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- Volume 13(1); March 2012
Volume 13(1); March 2012
Research Articles
Optimization of a Dual Mechanism Gastrofloatable and Gastroadhesive Delivery System for Narrow Absorption Window Drugs
Caragh Murphy, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit, Valence M. K. Ndesendo, Nthato Chirwa, Pradeep Kumar
AAPS PharmSciTech. 2012 March; 13(1): 1–15. Published online 2011 November 3. doi: 10.1208/s12249-011-9711-1
- PMCID:
- PMC3299464
Free in PMC on 2012/11/03
Terminalia Gum as a Directly Compressible Excipient for Controlled Drug Delivery
Oluyemisi A. Bamiro, Oluwatoyin A. Odeku, Vivek R. Sinha, Ruchita Kumar
AAPS PharmSciTech. 2012 March; 13(1): 16–23. Published online 2011 November 9. doi: 10.1208/s12249-011-9712-0
- PMCID:
- PMC3299455
Free in PMC on 2012/11/09
Effect of Sorbed Water on Disintegrant Performance of Four Brands of Polacrilin Potassium NF
Mrudula H. Bele, Diliprao V. Derle
AAPS PharmSciTech. 2012 March; 13(1): 24–34. Published online 2011 November 9. doi: 10.1208/s12249-011-9717-8
- PMCID:
- PMC3299451
Free in PMC on 2012/11/09
Solubility of Drugs in Aqueous Polymeric Solution: Effect of Ovalbumin on Microencapsulation Process
Hesham Abdul Aziz, Yvonne Tze Fung Tan, Kok Khiang Peh
AAPS PharmSciTech. 2012 March; 13(1): 35–45. Published online 2011 November 19. doi: 10.1208/s12249-011-9707-x
- PMCID:
- PMC3299454
Free in PMC on 2012/11/19
Preparation and In Vitro/In Vivo Evaluation of Microparticle Formulations Containing Meloxicam
Hakan Eroglu, Nihan Burul-Bozkurt, Serdar Uma, Levent Oner
AAPS PharmSciTech. 2012 March; 13(1): 46–52. Published online 2011 November 19. doi: 10.1208/s12249-011-9718-7
- PMCID:
- PMC3299456
Free in PMC on 2012/11/19
Investigating the Use of Liquisolid Compacts Technique to Minimize the Influence of pH Variations on Loratadine Release
Mazen El-Hammadi, Nisrine Awad
AAPS PharmSciTech. 2012 March; 13(1): 53–58. Published online 2011 November 19. doi: 10.1208/s12249-011-9719-6
- PMCID:
- PMC3299474
Free in PMC on 2012/11/19
Soluplus-Solubilized Citrated Camptothecin—A Potential Drug Delivery Strategy in Colon Cancer
Naveen K. Thakral, Alok R. Ray, Daniel Bar-Shalom, André Huss Eriksson, Dipak K. Majumdar
AAPS PharmSciTech. 2012 March; 13(1): 59–66. Published online 2011 November 22. doi: 10.1208/s12249-011-9720-0
- PMCID:
- PMC3299461
Free in PMC on 2012/11/22
Preparation and Evaluation of Dermal Delivery System of Griseofulvin Containing Vitamin E-TPGS as Penetration Enhancer
Nidhi Aggarwal, Shishu Goindi, Swami Dass Mehta
AAPS PharmSciTech. 2012 March; 13(1): 67–74. Published online 2011 December 1. doi: 10.1208/s12249-011-9722-y
- PMCID:
- PMC3299441
Free in PMC on 2012/12/01
Influence of Some Formulation Variables on the Optimization of pH-dependent, Colon-targeted, Sustained-release Mesalamine Microspheres
Ahmed Abd El-Bary, Ahmed A. Aboelwafa, Ibrahim M. Al Sharabi
AAPS PharmSciTech. 2012 March; 13(1): 75–84. Published online 2011 December 1. doi: 10.1208/s12249-011-9721-z
- PMCID:
- PMC3299443
Free in PMC on 2012/12/01
Optimization Studies on Gastroretentive Floating System Using Response Surface Methodology
Rajendra Awasthi, Giriraj T. Kulkarni, Vivek K. Pawar, Garima Garg
