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Commentaries Basic and clinical significance of IGF-I-induced signatures in cancer Haim Werner and Ilan Bruchim BMC Med. 2010; 8: 2. Published online 2010 January 5. doi: 10.1186/1741-7015-8-2.PMCID: PMC2806256 The interleukin-1 cluster, dyslipidaemia and risk of myocardial infarction Bernard Keavney BMC Med. 2010; 8: 6. Published online 2010 January 13. doi: 10.1186/1741-7015-8-6.PMCID: PMC2822811 Transparent and accurate reporting increases reliability, utility, and impact of your research: reporting guidelines and the EQUATOR Network Iveta Simera, David Moher, Allison Hirst, John Hoey, Kenneth F Schulz, and Douglas G Altman BMC Med. 2010; 8: 24. Published online 2010 April 26. doi: 10.1186/1741-7015-8-24.PMCID: PMC2874506 Hypoxia-specific targets in cancer therapy: role of splice variants Dirk Vordermark BMC Med. 2010; 8: 45. Published online 2010 July 12. doi: 10.1186/1741-7015-8-45.PMCID: PMC2909930 Enhancement drugs: are there limits to what we should enhance and why? Morten Hesse BMC Med. 2010; 8: 50. Published online 2010 August 3. doi: 10.1186/1741-7015-8-50.PMCID: PMC2922074 Correspondence CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials Kenneth F Schulz, Douglas G Altman, and David Moher BMC Med. 2010; 8: 18. Published online 2010 March 24. doi: 10.1186/1741-7015-8-18.PMCID: PMC2860339 What is a clinical pathway? Development of a definition to inform the debate Leigh Kinsman, Thomas Rotter, Erica James, Pamela Snow, and Jon Willis BMC Med. 2010; 8: 31. Published online 2010 May 27. doi: 10.1186/1741-7015-8-31.PMCID: PMC2893088 Chronic fatigue syndrome: Harvey and Wessely's (bio)psychosocial model versus a bio(psychosocial) model based on inflammatory and oxidative and nitrosative stress pathways Michael Maes and Frank NM Twisk BMC Med. 2010; 8: 35. Published online 2010 June 15. doi: 10.1186/1741-7015-8-35.PMCID: PMC2901228 Debates Access to pain treatment as a human right Diederik Lohman, Rebecca Schleifer, and Joseph J Amon BMC Med. 2010; 8: 8. Published online 2010 January 20. doi: 10.1186/1741-7015-8-8.PMCID: PMC2823656 Current sample size conventions: Flaws, harms, and alternatives Peter Bacchetti BMC Med. 2010; 8: 17. Published online 2010 March 22. doi: 10.1186/1741-7015-8-17.PMCID: PMC2856520 Cardiovascular risk assessment - From individual risk prediction to estimation of global risk and change in risk in the population John A Batsis and Francisco Lopez-Jimenez BMC Med. 2010; 8: 29. Published online 2010 May 25. doi: 10.1186/1741-7015-8-29.PMCID: PMC2890533 The impact of herpes zoster and post-herpetic neuralgia on quality-of-life Robert W Johnson, Didier Bouhassira, George Kassianos, Alain Leplège, Kenneth E Schmader, and Thomas Weinke BMC Med. 2010; 8: 37. Published online 2010 June 21. doi: 10.1186/1741-7015-8-37.PMCID: PMC2905321 Minireview Recent advances in radiotherapy SA Bhide and CM Nutting BMC Med. 2010; 8: 25. Published online 2010 April 28. doi: 10.1186/1741-7015-8-25.PMCID: PMC2873246 Research Articles Brief psychological therapies for anxiety and depression in primary care: meta-analysis and meta-regression John Cape, Craig Whittington, Marta Buszewicz, Paul Wallace, and Lisa Underwood BMC Med. 2010; 8: 38. Published online 2010 June 25. doi: 10.1186/1741-7015-8-38.PMCID: PMC2908553 Does chocolate reduce blood pressure? A meta-analysis Karin Ried, Thomas Sullivan, Peter Fakler, Oliver R Frank, and Nigel P Stocks BMC Med. 2010; 8: 39. Published online 2010 June 28. doi: 10.1186/1741-7015-8-39.PMCID: PMC2908554 Reduced acquisition and reactivation of human papillomavirus infections among older women treated with cryotherapy: results from a randomized trial in South Africa Sylvia Taylor, Chunhui Wang, Thomas C Wright, Lynette Denny, Wei-Yann Tsai, and Louise Kuhn BMC Med. 2010; 8: 40. Published online 2010 June 29. doi: 