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Minireview No Splicing, No Dicing: Non-proteolytic Roles of the Ubiquitin-Proteasome System in Transcription Thomas Kodadek PMCID: PMC2807279 | Free in PMC on 2011/01/22 | Accelerated Publication Direct and Indirect Induction by 1,25-Dihydroxyvitamin D3 of the NOD2/CARD15-Defensin β2 Innate Immune Pathway Defective in Crohn Disease Tian-Tian Wang, Basel Dabbas, David Laperriere, Ari J. Bitton, Hafid Soualhine, Luz E. Tavera-Mendoza, Serge Dionne, Marc J. Servant, Alain Bitton, Ernest G. Seidman, Sylvie Mader, Marcel A. Behr, and John H. White PMCID: PMC2807280 | Free in PMC on 2011/01/22 | Glycobiology and Extracellular Matrices N- and O-Glycans Modulate Galectin-1 Binding, CD45 Signaling, and T Cell Death Lesley A. Earl, Shuguang Bi, and Linda G. Baum PMCID: PMC2807281 | Free in PMC on 2011/01/22 | Characterization of a New β(1–3)-Glucan Branching Activity of Aspergillus fumigatus Amandine Gastebois, Isabelle Mouyna, Catherine Simenel, Cécile Clavaud, Bernadette Coddeville, Muriel Delepierre, Jean-Paul Latgé, and Thierry Fontaine PMCID: PMC2807297 | Free in PMC on 2011/01/22 | The Endoplasmic Reticulum Chaperone Cosmc Directly Promotes in Vitro Folding of T-synthase Rajindra P. Aryal, Tongzhong Ju, and Richard D. Cummings PMCID: PMC2807302 | Free in PMC on 2011/01/22 | Mechanisms of Signal Transduction Cluster Analysis of Insulin Action in Adipocytes Reveals a Key Role for Akt at the Plasma Membrane Yvonne Ng, Georg Ramm, James G. Burchfield, Adelle C. F. Coster, Jacqueline Stöckli, and David E. James PMCID: PMC2807282 | Free in PMC on 2011/01/22 | BCAR3 Regulates Src/p130Cas Association, Src Kinase Activity, and Breast Cancer Adhesion Signaling Natasha R. Schuh, Michael S. Guerrero, Randy S. Schrecengost, and Amy H. Bouton PMCID: PMC2807288 | Free in PMC on 2011/01/22 | Inducible Priming Phosphorylation Promotes Ligand-independent Degradation of the IFNAR1 Chain of Type I Interferon Receptor Sabyasachi Bhattacharya, Wei-Chun HuangFu, Jianghuai Liu, Sudhakar Veeranki, Darren P. Baker, Constantinos Koumenis, J. Alan Diehl, and Serge Y. Fuchs PMCID: PMC2807289 | Free in PMC on 2011/01/22 | Transforming Growth Factor β-activated Kinase 1 (TAK1) Kinase Adaptor, TAK1-binding Protein 2, Plays Dual Roles in TAK1 Signaling by Recruiting Both an Activator and an Inhibitor of TAK1 Kinase in Tumor Necrosis Factor Signaling Pathway Peter Broglie, Kunihiro Matsumoto, Shizuo Akira, David L. Brautigan, and Jun Ninomiya-Tsuji PMCID: PMC2807291 | Free in PMC on 2011/01/22 | Reciprocal Negative Regulation of PDK1 and ASK1 Signaling by Direct Interaction and Phosphorylation Hyun-A Seong, Haiyoung Jung, Hidenori Ichijo, and Hyunjung Ha PMCID: PMC2807298 | Free in PMC on 2011/01/22 | PGC-1α Serine 570 Phosphorylation and GCN5-mediated Acetylation by Angiotensin II Drive Catalase Down-regulation and Vascular Hypertrophy Shiqin Xiong, Gloria Salazar, Alejandra San Martin, Mushtaq Ahmad, Nikolay Patrushev, Lula Hilenski, Rafal Robert Nazarewicz, Minhui Ma, Masuko Ushio-Fukai, and