AAPS PharmSciTech. 2012 March; 13(1): 85–93. Published online 2011 December 2. doi: 10.1208/s12249-011-9730-y
- PMCID:
- PMC3299452
Free in PMC on 2012/12/02
Miniaturization in Pharmaceutical Extrusion Technology: Feeding as a Challenge of Downscaling
Christian Muehlenfeld, Markus Thommes
AAPS PharmSciTech. 2012 March; 13(1): 94–100. Published online 2011 December 9. doi: 10.1208/s12249-011-9726-7
- PMCID:
- PMC3299444
Free in PMC on 2012/12/09
In Vitro Characterization of Chitosan Gels for Buccal Delivery of Celecoxib: Influence of a Penetration Enhancer
Yara Peluso Cid, Vinícius Pedrazzi, Valéria Pereira de Sousa, Maria Bernadete Riemma Pierre
AAPS PharmSciTech. 2012 March; 13(1): 101–111. Published online 2011 December 9. doi: 10.1208/s12249-011-9725-8
- PMCID:
- PMC3299462
Free in PMC on 2012/12/09
Nano-Intercalated Organophosphorus-Hydrolyzing Enzymes in Organophosphorus Antagonism
Ilona Petrikovics, Melinda Wales, Marianna Budai, Jorn C. C. Yu, Mária Szilasi
AAPS PharmSciTech. 2012 March; 13(1): 112–117. Published online 2011 December 9. doi: 10.1208/s12249-011-9728-5
- PMCID:
- PMC3299470
Free in PMC on 2012/12/09
Preparation, Characterization, and In Vitro Intestinal Permeability Evaluation of Thalidomide–Hydroxypropyl-β-Cyclodextrin Complexes
Jadel M. Kratz, Marina R. Teixeira, Karine Ferronato, Helder F. Teixeira, Letícia S. Koester, Cláudia M. O. Simões
AAPS PharmSciTech. 2012 March; 13(1): 118–124. Published online 2011 December 9. doi: 10.1208/s12249-011-9739-2
- PMCID:
- PMC3299449
Free in PMC on 2012/12/09
Duloxetine HCl Lipid Nanoparticles: Preparation, Characterization, and Dosage Form Design
Ketan Patel, Sameer Padhye, Mangal Nagarsenker
AAPS PharmSciTech. 2012 March; 13(1): 125–133. Published online 2011 December 14. doi: 10.1208/s12249-011-9727-6
- PMCID:
- PMC3299448
Free in PMC on 2012/12/14
Characterization of Oral Disintegrating Film Containing Donepezil for Alzheimer Disease
Kai Bin Liew, Yvonne Tze Fung Tan, Kok Khiang Peh
AAPS PharmSciTech. 2012 March; 13(1): 134–142. Published online 2011 December 14. doi: 10.1208/s12249-011-9729-4
- PMCID:
- PMC3299458
Free in PMC on 2012/12/14
Development and Characterization of Zein-Based Micro Carrier System for Sustained Delivery of Aceclofenac Sodium
K. Karthikeyan, Rachita Lakra, Rama Rajaram, Purna Sai Korrapati
AAPS PharmSciTech. 2012 March; 13(1): 143–149. Published online 2011 December 14. doi: 10.1208/s12249-011-9731-x
- PMCID:
- PMC3299440
Free in PMC on 2012/12/14
Nanostructured Lipid Carriers (NLC) for Parenteral Delivery of an Anticancer Drug
Akhayacatra Chinsriwongkul, Ponwanit Chareanputtakhun, Tanasait Ngawhirunpat, Theerasak Rojanarata, Warisada Sila-on, Uracha Ruktanonchai, Praneet Opanasopit
AAPS PharmSciTech. 2012 March; 13(1): 150–158. Published online 2011 December 14. doi: 10.1208/s12249-011-9733-8
- PMCID:
- PMC3299450
Free in PMC on 2012/12/14
Improved Bioavailability of Poorly Water-Soluble Drug Curcumin in Cellulose Acetate Solid Dispersion
Shuxin Wan, Yingqian Sun, Xiuxiang Qi, Fengping Tan
AAPS PharmSciTech. 2012 March; 13(1): 159–166. Published online 2011 December 16. doi: 10.1208/s12249-011-9732-9
- PMCID:
- PMC3299466