10.1186/1741-7015-8-40.PMCID: PMC2907297 Neonatal hypothermia and associated risk factors among newborns of southern Nepal Luke C Mullany, Joanne Katz, Subarna K Khatry, Steven C LeClerq, Gary L Darmstadt, and James M Tielsch BMC Med. 2010; 8: 43. Published online 2010 July 8. doi: 10.1186/1741-7015-8-43.PMCID: PMC2911389 Hypoxia inducible factor 1α gene (HIF-1α) splice variants: potential prognostic biomarkers in breast cancer Jean-Philippe Dales, Nathalie Beaufils, Monique Silvy, Christophe Picard, Vanessa Pauly, Vincent Pradel, Christine Formisano-Tréziny, Pascal Bonnier, Sophie Giusiano, Colette Charpin, and Jean Gabert BMC Med. 2010; 8: 44. Published online 2010 July 12. doi: 10.1186/1741-7015-8-44.PMCID: PMC2917392 Targeted exercise against osteoporosis: A systematic review and meta-analysis for optimising bone strength throughout life Riku Nikander, Harri Sievänen, Ari Heinonen, Robin M Daly, Kirsti Uusi-Rasi, and Pekka Kannus BMC Med. 2010; 8: 47. Published online 2010 July 21. doi: 10.1186/1741-7015-8-47.PMCID: PMC2918523 Relationship between knee and ankle degeneration in a population of organ donors Carol Muehleman, Arkady Margulis, Won C Bae, and Koichi Masuda BMC Med. 2010; 8: 48. Published online 2010 July 28. doi: 10.1186/1741-7015-8-48.PMCID: PMC2925325 Research articles IGF-I induced genes in stromal fibroblasts predict the clinical outcome of breast and lung cancer patients Michal Rajski, Rosanna Zanetti-Dällenbach, Brigitte Vogel, Richard Herrmann, Christoph Rochlitz, and Martin Buess BMC Med. 2010; 8: 1. Published online 2010 January 5. doi: 10.1186/1741-7015-8-1.PMCID: PMC2823652 A randomized phase II study of carboplatin plus pegylated liposomal doxorubicin versus carboplatin plus paclitaxel in platinum sensitive ovarian cancer patients: a Hellenic Cooperative Oncology Group study Dimitrios Bafaloukos, Helena Linardou, Gerasimos Aravantinos, Christos Papadimitriou, Aristotelis Bamias, George Fountzilas, Haralabos P Kalofonos, Paris Kosmidis, Eleni Timotheadou, Thomas Makatsoris, Epaminondas Samantas, Evangelos Briasoulis, Christos Christodoulou, Pavlos Papakostas, Dimitrios Pectasides, and Athanasios M Dimopoulos BMC Med. 2010; 8: 3. Published online 2010 January 7. doi: 10.1186/1741-7015-8-3.PMCID: PMC2823653 Suicide-related behaviors in older patients with new anti-epileptic drug use: data from the VA hospital system Anne C VanCott, Joyce A Cramer, Laurel A Copeland, John E Zeber, Michael A Steinman, Jeffrey J Dersh, Mark E Glickman, Eric M Mortensen, Megan E Amuan, and Mary Jo Pugh BMC Med. 2010; 8: 4. Published online 2010 January 11. doi: 10.1186/1741-7015-8-4.PMCID: PMC2823654 An evaluation of inflammatory gene polymorphisms in sibships discordant for premature coronary artery disease: the GRACE-IMMUNE study Benjamin D Brown, Jérémie Nsengimana, Jennifer H Barrett, Richard A Lawrence, Lori Steiner, Suzanne Cheng, D Timothy Bishop, Nilesh J Samani, Stephen G Ball, Anthony J Balmforth, and Alistair S Hall BMC Med. 2010; 8: 5. Published online 2010 January 13. doi: 10.1186/1741-7015-8-5.PMCID: PMC2823655 An in-depth assessment of a diagnosis-based risk adjustment model based on national health insurance claims: the application of the Johns Hopkins Adjusted Clinical Group case-mix system in Taiwan Hsien-Yen Chang and Jonathan P Weiner BMC Med. 2010; 8: 7. Published online 2010 January 18. doi: 10.1186/1741-7015-8-7.PMCID: PMC2830174 Ruling out coronary heart disease in primary care patients with chest pain: a clinical prediction score Baris Gencer, Paul Vaucher, Lilli Herzig, François Verdon, Christiane Ruffieux, Stefan Bösner, Bernard Burnand, Thomas Bischoff, Norbert Donner-Banzhoff, and Bernard Favrat BMC Med. 2010; 8: 9. Published online 2010 January 21. doi: 10.1186/1741-7015-8-9.PMCID: PMC2832616 The effectiveness of the McKenzie method in addition to first-line care for acute low