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Volume 59(3);  2015 Mar

Articles from this journal are usually available in PMC after a 6-month delay (embargo). Some articles may be available sooner.

Mechanisms of Action: Physiological Effects

In Vitro Activity of Fosfomycin Alone and in Combination with Ceftriaxone or Azithromycin against Clinical Neisseria gonorrhoeae Isolates
Christoph Hauser, Lea Hirzberger, Magnus Unemo, Hansjakob Furrer, Andrea Endimiani
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1605–1611. Published online 2014 Dec 29. doi: 10.1128/AAC.04536-14
PMCID:
PMC4325783
Molecular Mechanisms of Sulbactam Antibacterial Activity and Resistance Determinants in Acinetobacter baumannii
William F. Penwell, Adam B. Shapiro, Robert A. Giacobbe, Rong-Fang Gu, Ning Gao, Jason Thresher, Robert E. McLaughlin, Michael D. Huband, Boudewijn L. M. DeJonge, David E. Ehmann, Alita A. Miller
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1680–1689. Published online 2015 Jan 5. doi: 10.1128/AAC.04808-14
PMCID:
PMC4325763
Insect-Derived Cecropins Display Activity against Acinetobacter baumannii in a Whole-Animal High-Throughput Caenorhabditis elegans Model
Elamparithi Jayamani, Rajmohan Rajamuthiah, Jonah Larkins-Ford, Beth Burgwyn Fuchs, Annie L. Conery, Andreas Vilcinskas, Frederick M. Ausubel, Eleftherios Mylonakis
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1728–1737. Published online 2015 Jan 12. doi: 10.1128/AAC.04198-14
PMCID:
PMC4325797
Involvement of Holliday Junction Resolvase in Fluoroquinolone-Mediated Killing of Mycobacterium smegmatis
Quanxin Long, Qinglin Du, Tiwei Fu, Karl Drlica, Xilin Zhao, Jianping Xie
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1782–1785. Published online 2014 Dec 22. doi: 10.1128/AAC.04434-14
PMCID:
PMC4325773

