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- Volume 14(2); June 2012
Volume 14(2); June 2012
Research Articles
A mechanism-Based Approach for Absorption Modeling: The Gastro-Intestinal Transit Time (GITT) Model
Emilie Hénin, Martin Bergstrand, Joseph F. Standing, Mats O. Karlsson
AAPS J. 2012 June; 14(2): 155–163. Published online 2012 January 28. doi: 10.1208/s12248-012-9324-y
- PMCID:
- PMC3326175
Free in PMC on 2013/01/28
Population Analyses of Efficacy and Safety of ABT-594 in Subjects with Diabetic Peripheral Neuropathic Pain
Sandeep Dutta, Balakrishna S. Hosmane, Walid M. Awni
AAPS J. 2012 June; 14(2): 168–175. Published online 2012 February 11. doi: 10.1208/s12248-012-9328-7
- PMCID:
- PMC3326158
Free in PMC on 2013/02/11
Rapid Sample Size Calculations for a Defined Likelihood Ratio Test-Based Power in Mixed-Effects Models
Camille Vong, Martin Bergstrand, Joakim Nyberg, Mats O. Karlsson
AAPS J. 2012 June; 14(2): 176–186. Published online 2012 February 17. doi: 10.1208/s12248-012-9327-8
- PMCID:
- PMC3326172
Free in PMC on 2013/02/17
Cutaneous Microdialysis: Cytokine Evidence for Altered Innate Reactivity in the Skin of Psoriasis Patients?
Florence Sjögren, Karin Davidsson, Michael Sjöström, Chris D. Anderson
AAPS J. 2012 June; 14(2): 187–195. Published online 2012 February 29. doi: 10.1208/s12248-012-9331-z
- PMCID:
- PMC3326164
Free in PMC on 2013/02/28
Conformational Analysis of Therapeutic Proteins by Hydroxyl Radical Protein Footprinting
Caroline Watson, Joshua S. Sharp
AAPS J. 2012 June; 14(2): 206–217. Published online 2012 March 2. doi: 10.1208/s12248-012-9336-7
- PMCID:
- PMC3326162
Free in PMC on 2013/03/02
Pharmacokinetic Evaluation of Intranasally Administered Vinyl Polymer-Coated Lorazepam Microparticles in Rabbits
Yanjun Zhao, Marc B. Brown, Rajeshree H. Khengar, Matthew J. Traynor, Pedro Barata, Stuart A. Jones
AAPS J. 2012 June; 14(2): 218–224. Published online 2012 March 1. doi: 10.1208/s12248-012-9325-x
- PMCID:
- PMC3326174
Free in PMC on 2013/03/01
Design and Characterization of Novel Peptide-Coated Lipid Nanoparticles for Targeting Anti-HIV Drug to CD4 Expressing Cells
Aaron N. Endsley, Rodney J. Y. Ho
AAPS J. 2012 June; 14(2): 225–235. Published online 2012 March 6. doi: 10.1208/s12248-012-9329-6
- PMCID:
- PMC3326167
Free in PMC on 2013/03/06
Issues and Challenges of Subvisible and Submicron Particulate Analysis in Protein Solutions
Thomas M. Scherer, Stephenie Leung, Laura Owyang, Steven J. Shire
AAPS J. 2012 June; 14(2): 236–243. Published online 2012 March 6. doi: 10.1208/s12248-012-9335-8
- PMCID:
- PMC3326173
Free in PMC on 2013/03/06
The Solubility–Permeability Interplay and Its Implications in Formulation Design and Development for Poorly Soluble Drugs
Arik Dahan, Jonathan M. Miller
AAPS J. 2012 June; 14(2): 244–251. Published online 2012 March 6. doi: 10.1208/s12248-012-9337-6
- PMCID:
- PMC3326160
Free in PMC on 2013/03/06
Pharmacokinetics, Lymph Node Uptake, and Mechanistic PK Model of Near-Infrared Dye-Labeled Bevacizumab After IV and SC Administration in Mice
Fang Wu, Mitalee Tamhane, Marilyn E. Morris
AAPS J. 2012 June; 14(2): 252–261. Published online 2012 March 6. doi: 10.1208/s12248-012-9342-9
- PMCID:
- PMC3326166
Free in PMC on 2013/03/06
Role of Metabolism in the Effects of Genistein and Its Phase II Conjugates on the Growth of Human Breast Cell Lines
Bo Yuan, Linglan Wang, Yi Jin, Huijuan Zhen, Pingwei Xu, Youjun Xu, Chibing Li, Haiyan Xu