back pain: a randomized controlled trial Luciana AC Machado, Chris G Maher, Rob D Herbert, Helen Clare, and James H McAuley BMC Med. 2010; 8: 10. Published online 2010 January 26. doi: 10.1186/1741-7015-8-10.PMCID: PMC2842230 Incidence, detection, and tumour stage of breast cancer in a cohort of Italian women with negative screening mammography report recommending early (short-interval) rescreen Alessandra Ravaioli, Flavia Foca, Americo Colamartini, Fabio Falcini, Carlo Naldoni, Alba C Finarelli, Priscilla Sassoli de Bianchi, and Lauro Bucchi BMC Med. 2010; 8: 11. Published online 2010 February 1. doi: 10.1186/1741-7015-8-11.PMCID: PMC2829482 A functional polymorphism in the DNA methyltransferase-3A promoter modifies the susceptibility in gastric cancer but not in esophageal carcinoma Hong Fan, Dongsheng Liu, Xuemei Qiu, Fengchang Qiao, Qingxiang Wu, Xianwei Su, Feng Zhang, Yunwei Song, Zhujiang Zhao, and Wei Xie BMC Med. 2010; 8: 12. Published online 2010 February 3. doi: 10.1186/1741-7015-8-12.PMCID: PMC2829483 Reduced levels of hydroxylated, polyunsaturated ultra long-chain fatty acids in the serum of colorectal cancer patients: implications for early screening and detection Shawn A Ritchie, Pearson WK Ahiahonu, Dushmanthi Jayasinghe, Doug Heath, Jun Liu, Yingshen Lu, Wei Jin, Amir Kavianpour, Yasuyo Yamazaki, Amin M Khan, Mohammad Hossain, Khine Khine Su-Myat, Paul L Wood, Kevin Krenitsky, Ichiro Takemasa, Masakazu Miyake, Mitsugu Sekimoto, Morito Monden, Hisahiro Matsubara, Fumio Nomura, and Dayan B Goodenowe BMC Med. 2010; 8: 13. Published online 2010 February 15. doi: 10.1186/1741-7015-8-13.PMCID: PMC2833138 Mitf-Mdel, a novel melanocyte/melanoma-specific isoform of microphthalmia-associated transcription factor-M, as a candidate biomarker for melanoma Yixiang Wang, Soroosh Radfar, Suhu Liu, Adam I Riker, and Hung T Khong BMC Med. 2010; 8: 14. Published online 2010 February 17. doi: 10.1186/1741-7015-8-14.PMCID: PMC2839965 Frequency and circumstances of placebo use in clinical practice - a systematic review of empirical studies Margrit Fässler, Karin Meissner, Antonius Schneider, and Klaus Linde BMC Med. 2010; 8: 15. Published online 2010 February 23. doi: 10.1186/1741-7015-8-15.PMCID: PMC2837612 Neonatal seizures in a rural Kenyan District Hospital: aetiology, Incidence and outcome of hospitalization Michael Mwaniki, Ali Mathenge, Samson Gwer, Neema Mturi, Evasius Bauni, Charles RJC Newton, James Berkley, and Richard Idro BMC Med. 2010; 8: 16. Published online 2010 March 17. doi: 10.1186/1741-7015-8-16.PMCID: PMC2846860 The cytoprotective drug amifostine modifies both expression and activity of the pro-angiogenic factor VEGF-A S Dedieu, X Canron, HR Rezvani, M Bouchecareilh, F Mazurier, R Sinisi, M Zanda, M Moenner, A Bikfalvi, and S North BMC Med. 2010; 8: 19. Published online 2010 March 24. doi: 10.1186/1741-7015-8-19.PMCID: PMC2859403 Reporting methods in studies developing prognostic models in cancer: a review Susan Mallett, Patrick Royston, Susan Dutton, Rachel Waters, and Douglas G Altman BMC Med. 2010; 8: 20. Published online 2010 March 30. doi: 10.1186/1741-7015-8-20.PMCID: PMC2856521 Reporting performance of prognostic models in cancer: a review Susan Mallett, Patrick Royston, Rachel Waters, Susan Dutton, and Douglas G Altman BMC Med. 2010; 8: 21. Published online 2010 March 30. doi: 10.1186/1741-7015-8-21.PMCID: PMC2857810 Does targeting manual therapy and/or exercise improve patient outcomes in nonspecific low back pain? A systematic review Peter Kent, Hanne L Mjøsund, and Ditte HD Petersen BMC Med. 2010; 8: 22. Published online 2010 April 8. doi: 10.1186/1741-7015-8-22.PMCID: PMC2873245 Temporal trends in hospitalisation for stroke recurrence following incident hospitalisation for stroke in Scotland James Lewsey, Pardeep S Jhund, Michelle Gillies, Jim WT Chalmers, Adam Redpath, Andrew Briggs, Matthew