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Volume 174(6);  June 2009
This Month in AJP
This Month in AJP
Am J Pathol. 2009 June; 174(6): 1983–1984. doi: 10.2353/ajpath.2009.090277.
PMCID: PMC2684161
Mini-Review
Very Small Embryonic/Epiblast-Like Stem Cells : A Missing Link To Support the Germ Line Hypothesis of Cancer Development?
Mariusz Z. Ratajczak, Dong-Myung Shin, and Magda Kucia
Am J Pathol. 2009 June; 174(6): 1985–1992. doi: 10.2353/ajpath.2009.081143.
PMCID: PMC2684162
Commentaries
Hyaluronan, Platelets, and Monocytes : A Novel Pro-Inflammatory Triad
Gustavo B. Menezes, Erin F. McAvoy, and Paul Kubes
Am J Pathol. 2009 June; 174(6): 1993–1995. doi: 10.2353/ajpath.2009.081138.
PMCID: PMC2684163
Quis Custodiet Ipsos Custodies : Who Watches the Watchmen?
Cyrus M. Ghajar, Roland Meier, and Mina J. Bissell
Am J Pathol. 2009 June; 174(6): 1996–1999. doi: 10.2353/ajpath.2009.090363.
PMCID: PMC2684164
Short Communications
Molecular Identification of “Latent Precancers” for Endometrial Serous Carcinoma in Benign-Appearing Endometrium
Xi Zhang, Sharon X. Liang, Lin Jia, Ning Chen, Oluwole Fadare, Peter E. Schwartz, Beihua Kong, and Wenxin Zheng
Am J Pathol. 2009 June; 174(6): 2000–2006. doi: 10.2353/ajpath.2009.081085.
PMCID: PMC2684165
Atherosclerosis in LDLR-Knockout Mice Is Inhibited, but Not Reversed, by the PPARγ Ligand Pioglitazone
Hideaki Nakaya, Barbara D. Summers, Andrew C. Nicholson, Antonio M. Gotto, Jr., David P. Hajjar, and Jihong Han
Am J Pathol. 2009 June; 174(6): 2007–2014. doi: 10.2353/ajpath.2009.080611.
PMCID: PMC2684166
Loss of Matriptase Suppression Underlies Spint1 Mutation-Associated Ichthyosis and Postnatal Lethality
Roman Szabo, Peter Kosa, Karin List, and Thomas H. Bugge
Am J Pathol. 2009 June; 174(6): 2015–2022. doi: 10.2353/ajpath.2009.090053.
PMCID: PMC2684167
Regular Articles
Biomarkers, Genomics, Proteomics, and Gene Regulation
An Absence of Stromal Caveolin-1 Expression Predicts Early Tumor Recurrence and Poor Clinical Outcome in Human Breast Cancers
Agnieszka K. Witkiewicz, Abhijit Dasgupta, Federica Sotgia, Isabelle Mercier, Richard G. Pestell, Michael Sabel, Celina G. Kleer, Jonathan R. Brody, and Michael P. Lisanti
Am J Pathol. 2009 June; 174(6): 2023–2034. doi: 10.2353/ajpath.2009.080873.
PMCID: PMC2684168
Stromal Cell Expression of Caveolin-1 Predicts Outcome in Breast Cancer
Erica K. Sloan, Daniel R. Ciocca, Normand Pouliot, Anthony Natoli, Christina Restall, Michael A. Henderson, Mariel A. Fanelli, Fernando D. Cuello-Carrión, Francisco E. Gago, and Robin L. Anderson
Am J Pathol. 2009 June; 174(6): 2035–2043. doi: 10.2353/ajpath.2009.080924.
PMCID: PMC2684169
Staphylococcal Nuclease Domain-Containing Protein 1 as a Potential Tissue Marker for Prostate Cancer
Hidetoshi Kuruma, Yuko Kamata, Hiroyuki Takahashi, Koji Igarashi, Takahiro Kimura, Kenta Miki, Jun Miki, Hiroshi Sasaki, Norihiro Hayashi, and Shin Egawa
Am J Pathol. 2009 June; 174(6): 2044–2050. doi: 10.2353/ajpath.2009.080776.