Free in PMC on 2012/12/16
Optimization of Protocell of Silica Nanoparticles Using 32 Factorial Designs
Gunjeet Kaur, Goutam Rath, Hemraj Heer, Amit K. Goyal
AAPS PharmSciTech. 2012 March; 13(1): 167–173. Published online 2011 December 16. doi: 10.1208/s12249-011-9741-8
- PMCID:
- PMC3299445
Free in PMC on 2012/12/16
Solubility-Modulated Asymmetric Membrane Tablets of Triprolidine Hydrochloride: Statistical Optimization and Evaluation
Rahul Dev, Anil Kumar, Kamla Pathak
AAPS PharmSciTech. 2012 March; 13(1): 174–183. Published online 2011 December 20. doi: 10.1208/s12249-011-9738-3
- PMCID:
- PMC3299447
Free in PMC on 2012/12/20
Microemulsion-Based Gel of Terbinafine for the Treatment of Onychomycosis: Optimization of Formulation Using D-Optimal Design
Bhavesh S. Barot, Punit B. Parejiya, Hetal K. Patel, Mukesh C. Gohel, Pragna K. Shelat
AAPS PharmSciTech. 2012 March; 13(1): 184–192. Published online 2011 December 22. doi: 10.1208/s12249-011-9742-7
- PMCID:
- PMC3299475
Free in PMC on 2012/12/22
Variation Transmission Model for Setting Acceptance Criteria in a Multi-staged Pharmaceutical Manufacturing Process
Richard O. Montes
AAPS PharmSciTech. 2012 March; 13(1): 193–201. Published online 2011 December 23. doi: 10.1208/s12249-011-9734-7
- PMCID:
- PMC3299465
Free in PMC on 2012/12/23
Microchip for Sustained Drug Delivery by Diffusion Through Microchannels
Seung Ho Lee, Min Park, Chun Gwon Park, Ji Eun Lee, Mark R. Prausnitz, Young Bin Choy
AAPS PharmSciTech. 2012 March; 13(1): 211–217. Published online 2012 January 4. doi: 10.1208/s12249-011-9743-6
- PMCID:
- PMC3299442
Free in PMC on 2013/01/04
Improvement of Tablet Coating Uniformity Using a Quality by Design Approach
Atul Dubey, Fani Boukouvala, Golshid Keyvan, Richard Hsia, Kostas Saranteas, Dean Brone, Tushar Misra, Marianthi G. Ierapetritou, Fernando J. Muzzio
AAPS PharmSciTech. 2012 March; 13(1): 231–246. Published online 2012 January 10. doi: 10.1208/s12249-011-9723-x
- PMCID:
- PMC3299457
Free in PMC on 2013/01/10
The Influence of the Polar Head and the Hydrophobic Chain on the Skin Penetration Enhancement Effect of Poly(Ethylene Glycol) Derivatives
Antonella Casiraghi, Maurizio Di Grigoli, Francesco Cilurzo, Chiara Grazia Milena Gennari, Giuseppe Rossoni, Paola Minghetti
AAPS PharmSciTech. 2012 March; 13(1): 247–253. Published online 2012 January 10. doi: 10.1208/s12249-011-9745-4
- PMCID:
- PMC3299471
Free in PMC on 2013/01/10
Rice Germ Oil as Multifunctional Excipient in Preparation of Self-Microemulsifying Drug Delivery System (SMEDDS) of Tacrolimus
Smita K. Pawar, Pradeep R. Vavia
AAPS PharmSciTech. 2012 March; 13(1): 254–261. Published online 2012 January 10. doi: 10.1208/s12249-011-9748-1
- PMCID:
- PMC3299476
Free in PMC on 2013/01/10
A Novel Synergistic Galactomannan-Based Unit Dosage Form for Sustained Release of Acarbose
Ruchita V. Kumar, Vivek Ranjan Sinha
AAPS PharmSciTech. 2012 March; 13(1): 262–275. Published online 2012 January 11. doi: 10.1208/s12249-011-9724-9
- PMCID:
- PMC3299472
Free in PMC on 2013/01/11
Nanostructured Lipid Carriers Improve Skin Permeation and Chemical Stability of Idebenone
Bei Li, Zhi-Qiang Ge
AAPS PharmSciTech. 2012 March; 13(1): 276–283. Published online 2012 January 11. doi: 10.1208/s12249-011-9746-3
