Volume 6; 2012

Methodology Articles

Simplification of biochemical models: a general approach based on the analysis of the impact of individual species and reactions on the systems dynamics

Irina Surovtsova, Natalia Simus, Katrin Hübner, Sven Sahle, Ursula Kummer

BMC Syst Biol. 2012; 6: 14. Published online 2012 March 5. doi: 10.1186/1752-0509-6-14

PMCID:: PMC3349553

Abstract Full Text PDF–2.2M Supplementary Material

A new essential protein discovery method based on the integration of protein-protein interaction and gene expression data

Min Li, Hanhui Zhang, Jian-xin Wang, Yi Pan

BMC Syst Biol. 2012; 6: 15. Published online 2012 March 10. doi: 10.1186/1752-0509-6-15

PMCID:: PMC3325894

Abstract Full Text PDF–337K Supplementary Material

Research Articles

Modeling of leishmaniasis infection dynamics: novel application to the design of effective therapies

Bettina M Länger, Cristina Pou-Barreto, Carlos González-Alcón, Basilio Valladares, Bettina Wimmer, Néstor V Torres

BMC Syst Biol. 2012; 6: 1. Published online 2012 January 5. doi: 10.1186/1752-0509-6-1

PMCID:: PMC3293051

Abstract Full Text PDF–719K

Systems analysis of the transcriptional response of human ileocecal epithelial cells to Clostridium difficile toxins and effects on cell cycle control

Kevin M D'Auria, Gina M Donato, Mary C Gray, Glynis L Kolling, Cirle A Warren, Lauren M Cave, Michael D Solga, Joanne A Lannigan, Jason A Papin, Erik L Hewlett

BMC Syst Biol. 2012; 6: 2. Published online 2012 January 6. doi: 10.1186/1752-0509-6-2

PMCID:: PMC3266197

Abstract Full Text PDF–1016K Supplementary Material

Biomarker robustness reveals the PDGF network as driving disease outcome in ovarian cancer patients in multiple studies

Rotem Ben-Hamo, Sol Efroni

BMC Syst Biol. 2012; 6: 3. Published online 2012 January 11. doi: 10.1186/1752-0509-6-3

PMCID:: PMC3298526

Abstract Full Text PDF–1.9M Supplementary Material

Identifying co-targets to fight drug resistance based on a random walk model

Liang-Chun Chen, Hsiang-Yuan Yeh, Cheng-Yu Yeh, Carlos Roberto Arias, Von-Wun Soo

BMC Syst Biol. 2012; 6: 5. Published online 2012 January 19. doi: 10.1186/1752-0509-6-5

PMCID:: PMC3296574

Abstract Full Text PDF–594K Supplementary Material

Regulatory interactions for iron homeostasis in Aspergillus fumigatus inferred by a Systems Biology approach

Jörg Linde, Peter Hortschansky, Eugen Fazius, Axel A Brakhage, Reinhard Guthke, Hubertus Haas

BMC Syst Biol. 2012; 6: 6. Published online 2012 January 19. doi: 10.1186/1752-0509-6-6

PMCID:: PMC3305660

Abstract Full Text PDF–471K Supplementary Material

Evolvability of feed-forward loop architecture biases its abundance in transcription networks

Stefanie Widder, Ricard Solé, Javier Macía

BMC Syst Biol. 2012; 6: 7. Published online 2012 January 19. doi: 10.1186/1752-0509-6-7

PMCID:: PMC3349539

Abstract Full Text PDF–941K

Predicting outcomes of steady-state ¹³C isotope tracing experiments using Monte Carlo sampling

Jan Schellenberger, Daniel C Zielinski, Wing Choi, Sunthosh Madireddi, Vasiliy Portnoy, David A Scott, Jennifer L Reed, Andrei L Osterman, Bernhard [empty]