PMCID: PMC2684170
A Reduction in Pten Tumor Suppressor Activity Promotes ErbB-2-Induced Mouse Prostate Adenocarcinoma Formation through the Activation of Signaling Cascades Downstream of PDK1
Olga C. Rodriguez, Edwin W. Lai, Sarada Vissapragada, Caroline Cromelin, Maral Avetian, Patricia Salinas, Hida Ramos, Bhaskar Kallakury, Mathew Casimiro, Michael P. Lisanti, Herbert B. Tanowitz, Karel Pacak, Robert I. Glazer, Maria Avantaggiati, and Chris Albanese
Am J Pathol. 2009 June; 174(6): 2051–2060. doi: 10.2353/ajpath.2009.080859.
PMCID: PMC2684171
CXCL16 Is Expressed in Podocytes and Acts as a Scavenger Receptor for Oxidized Low-Density Lipoprotein
Paul Gutwein, Mohamed Sadek Abdel-Bakky, Anja Schramme, Kai Doberstein, Nicole Kämpfer-Kolb, Kerstin Amann, Ingeborg A. Hauser, Nicholas Obermüller, Christine Bartel, Abdel-Aziz H. Abdel-Aziz, El Sayed M. El Sayed, and Josef Pfeilschifter
Am J Pathol. 2009 June; 174(6): 2061–2072. doi: 10.2353/ajpath.2009.080960.
PMCID: PMC2684172
Renal Gene and Protein Expression Signatures for Prediction of Kidney Disease Progression
Wenjun Ju, Felix Eichinger, Markus Bitzer, Jun Oh, Shannon McWeeney, Celine C. Berthier, Kerby Shedden, Clemens D. Cohen, Anna Henger, Stefanie Krick, Jeffrey B. Kopp, Christian J. Stoeckert, Jr., Steven Dikman, Bernd Schröppel, David B. Thomas, Detlef Schlondorff, Matthias Kretzler, and Erwin P. Böttinger
Am J Pathol. 2009 June; 174(6): 2073–2085. doi: 10.2353/ajpath.2009.080888.
PMCID: PMC2684173
Cardiovascular, Pulmonary and Renal Pathology
Soluble Epoxide Inhibition Is Protective Against Cerebral Ischemia via Vascular and Neural Protection
Alexis N. Simpkins, R. Daniel Rudic, Derek A. Schreihofer, Sid Roy, Marlina Manhiani, Hsing-Ju Tsai, Bruce D. Hammock, and John D. Imig
Am J Pathol. 2009 June; 174(6): 2086–2095. doi: 10.2353/ajpath.2009.080544.
PMCID: PMC2684174
Urinary Excretion of Liver Type Fatty Acid Binding Protein Accurately Reflects the Degree of Tubulointerstitial Damage
Takeshi Yokoyama, Atsuko Kamijo-Ikemori, Takeshi Sugaya, Seiko Hoshino, Takashi Yasuda, and Kenjiro Kimura
Am J Pathol. 2009 June; 174(6): 2096–2106. doi: 10.2353/ajpath.2009.080780.
PMCID: PMC2684175
Epithelial and Mesenchymal Cell Biology
Requirement of the Akt/β-Catenin Pathway for Uterine Carcinosarcoma Genesis, Modulating E-Cadherin Expression Through the Transactivation of Slug
Makoto Saegusa, Miki Hashimura, Takeshi Kuwata, and Isao Okayasu
Am J Pathol. 2009 June; 174(6): 2107–2115. doi: 10.2353/ajpath.2009.081018.
PMCID: PMC2684176
Alternative Proteolytic Processing of Hepatocyte Growth Factor during Wound Repair
Nils Buchstein, Daniel Hoffmann, Hans Smola, Sabina Lang, Mats Paulsson, Catherin Niemann, Thomas Krieg, and Sabine A. Eming
Am J Pathol. 2009 June; 174(6): 2116–2128. doi: 10.2353/ajpath.2009.080597.
PMCID: PMC2684177
Growth Factors, Cytokines, Cell Cycle Molecules
Disruption of Interleukin-1 Signaling Improves the Quality of Wound Healing
Alan A. Thomay, Jean M. Daley, Edmond Sabo, Patrick J. Worth, Leslie J. Shelton, Mark W. Harty, Jonathan S. Reichner, and Jorge E. Albina
Am J Pathol. 2009 June; 174(6): 2129–2136. doi: 10.2353/ajpath.2009.080765.
