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Volume 112(11);  2015 Mar 17

Articles from this journal are usually available in PMC after a 6-month delay (embargo). Some articles may be available sooner.

This Week in PNAS

In This Issue
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3171–3172. Published online 2015 Mar 17. doi: 10.1073/iti1115112
PMCID:
PMC4371961

Letters

Big changes before big birthdays? Panel data provide no evidence of end-of-decade crises
Simon Kühne, Thorsten Schneider, David Richter
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1170. Published online 2015 Feb 18. doi: 10.1073/pnas.1424903112
PMCID:
PMC4371915
Reply to Kühne et al.: Still good evidence that people search for meaning when they approach a new decade in chronological age
Adam L. Alter, Hal E. Hershfield
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1171. Published online 2015 Feb 18. doi: 10.1073/pnas.1500787112
PMCID:
PMC4371988
Titin ruler hypothesis not refuted
Larissa Tskhovrebova, Pauline Bennett, Mathias Gautel, John Trinick
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1172. Published online 2015 Feb 18. doi: 10.1073/pnas.1422326112
PMCID:
PMC4371926
Reply to Tskhovrebova et al.: Titin’s IA junction does not control thick filament length
Henk L. Granzier
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1173. Published online 2015 Feb 18. doi: 10.1073/pnas.1500871112
PMCID:
PMC4371903

Inner Workings

David J. Harris
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3176–3177. Published online 2015 Mar 17. doi: 10.1073/pnas.1500872112
PMCID:
PMC4371921

Commentaries

Hubble’s Law and the expanding universe
Neta A. Bahcall
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3173–3175. Published online 2015 Mar 17. doi: 10.1073/pnas.1424299112
PMCID:
PMC4371983
Circulating tumor-derived DNA is shorter than somatic DNA in plasma
Florent Mouliere, Nitzan Rosenfeld
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3178–3179. Published online 2015 Mar 2. doi: 10.1073/pnas.1501321112
PMCID:
PMC4371901
Mitochondrial metabolism is regulated by thioredoxin
Ian Max Møller
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3180–3181. Published online 2015 Mar 9. doi: 10.1073/pnas.1502425112
PMCID:
PMC4371930
Stimulating minds to wander
James M. Broadway, Claire M. Zedelius, Benjamin W. Mooneyham, Michael D. Mrazek, Jonathan W. Schooler
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3182–3183. Published online 2015 Mar 9. doi: 10.1073/pnas.1503093112
PMCID:
PMC4371902
Cortical computation in mammals and birds
Kenneth D. Harris
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3184–3185. Published online 2015 Mar 9. doi: 10.1073/pnas.1502209112
PMCID:
PMC4371977

PNAS Plus Significance Statements

PNAS Plus Significance Statements
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3186–3190. Published online 2015 Mar 17. doi: 10.1073/pnas.ss11211
PMCID:
PMC4371948