Mechanisms of Resistance

Vancomycin-Variable Enterococci Can Give Rise to Constitutive Resistance during Antibiotic Therapy
Maulik N. Thaker, Lindsay Kalan, Nicholas Waglechner, Alireza Eshaghi, Samir N. Patel, Susan Poutanen, Barbara Willey, Bryan Coburn, Allison McGeer, Donald E. Low, Gerard D. Wright
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1405–1410. Published online 2014 Dec 15. doi: 10.1128/AAC.04490-14
PMCID:
PMC4325790
Effect of Asparagine Substitutions in the YXN Loop of a Class C β-Lactamase of Acinetobacter baumannii on Substrate and Inhibitor Kinetics
Marion J. Skalweit, Mei Li, Magda A. Taracila
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1472–1477. Published online 2014 Dec 22. doi: 10.1128/AAC.03537-14
PMCID:
PMC4325782
Characterization of the Novel DNA Gyrase Inhibitor AZD0914: Low Resistance Potential and Lack of Cross-Resistance in Neisseria gonorrhoeae
Richard A. Alm, Sushmita D. Lahiri, Amy Kutschke, Linda G. Otterson, Robert E. McLaughlin, James D. Whiteaker, Lisa A. Lewis, Xiaohong Su, Michael D. Huband, Humphrey Gardner, John P. Mueller
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1478–1486. Published online 2014 Dec 22. doi: 10.1128/AAC.04456-14
PMCID:
PMC4325766
Molecular Diagnosis of Fluoroquinolone Resistance in Mycobacterium tuberculosis
Christine Bernard, Nicolas Veziris, Florence Brossier, Wladimir Sougakoff, Vincent Jarlier, Jérôme Robert, Alexandra Aubry
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1519–1524. Published online 2014 Dec 22. doi: 10.1128/AAC.04058-14
PMCID:
PMC4325825
Molecular Analysis of Codon 548 in the rpoB Gene Involved in Mycobacterium tuberculosis Resistance to Rifampin
Yu-Tze Horng, Wen-Yih Jeng, Yih-Yuan Chen, Che-Hung Liu, Horng-Yunn Dou, Jen-Jyh Lee, Kai-Chih Chang, Chih-Ching Chien, Po-Chi Soo
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1542–1548. Published online 2014 Dec 22. doi: 10.1128/AAC.04374-14
PMCID:
PMC4325785
Tn6249, a New Tn6162 Transposon Derivative Carrying a Double-Integron Platform and Involved with Acquisition of the blaVIM-1 Metallo-β-Lactamase Gene in Pseudomonas aeruginosa
Vincenzo Di Pilato, Simona Pollini, Gian Maria Rossolini
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1583–1587. Published online 2014 Dec 29. doi: 10.1128/AAC.04047-14
PMCID:
PMC4325805
Inhibition of Nucleic Acid Biosynthesis Makes Little Difference to Formation of Amphotericin B-Tolerant Persisters in Candida albicans Biofilm
Jing Sun, Xiaohua Liu, Guangshui Jiang, Qingguo Qi
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1627–1633. Published online 2014 Dec 29. doi: 10.1128/AAC.03765-14
PMCID:
PMC4325803
Amy J. Mathers, Nicole Stoesser, Anna E. Sheppard, Louise Pankhurst, Adam Giess, Anthony J. Yeh, Xavier Didelot, Stephen D. Turner, Robert Sebra, Andrew Kasarskis, Tim Peto, Derrick Crook, Costi D. Sifri
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1656–1663. Published online 2015 Jan 5. doi: 10.1128/AAC.04292-14
PMCID:
PMC4325807
In Vitro Prediction of the Evolution of GES-1 β-Lactamase Hydrolytic Activity
Séverine Bontron, Laurent Poirel, Patrice Nordmann
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1664–1670. Published online 2015 Jan 5. doi: 10.1128/AAC.04450-14
PMCID:
PMC4325776
Phenotypic and Genotypic Characterization of Pyrazinamide Resistance among Multidrug-Resistant Mycobacterium tuberculosis Isolates in Zhejiang, China
Qiang Xia, Li-li Zhao, Feng Li, Yu-mei Fan, Yuan-yuan Chen, Bei-bei Wu, Zheng-wei Liu, Ai-zhen Pan, Min Zhu
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1690–1695. Published online 2015 Jan 12. doi: 10.1128/AAC.04541-14
PMCID:
PMC4325781
Whole-Genome Sequence of Chryseobacterium oranimense, a Colistin-Resistant Bacterium Isolated from a Cystic Fibrosis Patient in France
Poonam Sharma, Sushim Kumar Gupta, Seydina M. Diene, Jean-Marc Rolain
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1696–1706. Published online 2015 Jan 12. doi: 10.1128/AAC.02417-14
PMCID:
PMC4325762
Sublethal Concentrations of Carbapenems Alter Cell Morphology and Genomic Expression of Klebsiella pneumoniae Biofilms
Tricia A. Van Laar, Tsute Chen, Tao You, Kai P. Leung
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1707–1717. Published online 2015 Jan 12. doi: 10.1128/AAC.04581-14
PMCID:
PMC4325768
Elisabeth Thulin, Martin Sundqvist, Dan I. Andersson
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1718–1727. Published online 2015 Jan 12. doi: 10.1128/AAC.04819-14
PMCID:
PMC4325821
Biochemical Characterization of the POM-1 Metallo-β-Lactamase from Pseudomonas otitidis
Luisa Borgianni, Filomena De Luca, Maria Cristina Thaller, Yunsop Chong, Gian Maria Rossolini, Jean-Denis Docquier
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1755–1758. Published online 2014 Dec 15. doi: 10.1128/AAC.03843-14
PMCID:
PMC4325775
Lynette Isabella Ochola-Oyier, John Okombo, Leah Mwai, Steven M. Kiara, Lewa Pole, Kevin K. A. Tetteh, Alexis Nzila, Kevin Marsh
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1770–1775. Published online 2014 Dec 22. doi: 10.1128/AAC.03522-14
PMCID:
PMC4325780
Fluoroquinolone Resistance Does Not Impose a Cost on the Fitness of Clostridium difficile In Vitro
François Wasels, Sarah A. Kuehne, Stephen T. Cartman, Patrizia Spigaglia, Fabrizio Barbanti, Nigel P. Minton, Paola Mastrantonio
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1794–1796. Published online 2014 Dec 22. doi: 10.1128/AAC.04503-14
PMCID:
PMC4325769
Milena Dropa, Barbara Ghiglione, Maria Helena Matté, Livia Carminato Balsalobre, Nilton Lincopan, Glavur Rogério Matté, Gabriel Gutkind, Pablo Power
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1815–1817. Published online 2015 Jan 12. doi: 10.1128/AAC.04116-14
PMCID:
PMC4325771