R. Wayne Alexander PMCID: PMC2807304 | Free in PMC on 2011/01/22 | Facilitating Akt Clearance via Manipulation of Hsp70 Activity and Levels John Koren, III, Umesh K. Jinwal, Ying Jin, John O'Leary, Jeff R. Jones, Amelia G. Johnson, Laura J. Blair, Jose F. Abisambra, Lyra Chang, Yoshinari Miyata, Anna M. Cheng, Jianping Guo, Jin Q. Cheng, Jason E. Gestwicki, and Chad A. Dickey PMCID: PMC2807306 | Free in PMC on 2011/01/22 | Phosphorylation of α-Actinin 4 upon Epidermal Growth Factor Exposure Regulates Its Interaction with Actin Hanshuang Shao, Chuanyue Wu, and Alan Wells PMCID: PMC2807316 | Free in PMC on 2011/01/22 | Constitutive Activity of the Human TRPML2 Channel Induces Cell Degeneration Shaya Lev, David A. Zeevi, Ayala Frumkin, Vered Offen-Glasner, Gideon Bach, and Baruch Minke PMCID: PMC2807332 | Free in PMC on 2011/01/22 | Soluble Nogo Receptor Down-regulates Expression of Neuronal Nogo-A to Enhance Axonal Regeneration Xiangmin Peng, Zhigang Zhou, Jian Hu, David J. Fink, and Marina Mata PMCID: PMC2807333 | Free in PMC on 2011/01/22 | Role of Interfacial Water Molecules in Proline-rich Ligand Recognition by the Src Homology 3 Domain of Abl Andres Palencia, Ana Camara-Artigas, M. Teresa Pisabarro, Jose C. Martinez, and Irene Luque PMCID: PMC2807336 | Free in PMC on 2011/01/22 | Nuclear Isoforms of Fibroblast Growth Factor 2 Are Novel Inducers of Hypophosphatemia via Modulation of FGF23 and KLOTHO Liping Xiao, Takahiro Naganawa, Joseph Lorenzo, Thomas O. Carpenter, J. Douglas Coffin, and Marja M. Hurley PMCID: PMC2807337 | Free in PMC on 2011/01/22 | Phosphoinositide 3-Kinase p110β Regulates Integrin αIIbβ3 Avidity and the Cellular Transmission of Contractile Forces Simone M. Schoenwaelder, Akiko Ono, Warwick S. Nesbitt, Joanna Lim, Kate Jarman, and Shaun P. Jackson PMCID: PMC2807342 | Free in PMC on 2011/01/22 | Transcription, Chromatin, and Epigenetics Regulation of SIVmac239 Basal Long Terminal Repeat Activity and Viral Replication in Macrophages: FUNCTIONAL ROLES OF TWO CCAAT/ENHANCER-BINDING PROTEIN β SITES IN ACTIVATION AND INTERFERON β-MEDIATED SUPPRESSION Shruthi Ravimohan, Lucio Gama, Sheila A. Barber, and Janice E. Clements PMCID: PMC2807283 | Free in PMC on 2011/01/22 | The SWI/SNF Chromatin-remodeling Complex Modulates Peripheral T Cell Activation and Proliferation by Controlling AP-1 Expression Seung Min Jeong, Changjin Lee, Sung Kyu Lee, Jieun Kim, and Rho Hyun Seong PMCID: PMC2807292 | Free in PMC on 2011/01/22 | A Bre1-associated Protein, Large 1 (Lge1), Promotes H2B Ubiquitylation during the Early Stages of Transcription Elongation Young-Ha Song and Seong Hoon Ahn PMCID: PMC2807294 | Free in PMC on 2011/01/22 | Regulation of Pyruvate Dehydrogenase Kinase 4 (PDK4) by Thyroid Hormone: ROLE OF THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR γ COACTIVATOR (PGC-1α) Ramy R. Attia, Sara Connnaughton, Lindsey R. Boone, Fang Wang, Marshall B. Elam, Gene C. Ness, George A. Cook, and Edwards A. Park PMCID: PMC2807296 | Free in PMC on 2011/01/22 | Activator Gcn4 Employs Multiple