PMCID: PMC2684178
Homeostatic Role of Transforming Growth Factor-β in the Oral Cavity and Esophagus of Mice and Its Expression by Mast Cells in These Tissues
Allison Vitsky, James Waire, Robert Pawliuk, Arden Bond, Douglas Matthews, Emily LaCasse, Michael L. Hawes, Carol Nelson, Susan Richards, Peter A. Piepenhagen, Richard D. Garman, Laura Andrews, Beth L. Thurberg, Scott Lonning, Steve Ledbetter, and Melanie C. Ruzek
Am J Pathol. 2009 June; 174(6): 2137–2149. doi: 10.2353/ajpath.2009.080723.
PMCID: PMC2684179
The Methylation of the TSC2 Promoter Underlies the Abnormal Growth of TSC2 Angiomyolipoma-Derived Smooth Muscle Cells
Elena Lesma, Silvia Maria Sirchia, Silvia Ancona, Stephana Carelli, Silvano Bosari, Filippo Ghelma, Emanuele Montanari, Anna Maria Di Giulio, and Alfredo Gorio
Am J Pathol. 2009 June; 174(6): 2150–2159. doi: 10.2353/ajpath.2009.080799.
PMCID: PMC2684180
Osteoprotegerin Abrogated Cortical Porosity and Bone Marrow Fibrosis in a Mouse Model of Constitutive Activation of the PTH/PTHrP Receptor
Masanobu Ohishi, Riccardo Chiusaroli, Michael Ominsky, Frank Asuncion, Clare Thomas, Richa Khatri, Paul Kostenuik, and Ernestina Schipani
Am J Pathol. 2009 June; 174(6): 2160–2171. doi: 10.2353/ajpath.2009.081026.
PMCID: PMC2684181
Immunopathology and Infectious Disease
Monokine Induced by Interferon-γ (MIG/CXCL9) Is Derived from Both Donor and Recipient Sources during Rejection of Class II Major Histocompatibility Complex Disparate Skin Allografts
Michael B. Auerbach, Naohiko Shimoda, Hiroyuki Amano, Joshua M. Rosenblum, Danielle D. Kish, Joshua M. Farber, and Robert L. Fairchild
Am J Pathol. 2009 June; 174(6): 2172–2181. doi: 10.2353/ajpath.2009.080516.
PMCID: PMC2684182
Urokinase Plasminogen Activator Receptor-Deficient Mice Demonstrate Reduced Hyperoxia-Induced Lung Injury
Marieke A.D. van Zoelen, Sandrine Florquin, Regina de Beer, Jennie M. Pater, Marleen I. Verstege, Joost C.M. Meijers, and Tom van der Poll
Am J Pathol. 2009 June; 174(6): 2182–2189. doi: 10.2353/ajpath.2009.080914.
PMCID: PMC2684183
Dominant Role of the sst1 Locus in Pathogenesis of Necrotizing Lung Granulomas during Chronic Tuberculosis Infection and Reactivation in Genetically Resistant Hosts
Alexander V. Pichugin, Bo-Shiun Yan, Alex Sloutsky, Lester Kobzik, and Igor Kramnik
Am J Pathol. 2009 June; 174(6): 2190–2201. doi: 10.2353/ajpath.2009.081075.
PMCID: PMC2684184
Mucosal Tolerance Induced by an Immunodominant Peptide from Rat α3(IV)NC1 in Established Experimental Autoimmune Glomerulonephritis
John Reynolds, Danielle S. Abbott, Julieta Karegli, David J. Evans, and Charles D. Pusey
Am J Pathol. 2009 June; 174(6): 2202–2210. doi: 10.2353/ajpath.2009.081041.
PMCID: PMC2684185
Compartmentalization of Immune Responses in Human Tuberculosis : Few CD8+ Effector T Cells but Elevated Levels of FoxP3+ Regulatory T Cells in the Granulomatous Lesions
Sayma Rahman, Berhanu Gudetta, Joshua Fink, Anna Granath, Senait Ashenafi, Abraham Aseffa, Milliard Derbew, Mattias Svensson, Jan Andersson, and Susanna Grundström Brighenti
Am J Pathol. 2009 June; 174(6): 2211–2224. doi: 10.2353/ajpath.2009.080941.
PMCID: PMC2684186
Establishment of Experimental Eosinophilic Vasculitis by IgE-Mediated Cutaneous Reverse Passive Arthus Reaction
Takayuki Ishii, Tomoyuki Fujita, Takashi Matsushita, Koichi Yanaba, Minoru Hasegawa, Hiroko Nakashima, Fumihide Ogawa, Kazuhiro Shimizu, Kazuhiko Takehara, Thomas F. Tedder, Shinichi Sato, and Manabu Fujimoto
Am J Pathol. 2009 June; 174(6): 2225–2233. doi: 10.2353/ajpath.2009.080223.
