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Volume 10(4);  December 2008
Research Articles
Preparation of Alendronate Liposomes for Enhanced Stability and Bioactivity: In Vitro and In Vivo Characterization
Hila Epstein, Dikla Gutman, Einat Cohen-Sela, Elran Haber, Omar Elmalak, Nickolay Koroukhov, Haim D. Danenberg, and Gershon Golomb
AAPS J. 2008 December; 10(4): 505–515. Published online 2008 October 21. doi: 10.1208/s12248-008-9060-5.
PMCID: PMC2628204
Epidermal Growth Factor Receptor-Targeted Gelatin-Based Engineered Nanocarriers for DNA Delivery and Transfection in Human Pancreatic Cancer Cells
Padmaja Magadala and Mansoor Amiji
AAPS J. 2008 December; 10(4): 565–576. Published online 2008 November 26. doi: 10.1208/s12248-008-9065-0.
PMCID: PMC2628214
P-gp Inhibition Potential in Cell-Based Models: Which “Calculation” Method is the Most Accurate?
Praveen V. Balimane, Anthony Marino, and Saeho Chong
AAPS J. 2008 December; 10(4): 577–586. Published online 2008 December 11. doi: 10.1208/s12248-008-9068-x.
PMCID: PMC2628205
Method to Screen Substrates of Apical Sodium-Dependent Bile Acid Transporter
Rana Rais, Pablo M. Gonzalez, Xiaowan Zheng, Stephen A. Wring, and James E. Polli
AAPS J. 2008 December; 10(4): 596–605. Published online 2008 December 16. doi: 10.1208/s12248-008-9069-9.
PMCID: PMC2628203
Characterization of Cyclodextrin Inclusion Complexes of the Anti-HIV Non-Nucleoside Reverse Transcriptase Inhibitor UC781
Haitao Yang, Michael A. Parniak, Charles E. Isaacs, Sharon L. Hillier, and Lisa C. Rohan
AAPS J. 2008 December; 10(4): 606–613. Published online 2008 December 17. doi: 10.1208/s12248-008-9070-3.
PMCID: PMC2628202
Towards Integrated Adme Prediction: Past, Present, and Future Directions
Understanding the Effect of API Properties on Bioavailability Through Absorption Modeling
Filippos Kesisoglou and Yunhui Wu
AAPS J. 2008 December; 10(4): 516–525. Published online 2008 November 6. doi: 10.1208/s12248-008-9061-4.
PMCID: PMC2628211
Intellectual Property Law and the Pharmaceutical Sciences
The International Patent System and Biomedical Research: Reconciling Aspiration, Policy and Practice
Antony Taubman
AAPS J. 2008 December; 10(4): 526–536. Published online 2008 November 7. doi: 10.1208/s12248-008-9049-0.
PMCID: PMC2628210
Therapeutic Tolerance: Pharmacokinetic-Pharmacodynamic Mechanisms
Opioid Tolerance Development: A Pharmacokinetic/Pharmacodynamic Perspective
Emily O. Dumas and Gary M. Pollack
AAPS J. 2008 December; 10(4): 537–551. Published online 2008 November 7. doi: 10.1208/s12248-008-9056-1.
PMCID: PMC2628209
Quantitative Pharmacology, a Roadmap for Rational, Model-Based Drug Development
Concepts and Challenges in Quantitative Pharmacology and Model-Based Drug Development
Liping Zhang, Marc Pfister, and Bernd Meibohm
AAPS J. 2008 December; 10(4): 552–559. Published online 2008 November 12. doi: 10.1208/s12248-008-9062-3.
PMCID: PMC2628212
Brief/Technical Note
Microstructural Analysis of Porous Composite Materials: Dynamic Imaging of Drug Dissolution and Diffusion Through Porous Matrices
Paul M. Young, Kathy Nguyen, Allan S. Jones, and Daniela Traini
AAPS J. 2008 December; 10(4): 560–564. Published online 2008 November 14. doi: 10.1208/s12248-008-9063-2.
PMCID: PMC2628213
Advances in CNS Delivery of Therapeutic Molecules
Commentary: Current Advances and Future Directions for CNS Delivery
Craig K. Svensson and Jean-Michel Scherrmann
AAPS J. 2008 December; 10(4): 587–588. Published online 2008 December 12. doi: 10.1208/s12248-008-9064-1.
PMCID: PMC2628206
Emerging Drug Delivery Technologies
Physical Approaches for Nucleic Acid Delivery to Liver
Kenya Kamimura and Dexi Liu
AAPS J. 2008 December; 10(4): 589–595. Published online 2008 December 13. doi: 10.1208/s12248-008-9067-y.
PMCID: PMC2628207
PTD-mediated Loading of Tumor-Seeking Lymphocytes with Prodrug-Activating Enzymes
Qin Yang, Stine K. Larsen, Zhibao Mi, Paul D. Robbins, and Per H. Basse
AAPS J. 2008 December; 10(4): 614–621. Published online 2008 December 23. doi: 10.1208/s12248-008-9066-z.
PMCID: PMC2628208
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