Segments of Med15/Gal11, Including the KIX Domain, to Recruit Mediator to Target Genes in Vivo Iness Jedidi, Fan Zhang, Hongfang Qiu, Stephen J. Stahl, Ira Palmer, Joshua D. Kaufman, Philippe S. Nadaud, Sujoy Mukherjee, Paul T. Wingfield, Christopher P. Jaroniec, and Alan G. Hinnebusch PMCID: PMC2807301 | Free in PMC on 2011/01/22 | Ikaros Silences T-bet Expression and Interferon-γ Production during T Helper 2 Differentiation Rajan M. Thomas, Chunxia Chen, Neelanjana Chunder, Lingzhi Ma, Justin Taylor, Edward J. Pearce, and Andrew D. Wells PMCID: PMC2807311 | Free in PMC on 2011/01/22 | Complex Regulation of the Transactivation Function of Hypoxia-inducible Factor-1α by Direct Interaction with Two Distinct Domains of the CREB-binding Protein/p300 Jorge L. Ruas, Utta Berchner-Pfannschmidt, Sohail Malik, Katarina Gradin, Joachim Fandrey, Robert G. Roeder, Teresa Pereira, and Lorenz Poellinger PMCID: PMC2807317 | Free in PMC on 2011/01/22 | Nuclear Factor 1 Synergizes with Progesterone Receptor on the Mouse Mammary Tumor Virus Promoter Wrapped around a Histone H3/H4 Tetramer by Facilitating Access to the Central Hormone-responsive Elements Guillermo Pablo Vicent, Roser Zaurin, A. Silvina Nacht, Jofre Font-Mateu, Francois Le Dily, and Miguel Beato PMCID: PMC2807319 | Free in PMC on 2011/01/22 | Glucocorticoid Regulation of Mouse and Human Dual Specificity Phosphatase 1 (DUSP1) Genes: UNUSUAL CIS-ACTING ELEMENTS AND UNEXPECTED EVOLUTIONARY DIVERGENCE Carmen R. Tchen, Joana R. S. Martins, Nasren Paktiawal, Roberta Perelli, Jeremy Saklatvala, and Andrew R. Clark PMCID: PMC2807321 | Free in PMC on 2011/01/22 | Estrogen-mediated Regulation of Igf1 Transcription and Uterine Growth Involves Direct Binding of Estrogen Receptor α to Estrogen-responsive Elements Sylvia C. Hewitt, Yin Li, Leping Li, and Kenneth S. Korach PMCID: PMC2807324 | Free in PMC on 2011/01/22 | The C53/C37 Subcomplex of RNA Polymerase III Lies Near the Active Site and Participates in Promoter Opening George A. Kassavetis, Prachee Prakash, and Eunjung Shim PMCID: PMC2807326 | Free in PMC on 2011/01/22 | Membrane Transport, Structure, Function, and Biogenesis Prm1 Functions as a Disulfide-linked Complex in Yeast Mating Valerie N. Olmo and Eric Grote PMCID: PMC2807284 | Free in PMC on 2011/01/22 | Subunit Organization in the TatA Complex of the Twin Arginine Protein Translocase: A SITE-DIRECTED EPR SPIN LABELING STUDY Gaye F. White, Sonya M. Schermann, Justin Bradley, Andrew Roberts, Nicholas P. Greene, Ben C. Berks, and Andrew J. Thomson PMCID: PMC2807286 Crystal Structures of Progressive Ca2+ Binding States of the Ca2+ Sensor Ca2+ Binding Domain 1 (CBD1) from the CALX Na+/Ca2+ Exchanger Reveal Incremental Conformational Transitions Mousheng Wu, Hoa Dinh Le, Meitian Wang, Vladimir Yurkov, Alexander Omelchenko, Mark Hnatowich, Jay Nix, Larry V. Hryshko, and Lei Zheng PMCID: PMC2807312 | Free in PMC on 2011/01/22 | The ClC-3 Cl−/H+ Antiporter Becomes Uncoupled at Low Extracellular pH James J. Matsuda, Mohammed S. Filali, Malia M. Collins, Kenneth