Susceptibility

Multicenter Evaluation of MIC Distributions for Epidemiologic Cutoff Value Definition To Detect Amphotericin B, Posaconazole, and Itraconazole Resistance among the Most Clinically Relevant Species of Mucorales
A. Espinel-Ingroff, A. Chakrabarti, A. Chowdhary, S. Cordoba, E. Dannaoui, P. Dufresne, A. Fothergill, M. Ghannoum, G. M. Gonzalez, J. Guarro, S. Kidd, C. Lass-Flörl, J. F. Meis, T. Pelaez, A. M. Tortorano, J. Turnidge
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1745–1750. Published online 2015 Jan 12. doi: 10.1128/AAC.04435-14
PMCID:
PMC4325796
In Vitro Spectrum of Pexiganan Activity When Tested against Pathogens from Diabetic Foot Infections and with Selected Resistance Mechanisms
Robert K. Flamm, Paul R. Rhomberg, Katie M. Simpson, David J. Farrell, Helio S. Sader, Ronald N. Jones
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1751–1754. Published online 2015 Jan 12. doi: 10.1128/AAC.04773-14
PMCID:
PMC4325814
Multilaboratory Testing of Antifungal Drug Combinations against Candida Species and Aspergillus fumigatus: Utility of 100 Percent Inhibition as the Endpoint
Ping Ren, Ming Luo, Shao Lin, Mahmoud A. Ghannoum, Nancy Isham, Dan J. Diekema, Michael A. Pfaller, Shawn Messer, Shawn R. Lockhart, Naureen Iqbal, Vishnu Chaturvedi
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1759–1766. Published online 2014 Dec 15. doi: 10.1128/AAC.04545-14
PMCID:
PMC4325810
In Vitro Susceptibility of Characterized β-Lactamase-Producing Strains Tested with Avibactam Combinations
Henry Li, Mark Estabrook, George A. Jacoby, Wright W. Nichols, Raymond T. Testa, Karen Bush
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1789–1793. Published online 2014 Dec 22. doi: 10.1128/AAC.04191-14
PMCID:
PMC4325778
Activity of Eravacycline against Enterobacteriaceae and Acinetobacter baumannii, Including Multidrug-Resistant Isolates, from New York City
Marie Abdallah, Olawole Olafisoye, Christopher Cortes, Carl Urban, David Landman, John Quale
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1802–1805. Published online 2014 Dec 22. doi: 10.1128/AAC.04809-14
PMCID:
PMC4325809
Effect of Reduced Oxygen on the Antifungal Susceptibility of Clinically Relevant Aspergilli
Ulrike Binder, Elisabeth Maurer, Michaela Lackner, Cornelia Lass-Flörl
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1806–1810. Published online 2014 Dec 29. doi: 10.1128/AAC.04204-14
PMCID:
PMC4325812
Molecular Characterization of the Cytochrome b Gene and In Vitro Atovaquone Susceptibility of Plasmodium falciparum Isolates from Kenya
Luicer A. Ingasia, Hoseah M. Akala, Mabel O. Imbuga, Benjamin H. Opot, Fredrick L. Eyase, Jacob D. Johnson, Wallace D. Bulimo, Edwin Kamau
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1818–1821. Published online 2015 Jan 12. doi: 10.1128/AAC.03956-14
PMCID:
PMC4325819