PNAS Plus

Huixia Luo, Weiwei Xie, Jing Tao, Hiroyuki Inoue, András Gyenis, Jason W. Krizan, Ali Yazdani, Yimei Zhu, Robert Joseph Cava
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1174–E1180. Published online 2015 Mar 3. doi: 10.1073/pnas.1502460112
PMCID:
PMC4371928
Comprehensive analysis of heterotrimeric G-protein complex diversity and their interactions with GPCRs in solution
Matthias Hillenbrand, Christian Schori, Jendrik Schöppe, Andreas Plückthun
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1181–E1190. Published online 2015 Mar 2. doi: 10.1073/pnas.1417573112
PMCID:
PMC4371982
Dramatically reduced spliceosome in Cyanidioschyzon merolae
Martha R. Stark, Elizabeth A. Dunn, William S. C. Dunn, Cameron J. Grisdale, Anthony R. Daniele, Matthew R. G. Halstead, Naomi M. Fast, Stephen D. Rader
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1191–E1200. Published online 2015 Mar 2. doi: 10.1073/pnas.1416879112
PMCID:
PMC4371933
Olena Pylypenko, Lin Song, Ai Shima, Zhaohui Yang, Anne M. Houdusse, H. Lee Sweeney
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1201–E1209. Published online 2015 Mar 6. doi: 10.1073/pnas.1420989112
PMCID:
PMC4371908
BRUCE regulates DNA double-strand break response by promoting USP8 deubiquitination of BRIT1
Chunmin Ge, Lixiao Che, Jinyu Ren, Raj K. Pandita, Jing Lu, Kaiyi Li, Tej K. Pandita, Chunying Du
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1210–E1219. Published online 2015 Mar 2. doi: 10.1073/pnas.1418335112
PMCID:
PMC4371995
Alla Polotskaia, Gu Xiao, Katherine Reynoso, Che Martin, Wei-Gang Qiu, Ronald C. Hendrickson, Jill Bargonetti
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1220–E1229. Published online 2015 Mar 2. doi: 10.1073/pnas.1416318112
PMCID:
PMC4371979
Takuro Nunoura, Yoshihiro Takaki, Miho Hirai, Shigeru Shimamura, Akiko Makabe, Osamu Koide, Tohru Kikuchi, Junichi Miyazaki, Keisuke Koba, Naohiro Yoshida, Michinari Sunamura, Ken Takai
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1230–E1236. Published online 2015 Feb 23. doi: 10.1073/pnas.1421816112
PMCID:
PMC4371994
A. Ross Brown, Stewart F. Owen, James Peters, Yong Zhang, Marta Soffker, Gregory C. Paull, David J. Hosken, M. Abdul Wahab, Charles R. Tyler
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1237–E1246. Published online 2015 Mar 2. doi: 10.1073/pnas.1416269112
PMCID:
PMC4371911
Ryo Futahashi, Ryouka Kawahara-Miki, Michiyo Kinoshita, Kazutoshi Yoshitake, Shunsuke Yajima, Kentaro Arikawa, Takema Fukatsu
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1247–E1256. Published online 2015 Feb 23. doi: 10.1073/pnas.1424670112
PMCID:
PMC4371951
Whole-genome sequence of the Tibetan frog Nanorana parkeri and the comparative evolution of tetrapod genomes
Yan-Bo Sun, Zi-Jun Xiong, Xue-Yan Xiang, Shi-Ping Liu, Wei-Wei Zhou, Xiao-Long Tu, Li Zhong, Lu Wang, Dong-Dong Wu, Bao-Lin Zhang, Chun-Ling Zhu, Min-Min Yang, Hong-Man Chen, Fang Li, Long Zhou, Shao-Hong Feng, Chao Huang, Guo-Jie Zhang, David Irwin, David M. Hillis, Robert W. Murphy, Huan-Ming Yang, Jing Che, Jun Wang, Ya-Ping Zhang
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1257–E1262. Published online 2015 Mar 2. doi: 10.1073/pnas.1501764112
PMCID:
PMC4371989
Yalin Liu, Handong Su, Junling Pang, Zhi Gao, Xiu-Jie Wang, James A. Birchler, Fangpu Han
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1263–E1271. Published online 2015 Mar 2. doi: 10.1073/pnas.1418248112
PMCID:
PMC4371999
Recurrent BCAM-AKT2 fusion gene leads to a constitutively activated AKT2 fusion kinase in high-grade serous ovarian carcinoma
Kalpana Kannan, Cristian Coarfa, Pei-Wen Chao, Liming Luo, Yan Wang, Amy E. Brinegar, Shannon M. Hawkins, Aleksandar Milosavljevic, Martin M. Matzuk, Laising Yen
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1272–E1277. Published online 2015 Mar 2. doi: 10.1073/pnas.1501735112
PMCID:
PMC4371965
Implantable hydrogel embedded dark-gold nanoswitch as a theranostic probe to sense and overcome cancer multidrug resistance
João Conde, Nuria Oliva, Natalie Artzi
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1278–E1287. Published online 2015 Mar 2. doi: 10.1073/pnas.1421229112
PMCID:
PMC4371927
Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer
Anthony C. Faber, Anna F. Farago, Carlotta Costa, Anahita Dastur, Maria Gomez-Caraballo, Rebecca Robbins, Bethany L. Wagner, William M. Rideout, III, Charles T. Jakubik, Jungoh Ham, Elena J. Edelman, Hiromichi Ebi, Alan T. Yeo, Aaron N. Hata, Youngchul Song, Neha U. Patel, Ryan J. March, Ah Ting Tam, Randy J. Milano, Jessica L. Boisvert, Mark A. Hicks, Sarah Elmiligy, Scott E. Malstrom, Miguel N. Rivera, Hisashi Harada, Brad E. Windle, Sridhar Ramaswamy, Cyril H. Benes, Tyler Jacks, Jeffrey A. Engelman
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1288–E1296. Published online 2015 Mar 3. doi: 10.1073/pnas.1411848112
PMCID:
PMC4371986
Nathaniel Washburn, Inessa Schwab, Daniel Ortiz, Naveen Bhatnagar, Jonathan C. Lansing, Amy Medeiros, Steven Tyler, Divya Mekala, Edward Cochran, Hetal Sarvaiya, Kevin Garofalo, Robin Meccariello, James W. Meador, III, Laura Rutitzky, Birgit C. Schultes, Leona Ling, William Avery, Falk Nimmerjahn, Anthony M. Manning, Ganesh V. Kaundinya, Carlos J. Bosques
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1297–E1306. Published online 2015 Mar 2. doi: 10.1073/pnas.1422481112
PMCID:
PMC4371931
Oncogenic fusion protein EWS-FLI1 is a network hub that regulates alternative splicing
Saravana P. Selvanathan, Garrett T. Graham, Hayriye V. Erkizan, Uta Dirksen, Thanemozhi G. Natarajan, Aleksandra Dakic, Songtao Yu, Xuefeng Liu, Michelle T. Paulsen, Mats E. Ljungman, Cathy H. Wu, Elizabeth R. Lawlor, Aykut Üren, Jeffrey A. Toretsky
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1307–E1316. Published online 2015 Mar 3. doi: 10.1073/pnas.1500536112
PMCID:
PMC4371969
Peiyong Jiang, Carol W. M. Chan, K. C. Allen Chan, Suk Hang Cheng, John Wong, Vincent Wai-Sun Wong, Grace L. H. Wong, Stephen L. Chan, Tony S. K. Mok, Henry L. Y. Chan, Paul B. S. Lai, Rossa W. K. Chiu, Y. M. Dennis Lo
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1317–E1325. Published online 2015 Feb 2. doi: 10.1073/pnas.1500076112
PMCID:
PMC4372002
Disentangling mechanisms that mediate the balance between stochastic and deterministic processes in microbial succession
Francisco Dini-Andreote, James C. Stegen, Jan Dirk van Elsas, Joana Falcão Salles
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1326–E1332. Published online 2015 Mar 2. doi: 10.1073/pnas.1414261112
PMCID:
PMC4371938
NFκB activation by modified vaccinia virus as a novel strategy to enhance neutrophil migration and HIV-specific T-cell responses
Mauro Di Pilato, Ernesto Mejías-Pérez, Manuela Zonca, Beatriz Perdiguero, Carmen Elena Gómez, Marianna Trakala, Jacobo Nieto, José Luis Nájera, Carlos Oscar S. Sorzano, Christophe Combadière, Giuseppe Pantaleo, Lourdes Planelles, Mariano Esteban
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1333–E1342. Published online 2015 Mar 4. doi: 10.1073/pnas.1424341112
PMCID:
PMC4371968
Mirela D’arc, Ahidjo Ayouba, Amandine Esteban, Gerald H. Learn, Vanina Boué, Florian Liegeois, Lucie Etienne, Nikki Tagg, Fabian H. Leendertz, Christophe Boesch, Nadège F. Madinda, Martha M. Robbins, Maryke Gray, Amandine Cournil, Marcel Ooms, Michael Letko, Viviana A. Simon, Paul M. Sharp, Beatrice H. Hahn, Eric Delaporte, Eitel Mpoudi Ngole, Martine Peeters
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1343–E1352. Published online 2015 Mar 2. doi: 10.1073/pnas.1502022112
PMCID:
PMC4371950
Disruption of hierarchical predictive coding during sleep
Melanie Strauss, Jacobo D. Sitt, Jean-Remi King, Maxime Elbaz, Leila Azizi, Marco Buiatti, Lionel Naccache, Virginie van Wassenhove, Stanislas Dehaene
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1353–E1362. Published online 2015 Mar 3. doi: 10.1073/pnas.1501026112
PMCID:
PMC4371991
Activation of TRPM3 by a potent synthetic ligand reveals a role in peptide release
Katharina Held, Tatjana Kichko, Katrien De Clercq, Hugo Klaassen, Rieta Van Bree, Jean-Christophe Vanherck, Arnaud Marchand, Peter W. Reeh, Patrick Chaltin, Thomas Voets, Joris Vriens
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1363–E1372. Published online 2015 Mar 2. doi: 10.1073/pnas.1419845112
PMCID:
PMC4371942
Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation
Wuyang Wang, Qiong Gao, Meimei Yang, Xiaoli Zhang, Lu Yu, Maria Lawas, Xinran Li, Marthe Bryant-Genevier, Noel T. Southall, Juan Marugan, Marc Ferrer, Haoxing Xu
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1373–E1381. Published online 2015 Mar 2. doi: 10.1073/pnas.1419669112
PMCID:
PMC4371935
Activation of protein synthesis in mouse uterine epithelial cells by estradiol-17β is mediated by a PKC–ERK1/2–mTOR signaling pathway
Yuxiang Wang, Liyin Zhu, Satu Kuokkanen, Jeffrey W. Pollard
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1382–E1391. Published online 2015 Mar 2. doi: 10.1073/pnas.1418973112
PMCID:
PMC4371960
Thioredoxin, a master regulator of the tricarboxylic acid cycle in plant mitochondria
Danilo M. Daloso, Karolin Müller, Toshihiro Obata, Alexandra Florian, Takayuki Tohge, Alexandra Bottcher, Christophe Riondet, Laetitia Bariat, Fernando Carrari, Adriano Nunes-Nesi, Bob B. Buchanan, Jean-Philippe Reichheld, Wagner L. Araújo, Alisdair R. Fernie
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1392–E1400. Published online 2015 Feb 2. doi: 10.1073/pnas.1424840112
PMCID:
PMC4371975