AAPS J. 2012 June; 14(2): 329–344. Published online 2012 March 14. doi: 10.1208/s12248-012-9338-5
- PMCID:
- PMC3326171
Free in PMC on 2013/03/14
Acarbose Bioequivalence: Exploration of New Pharmacodynamic Parameters
Min Zhang, Jin Yang, Lei Tao, Lingjun Li, Pengcheng Ma, John Paul Fawcett
AAPS J. 2012 June; 14(2): 345–351. Published online 2012 March 15. doi: 10.1208/s12248-012-9341-x
- PMCID:
- PMC3326157
Free in PMC on 2013/03/15
A Physiologically Based Pharmacokinetic Model of Mitoxantrone in Mice and Scale-up to Humans: a Semi-Mechanistic Model Incorporating DNA and Protein Binding
Guohua An, Marilyn E. Morris
AAPS J. 2012 June; 14(2): 352–364. Published online 2012 March 27. doi: 10.1208/s12248-012-9344-7
- PMCID:
- PMC3326165
Free in PMC on 2013/03/27
Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling of Rat Prefrontal Cortical Dopamine Response to Dual Acting Norepinephrine Reuptake Inhibitor and 5-HT1A Partial Agonist
Cheryl Shuang-wu Li, Liming Zhang, Taraneh Haske, Amy Dounay, David Gray, Nancy Barta, Joanne Brodfuehrer, Christopher Lepsy, Brian Campbell
AAPS J. 2012 June; 14(2): 365–376. Published online 2012 March 28. doi: 10.1208/s12248-012-9343-8
- PMCID:
- PMC3326163
Free in PMC on 2013/03/28
Commentary
Benet L Z and Galeazzi R L: Noncompartmental Determination of the Steady-State Volume of Distribution, J Pharm Sci 68, 1071–1074, 1979—the Backstory
Leslie Z. Benet
AAPS J. 2012 June; 14(2): 164–167. Published online 2012 February 3. doi: 10.1208/s12248-012-9326-9
- PMCID:
- PMC3326156
Free in PMC on 2013/02/03
Research Paper
An Investigation into the Utility of a Multi-compartmental, Dynamic, System of the Upper Gastrointestinal Tract to Support Formulation Development and Establish Bioequivalence of Poorly Soluble Drugs
Paul A. Dickinson, Ragheb Abu Rmaileh, Lee Ashworth, Richard A. Barker, Wendy M. Burke, Claire M. Patterson, Nick Stainforth, Mohammed Yasin
AAPS J. 2012 June; 14(2): 196–205. Published online 2012 February 29. doi: 10.1208/s12248-012-9333-x
- PMCID:
- PMC3326170
Free in PMC on 2013/02/28
Review Articles
Applications of Human Pharmacokinetic Prediction in First-in-Human Dose Estimation
Peng Zou, Yanke Yu, Nan Zheng, Yongsheng Yang, Hayley J. Paholak, Lawrence X. Yu, Duxin Sun
AAPS J. 2012 June; 14(2): 262–281. Published online 2012 March 10. doi: 10.1208/s12248-012-9332-y
- PMCID:
- PMC3326168
Free in PMC on 2013/03/10
Neil Desai
AAPS J. 2012 June; 14(2): 282–295. Published online 2012 March 10. doi: 10.1208/s12248-012-9339-4
- PMCID:
- PMC3326161
Immunogenicity to Therapeutic Proteins: Impact on PK/PD and Efficacy
Narendra Chirmule, Vibha Jawa, Bernd Meibohm
AAPS J. 2012 June; 14(2): 296–302. Published online 2012 March 10. doi: 10.1208/s12248-012-9340-y
- PMCID:
- PMC3326159
Free in PMC on 2013/03/10
Challenges in Development of Targeted Liposomal Therapeutics
Rupa R. Sawant, Vladimir P. Torchilin
AAPS J. 2012 June; 14(2): 303–315. Published online 2012 March 14. doi: 10.1208/s12248-012-9330-0
- PMCID:
- PMC3326155
Free in PMC on 2013/03/14
White Paper
Ligand Binding Assays in the 21st Century Laboratory: Recommendations for Characterization and Supply of Critical Reagents
Denise M. O’Hara, Valerie Theobald, Adrienne Clements Egan, Joel Usansky, Murli Krishna, Julie TerWee, Mauricio Maia, Frank P. Spriggs, John Kenney, Afshin Safavi, Jeannine Keefe
AAPS J. 2012 June; 14(2): 316–328. Published online 2012 March 14. doi: 10.1208/s12248-012-9334-9
- PMCID:
- PMC3326169
Free in PMC on 2013/03/14