A. Volk, and Fred S. Lamb PMCID: PMC2807314 | Free in PMC on 2011/01/22 | Rhesus Glycoprotein P2 (Rhp2) Is a Novel Member of the Rh Family of Ammonia Transporters Highly Expressed in Shark Kidney Tsutomu Nakada, Connie M. Westhoff, Yoko Yamaguchi, Susumu Hyodo, Xiaojin Li, Takayuki Muro, Akira Kato, Nobuhiro Nakamura, and Shigehisa Hirose PMCID: PMC2807322 | Free in PMC on 2011/01/22 | Identification of Transport-critical Residues in a Folate Transporter from the Folate-Biopterin Transporter (FBT) Family Aymerick Eudes, Edmund R. S. Kunji, Alexandre Noiriel, Sebastian M. J. Klaus, Tim J. Vickers, Stephen M. Beverley, Jesse F. Gregory, III, and Andrew D. Hanson PMCID: PMC2807340 | Free in PMC on 2011/01/22 | Protein Structure and Folding Analysis of Transmembrane Domains 1 and 4 of the Human Angiotensin II AT1 Receptor by Cysteine-scanning Mutagenesis Liping Yan, Brian J. Holleran, Pierre Lavigne, Emanuel Escher, Gaétan Guillemette, and Richard Leduc PMCID: PMC2807285 | Free in PMC on 2011/01/22 | Structure of a Eukaryotic Nonribosomal Peptide Synthetase Adenylation Domain That Activates a Large Hydroxamate Amino Acid in Siderophore Biosynthesis T. Verne Lee, Linda J. Johnson, Richard D. Johnson, Albert Koulman, Geoffrey A. Lane, J. Shaun Lott, and Vickery L. Arcus PMCID: PMC2807299 | Free in PMC on 2011/01/22 | The Binding Mode of ATP Revealed by the Solution Structure of the N-domain of Human ATP7A Lucia Banci, Ivano Bertini, Francesca Cantini, Sayaka Inagaki, Manuele Migliardi, and Antonio Rosato PMCID: PMC2807310 | Free in PMC on 2011/01/22 | Location of 3-Hydroxyproline Residues in Collagen Types I, II, III, and V/XI Implies a Role in Fibril Supramolecular Assembly Mary Ann Weis, David M. Hudson, Lammy Kim, Melissa Scott, Jiann-Jiu Wu, and David R. Eyre PMCID: PMC2807315 | Free in PMC on 2011/01/22 | Troponin Regulatory Function and Dynamics Revealed by H/D Exchange-Mass Spectrometry Devanand Kowlessur and Larry S. Tobacman PMCID: PMC2807325 | Free in PMC on 2011/01/22 | The p53 Core Domain Is a Molten Globule at Low pH: FUNCTIONAL IMPLICATIONS OF A PARTIALLY UNFOLDED STRUCTURE Ana Paula D. Ano Bom, Monica S. Freitas, Flavia S. Moreira, Danielly Ferraz, Daniel Sanches, Andre M. O. Gomes, Ana Paula Valente, Yraima Cordeiro, and Jerson L. Silva PMCID: PMC2807339 Enzyme Catalysis and Regulation IscS Functions as a Primary Sulfur-donating Enzyme by Interacting Specifically with MoeB and MoaD in the Biosynthesis of Molybdopterin in Escherichia coli Wanjiao Zhang, Alexander Urban, Hisaaki Mihara, Silke Leimkühler, Tatsuo Kurihara, and Nobuyoshi Esaki PMCID: PMC2807287 | Free in PMC on 2011/01/22 | Structural Insights into the Specificity of Xyn10B from Paenibacillus barcinonensis and Its Improved Stability by Forced Protein Evolution Óscar Gallardo, F. I. Javier Pastor, Julio Polaina, Pilar Diaz, Robert Łysek, Pierre Vogel, Pablo Isorna, Beatriz González, and Julia Sanz-Aparicio PMCID: PMC2807328 | Free in PMC on 2011/01/22 | Molecular Basis of Cell and Developmental Biology The Neurospora Peptide:N-Glycanase