker, Gregory L. Kearns, Mark A. Turner, Evelyne Jacqz-Aigrain
Antimicrob Agents Chemother. Nov 2014; 58(11): 6572–6580. doi: 10.1128/AAC.03568-14
PMCID:
PMC4249352
Development of a Population Pharmacokinetic Model Characterizing the Tissue Distribution of Azithromycin in Healthy Subjects
Songmao Zheng, Peter Matzneller, Markus Zeitlinger, Stephan Schmidt
Antimicrob Agents Chemother. Nov 2014; 58(11): 6675–6684. doi: 10.1128/AAC.02904-14
PMCID:
PMC4249372
A Population Pharmacokinetic Modeling Approach Shows that Serum Penicillin G Concentrations Are Below Inhibitory Concentrations by Two Weeks after Benzathine Penicillin G Injection in the Majority of Young Adults
Michael Neely, Edward L. Kaplan, Jeffrey L. Blumer, Dennis J. Faix, Michael P. Broderick
Antimicrob Agents Chemother. Nov 2014; 58(11): 6735–6741. doi: 10.1128/AAC.02744-14
PMCID:
PMC4249386
Impact of Hypoalbuminemia on Voriconazole Pharmacokinetics in Critically Ill Adult Patients
Kim Vanstraelen, Joost Wauters, Ine Vercammen, Henriette de Loor, Johan Maertens, Katrien Lagrou, Pieter Annaert, Isabel Spriet
Antimicrob Agents Chemother. Nov 2014; 58(11): 6782–6789. doi: 10.1128/AAC.03641-14
PMCID:
PMC4249353
Understanding Variability in Posaconazole Exposure Using an Integrated Population Pharmacokinetic Analysis
Michael J. Dolton, Roger J. M. Brüggemann, David M. Burger, Andrew J. McLachlan
Antimicrob Agents Chemother. Nov 2014; 58(11): 6879–6885. doi: 10.1128/AAC.03777-14
PMCID:
PMC4249414
In Vivo Efficacy of Humanized Exposures of Ceftazidime-Avibactam in Comparison with Ceftazidime against Contemporary Enterobacteriaceae Isolates
Shawn H. MacVane, Jared L. Crandon, Wright W. Nichols, David P. Nicolau
Antimicrob Agents Chemother. Nov 2014; 58(11): 6913–6919. doi: 10.1128/AAC.03267-14
PMCID:
PMC4249385
Comparison of In Vivo and In Vitro Pharmacodynamics of a Humanized Regimen of 600 Milligrams of Ceftaroline Fosamil Every 12 Hours against Staphylococcus aureus at Initial Inocula of 106 and 108 CFU per Milliliter
Wonhee So, Jared L. Crandon, George G. Zhanel, David P. Nicolau
Antimicrob Agents Chemother. Nov 2014; 58(11): 6931–6933. doi: 10.1128/AAC.03652-14
PMCID:
PMC4249378
In Vitro Combination of Isavuconazole with Micafungin or Amphotericin B Deoxycholate against Medically Important Molds
Aspasia Katragkou, Matthew McCarthy, Joseph Meletiadis, Vidmantas Petraitis, Patriss W. Moradi, Gittel E. Strauss, Monique M. Fouant, Laura L. Kovanda, Ruta Petraitiene, Emmanuel Roilides, Thomas J. Walsh
Antimicrob Agents Chemother. Nov 2014; 58(11): 6934–6937. doi: 10.1128/AAC.03261-14
PMCID:
PMC4249375
Unexpected In Vivo Activity of Ceftazidime Alone and in Combination with Avibactam against New Delhi Metallo-β-Lactamase-Producing Enterobacteriaceae in a Murine Thigh Infection Model
Shawn H. MacVane, Jared L. Crandon, Wright W. Nichols, David P. Nicolau
Antimicrob Agents Chemother. Nov 2014; 58(11): 7007–7009. doi: 10.1128/AAC.02662-14
PMCID:
PMC4249434

Letters to the Editor

Common Clinical Substitutions Enhance the Carbapenemase Activity of OXA-51-Like Class D β-Lactamases from Acinetobacter spp.
Joshua M. Mitchell, David A. Leonard
Antimicrob Agents Chemother. Nov 2014; 58(11): 7015–7016. doi: 10.1128/AAC.03651-14
PMCID:
PMC4249439
A blaVIM-2 Plasmid Disseminating in Extensively Drug-Resistant Clinical Pseudomonas aeruginosa and Serratia marcescens Isolates
Elisabet Vilacoba, Cecilia Quiroga, Mariano Pistorio, Angela Famiglietti, Hernán Rodríguez, Jaime Kovensky, Maxime Déraspe, Frédéric Raymond, Paul H. Roy, Daniela Centrón
Antimicrob Agents Chemother. Nov 2014; 58(11): 7017–7018. doi: 10.1128/AAC.02934-14
PMCID:
PMC4249447
In Vitro Activity of Nitroxoline against Escherichia coli Urine Isolates from Outpatient Departments in Germany
Michael Kresken, Barbara Körber-Irrgang
Antimicrob Agents Chemother. Nov 2014; 58(11): 7019–7020. doi: 10.1128/AAC.03946-14
PMCID:
PMC4249399
Therapeutic Outcomes of Pyogenic Vertebral Osteomyelitis Requiring Spinal Instrumentation
Ki-Ho Park, Oh-Hyun Cho, In-Gyu Bae, Mi Suk Lee
Antimicrob Agents Chemother. Nov 2014; 58(11): 7021. doi: 10.1128/AAC.03934-14
PMCID:
PMC4249389
Reply to “Therapeutic Outcomes of Pyogenic Vertebral Osteomyelitis Requiring Spinal Instrumentation”
Ryan Arnold, Clare Rock, Lindsay Croft, Bruce L. Gilliam, Daniel J. Morgan
Antimicrob Agents Chemother. Nov 2014; 58(11): 7022. doi: 10.1128/AAC.04063-14
PMCID:
PMC4249395

Masthead

Editorial Board
Antimicrob Agents Chemother. Nov 2014; 58(11): A3. doi: 10.1128/AAC.masthead.58-11
PMCID:
PMC4249355

Erratum

Erratum for El Haj et al., Comparative Efficacies of Cloxacillin-Daptomycin and the Standard Cloxacillin-Rifampin Therapies against an Experimental Foreign-Body Infection by Methicillin-Susceptible Staphylococcus aureus
Cristina El Haj, Oscar Murillo, Alba Ribera, Mireia Vivas, Dolors Garcia-Somoza, Fe Tubau, Javier Cabo, Javier Ariza
Antimicrob Agents Chemother. Nov 2014; 58(11): 7023. doi: 10.1128/AAC.04237-14
PMCID:
PMC4249360

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)