Physical Sciences

Applied Physical Sciences

Wenhao Sun, Saivenkataraman Jayaraman, Wei Chen, Kristin A. Persson, Gerbrand Ceder
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3199–3204. Published online 2015 Mar 4. doi: 10.1073/pnas.1423898112
PMCID:
PMC4371997
Huixia Luo, Weiwei Xie, Jing Tao, Hiroyuki Inoue, András Gyenis, Jason W. Krizan, Ali Yazdani, Yimei Zhu, Robert Joseph Cava
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1174–E1180. Published online 2015 Mar 3. doi: 10.1073/pnas.1502460112
PMCID:
PMC4371928

Chemistry

Stephanie Brown, Marc Clastre, Vincent Courdavault, Sarah E. O’Connor
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3205–3210. Published online 2015 Feb 9. doi: 10.1073/pnas.1423555112
PMCID:
PMC4371906
Glutathione and multidrug resistance protein transporter mediate a self-propelled disposal of bismuth in human cells
Yifan Hong, Yau-Tsz Lai, Godfrey Chi-Fung Chan, Hongzhe Sun
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3211–3216. Published online 2015 Mar 3. doi: 10.1073/pnas.1421002112
PMCID:
PMC4371909
Spray-combustion synthesis: Efficient solution route to high-performance oxide transistors
Xinge Yu, Jeremy Smith, Nanjia Zhou, Li Zeng, Peijun Guo, Yu Xia, Ana Alvarez, Stefano Aghion, Hui Lin, Junsheng Yu, Robert P. H. Chang, Michael J. Bedzyk, Rafael Ferragut, Tobin J. Marks, Antonio Facchetti
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3217–3222. Published online 2015 Mar 2. doi: 10.1073/pnas.1501548112
PMCID:
PMC4371916
Structure of superhard tungsten tetraboride: A missing link between MB2 and MB12 higher borides
Andrew T. Lech, Christopher L. Turner, Reza Mohammadi, Sarah H. Tolbert, Richard B. Kaner
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3223–3228. Published online 2015 Mar 2. doi: 10.1073/pnas.1415018112
PMCID:
PMC4371990
Two-dimensional IR spectroscopy of the anti-HIV agent KP1212 reveals protonated and neutral tautomers that influence pH-dependent mutagenicity
Chunte Sam Peng, Bogdan I. Fedeles, Vipender Singh, Deyu Li, Tiffany Amariuta, John M. Essigmann, Andrei Tokmakoff
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3229–3234. Published online 2015 Mar 2. doi: 10.1073/pnas.1415974112
PMCID:
PMC4371980
Locating landmarks on high-dimensional free energy surfaces
Ming Chen, Tang-Qing Yu, Mark E. Tuckerman
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3235–3240. Published online 2015 Mar 3. doi: 10.1073/pnas.1418241112
PMCID:
PMC4371946

Earth, Atmospheric, and Planetary Sciences

Hubble’s Law and the expanding universe
Neta A. Bahcall
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3173–3175. Published online 2015 Mar 17. doi: 10.1073/pnas.1424299112
PMCID:
PMC4371983
Climate change in the Fertile Crescent and implications of the recent Syrian drought
Colin P. Kelley, Shahrzad Mohtadi, Mark A. Cane, Richard Seager, Yochanan Kushnir
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3241–3246. Published online 2015 Mar 2. doi: 10.1073/pnas.1421533112
PMCID:
PMC4371967
Galen Gorski, Courtenay Strong, Stephen P. Good, Ryan Bares, James R. Ehleringer, Gabriel J. Bowen
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3247–3252. Published online 2015 Mar 2. doi: 10.1073/pnas.1424728112
PMCID:
PMC4371996
Anastasios A. Tsonis, Ethan R. Deyle, Robert M. May, George Sugihara, Kyle Swanson, Joshua D. Verbeten, Geli Wang
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3253–3256. Published online 2015 Mar 2. doi: 10.1073/pnas.1420291112
PMCID:
PMC4371914
N. Devaraju, Govindasamy Bala, Angshuman Modak
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3257–3262. Published online 2015 Mar 2. doi: 10.1073/pnas.1423439112
PMCID:
PMC4371945
Yan Liu, John C. Moore, Xiao Cheng, Rupert M. Gladstone, Jeremy N. Bassis, Hongxing Liu, Jiahong Wen, Fengming Hui
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3263–3268. Published online 2015 Mar 2. doi: 10.1073/pnas.1415137112
PMCID:
PMC4371949

Engineering

Quorum-sensing Salmonella selectively trigger protein expression within tumors
Charles A. Swofford, Nele Van Dessel, Neil S. Forbes
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3457–3462. Published online 2015 Mar 3. doi: 10.1073/pnas.1414558112
PMCID:
PMC4371937
Implantable hydrogel embedded dark-gold nanoswitch as a theranostic probe to sense and overcome cancer multidrug resistance
João Conde, Nuria Oliva, Natalie Artzi
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1278–E1287. Published online 2015 Mar 2. doi: 10.1073/pnas.1421229112
PMCID:
PMC4371927

Physics

n-type thermoelectric material Mg2Sn0.75Ge0.25 for high power generation
Weishu Liu, Hee Seok Kim, Shuo Chen, Qing Jie, Bing Lv, Mengliang Yao, Zhensong Ren, Cyril P. Opeil, Stephen Wilson, Ching-Wu Chu, Zhifeng Ren
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3269–3274. Published online 2015 Mar 2. doi: 10.1073/pnas.1424388112
PMCID:
PMC4371904
The second laws of quantum thermodynamics
Fernando Brandão, Michał Horodecki, Nelly Ng, Jonathan Oppenheim, Stephanie Wehner
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3275–3279. Published online 2015 Feb 9. doi: 10.1073/pnas.1411728112
PMCID:
PMC4372001
Kelvin–Helmholtz instability in an ultrathin air film causes drop splashing on smooth surfaces
Yuan Liu, Peng Tan, Lei Xu
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3280–3284. Published online 2015 Feb 23. doi: 10.1073/pnas.1417718112
PMCID:
PMC4371919
Avoided valence transition in a plutonium superconductor
B. J. Ramshaw, Arkady Shekhter, Ross D. McDonald, Jon B. Betts, J. N. Mitchell, P. H. Tobash, C. H. Mielke, E. D. Bauer, Albert Migliori
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3285–3289. Published online 2015 Mar 3. doi: 10.1073/pnas.1421174112
PMCID:
PMC4371925
Jens Klinder, Hans Keßler, Matthias Wolke, Ludwig Mathey, Andreas Hemmerich
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3290–3295. Published online 2015 Mar 2. doi: 10.1073/pnas.1417132112
PMCID:
PMC4371957

Social Sciences

Anthropology

Core questions in domestication research
Melinda A. Zeder
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3191–3198. Published online 2015 Feb 20. doi: 10.1073/pnas.1501711112
PMCID:
PMC4371924
Impacts of biological globalization in the Mediterranean: Unveiling the deep history of human-mediated gamebird dispersal
Giovanni Forcina, Monica Guerrini, Hein van Grouw, Brij K. Gupta, Panicos Panayides, Pantelis Hadjigerou, Omar F. Al-Sheikhly, Muhammad N. Awan, Aleem A. Khan, Melinda A. Zeder, Filippo Barbanera
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3296–3301. Published online 2015 Mar 2. doi: 10.1073/pnas.1500677112
PMCID:
PMC4371972
Evidence for recent, population-specific evolution of the human mutation rate
Kelley Harris
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3439–3444. Published online 2015 Mar 2. doi: 10.1073/pnas.1418652112
PMCID:
PMC4371947