PMCID: PMC2684187
Synthetic Retinoid AM80 Inhibits Th17 Cells and Ameliorates Experimental Autoimmune Encephalomyelitis
Christian Klemann, Benjamin J.E. Raveney, Anna K. Klemann, Tomoko Ozawa, Stephan von Hörsten, Koichi Shudo, Shinji Oki, and Takashi Yamamura
Am J Pathol. 2009 June; 174(6): 2234–2245. doi: 10.2353/ajpath.2009.081084.
PMCID: PMC2684188
Matrix Pathobiology
Amplification of the Urokinase-Type Plasminogen Activator Receptor (uPAR) Gene in Ductal Pancreatic Carcinomas Identifies a Clinically High-Risk Group
Ralf Hildenbrand, Marco Niedergethmann, Alexander Marx, Djeda Belharazem, Heike Allgayer, Christiane Schleger, and Philipp Ströbel
Am J Pathol. 2009 June; 174(6): 2246–2253. doi: 10.2353/ajpath.2009.080785.
PMCID: PMC2684189
Platelet-Derived Hyaluronidase 2 Cleaves Hyaluronan into Fragments that Trigger Monocyte-Mediated Production of Proinflammatory Cytokines
Carol de la Motte, Julie Nigro, Amit Vasanji, Hyunjin Rho, Sean Kessler, Sudip Bandyopadhyay, Silvio Danese, Claudio Fiocchi, and Robert Stern
Am J Pathol. 2009 June; 174(6): 2254–2264. doi: 10.2353/ajpath.2009.080831.
PMCID: PMC2684190
Inducible Nitric Oxide Synthase Deficiency Impairs Matrix Metalloproteinase-9 Activity and Disrupts Leukocyte Migration in Hepatic Ischemia/Reperfusion Injury
Takashi Hamada, Sergio Duarte, Seiichiro Tsuchihashi, Ronald W. Busuttil, and Ana J. Coito
Am J Pathol. 2009 June; 174(6): 2265–2277. doi: 10.2353/ajpath.2009.080872.
PMCID: PMC2684191
Neurobiology
Expression of a Soluble Isoform of Cell Adhesion Molecule 1 in the Brain and Its Involvement in Directional Neurite Outgrowth
Man Hagiyama, Naoki Ichiyanagi, Keiko B. Kimura, Yoshinori Murakami, and Akihiko Ito
Am J Pathol. 2009 June; 174(6): 2278–2289. doi: 10.2353/ajpath.2009.080743.
PMCID: PMC2684192
Accelerated Course of Experimental Autoimmune Encephalomyelitis in PD-1-Deficient Central Nervous System Myelin Mutants
Antje Kroner, Nicholas Schwab, Chi Wang Ip, Sonja Ortler, Kerstin Göbel, Klaus-Armin Nave, Mathias Mäurer, Rudolf Martini, and Heinz Wiendl
Am J Pathol. 2009 June; 174(6): 2290–2299. doi: 10.2353/ajpath.2009.081012.
PMCID: PMC2684193
Protection of Hippocampal Neurogenesis from Toll-Like Receptor 4-Dependent Innate Immune Activation by Ablation of Prostaglandin E2 Receptor Subtype EP1 or EP2
C. Dirk Keene, Rubens Chang, Christina Stephen, Mary Nivison, Samuel E. Nutt, Amy Look, Richard M. Breyer, Phillip J. Horner, Robert Hevner, and Thomas J. Montine
Am J Pathol. 2009 June; 174(6): 2300–2309. doi: 10.2353/ajpath.2009.081153.
PMCID: PMC2684194
Cooperative Phagocytes : Resident Microglia and Bone Marrow Immigrants Remove Dead Photoreceptors in Retinal Lesions
Sandrine Joly, Mike Francke, Elke Ulbricht, Susanne Beck, Matthias Seeliger, Petra Hirrlinger, Johannes Hirrlinger, Karl S. Lang, Martin Zinkernagel, Bernhard Odermatt, Marijana Samardzija, Andreas Reichenbach, Christian Grimm, and Charlotte E. Remé
Am J Pathol. 2009 June; 174(6): 2310–2323. doi: 10.2353/ajpath.2009.090023.