Ortholog PNG1 Is Essential for Cell Polarity despite Its Lack of Enzymatic Activity Sabine Maerz, Yoko Funakoshi, Yuki Negishi, Tadashi Suzuki, and Stephan Seiler PMCID: PMC2807290 | Free in PMC on 2011/01/22 | Structure, Affinity, and Availability of Estrogen Receptor Complexes in the Cellular Environment Eric M. Kofoed, Martin Guerbadot, and Fred Schaufele PMCID: PMC2807300 | Free in PMC on 2011/01/22 | The Cleavage of Semaphorin 3C Induced by ADAMTS1 Promotes Cell Migration Cary Esselens, Jordi Malapeira, Núria Colomé, Carmen Casal, Juan Carlos Rodríguez-Manzaneque, Francesc Canals, and Joaquín Arribas PMCID: PMC2807303 | Free in PMC on 2011/01/22 | Dimerization of CPAP Orchestrates Centrosome Cohesion Plasticity Lingli Zhao, Changjiang Jin, Youjun Chu, Chris Varghese, Shasha Hua, Feng Yan, Yong Miao, Jing Liu, David Mann, Xia Ding, Jiancun Zhang, Zhiyong Wang, Zhen Dou, and Xuebiao Yao PMCID: PMC2807305 | Free in PMC on 2011/01/22 | β-Amyloid Causes Depletion of Synaptic Vesicles Leading to Neurotransmission Failure Jorge Parodi, Fernando J. Sepúlveda, Jorge Roa, Carlos Opazo, Nibaldo C. Inestrosa, and Luis G. Aguayo PMCID: PMC2807307 | Free in PMC on 2011/01/22 | The β Subunit of Voltage-gated Ca2+ Channels Interacts with and Regulates the Activity of a Novel Isoform of Pax6 Yun Zhang, Yoichi Yamada, Mingming Fan, Saroja D. Bangaru, Bochao Lin, and Jian Yang PMCID: PMC2807309 | Free in PMC on 2011/01/22 | The Full-length Unprocessed Hedgehog Protein Is an Active Signaling Molecule Robert Tokhunts, Samer Singh, Tehyen Chu, Gisela D'Angelo, Valerie Baubet, John A. Goetz, Zhen Huang, Ziqiang Yuan, Manuel Ascano, Yana Zavros, Pascal P. Thérond, Sam Kunes, Nadia Dahmane, and David J. Robbins PMCID: PMC2807313 | Free in PMC on 2011/01/22 | Modulation of SCFβ-TrCP-dependent IκBα Ubiquitination by Hydrogen Peroxide Sami Banerjee, Jaroslaw W. Zmijewski, Emmanuel Lorne, Gang Liu, Yonggang Sha, and Edward Abraham PMCID: PMC2807323 | Free in PMC on 2011/01/22 | Direct Observation of the Uncapping of Capping Protein-capped Actin Filaments by CARMIL Homology Domain 3 Ikuko Fujiwara, Kirsten Remmert, and John A. Hammer, III PMCID: PMC2807327 | Free in PMC on 2011/01/22 | Molecular Basis for Association of PIPKIγ-p90 with Clathrin Adaptor AP-2 Nina Kahlfeldt, Ardeschir Vahedi-Faridi, Seong Joo Koo, Johannes G. Schäfer, Georg Krainer, Sandro Keller, Wolfram Saenger, Michael Krauss, and Volker Haucke PMCID: PMC2807329 | Free in PMC on 2011/01/22 | In Vivo Nano-imaging of Membrane Dynamics in Metastatic Tumor Cells Using Quantum Dots Kohsuke Gonda, Tomonobu M. Watanabe, Noriaki Ohuchi, and Hideo Higuchi PMCID: PMC2807330 | Free in PMC on 2011/01/22 | Jmjd1a Demethylase-regulated Histone Modification Is Essential for cAMP-response Element Modulator-regulated Gene Expression and Spermatogenesis Zhaoliang Liu, Suoling Zhou, Lan Liao, Xian Chen, Marvin Meistrich, and Jianming Xu PMCID: PMC2807331 | Free in PMC on 2011/01/22 | DNA: Replication, Repair, Recombination, and Chromosome Dynamics Mechanism of Action