Environmental Sciences

Climate change in the Fertile Crescent and implications of the recent Syrian drought
Colin P. Kelley, Shahrzad Mohtadi, Mark A. Cane, Richard Seager, Yochanan Kushnir
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3241–3246. Published online 2015 Mar 2. doi: 10.1073/pnas.1421533112
PMCID:
PMC4371967
Galen Gorski, Courtenay Strong, Stephen P. Good, Ryan Bares, James R. Ehleringer, Gabriel J. Bowen
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3247–3252. Published online 2015 Mar 2. doi: 10.1073/pnas.1424728112
PMCID:
PMC4371996

Political Sciences

Prepregnancy body mass and weight gain during pregnancy in India and sub-Saharan Africa
Diane Coffey
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3302–3307. Published online 2015 Mar 2. doi: 10.1073/pnas.1416964112
PMCID:
PMC4371959

Psychological and Cognitive Sciences

Stimulating minds to wander
James M. Broadway, Claire M. Zedelius, Benjamin W. Mooneyham, Michael D. Mrazek, Jonathan W. Schooler
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3182–3183. Published online 2015 Mar 9. doi: 10.1073/pnas.1503093112
PMCID:
PMC4371902
Meghan H. Puglia, Travis S. Lillard, James P. Morris, Jessica J. Connelly
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3308–3313. Published online 2015 Feb 9. doi: 10.1073/pnas.1422096112
PMCID:
PMC4372000
Increasing propensity to mind-wander with transcranial direct current stimulation
Vadim Axelrod, Geraint Rees, Michal Lavidor, Moshe Bar
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3314–3319. Published online 2015 Feb 17. doi: 10.1073/pnas.1421435112
PMCID:
PMC4371998
Big changes before big birthdays? Panel data provide no evidence of end-of-decade crises
Simon Kühne, Thorsten Schneider, David Richter
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1170. Published online 2015 Feb 18. doi: 10.1073/pnas.1424903112
PMCID:
PMC4371915
Reply to Kühne et al.: Still good evidence that people search for meaning when they approach a new decade in chronological age
Adam L. Alter, Hal E. Hershfield
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1171. Published online 2015 Feb 18. doi: 10.1073/pnas.1500787112
PMCID:
PMC4371988
Disruption of hierarchical predictive coding during sleep
Melanie Strauss, Jacobo D. Sitt, Jean-Remi King, Maxime Elbaz, Leila Azizi, Marco Buiatti, Lionel Naccache, Virginie van Wassenhove, Stanislas Dehaene
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1353–E1362. Published online 2015 Mar 3. doi: 10.1073/pnas.1501026112
PMCID:
PMC4371991

Biological Sciences

Applied Biological Sciences

Antigen specificity can be irrelevant to immunocytokine efficacy and biodistribution
Alice Tzeng, Byron H. Kwan, Cary F. Opel, Tejas Navaratna, K. Dane Wittrup
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3320–3325. Published online 2015 Mar 2. doi: 10.1073/pnas.1416159112
PMCID:
PMC4371941

Biochemistry

Stephanie Brown, Marc Clastre, Vincent Courdavault, Sarah E. O’Connor
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3205–3210. Published online 2015 Feb 9. doi: 10.1073/pnas.1423555112
PMCID:
PMC4371906
Steric clashes with bound OMP peptides activate the DegS stress-response protease
Anna K. de Regt, Tania A. Baker, Robert T. Sauer
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3326–3331. Published online 2015 Mar 2. doi: 10.1073/pnas.1502372112
PMCID:
PMC4371955
Functional analysis of (4S)-limonene synthase mutants reveals determinants of catalytic outcome in a model monoterpene synthase
Narayanan Srividya, Edward M. Davis, Rodney B. Croteau, B. Markus Lange
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3332–3337. Published online 2015 Mar 2. doi: 10.1073/pnas.1501203112
PMCID:
PMC4371936
Rationally designed fluorogenic protease reporter visualizes spatiotemporal dynamics of apoptosis in vivo
Tsz-Leung To, Beverly J. Piggott, Kalpana Makhijani, Dan Yu, Yuh Nung Jan, Xiaokun Shu
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3338–3343. Published online 2015 Mar 2. doi: 10.1073/pnas.1502857112
PMCID:
PMC4371907
Shangyu Dang, Shenjie Wu, Jiawei Wang, Hongbo Li, Min Huang, Wei He, Yue-Ming Li, Catherine C. L. Wong, Yigong Shi
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3344–3349. Published online 2015 Mar 2. doi: 10.1073/pnas.1502150112
PMCID:
PMC4371958
Atg13 HORMA domain recruits Atg9 vesicles during autophagosome formation
Sho W. Suzuki, Hayashi Yamamoto, Yu Oikawa, Chika Kondo-Kakuta, Yayoi Kimura, Hisashi Hirano, Yoshinori Ohsumi
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3350–3355. Published online 2015 Mar 3. doi: 10.1073/pnas.1421092112
PMCID:
PMC4371973
Narinobu Juge, Sawako Moriyama, Takaaki Miyaji, Mamiyo Kawakami, Haruka Iwai, Tomoya Fukui, Nathan Nelson, Hiroshi Omote, Yoshinori Moriyama
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3356–3361. Published online 2015 Mar 2. doi: 10.1073/pnas.1417102112
PMCID:
PMC4371956
Comprehensive analysis of heterotrimeric G-protein complex diversity and their interactions with GPCRs in solution
Matthias Hillenbrand, Christian Schori, Jendrik Schöppe, Andreas Plückthun
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1181–E1190. Published online 2015 Mar 2. doi: 10.1073/pnas.1417573112
PMCID:
PMC4371982
Dramatically reduced spliceosome in Cyanidioschyzon merolae
Martha R. Stark, Elizabeth A. Dunn, William S. C. Dunn, Cameron J. Grisdale, Anthony R. Daniele, Matthew R. G. Halstead, Naomi M. Fast, Stephen D. Rader
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1191–E1200. Published online 2015 Mar 2. doi: 10.1073/pnas.1416879112
PMCID:
PMC4371933
Olena Pylypenko, Lin Song, Ai Shima, Zhaohui Yang, Anne M. Houdusse, H. Lee Sweeney
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1201–E1209. Published online 2015 Mar 6. doi: 10.1073/pnas.1420989112
PMCID:
PMC4371908