Analytical Procedures

Pharmacokinetic-Pharmacodynamic Model To Evaluate Intramuscular Tetracycline Treatment Protocols To Prevent Antimicrobial Resistance in Pigs
Amais Ahmad, Kaare Græsbøll, Lasse Engbo Christiansen, Nils Toft, Louise Matthews, Søren Saxmose Nielsen
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1634–1642. Published online 2014 Dec 29. doi: 10.1128/AAC.03919-14
PMCID:
PMC4325798

Antiviral Agents

Sialic Acid-Binding Protein Sp2CBMTD Protects Mice against Lethal Challenge with Emerging Influenza A (H7N9) Virus
Elena A. Govorkova, Tatiana Baranovich, Bindumadhav M. Marathe, Lei Yang, Margaret A. Taylor, Robert G. Webster, Garry L. Taylor, Helen Connaris
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1495–1504. Published online 2014 Dec 22. doi: 10.1128/AAC.04431-14
PMCID:
PMC4325779
Warren Kati, Gennadiy Koev, Michelle Irvin, Jill Beyer, Yaya Liu, Preethi Krishnan, Thomas Reisch, Rubina Mondal, Rolf Wagner, Akhteruzzaman Molla, Clarence Maring, Christine Collins
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1505–1511. Published online 2014 Dec 22. doi: 10.1128/AAC.04619-14
PMCID:
PMC4325770
A High-Affinity Native Human Antibody Neutralizes Human Cytomegalovirus Infection of Diverse Cell Types
Lawrence M. Kauvar, Keyi Liu, Minha Park, Neal DeChene, Robert Stephenson, Edgar Tenorio, Stote L. Ellsworth, Takako Tabata, Matthew Petitt, Mitsuru Tsuge, June Fang-Hoover, Stuart P. Adler, Xiaohong Cui, Michael A. McVoy, Lenore Pereira
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1558–1568. Published online 2014 Dec 22. doi: 10.1128/AAC.04295-14
PMCID:
PMC4325823
Preclinical Activity of VX-787, a First-in-Class, Orally Bioavailable Inhibitor of the Influenza Virus Polymerase PB2 Subunit
Randal A. Byrn, Steven M. Jones, Hamilton B. Bennett, Chris Bral, Michael P. Clark, Marc D. Jacobs, Ann D. Kwong, Mark W. Ledeboer, Joshua R. Leeman, Colleen F. McNeil, Mark A. Murcko, Azin Nezami, Emanuele Perola, Rene Rijnbrand, Kumkum Saxena, Alice W. Tsai, Yi Zhou, Paul S. Charifson
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1569–1582. Published online 2014 Dec 29. doi: 10.1128/AAC.04623-14
PMCID:
PMC4325764
Influenza Viral Load and Peramivir Kinetics after Single Administration and Proposal of Regimens for Peramivir Administration against Resistant Variants
Masatoki Sato, Masaki Ito, Shigeo Suzuki, Hiroko Sakuma, Aya Takeyama, Shinichi Oda, Masahiro Watanabe, Koichi Hashimoto, Kyohei Miyazaki, Yukihiko Kawasaki, Mitsuaki Hosoya
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1643–1649. Published online 2014 Dec 29. doi: 10.1128/AAC.04263-14
PMCID:
PMC4325767

Epidemiology and Surveillance

Rodrigo E. Mendes, Helio S. Sader, Robert K. Flamm, David J. Farrell, Ronald N. Jones
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1811–1814. Published online 2015 Jan 5. doi: 10.1128/AAC.04616-14
PMCID:
PMC4325802