PMCID: PMC2684195
Tumorigenesis and Neoplastic Progression
SV40-Induced Expression of Calretinin Protects Mesothelial Cells from Asbestos Cytotoxicity and May Be a Key Factor Contributing to Mesothelioma Pathogenesis
Thomas Henzi, Walter-Vincent Blum, Martine Pfefferli, Tadeusz J. Kawecki, Valerie Salicio, and Beat Schwaller
Am J Pathol. 2009 June; 174(6): 2324–2336. doi: 10.2353/ajpath.2009.080352.
PMCID: PMC2684196
Activation of the Endoplasmic Reticulum Stress-Associated Transcription Factor X Box-Binding Protein-1 Occurs in a Subset of Normal Germinal-Center B Cells and in Aggressive B-Cell Lymphomas with Prognostic Implications
Olga Balague, Ana Mozos, Daniel Martinez, Luis Hernandez, Lluis Colomo, Jose Luis Mate, Julie Teruya-Feldstein, Oscar Lin, Elias Campo, Armando Lopez-Guillermo, and Antonio Martinez
Am J Pathol. 2009 June; 174(6): 2337–2346. doi: 10.2353/ajpath.2009.080848.
PMCID: PMC2684197
Coordinate Expression of Colony-Stimulating Factor-1 and Colony-Stimulating Factor-1-Related Proteins Is Associated with Poor Prognosis in Gynecological and Nongynecological Leiomyosarcoma
Inigo Espinosa, Andrew H. Beck, Cheng-Han Lee, Shirley Zhu, Kelli D. Montgomery, Robert J. Marinelli, Kristen N. Ganjoo, Torsten O. Nielsen, C. Blake Gilks, Robert B. West, and Matt van de Rijn
Am J Pathol. 2009 June; 174(6): 2347–2356. doi: 10.2353/ajpath.2009.081037.
PMCID: PMC2684198
Erbb2 Suppresses DNA Damage-Induced Checkpoint Activation and UV-Induced Mouse Skin Tumorigenesis
Justin G. Madson, David T. Lynch, Jessica Svoboda, Rebecca Ophardt, Jodi Yanagida, Sumanth K. Putta, Andrew Bowles, Carol S. Trempus, Raymond W. Tennant, and Laura A. Hansen
Am J Pathol. 2009 June; 174(6): 2357–2366. doi: 10.2353/ajpath.2009.080638.
PMCID: PMC2684199
The Role of BRAF Mutation and p53 Inactivation during Transformation of a Subpopulation of Primary Human Melanocytes
Hong Yu, Ronan McDaid, John Lee, Patricia Possik, Ling Li, Suresh M. Kumar, David E. Elder, Patricia Van Belle, Phyllis Gimotty, Matt Guerra, Rachel Hammond, Katharine L. Nathanson, Maria Dalla Palma, Meenhard Herlyn, and Xiaowei Xu
Am J Pathol. 2009 June; 174(6): 2367–2377. doi: 10.2353/ajpath.2009.081057.
PMCID: PMC2684200
Vascular Biology, Atherosclerosis and Endothelium Biology
α5β1 Integrin Blockade Inhibits Lymphangiogenesis in Airway Inflammation
Tatsuma Okazaki, Amy Ni, Oluwasheyi A. Ayeni, Peter Baluk, Li-Chin Yao, Doerte Vossmeyer, Gunther Zischinsky, Grit Zahn, Jochen Knolle, Claudia Christner, and Donald M. McDonald
Am J Pathol. 2009 June; 174(6): 2378–2387. doi: 10.2353/ajpath.2009.080942.
PMCID: PMC2684201
Capillary Defects and Exaggerated Inflammatory Response in the Airways of EphA2-Deficient Mice
Tatsuma Okazaki, Amy Ni, Peter Baluk, Oluwasheyi A. Ayeni, Jennifer Kearley, Anthony J. Coyle, Alison Humbles, and Donald M. McDonald
Am J Pathol. 2009 June; 174(6): 2388–2399. doi: 10.2353/ajpath.2009.080949.
PMCID: PMC2684202
Oxidative Stress and Compartment of Gene Expression Determine Proatherosclerotic Effects of Inducible Nitric Oxide Synthase
Padmapriya Ponnuswamy, Eva Ostermeier, Angelika Schröttle, Jiqiu Chen, Paul L. Huang, Georg Ertl, Bernhard Nieswandt, and Peter J. Kuhlencordt
Am J Pathol. 2009 June; 174(6): 2400–2410. doi: 10.2353/ajpath.2009.080730.
PMCID: PMC2684203
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