of an Imidopiperidine Inhibitor of Human Polynucleotide Kinase/Phosphatase Gary K. Freschauf, Rajam S. Mani, Todd R. Mereniuk, Mesfin Fanta, Caesar A. Virgen, Grigory L. Dianov, Jean-Marie Grassot, Dennis G. Hall, and Michael Weinfeld PMCID: PMC2807293 | Free in PMC on 2011/01/22 | Characterization of the Mycobacterial AdnAB DNA Motor Provides Insights into the Evolution of Bacterial Motor-Nuclease Machines Mihaela-Carmen Unciuleac and Stewart Shuman PMCID: PMC2807320 | Free in PMC on 2011/01/22 | Uracil DNA Glycosylase Activity on Nucleosomal DNA Depends on Rotational Orientation of Targets Hope A. Cole, Jenna M. Tabor-Godwin, and Jeffrey J. Hayes PMCID: PMC2807341 | Free in PMC on 2011/01/22 | Protein Synthesis, Post-Translational Modification, and Degradation ERK Regulates Calpain 2-induced Androgen Receptor Proteolysis in CWR22 Relapsed Prostate Tumor Cell Lines Honglin Chen, Stephen J. Libertini, Yu Wang, Hsing-Jien Kung, Paramita Ghosh, and Maria Mudryj PMCID: PMC2807295 | Free in PMC on 2011/01/22 | Splicing of the Mycobacteriophage Bethlehem DnaB Intein: IDENTIFICATION OF A NEW MECHANISTIC CLASS OF INTEINS THAT CONTAIN AN OBLIGATE BLOCK F NUCLEOPHILE Kazuo Tori, Bareket Dassa, Margaret A. Johnson, Maurice W. Southworth, Lear E. Brace, Yoshizumi Ishino, Shmuel Pietrokovski, and Francine B. Perler PMCID: PMC2807308 Cordycepin Inhibits Protein Synthesis and Cell Adhesion through Effects on Signal Transduction Ying Ying Wong, Alice Moon, Ruth Duffin, Adeline Barthet-Barateig, Hedda A. Meijer, Michael J. Clemens, and Cornelia H. de Moor PMCID: PMC2807318 Phosphorylation of Synucleins by Members of the Polo-like Kinase Family Martial K. Mbefo, Katerina E. Paleologou, Ahmed Boucharaba, Abid Oueslati, Heinrich Schell, Margot Fournier, Diana Olschewski, Guowei Yin, Markus Zweckstetter, Eliezer Masliah, Philipp J. Kahle, Harald Hirling, and Hilal A. Lashuel PMCID: PMC2807335 | Free in PMC on 2011/01/22 | Lipids and Lipoproteins: Metabolism, Regulation, and Signaling Lipid Droplets Are Novel Sites of N-Acylethanolamine Inactivation by Fatty Acid Amide Hydrolase-2 Martin Kaczocha, Sherrye T. Glaser, Janiper Chae, Deborah A. Brown, and Dale G. Deutsch PMCID: PMC2807334 | Free in PMC on 2011/01/22 | Molecular Basis Of Cell and Developmental Biology Differential Regulation of Kainate Receptor Trafficking by Phosphorylation of Distinct Sites on GluR6 Yukiko Nasu-Nishimura, Howard Jaffe, John T. R. Isaac, and Katherine W. Roche PMCID: PMC2807338 | Free in PMC on 2011/01/22 | Papers of the Week A Trio of Binding Partners for Gcn4♦: Activator Gcn4 Employs Multiple Segments of Med15/Gal11, Including the KIX Domain, to Recruit Mediator to Target Genes in Vivo PMCID: PMC2807343 | Free in PMC on 2011/01/22 | Oh Little Intein of Bethlehem♦: Splicing of the Mycobacteriophage Bethlehem DnaB Intein. Identification of a New Mechanistic Class of Inteins That Contain an Obligate Block F Nucleophile PMCID: PMC2807344 | Free in PMC on 2011/01/22 | Other Issues: Journal List
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