Experimental Therapeutics

Potent Plasmodium falciparum Gametocytocidal Activity of Diaminonaphthoquinones, Lead Antimalarial Chemotypes Identified in an Antimalarial Compound Screen
Takeshi Q Tanaka, W. Armand Guiguemde, David S. Barnett, Maxim I. Maron, Jaeki Min, Michele C. Connelly, Praveen Kumar Suryadevara, R. Kiplin Guy, Kim C. Williamson
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1389–1397. Published online 2014 Dec 15. doi: 10.1128/AAC.01930-13
PMCID:
PMC4325765
Identification of a New Amide-Containing Thiazole as a Drug Candidate for Treatment of Chagas' Disease
Guzmán Álvarez, Javier Varela, Eugenia Cruces, Marcelo Fernández, Martín Gabay, Sandra M. Leal, Patricia Escobar, Luis Sanabria, Elva Serna, Susana Torres, Susy J. Figueredo Thiel, Gloria Yaluff, Ninfa I. Vera de Bilbao, Hugo Cerecetto, Mercedes González
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1398–1404. Published online 2014 Dec 15. doi: 10.1128/AAC.03814-14
PMCID:
PMC4325761
Antimalarial Iron Chelator FBS0701 Blocks Transmission by Plasmodium falciparum Gametocyte Activation Inhibition
Patricia Ferrer, Joel Vega-Rodriguez, Abhai K. Tripathi, Marcelo Jacobs-Lorena, David J. Sullivan, Jr.
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1418–1426. Published online 2014 Dec 15. doi: 10.1128/AAC.04642-14
PMCID:
PMC4325789
Small-Molecule Xenomycins Inhibit All Stages of the Plasmodium Life Cycle
Jessey Erath, Julio Gallego-Delgado, Wenyue Xu, Grasiella Andriani, Scott Tanghe, Katerina V. Gurova, Andrei Gudkov, Andrei Purmal, Elena Rydkina, Ana Rodriguez
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1427–1434. Published online 2014 Dec 15. doi: 10.1128/AAC.04704-14
PMCID:
PMC4325811
Novel Quorum-Quenching Agents Promote Methicillin-Resistant Staphylococcus aureus (MRSA) Wound Healing and Sensitize MRSA to β-Lactam Antibiotics
David Kuo, Guanping Yu, Wyatt Hoch, Dean Gabay, Lisa Long, Mahmoud Ghannoum, Nancy Nagy, Clifford V. Harding, Rajesh Viswanathan, Menachem Shoham
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1512–1518. Published online 2014 Dec 22. doi: 10.1128/AAC.04767-14
PMCID:
PMC4325784
Protection against Klebsiella pneumoniae Using Lithium Chloride in an Intragastric Infection Model
Nina Tsao, Chih-Feng Kuo, Ching-Chen Chiu, Wei-Chen Lin, Wan-Hui Huang, Li-Yang Chen
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1525–1533. Published online 2014 Dec 22. doi: 10.1128/AAC.04261-14
PMCID:
PMC4325792
Targeting Mycobacterium tuberculosis Topoisomerase I by Small-Molecule Inhibitors
Adwait Anand Godbole, Wareed Ahmed, Rajeshwari Subray Bhat, Erin K. Bradley, Sean Ekins, Valakunja Nagaraja
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1549–1557. Published online 2014 Dec 22. doi: 10.1128/AAC.04516-14
PMCID:
PMC4325804
Effects of Tigecycline and Vancomycin Administration on Established Clostridium difficile Infection
Casey M. Theriot, Cassie A. Schumacher, Christine M. Bassis, Anna M. Seekatz, Vincent B. Young
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1596–1604. Published online 2014 Dec 29. doi: 10.1128/AAC.04296-14
PMCID:
PMC4325817