Biophysics and Computational Biology

Christopher Bergevin, Geoffrey A. Manley, Christine Köppl
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3362–3367. Published online 2015 Mar 3. doi: 10.1073/pnas.1418569112
PMCID:
PMC4371923
Electron crystallography of ultrathin 3D protein crystals: Atomic model with charges
Koji Yonekura, Kazuyuki Kato, Mitsuo Ogasawara, Masahiro Tomita, Chikashi Toyoshima
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3368–3373. Published online 2015 Feb 17. doi: 10.1073/pnas.1500724112
PMCID:
PMC4372003
Conformation and dynamics of the Gag polyprotein of the human immunodeficiency virus 1 studied by NMR spectroscopy
Lalit Deshmukh, Rodolfo Ghirlando, G. Marius Clore
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3374–3379. Published online 2015 Feb 23. doi: 10.1073/pnas.1501985112
PMCID:
PMC4371905
Nanomechanics and intermolecular forces of amyloid revealed by four-dimensional electron microscopy
Anthony W. P. Fitzpatrick, Giovanni M. Vanacore, Ahmed H. Zewail
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3380–3385. Published online 2015 Mar 2. doi: 10.1073/pnas.1502214112
PMCID:
PMC4371943
L596–W733 bond between the start of the S4–S5 linker and the TRP box stabilizes the closed state of TRPV4 channel
Jinfeng Teng, Stephen H. Loukin, Andriy Anishkin, Ching Kung
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3386–3391. Published online 2015 Mar 3. doi: 10.1073/pnas.1502366112
PMCID:
PMC4371962
Pigeons trade efficiency for stability in response to level of challenge during confined flight
C. David Williams, Andrew A. Biewener
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3392–3396. Published online 2015 Mar 2. doi: 10.1073/pnas.1407298112
PMCID:
PMC4371974
Mutation of a single residue in the ba3 oxidase specifically impairs protonation of the pump site
Christoph von Ballmoos, Nathalie Gonska, Peter Lachmann, Robert B. Gennis, Pia Ädelroth, Peter Brzezinski
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3397–3402. Published online 2015 Mar 2. doi: 10.1073/pnas.1422434112
PMCID:
PMC4371939
Cation-induced kinetic heterogeneity of the intron–exon recognition in single group II introns
Danny Kowerko, Sebastian L. B. König, Miriam Skilandat, Daniela Kruschel, Mélodie C. A. S. Hadzic, Lucia Cardo, Roland K. O. Sigel
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3403–3408. Published online 2015 Mar 3. doi: 10.1073/pnas.1322759112
PMCID:
PMC4371910
Structure and dynamics of the MKK7–JNK signaling complex
Jaka Kragelj, Andrés Palencia, Max H. Nanao, Damien Maurin, Guillaume Bouvignies, Martin Blackledge, Malene Ringkjøbing Jensen
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3409–3414. Published online 2015 Mar 3. doi: 10.1073/pnas.1419528112
PMCID:
PMC4371970

Cell Biology

Endocannabinoids are conserved inhibitors of the Hedgehog pathway
Helena Khaliullina, Mesut Bilgin, Julio L. Sampaio, Andrej Shevchenko, Suzanne Eaton
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3415–3420. Published online 2015 Mar 2. doi: 10.1073/pnas.1416463112
PMCID:
PMC4371992
Genomically amplified Akt3 activates DNA repair pathway and promotes glioma progression
Kristen M. Turner, Youting Sun, Ping Ji, Kirsi J. Granberg, Brady Bernard, Limei Hu, David E. Cogdell, Xinhui Zhou, Olli Yli-Harja, Matti Nykter, Ilya Shmulevich, W. K. Alfred Yung, Gregory N. Fuller, Wei Zhang
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3421–3426. Published online 2015 Mar 3. doi: 10.1073/pnas.1414573112
PMCID:
PMC4371922
BRUCE regulates DNA double-strand break response by promoting USP8 deubiquitination of BRIT1
Chunmin Ge, Lixiao Che, Jinyu Ren, Raj K. Pandita, Jing Lu, Kaiyi Li, Tej K. Pandita, Chunying Du
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1210–E1219. Published online 2015 Mar 2. doi: 10.1073/pnas.1418335112
PMCID:
PMC4371995
Alla Polotskaia, Gu Xiao, Katherine Reynoso, Che Martin, Wei-Gang Qiu, Ronald C. Hendrickson, Jill Bargonetti
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1220–E1229. Published online 2015 Mar 2. doi: 10.1073/pnas.1416318112
PMCID:
PMC4371979

Ecology

Rapid behavioral maturation accelerates failure of stressed honey bee colonies
Clint J. Perry, Eirik Søvik, Mary R. Myerscough, Andrew B. Barron
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3427–3432. Published online 2015 Feb 9. doi: 10.1073/pnas.1422089112
PMCID:
PMC4371971
Matthew G. Betts, Adam S. Hadley, W. John Kress
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3433–3438. Published online 2015 Mar 2. doi: 10.1073/pnas.1419522112
PMCID:
PMC4371984
Takuro Nunoura, Yoshihiro Takaki, Miho Hirai, Shigeru Shimamura, Akiko Makabe, Osamu Koide, Tohru Kikuchi, Junichi Miyazaki, Keisuke Koba, Naohiro Yoshida, Michinari Sunamura, Ken Takai
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1230–E1236. Published online 2015 Feb 23. doi: 10.1073/pnas.1421816112
PMCID:
PMC4371994

Environmental Sciences

A. Ross Brown, Stewart F. Owen, James Peters, Yong Zhang, Marta Soffker, Gregory C. Paull, David J. Hosken, M. Abdul Wahab, Charles R. Tyler
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1237–E1246. Published online 2015 Mar 2. doi: 10.1073/pnas.1416269112
PMCID:
PMC4371911

Evolution

Core questions in domestication research
Melinda A. Zeder
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3191–3198. Published online 2015 Feb 20. doi: 10.1073/pnas.1501711112
PMCID:
PMC4371924
Evidence for recent, population-specific evolution of the human mutation rate
Kelley Harris
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3439–3444. Published online 2015 Mar 2. doi: 10.1073/pnas.1418652112
PMCID:
PMC4371947
Ryo Futahashi, Ryouka Kawahara-Miki, Michiyo Kinoshita, Kazutoshi Yoshitake, Shunsuke Yajima, Kentaro Arikawa, Takema Fukatsu
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1247–E1256. Published online 2015 Feb 23. doi: 10.1073/pnas.1424670112
PMCID:
PMC4371951
Whole-genome sequence of the Tibetan frog Nanorana parkeri and the comparative evolution of tetrapod genomes
Yan-Bo Sun, Zi-Jun Xiong, Xue-Yan Xiang, Shi-Ping Liu, Wei-Wei Zhou, Xiao-Long Tu, Li Zhong, Lu Wang, Dong-Dong Wu, Bao-Lin Zhang, Chun-Ling Zhu, Min-Min Yang, Hong-Man Chen, Fang Li, Long Zhou, Shao-Hong Feng, Chao Huang, Guo-Jie Zhang, David Irwin, David M. Hillis, Robert W. Murphy, Huan-Ming Yang, Jing Che, Jun Wang, Ya-Ping Zhang
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1257–E1262. Published online 2015 Mar 2. doi: 10.1073/pnas.1501764112
PMCID:
PMC4371989