Walters, Peter Langhorne, Simon Capewell, John JV McMurray, and Kate MacIntyre BMC Med. 2010; 8: 23. Published online 2010 April 9. doi: 10.1186/1741-7015-8-23.PMCID: PMC2859404 Chromosome copy number changes carry prognostic information independent of KIT/PDGFRA point mutations in gastrointestinal stromal tumors Mara Silva, Isabel Veiga, Franclim R Ribeiro, Joana Vieira, Carla Pinto, Manuela Pinheiro, Bárbara Mesquita, Catarina Santos, Marta Soares, José Dinis, Lúcio Santos, Paula Lopes, Mariana Afonso, Carlos Lopes, and Manuel R Teixeira BMC Med. 2010; 8: 26. Published online 2010 May 14. doi: 10.1186/1741-7015-8-26.PMCID: PMC2876987 The normal breast microenvironment of premenopausal women differentially influences the behavior of breast cancer cells in vitro and in vivo Jodie M Fleming, Tyler C Miller, Mariam Quinones, Zhen Xiao, Xia Xu, Matthew J Meyer, Erika Ginsburg, Timothy D Veenstra, and Barbara K Vonderhaar BMC Med. 2010; 8: 27. Published online 2010 May 21. doi: 10.1186/1741-7015-8-27.PMCID: PMC2894739 BODE-Index vs HADO-Score in Chronic Obstructive Pulmonary Disease: Which one to use in general practice? Cristóbal Esteban, José M Quintana, Javier Moraza, Myriam Aburto, Urko Aguirre, José I Aguirregomoscorta, Susana Aizpiri, Luis V Basualdo, and Alberto Capelastegui BMC Med. 2010; 8: 28. Published online 2010 May 24. doi: 10.1186/1741-7015-8-28.PMCID: PMC2880999 Symptomatic treatment (ibuprofen) or antibiotics (ciprofloxacin) for uncomplicated urinary tract infection? - Results of a randomized controlled pilot trial Jutta Bleidorn, Ildikó Gágyor, Michael M Kochen, Karl Wegscheider, and Eva Hummers-Pradier BMC Med. 2010; 8: 30. Published online 2010 May 26. doi: 10.1186/1741-7015-8-30.PMCID: PMC2890534 Physical activity and depressive symptoms in adolescents: a prospective study Catherine Rothon, Phil Edwards, Kamaldeep Bhui, Russell M Viner, Stephanie Taylor, and Stephen A Stansfeld BMC Med. 2010; 8: 32. Published online 2010 May 28. doi: 10.1186/1741-7015-8-32.PMCID: PMC2895574 US public opinion regarding proposed limits on resident physician work hours Alexander B Blum, Farbod Raiszadeh, Sandra Shea, David Mermin, Peter Lurie, Christopher P Landrigan, and Charles A Czeisler BMC Med. 2010; 8: 33. Published online 2010 June 1. doi: 10.1186/1741-7015-8-33.PMCID: PMC2901227 Triple antiplatelet therapy for preventing vascular events: a systematic review and meta-analysis Chamila Geeganage, Robert Wilcox, and Philip MW Bath BMC Med. 2010; 8: 36. Published online 2010 June 16. doi: 10.1186/1741-7015-8-36.PMCID: PMC2893089 Reviews Biomarkers in acute myocardial infarction Daniel Chan and Leong L Ng BMC Med. 2010; 8: 34. Published online 2010 June 7. doi: 10.1186/1741-7015-8-34.PMCID: PMC2898678 Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan H Teede, A Deeks, and L Moran BMC Med. 2010; 8: 41. Published online 2010 June 30. doi: 10.1186/1741-7015-8-41.PMCID: PMC2909929 Zinc Finger Nucleases as tools to understand and treat human diseases David Davis and David Stokoe BMC Med. 2010; 8: 42. Published online 2010 July 1. doi: 10.1186/1741-7015-8-42.PMCID: PMC2904710 Managing hyperemesis gravidarum: a multimodal challenge JK Jueckstock, R Kaestner, and I Mylonas BMC Med. 2010; 8: 46. Published online 2010 July 15. doi: 10.1186/1741-7015-8-46.PMCID: PMC2913953 Correction Development of lower limb range of motion from early childhood to adolescence in cerebral palsy: a population-based study Eva Nordmark, Gunnar Hägglund, Henrik Lauge-Pedersen, Philippe Wagner, and Lena Westbom BMC Med. 2010; 8: 49. Published online 2010 July 28. doi: 10.1186/1741-7015-8-49.PMCID: PMC2917393 Corrects: Eva Nordmark, et al. Development of lower limb range of motion from early childhood to adolescence in cerebral palsy: a population-based study. BMC Med. 2009; 7: 65.
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