Clinical Therapeutics

Comparison of the Accuracy and Precision of Pharmacokinetic Equations To Predict Free Meropenem Concentrations in Critically Ill Patients
Gloria Wong, Andras Farkas, Rachel Sussman, Gergely Daroczi, William W. Hope, Jeffrey Lipman, Jason A. Roberts
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1411–1417. Published online 2014 Dec 15. doi: 10.1128/AAC.04001-14
PMCID:
PMC4325820
Multicenter, Randomized Clinical Trial To Compare the Safety and Efficacy of LFF571 and Vancomycin for Clostridium difficile Infections
Kathleen Mullane, Christine Lee, Adam Bressler, Martha Buitrago, Karl Weiss, Kristina Dabovic, Jens Praestgaard, Jennifer A. Leeds, Johanne Blais, Peter Pertel
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1435–1440. Published online 2014 Dec 22. doi: 10.1128/AAC.04251-14
PMCID:
PMC4325808
Pharmacokinetics of LFF571 and Vancomycin in Patients with Moderate Clostridium difficile Infections
Suraj G. Bhansali, Kathleen Mullane, Lillian S. L. Ting, Jennifer A. Leeds, Kristina Dabovic, Jens Praestgaard, Peter Pertel
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1441–1445. Published online 2014 Dec 22. doi: 10.1128/AAC.04252-14
PMCID:
PMC4325791
Pharmacokinetics and Pharmacodynamics of Multiple-Dose Intravenous Nemonoxacin in Healthy Chinese Volunteers
Xiao-jie Wu, Jing Zhang, Bei-ning Guo, Ying-yuan Zhang, Ji-cheng Yu, Guo-ying Cao, Yuan-cheng Chen, De-mei Zhu, Xin-yu Ye, Ju-fang Wu, Yao-guo Shi, Li-wen Chang, Yu-ting Chang, Cheng-yuan Tsai
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1446–1454. Published online 2014 Dec 22. doi: 10.1128/AAC.04039-14
PMCID:
PMC4325800
Rapid Testing Using the Verigene Gram-Negative Blood Culture Nucleic Acid Test in Combination with Antimicrobial Stewardship Intervention against Gram-Negative Bacteremia
Jacqueline T. Bork, Surbhi Leekha, Emily L. Heil, LiCheng Zhao, Rilwan Badamas, J. Kristie Johnson
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1588–1595. Published online 2014 Dec 29. doi: 10.1128/AAC.04259-14
PMCID:
PMC4325795
Cardiac Effects of Echinocandins after Central Venous Administration in Adult Rats
Christian Koch, Florian Uhle, Matthias Wolff, Christoph Arens, Astrid Schulte, Ling Li, Bernd Niemann, Michael Henrich, Susanne Rohrbach, Markus A. Weigand, Christoph Lichtenstern
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1612–1619. Published online 2014 Dec 29. doi: 10.1128/AAC.04446-14
PMCID:
PMC4325794
J. Viljoen, N. Azie, A.-H. Schmitt-Hoffmann, M. Ghannoum
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1671–1679. Published online 2015 Jan 5. doi: 10.1128/AAC.04586-14
PMCID:
PMC4325824
Fidaxomicin Therapy in Critically Ill Patients with Clostridium difficile Infection
Samuel Penziner, Yanina Dubrovskaya, Robert Press, Amar Safdar
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1776–1781. Published online 2014 Dec 22. doi: 10.1128/AAC.04268-14
PMCID:
PMC4325788
Caprylic Acid and Glyceryl Trinitrate Combination for Eradication of Biofilm
Joel Rosenblatt, Ruth A. Reitzel, Issam Raad
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1786–1788. Published online 2014 Dec 22. doi: 10.1128/AAC.04561-14
PMCID:
PMC4325786
Doripenem MICs and ompK36 Porin Genotypes of Sequence Type 258, KPC-Producing Klebsiella pneumoniae May Predict Responses to Carbapenem-Colistin Combination Therapy among Patients with Bacteremia
Ryan K. Shields, M. Hong Nguyen, Brian A. Potoski, Ellen G. Press, Liang Chen, Barry N. Kreiswirth, Lloyd G. Clarke, Gregory A. Eschenauer, Cornelius J. Clancy
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1797–1801. Published online 2014 Dec 22. doi: 10.1128/AAC.03894-14
PMCID:
PMC4325815