Genetics

Impacts of biological globalization in the Mediterranean: Unveiling the deep history of human-mediated gamebird dispersal
Giovanni Forcina, Monica Guerrini, Hein van Grouw, Brij K. Gupta, Panicos Panayides, Pantelis Hadjigerou, Omar F. Al-Sheikhly, Muhammad N. Awan, Aleem A. Khan, Melinda A. Zeder, Filippo Barbanera
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3296–3301. Published online 2015 Mar 2. doi: 10.1073/pnas.1500677112
PMCID:
PMC4371972
Meghan H. Puglia, Travis S. Lillard, James P. Morris, Jessica J. Connelly
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3308–3313. Published online 2015 Feb 9. doi: 10.1073/pnas.1422096112
PMCID:
PMC4372000
Systematic discovery of regulated and conserved alternative exons in the mammalian brain reveals NMD modulating chromatin regulators
Qinghong Yan, Sebastien M. Weyn-Vanhentenryck, Jie Wu, Steven A. Sloan, Ye Zhang, Kenian Chen, Jia Qian Wu, Ben A. Barres, Chaolin Zhang
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3445–3450. Published online 2015 Mar 3. doi: 10.1073/pnas.1502849112
PMCID:
PMC4371929
Horizontal gene transfer and gene dosage drives adaptation to wood colonization in a tree pathogen
Braham Dhillon, Nicolas Feau, Andrea L. Aerts, Stéphanie Beauseigle, Louis Bernier, Alex Copeland, Adam Foster, Navdeep Gill, Bernard Henrissat, Padmini Herath, Kurt M. LaButti, Anthony Levasseur, Erika A. Lindquist, Eline Majoor, Robin A. Ohm, Jasmyn L. Pangilinan, Amadeus Pribowo, John N. Saddler, Monique L. Sakalidis, Ronald P. de Vries, Igor V. Grigoriev, Stephen B. Goodwin, Philippe Tanguay, Richard C. Hamelin
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3451–3456. Published online 2015 Mar 2. doi: 10.1073/pnas.1424293112
PMCID:
PMC4371944
Yalin Liu, Handong Su, Junling Pang, Zhi Gao, Xiu-Jie Wang, James A. Birchler, Fangpu Han
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1263–E1271. Published online 2015 Mar 2. doi: 10.1073/pnas.1418248112
PMCID:
PMC4371999
Recurrent BCAM-AKT2 fusion gene leads to a constitutively activated AKT2 fusion kinase in high-grade serous ovarian carcinoma
Kalpana Kannan, Cristian Coarfa, Pei-Wen Chao, Liming Luo, Yan Wang, Amy E. Brinegar, Shannon M. Hawkins, Aleksandar Milosavljevic, Martin M. Matzuk, Laising Yen
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1272–E1277. Published online 2015 Mar 2. doi: 10.1073/pnas.1501735112
PMCID:
PMC4371965

Medical Sciences

Circulating tumor-derived DNA is shorter than somatic DNA in plasma
Florent Mouliere, Nitzan Rosenfeld
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3178–3179. Published online 2015 Mar 2. doi: 10.1073/pnas.1501321112
PMCID:
PMC4371901
Quorum-sensing Salmonella selectively trigger protein expression within tumors
Charles A. Swofford, Nele Van Dessel, Neil S. Forbes
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3457–3462. Published online 2015 Mar 3. doi: 10.1073/pnas.1414558112
PMCID:
PMC4371937
Insulin resistance in brain alters dopamine turnover and causes behavioral disorders
Andre Kleinridders, Weikang Cai, Laura Cappellucci, Armen Ghazarian, William R. Collins, Sara G. Vienberg, Emmanuel N. Pothos, C. Ronald Kahn
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3463–3468. Published online 2015 Mar 2. doi: 10.1073/pnas.1500877112
PMCID:
PMC4371978
The RNA binding protein FXR1 is a new driver in the 3q26-29 amplicon and predicts poor prognosis in human cancers
Jun Qian, Mohamed Hassanein, Megan D. Hoeksema, Bradford K. Harris, Yong Zou, Heidi Chen, Pengcheng Lu, Rosana Eisenberg, Jing Wang, Allan Espinosa, Xiangming Ji, Fredrick T. Harris, S. M. Jamshedur Rahman, Pierre P. Massion
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3469–3474. Published online 2015 Mar 2. doi: 10.1073/pnas.1421975112
PMCID:
PMC4371932
Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics
Jan Balzarini, Kalyan Das, Jean A. Bernatchez, Sergio E. Martinez, Marianne Ngure, Sarah Keane, Alan Ford, Nuala Maguire, Niki Mullins, Jubi John, Youngju Kim, Wim Dehaen, Johan Vande Voorde, Sandra Liekens, Lieve Naesens, Matthias Götte, Anita R. Maguire, Eddy Arnold
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3475–3480. Published online 2015 Mar 2. doi: 10.1073/pnas.1420233112
PMCID:
PMC4371953
Macronutrient balance, reproductive function, and lifespan in aging mice
Samantha M. Solon-Biet, Kirsty A. Walters, Ulla K. Simanainen, Aisling C. McMahon, Kari Ruohonen, John William O. Ballard, David Raubenheimer, David J. Handelsman, David G. Le Couteur, Stephen J. Simpson
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3481–3486. Published online 2015 Mar 2. doi: 10.1073/pnas.1422041112
PMCID:
PMC4371964
Lei Xiong, Ji-Ung Jung, Haitao Wu, Wen-Fang Xia, Jin-Xiu Pan, Chengyong Shen, Lin Mei, Wen-Cheng Xiong
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3487–3492. Published online 2015 Mar 2. doi: 10.1073/pnas.1419714112
PMCID:
PMC4371963
Helen Y. Zou, Qiuhua Li, Lars D. Engstrom, Melissa West, Vicky Appleman, Katy A. Wong, Michele McTigue, Ya-Li Deng, Wei Liu, Alexei Brooun, Sergei Timofeevski, Scott R. P. McDonnell, Ping Jiang, Matthew D. Falk, Patrick B. Lappin, Timothy Affolter, Tim Nichols, Wenyue Hu, Justine Lam, Ted W. Johnson, Tod Smeal, Al Charest, Valeria R. Fantin
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3493–3498. Published online 2015 Mar 2. doi: 10.1073/pnas.1420785112
PMCID:
PMC4371934
p63 sustains self-renewal of mammary cancer stem cells through regulation of Sonic Hedgehog signaling
Elisa Maria Memmi, Anna Giulia Sanarico, Arianna Giacobbe, Angelo Peschiaroli, Valentina Frezza, Angelo Cicalese, Federica Pisati, Daniela Tosoni, Huiqing Zhou, Giovanni Tonon, Alexey Antonov, Gerry Melino, Pier Giuseppe Pelicci, Francesca Bernassola
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3499–3504. Published online 2015 Mar 4. doi: 10.1073/pnas.1500762112
PMCID:
PMC4372004
Implantable hydrogel embedded dark-gold nanoswitch as a theranostic probe to sense and overcome cancer multidrug resistance
João Conde, Nuria Oliva, Natalie Artzi
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1278–E1287. Published online 2015 Mar 2. doi: 10.1073/pnas.1421229112
PMCID:
PMC4371927
Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer
Anthony C. Faber, Anna F. Farago, Carlotta Costa, Anahita Dastur, Maria Gomez-Caraballo, Rebecca Robbins, Bethany L. Wagner, William M. Rideout, III, Charles T. Jakubik, Jungoh Ham, Elena J. Edelman, Hiromichi Ebi, Alan T. Yeo, Aaron N. Hata, Youngchul Song, Neha U. Patel, Ryan J. March, Ah Ting Tam, Randy J. Milano, Jessica L. Boisvert, Mark A. Hicks, Sarah Elmiligy, Scott E. Malstrom, Miguel N. Rivera, Hisashi Harada, Brad E. Windle, Sridhar Ramaswamy, Cyril H. Benes, Tyler Jacks, Jeffrey A. Engelman
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1288–E1296. Published online 2015 Mar 3. doi: 10.1073/pnas.1411848112
PMCID:
PMC4371986
Nathaniel Washburn, Inessa Schwab, Daniel Ortiz, Naveen Bhatnagar, Jonathan C. Lansing, Amy Medeiros, Steven Tyler, Divya Mekala, Edward Cochran, Hetal Sarvaiya, Kevin Garofalo, Robin Meccariello, James W. Meador, III, Laura Rutitzky, Birgit C. Schultes, Leona Ling, William Avery, Falk Nimmerjahn, Anthony M. Manning, Ganesh V. Kaundinya, Carlos J. Bosques
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1297–E1306. Published online 2015 Mar 2. doi: 10.1073/pnas.1422481112
PMCID:
PMC4371931
Oncogenic fusion protein EWS-FLI1 is a network hub that regulates alternative splicing
Saravana P. Selvanathan, Garrett T. Graham, Hayriye V. Erkizan, Uta Dirksen, Thanemozhi G. Natarajan, Aleksandra Dakic, Songtao Yu, Xuefeng Liu, Michelle T. Paulsen, Mats E. Ljungman, Cathy H. Wu, Elizabeth R. Lawlor, Aykut Üren, Jeffrey A. Toretsky
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1307–E1316. Published online 2015 Mar 3. doi: 10.1073/pnas.1500536112
PMCID:
PMC4371969
Peiyong Jiang, Carol W. M. Chan, K. C. Allen Chan, Suk Hang Cheng, John Wong, Vincent Wai-Sun Wong, Grace L. H. Wong, Stephen L. Chan, Tony S. K. Mok, Henry L. Y. Chan, Paul B. S. Lai, Rossa W. K. Chiu, Y. M. Dennis Lo
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1317–E1325. Published online 2015 Feb 2. doi: 10.1073/pnas.1500076112
PMCID:
PMC4372002