- PMCID:
- PMC3299459
Free in PMC on 2013/01/11
Biotherapeutic Formulation Factors Affecting Metal Leachables from Stainless Steel Studied by Design of Experiments
Shuxia Zhou, Brad Evans, Christian Schöneich, Satish K. Singh
AAPS PharmSciTech. 2012 March; 13(1): 284–294. Published online 2012 January 13. doi: 10.1208/s12249-011-9747-2
- PMCID:
- PMC3299453
Free in PMC on 2013/01/13
Fabrication of Carvedilol Nanosuspensions Through the Anti-Solvent Precipitation–Ultrasonication Method for the Improvement of Dissolution Rate and Oral Bioavailability
Dandan Liu, Heming Xu, Baocheng Tian, Kun Yuan, Hao Pan, Shilin Ma, Xinggang Yang, Weisan Pan
AAPS PharmSciTech. 2012 March; 13(1): 295–304. Published online 2012 January 13. doi: 10.1208/s12249-011-9750-7
- PMCID:
- PMC3299468
Free in PMC on 2013/01/13
Application of a Pull on a Disk Method to Measure Surface Tension of Liquids
Thiago C. Carvalho, Michelle Horng, Jason T. McConville
AAPS PharmSciTech. 2012 March; 13(1): 305–312. Published online 2012 January 19. doi: 10.1208/s12249-011-9737-4
- PMCID:
- PMC3299463
Free in PMC on 2013/01/19
Controlled Release of Modified Insulin Glargine from Novel Biodegradable Injectable Gels
Om Anand, Hassan Almoazen, Nitin Mehrotra, James Johnson, Atul Shukla
AAPS PharmSciTech. 2012 March; 13(1): 313–322. Published online 2012 January 19. doi: 10.1208/s12249-011-9744-5
- PMCID:
- PMC3299460
Free in PMC on 2013/01/19
Transdermal Absorption Enhancement of Rice Bran Bioactive Compounds Entrapped in Niosomes
Aranya Manosroi, Romchat Chutoprapat, Masahiko Abe, Worapaka Manosroi, Jiradej Manosroi
AAPS PharmSciTech. 2012 March; 13(1): 323–335. Published online 2012 January 19. doi: 10.1208/s12249-012-9751-1
- PMCID:
- PMC3299446
Free in PMC on 2013/01/19
Polymeric Micelles of PEG-PE as Carriers of All-Trans Retinoic Acid for Stability Improvement
Angkana Wichit, Anothai Tangsumranjit, Tasana Pitaksuteepong, Neti Waranuch
AAPS PharmSciTech. 2012 March; 13(1): 336–343. Published online 2012 January 25. doi: 10.1208/s12249-011-9749-0
- PMCID:
- PMC3299469
Free in PMC on 2013/01/25
Article
Sensitive and Rapid HPLC Quantification of Tenofovir from Hyaluronic Acid-Based Nanomedicine
Vivek Agrahari, Bi-Botti C. Youan
AAPS PharmSciTech. 2012 March; 13(1): 202–210. Published online 2012 January 4. doi: 10.1208/s12249-011-9735-6
- PMCID:
- PMC3299473
Free in PMC on 2013/01/04
White Paper
Glenn A. Van Buskirk, Daniel Arsulowicz, Prabir Basu, Lawrence Block, Bing Cai, Gary W. Cleary, Tapash Ghosh, Mario A. González, David Kanios, Margareth Marques, Patrick K. Noonan, Terrance Ocheltree, Peter Schwarz, Vinod Shah, Thomas S. Spencer, Lino Tavares, Katherine Ulman, Rajendra Uppoor, Thean Yeoh
AAPS PharmSciTech. 2012 March; 13(1): 218–230. Published online 2012 January 4. doi: 10.1208/s12249-011-9740-9
- PMCID:
- PMC3279638
Research Paper
Cavamax W7 Composite Ethosomal Gel of Clotrimazole for Improved Topical Delivery: Development and Comparison with Ethosomal Gel
Nida Akhtar, Kamla Pathak
AAPS PharmSciTech. 2012 March; 13(1): 344–355. Published online 2012 January 27. doi: 10.1208/s12249-012-9754-y
- PMCID:
- PMC3299477
Free in PMC on 2013/01/27