Pharmacology

A Novel Inhibitor of Gyrase B Is a Potent Drug Candidate for Treatment of Tuberculosis and Nontuberculosis Mycobacterial Infections
Christopher P. Locher, Steven M. Jones, Brian L. Hanzelka, Emanuele Perola, Carolyn M. Shoen, Michael H. Cynamon, Andile H. Ngwane, Ian J. Wiid, Paul D. van Helden, Fabrice Betoudji, Eric L. Nuermberger, John A. Thomson
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1455–1465. Published online 2014 Dec 22. doi: 10.1128/AAC.04347-14
PMCID:
PMC4325822
In Vitro Activities of Combinations of Rifampin with Other Antimicrobials against Multidrug-Resistant Acinetobacter baumannii
Yan Bai, Bin Liu, Tianlin Wang, Yun Cai, Beibei Liang, Rui Wang, Youning Liu, Jin Wang
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1466–1471. Published online 2014 Dec 22. doi: 10.1128/AAC.04089-14
PMCID:
PMC4325818
Posaconazole Prophylaxis in Experimental Azole-Resistant Invasive Pulmonary Aspergillosis
Seyedmojtaba Seyedmousavi, Johan W. Mouton, Willem J. G. Melchers, Paul E. Verweij
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1487–1494. Published online 2014 Dec 22. doi: 10.1128/AAC.03850-14
PMCID:
PMC4325774
The Efflux Pump Inhibitor Timcodar Improves the Potency of Antimycobacterial Agents
Trudy H. Grossman, Carolyn M. Shoen, Steven M. Jones, Peter L. Jones, Michael H. Cynamon, Christopher P. Locher
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1534–1541. Published online 2014 Dec 22. doi: 10.1128/AAC.04271-14
PMCID:
PMC4325793
Clavanin A Improves Outcome of Complications from Different Bacterial Infections
Osmar N. Silva, Isabel C. M. Fensterseifer, Elaine A. Rodrigues, Hortência H. S. Holanda, Natasha R. F. Novaes, Junia P. A. Cunha, Taia M. B. Rezende, Kelly G. Magalhães, Susana E. Moreno, Márcio S. Jerônimo, Anamélia L. Bocca, Octavio L. Franco
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1620–1626. Published online 2014 Dec 29. doi: 10.1128/AAC.03732-14
PMCID:
PMC4325816
Tigecycline Treatment Causes a Decrease in Fibrinogen Levels
Qian Zhang, Suming Zhou, Jing Zhou
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1650–1655. Published online 2014 Dec 29. doi: 10.1128/AAC.04305-14
PMCID:
PMC4325772
The Strength of Synergistic Interaction between Posaconazole and Caspofungin Depends on the Underlying Azole Resistance Mechanism of Aspergillus fumigatus
Eleftheria Mavridou, Joseph Meletiadis, Antony Rijs, Johan W. Mouton, Paul E. Verweij
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1738–1744. Published online 2015 Jan 12. doi: 10.1128/AAC.04469-14
PMCID:
PMC4325813
Do Formulation Differences between the Reference Listed Drug and Generic Piperacillin-Tazobactam Impact Reconstitution?
HaiAn Zheng, James Truong, Fred Carroll, Manjunath P. Pai
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1767–1769. Published online 2014 Dec 15. doi: 10.1128/AAC.04563-14
PMCID:
PMC4325799

Letters to the Editor

Secular Trends Associated with Enterobacteriaceae with a Cefepime Susceptible-Dose-Dependent MIC
Jamie L. Wagner, Rachel M. Kenney, Robert J. Tibbetts, Susan L. Davis
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1822–1823. Published online 2014 Dec 15. doi: 10.1128/AAC.04491-14
PMCID:
PMC4325806
Characterization of a Novel Metallo-β-Lactamase Variant, GIM-2, from a Clinical Isolate of Enterobacter cloacae in Germany
Andreas F. Wendel, Colin R. MacKenzie
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1824–1825. Published online 2014 Dec 29. doi: 10.1128/AAC.05062-14
PMCID:
PMC4325787

Masthead

Editorial Board
Antimicrob Agents Chemother. 2015 Mar; 59(3): A1. Published online 2015 Jan 27. doi: 10.1128/AAC.masthead.59-3
PMCID:
PMC4325777

Correction

Jean-Philippe Lanoix, Fabrice Betoudji, Eric Nuermberger
Antimicrob Agents Chemother. 2015 Mar; 59(3): 1826. Published online 2015 Jan 27. doi: 10.1128/AAC.05096-14
PMCID:
PMC4325801

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)