Microbiology

Retroviral vectors elevate coexpressed protein levels in trans through cap-dependent translation
Yongqiang Gou, Hyewon Byun, Adam E. Zook, Gurvani B. Singh, Andrea K. Nash, Mary M. Lozano, Jaquelin P. Dudley
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3505–3510. Published online 2015 Mar 3. doi: 10.1073/pnas.1420477112
PMCID:
PMC4371913
AcrB drug-binding pocket substitution confers clinically relevant resistance and altered substrate specificity
Jessica M. A. Blair, Vassiliy N. Bavro, Vito Ricci, Niraj Modi, Pierpaolo Cacciotto, Ulrich Kleinekathӧfer, Paolo Ruggerone, Attilio V. Vargiu, Alison J. Baylay, Helen E. Smith, Yvonne Brandon, David Galloway, Laura J. V. Piddock
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3511–3516. Published online 2015 Mar 3. doi: 10.1073/pnas.1419939112
PMCID:
PMC4371985
Disentangling mechanisms that mediate the balance between stochastic and deterministic processes in microbial succession
Francisco Dini-Andreote, James C. Stegen, Jan Dirk van Elsas, Joana Falcão Salles
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1326–E1332. Published online 2015 Mar 2. doi: 10.1073/pnas.1414261112
PMCID:
PMC4371938
NFκB activation by modified vaccinia virus as a novel strategy to enhance neutrophil migration and HIV-specific T-cell responses
Mauro Di Pilato, Ernesto Mejías-Pérez, Manuela Zonca, Beatriz Perdiguero, Carmen Elena Gómez, Marianna Trakala, Jacobo Nieto, José Luis Nájera, Carlos Oscar S. Sorzano, Christophe Combadière, Giuseppe Pantaleo, Lourdes Planelles, Mariano Esteban
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1333–E1342. Published online 2015 Mar 4. doi: 10.1073/pnas.1424341112
PMCID:
PMC4371968
Mirela D’arc, Ahidjo Ayouba, Amandine Esteban, Gerald H. Learn, Vanina Boué, Florian Liegeois, Lucie Etienne, Nikki Tagg, Fabian H. Leendertz, Christophe Boesch, Nadège F. Madinda, Martha M. Robbins, Maryke Gray, Amandine Cournil, Marcel Ooms, Michael Letko, Viviana A. Simon, Paul M. Sharp, Beatrice H. Hahn, Eric Delaporte, Eitel Mpoudi Ngole, Martine Peeters
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1343–E1352. Published online 2015 Mar 2. doi: 10.1073/pnas.1502022112
PMCID:
PMC4371950

Neuroscience

Cortical computation in mammals and birds
Kenneth D. Harris
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3184–3185. Published online 2015 Mar 9. doi: 10.1073/pnas.1502209112
PMCID:
PMC4371977
Coding principles of the canonical cortical microcircuit in the avian brain
Ana Calabrese, Sarah M. N. Woolley
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3517–3522. Published online 2015 Feb 17. doi: 10.1073/pnas.1408545112
PMCID:
PMC4371993
KCC2 activity is critical in limiting the onset and severity of status epilepticus
Liliya Silayeva, Tarek Z. Deeb, Rochelle M. Hines, Matt R. Kelley, Michaelanne B. Munoz, Henry H. C. Lee, Nicholas J. Brandon, John Dunlop, Jaime Maguire, Paul A. Davies, Stephen J. Moss
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3523–3528. Published online 2015 Mar 2. doi: 10.1073/pnas.1415126112
PMCID:
PMC4371976
Stochastic transitions into silence cause noise correlations in cortical circuits
Gabriela Mochol, Ainhoa Hermoso-Mendizabal, Shuzo Sakata, Kenneth D. Harris, Jaime de la Rocha
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3529–3534. Published online 2015 Mar 4. doi: 10.1073/pnas.1410509112
PMCID:
PMC4371940
Tae Kim, Stephen Thankachan, James T. McKenna, James M. McNally, Chun Yang, Jee Hyun Choi, Lichao Chen, Bernat Kocsis, Karl Deisseroth, Robert E. Strecker, Radhika Basheer, Ritchie E. Brown, Robert W. McCarley
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3535–3540. Published online 2015 Mar 2. doi: 10.1073/pnas.1413625112
PMCID:
PMC4371918
Tadashi Yamazaki, Soichi Nagao, William Lennon, Shigeru Tanaka
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3541–3546. Published online 2015 Mar 3. doi: 10.1073/pnas.1413798112
PMCID:
PMC4371920
Disruption of hierarchical predictive coding during sleep
Melanie Strauss, Jacobo D. Sitt, Jean-Remi King, Maxime Elbaz, Leila Azizi, Marco Buiatti, Lionel Naccache, Virginie van Wassenhove, Stanislas Dehaene
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1353–E1362. Published online 2015 Mar 3. doi: 10.1073/pnas.1501026112
PMCID:
PMC4371991
Activation of TRPM3 by a potent synthetic ligand reveals a role in peptide release
Katharina Held, Tatjana Kichko, Katrien De Clercq, Hugo Klaassen, Rieta Van Bree, Jean-Christophe Vanherck, Arnaud Marchand, Peter W. Reeh, Patrick Chaltin, Thomas Voets, Joris Vriens
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1363–E1372. Published online 2015 Mar 2. doi: 10.1073/pnas.1419845112
PMCID:
PMC4371942
Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation
Wuyang Wang, Qiong Gao, Meimei Yang, Xiaoli Zhang, Lu Yu, Maria Lawas, Xinran Li, Marthe Bryant-Genevier, Noel T. Southall, Juan Marugan, Marc Ferrer, Haoxing Xu
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1373–E1381. Published online 2015 Mar 2. doi: 10.1073/pnas.1419669112
PMCID:
PMC4371935

Pharmacology

Glutathione and multidrug resistance protein transporter mediate a self-propelled disposal of bismuth in human cells
Yifan Hong, Yau-Tsz Lai, Godfrey Chi-Fung Chan, Hongzhe Sun
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3211–3216. Published online 2015 Mar 3. doi: 10.1073/pnas.1421002112
PMCID:
PMC4371909

Physiology

Four basic residues critical for the ion selectivity and pore blocker sensitivity of TMEM16A calcium-activated chloride channels
Christian J. Peters, Haibo Yu, Jason Tien, Yuh Nung Jan, Min Li, Lily Yeh Jan
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3547–3552. Published online 2015 Mar 2. doi: 10.1073/pnas.1502291112
PMCID:
PMC4371966
Titin ruler hypothesis not refuted
Larissa Tskhovrebova, Pauline Bennett, Mathias Gautel, John Trinick
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1172. Published online 2015 Feb 18. doi: 10.1073/pnas.1422326112
PMCID:
PMC4371926
Reply to Tskhovrebova et al.: Titin’s IA junction does not control thick filament length
Henk L. Granzier
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1173. Published online 2015 Feb 18. doi: 10.1073/pnas.1500871112
PMCID:
PMC4371903
Activation of protein synthesis in mouse uterine epithelial cells by estradiol-17β is mediated by a PKC–ERK1/2–mTOR signaling pathway
Yuxiang Wang, Liyin Zhu, Satu Kuokkanen, Jeffrey W. Pollard
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1382–E1391. Published online 2015 Mar 2. doi: 10.1073/pnas.1418973112
PMCID:
PMC4371960

Plant Biology

Mitochondrial metabolism is regulated by thioredoxin
Ian Max Møller
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3180–3181. Published online 2015 Mar 9. doi: 10.1073/pnas.1502425112
PMCID:
PMC4371930
Regulatory link between DNA methylation and active demethylation in Arabidopsis
Mingguang Lei, Huiming Zhang, Russell Julian, Kai Tang, Shaojun Xie, Jian-Kang Zhu
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3553–3557. Published online 2015 Mar 2. doi: 10.1073/pnas.1502279112
PMCID:
PMC4371987
Arabidopsis OR proteins are the major posttranscriptional regulators of phytoene synthase in controlling carotenoid biosynthesis
Xiangjun Zhou, Ralf Welsch, Yong Yang, Daniel Álvarez, Matthias Riediger, Hui Yuan, Tara Fish, Jiping Liu, Theodore W. Thannhauser, Li Li
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3558–3563. Published online 2015 Feb 9. doi: 10.1073/pnas.1420831112
PMCID:
PMC4371912
Improving recombinant Rubisco biogenesis, plant photosynthesis and growth by coexpressing its ancillary RAF1 chaperone
Spencer M. Whitney, Rosemary Birch, Celine Kelso, Jennifer L. Beck, Maxim V. Kapralov
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3564–3569. Published online 2015 Mar 2. doi: 10.1073/pnas.1420536112
PMCID:
PMC4371954
Boosting CRISPR/Cas9 multiplex editing capability with the endogenous tRNA-processing system
Kabin Xie, Bastian Minkenberg, Yinong Yang
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3570–3575. Published online 2015 Mar 2. doi: 10.1073/pnas.1420294112
PMCID:
PMC4371917
Thioredoxin, a master regulator of the tricarboxylic acid cycle in plant mitochondria
Danilo M. Daloso, Karolin Müller, Toshihiro Obata, Alexandra Florian, Takayuki Tohge, Alexandra Bottcher, Christophe Riondet, Laetitia Bariat, Fernando Carrari, Adriano Nunes-Nesi, Bob B. Buchanan, Jean-Philippe Reichheld, Wagner L. Araújo, Alisdair R. Fernie
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1392–E1400. Published online 2015 Feb 2. doi: 10.1073/pnas.1424840112
PMCID:
PMC4371975

Psychological and Cognitive Sciences

Big changes before big birthdays? Panel data provide no evidence of end-of-decade crises
Simon Kühne, Thorsten Schneider, David Richter
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1170. Published online 2015 Feb 18. doi: 10.1073/pnas.1424903112
PMCID:
PMC4371915
Reply to Kühne et al.: Still good evidence that people search for meaning when they approach a new decade in chronological age
Adam L. Alter, Hal E. Hershfield
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1171. Published online 2015 Feb 18. doi: 10.1073/pnas.1500787112
PMCID:
PMC4371988

Systems Biology

Rare variants in neuronal excitability genes influence risk for bipolar disorder
Seth A. Ament, Szabolcs Szelinger, Gustavo Glusman, Justin Ashworth, Liping Hou, Nirmala Akula, Tatyana Shekhtman, Judith A. Badner, Mary E. Brunkow, Denise E. Mauldin, Anna-Barbara Stittrich, Katherine Rouleau, Sevilla D. Detera-Wadleigh, John I. Nurnberger, Jr., Howard J. Edenberg, Elliot S. Gershon, Nicholas Schork, The Bipolar Genome Study, Nathan D. Price, Richard Gelinas, Leroy Hood, David Craig, Francis J. McMahon, John R. Kelsoe, Jared C. Roach, John R. Kelsoe, Tiffany A. Greenwood, Caroline M. Nievergelt, Paul D. Shilling, Tatyana Shekhtman, Jared C. Roach, Seth A. Ament, Leroy Hood, John I. Nurnberger, Jr., Howard J. Edenberg, Tatiana Foroud, Daniel L. Koller, Elliot S. Gershon, Judith A. Badner, Chunyu Liu, William A. Scheftner, William B. Lawson, William Coryell, James B. Potash, John Rice, William Byerley, Francis J. McMahon, Liping Hou, Wade H. Berrettini, Peter P. Zandi, Melvin G. McInnis, David W. Craig, Szabolcs Szelinger, Thomas G. Schulze, Nicholas J. Schork, Danjuma Quarless
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): 3576–3581. Published online 2015 Feb 17. doi: 10.1073/pnas.1424958112
PMCID:
PMC4371952

Correction

Correction for Bartesaghi et al., Inhibition of oxidative metabolism leads to p53 genetic inactivation and transformation in neural stem cells
Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11): E1401. Published online 2015 Feb 20. doi: 10.1073/pnas.1503132112
PMCID:
PMC4371981

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences