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This journal provides early access to some articles. Letters Parameters that influence the prediction of epidemiological benefits of more-effective tuberculosis vaccines, drugs, and diagnosis Janakiraman Vani, Mohan S. Maddur, Sébastien Lacroix-Desmazes, Srini V. Kaveri, and Jagadeesh Bayry Proc Natl Acad Sci U S A. 2009 November 17; 106(46): E129. Published online 2009 October 26. doi: 10.1073/pnas.0911020106.PMCID: PMC2780754 | Free in PMC on 2010/05/17 | Reply to Vani et al.: Tuberculosis models and complexity M. Elizabeth Halloran, Jerusha T. Achterberg, Lorenzo Sabatelli, Jonathan D. Sugimoto, Christopher Dye, and Ira M. Longini, Jr. Proc Natl Acad Sci U S A. 2009 November 17; 106(46): E130. Published online 2009 October 26. doi: 10.1073/pnas.0911578106.PMCID: PMC2780744 | Free in PMC on 2010/05/17 | This Week in PNAS Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19205–19206. doi: 10.1073/iti4609106.PMCID: PMC2780788 | Free in PMC on 2010/05/17 | Commentaries How to learn new and interesting things from model systems based on “exotic” biological species John M. Sedivy Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19207–19208. Published online 2009 November 11. doi: 10.1073/pnas.0911232106.PMCID: PMC2780764 | Free in PMC on 2010/05/17 | Enter the ratrix Bijan Pesaran and David Kleinfeld Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19209–19210. Published online 2009 November 11. doi: 10.1073/pnas.0911424106.PMCID: PMC2780815 | Free in PMC on 2010/05/17 | Perspective Climate, carbon cycling, and deep-ocean ecosystems K. L. Smith, Jr, H. A. Ruhl, B. J. Bett, D. S. M. Billett, R. S. Lampitt, and R. S. Kaufmann Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19211–19218. Published online 2009 November 9. doi: 10.1073/pnas.0908322106.PMCID: PMC2780780 | Free in PMC on 2010/05/17 | Physical Sciences Applied Physical Sciences Propulsion of African trypanosomes is driven by bihelical waves with alternating chirality separated by kinks Jose A. Rodríguez, Miguel A. Lopez, Michelle C. Thayer, Yunzhe Zhao, Michael Oberholzer, Donald D. Chang, Neville K. Kisalu, Manuel L. Penichet, Gustavo Helguera, Robijn Bruinsma, Kent L. Hill, and Jianwei Miao Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19322–19327. Published online 2009 October 30. doi: 10.1073/pnas.0907001106.PMCID: PMC2780783 | Free in PMC on 2010/05/17 | Engineering Ultra-sensitive vibrational spectroscopy of protein monolayers with plasmonic nanoantenna arrays Ronen Adato, Ahmet A. Yanik, Jason J. Amsden, David L. Kaplan, Fiorenzo G. Omenetto, Mi K. Hong, Shyamsunder Erramilli, and Hatice Altug Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19227–19232. Published online 2009 October 30. doi: 10.1073/pnas.0907459106.PMCID: PMC2770897 Environmental Sciences Sodium shortage as a constraint on the carbon cycle in an inland tropical rainforest Michael Kaspari, Stephen P. Yanoviak, Robert Dudley, May Yuan, and Natalie A. Clay Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19405–19409. Published online 2009 November 2. doi: 10.1073/pnas.0906448106.PMCID: PMC2780770 | Free in PMC on 2010/05/17 | Geophysics High-pressure highly reduced nitrides and oxides from chromitite of a Tibetan ophiolite Larissa F. Dobrzhinetskaya, Richard Wirth, Jingsui Yang, Ian D. Hutcheon, Peter K. Weber, and Harry W. Green, II Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19233–19238. Published online 2009 October 30. doi: 10.1073/pnas.0905514106.PMCID: PMC2780801 | Free in PMC on 2010/05/17 | Physics Emergent gene order in a model of modular polyketide synthases Benjamin Callahan, Mukund Thattai, and Boris I. Shraiman Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19410–19415. Published online 2009 October 28. doi: 10.1073/pnas.0902364106.PMCID: PMC2780807 | Free in PMC on 2010/05/17 | Statistics Direct observation of twisting steps during Rad51 polymerization on DNA Hideyuki Arata, Aurélie Dupont, Judith Miné-Hattab, Ludovic Disseau, Axelle Renodon-Cornière, Masayuki Takahashi, Jean-Louis Viovy, and Giovanni Cappello Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19239–19244. Published online 2009 November 2. doi: 10.1073/pnas.0902234106.PMCID: PMC2780809 | Free in PMC on 2010/05/17 | Biological Sciences Agricultural Sciences A nonsense mutation in cGMP-dependent type II protein kinase (PRKG2) causes dwarfism in American Angus cattle James E. Koltes, Bishnu P. Mishra, Dinesh Kumar, Ranjit S. Kataria, Liviu R. Totir, Rohan L. Fernando, Rowland Cobbold, David Steffen, Wouter Coppieters, Michel Georges, and James M. Reecy Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19250–19255. Published online 2009 November 3. doi: 10.1073/pnas.0904513106.PMCID: PMC2780805 | Free in PMC on 2010/05/17 | A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota Yingzi Cong, Ting Feng, Kohtaro Fujihashi, Trenton R. Schoeb, and Charles O. Elson Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19256–19261. Published online 2009 November 4. doi: 10.1073/pnas.0812681106.PMCID: PMC2780781 | Free in PMC on 2010/05/17 | Anthropology Contagious yawning in gelada baboons as a possible expression of empathy E. Palagi, A. Leone, G. Mancini, and P. F. Ferrari Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19262–19267. Published online 2009 November 4. doi: 10.1073/pnas.0910891106.PMCID: PMC2780782 | Free in PMC on 2010/05/17 | Applied Biological Sciences From the Cover: Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier Benjamin C. Tang, Michelle Dawson, Samuel K. Lai, Ying-Ying Wang, Jung Soo Suk, Ming Yang, Pamela Zeitlin, Michael P. Boyle, Jie Fu, and Justin Hanes Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19268–19273. Published online 2009 November 9. doi: 10.1073/pnas.0905998106.PMCID: PMC2780804 | Free in PMC on 2010/05/17 | Biochemistry Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor Masashi Akiyama, Soichi Takeda, Koichi Kokame, Junichi Takagi, and Toshiyuki Miyata Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19274–19279. Published online 2009 October 30. doi: 10.1073/pnas.0909755106.PMCID: PMC2780749 | Free in PMC on 2010/05/17 | Relapsing fever Borrelia binds to neolacto glycans and mediates rosetting of human erythrocytes Betty P. Guo, Susann Teneberg, Robert Münch, Daiyo Terunuma, Ken Hatano, Koji Matsuoka, Jonas Ångström, Thomas Borén, and Sven Bergström Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19280–19285. Published online 2009 November 2. doi: 10.1073/pnas.0905470106.PMCID: PMC2771742 Dynamic bookmarking of primary response genes by p300 and RNA polymerase II complexes Jung S. Byun, Madeline M. Wong, Wenwu Cui, Gila Idelman, Quentin Li, Adriana De Siervi, Sven Bilke, Cynthia M. Haggerty, Audrey Player, Yong Hong Wang, Michael J. Thirman, Joseph J. Kaberlein, Constantinos Petrovas, Richard A. Koup, Dan Longo, Keiko Ozato, and Kevin Gardner Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19286–19291. Published online 2009 October 30. doi: 10.1073/pnas.0905469106.PMCID: PMC2780808 | Free in PMC on 2010/05/17 | Structure of Escherichia coli Hfq bound to polyriboadenylate RNA Todd M. Link, Poul Valentin-Hansen, and Richard G. Brennan Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19292–19297. Published online 2009 November 4. doi: 10.1073/pnas.0908744106.PMCID: PMC2773200 Telomere capping proteins are structurally related to RPA with an additional telomere-specific domain Amy D. Gelinas, Margherita Paschini, Francis E. Reyes, Annie Héroux, Robert T. Batey, Victoria Lundblad, and Deborah S. Wuttke Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19298–19303. Published online 2009 November 2. doi: 10.1073/pnas.0909203106.PMCID: PMC2780795 | Free in PMC on 2010/05/17 | Functional genomic screens identify CINP as a genome maintenance protein Courtney A. Lovejoy, Xin Xu, Carol E. Bansbach, Gloria G. Glick, Runxiang Zhao, Fei Ye, Bianca M. Sirbu, Laura C. Titus, Yu Shyr, and David Cortez Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19304–19309. Published online 2009 November 4. doi: 10.1073/pnas.0909345106.PMCID: PMC2780779 | Free in PMC on 2010/05/17 | Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini Guoqiang Xu, Sung Bin Y. Shin, and Samie R. Jaffrey Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19310–19315. Published online 2009 November 5. doi: 10.1073/pnas.0908958106.PMCID: PMC2780798 | Free in PMC on 2010/05/17 | Cyclodextrin overcomes deficient lysosome-to-endoplasmic reticulum transport of cholesterol in Niemann-Pick type C cells Lina Abi-Mosleh, Rodney E. Infante, Arun Radhakrishnan, Joseph L. Goldstein, and Michael S. Brown Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19316–19321. Published online 2009 November 2. doi: 10.1073/pnas.0910916106.PMCID: PMC2780767 | Free in PMC on 2010/05/17 | Biophysics and Computational Biology Ultra-sensitive vibrational spectroscopy of protein monolayers with plasmonic nanoantenna arrays Ronen Adato, Ahmet A. Yanik, Jason J. Amsden, David L. Kaplan, Fiorenzo G. Omenetto, Mi K. Hong, Shyamsunder Erramilli, and Hatice Altug Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19227–19232. Published online 2009 October 30. doi: 10.1073/pnas.0907459106.PMCID: PMC2770897 Direct observation of twisting steps during Rad51 polymerization on DNA Hideyuki Arata, Aurélie Dupont, Judith Miné-Hattab, Ludovic Disseau, Axelle Renodon-Cornière, Masayuki Takahashi, Jean-Louis Viovy, and Giovanni Cappello Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19239–19244. Published online 2009 November 2. doi: 10.1073/pnas.0902234106.PMCID: PMC2780809 | Free in PMC on 2010/05/17 | Propulsion of African trypanosomes is driven by bihelical waves with alternating chirality separated by kinks Jose A. Rodríguez, Miguel A. Lopez, Michelle C. Thayer, Yunzhe Zhao, Michael Oberholzer, Donald D. Chang, Neville K. Kisalu, Manuel L. Penichet, Gustavo Helguera, Robijn Bruinsma, Kent L. Hill, and Jianwei Miao Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19322–19327. Published online 2009 October 30. doi: 10.1073/pnas.0907001106.PMCID: PMC2780783 | Free in PMC on 2010/05/17 | Kinetic enhancement of NF-κB·DNA dissociation by IκBα Simon Bergqvist, Vera Alverdi, Benedicte Mengel, Alexander Hoffmann, Gourisankar Ghosh, and Elizabeth A. Komives Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19328–19333. Published online 2009 November 3. doi: 10.1073/pnas.0908797106.PMCID: PMC2780789 | Free in PMC on 2010/05/17 | The physical state of water in bacterial spores Erik P. Sunde, Peter Setlow, Lars Hederstedt, and Bertil Halle Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19334–19339. Published online 2009 November 5. doi: 10.1073/pnas.0908712106.PMCID: PMC2780810 | Free in PMC on 2010/05/17 | Single-molecule denaturation and degradation of proteins by the AAA+ ClpXP protease Yongdae Shin, Joseph H. Davis, Ricardo R. Brau, Andreas Martin, Jon A. Kenniston, Tania A. Baker, Robert T. Sauer, and Matthew J. Lang Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19340–19345. Published online 2009 November 5. doi: 10.1073/pnas.0910484106.PMCID: PMC2773733 Conformational selection and induced fit mechanism underlie specificity in noncovalent interactions with ubiquitin Tomasz Wlodarski and Bojan Zagrovic Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19346–19351. Published online 2009 November 3. doi: 10.1073/pnas.0906966106.PMCID: PMC2780739 | Free in PMC on 2010/05/17 | Cell Biology From the Cover: Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat Andrei Seluanov, Christopher Hine, Jorge Azpurua, Marina Feigenson, Michael Bozzella, Zhiyong Mao, Kenneth C. Catania, and Vera Gorbunova Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19352–19357. Published online 2009 October 26. doi: 10.1073/pnas.0905252106.PMCID: PMC2780760 | Free in PMC on 2010/05/17 | From the Cover: STIM1-induced precortical and cortical subdomains of the endoplasmic reticulum Lelio Orci, Mariella Ravazzola, Marion Le Coadic, Wei-wei Shen, Nicolas Demaurex, and Pierre Cosson Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19358–19362. Published online 2009 November 11. doi: 10.1073/pnas.0911280106.PMCID: PMC2775999 G9a selectively represses a class of late-replicating genes at the nuclear periphery Tomoki Yokochi, Kristina Poduch, Tyrone Ryba, Junjie Lu, Ichiro Hiratani, Makoto Tachibana, Yoichi Shinkai, and David M. Gilbert Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19363–19368. Published online 2009 November 4. doi: 10.1073/pnas.0906142106.PMCID: PMC2780741 | Free in PMC on 2010/05/17 | Movement and equipositioning of plasmids by ParA filament disassembly Simon Ringgaard, Jeroen van Zon, Martin Howard, and Kenn Gerdes Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19369–19374. Published online 2009 November 11. doi: 10.1073/pnas.0908347106.PMCID: PMC2775997 Soft X-ray tomography of phenotypic switching and the cellular response to antifungal peptoids in Candida albicans Maho Uchida, Gerry McDermott, Modi Wetzler, Mark A. Le Gros, Markko Myllys, Christian Knoechel, Annelise E. Barron, and Carolyn A. Larabell Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19375–19380. Published online 2009 October 30. doi: 10.1073/pnas.0906145106.PMCID: PMC2780763 | Free in PMC on 2010/05/17 | Tug-of-war between dissimilar teams of microtubule motors regulates transport and fission of endosomes Virupakshi Soppina, Arpan Kumar Rai, Avin Jayesh Ramaiya, Pradeep Barak, and Roop Mallik Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19381–19386. Published online 2009 October 28. doi: 10.1073/pnas.0906524106.PMCID: PMC2770008 Oscillatory recruitment of signaling proteins to cell tips promotes coordinated behavior during cell fusion André Fleissner, Abigail C. Leeder, M. Gabriela Roca, Nick D. Read, and N. Louise Glass Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19387–19392. Published online 2009 November 2. doi: 10.1073/pnas.0907039106.PMCID: PMC2780775 | Free in PMC on 2010/05/17 | Telomere shortening relaxes X chromosome inactivation and forces global transcriptome alterations Stefan Schoeftner, Raquel Blanco, Isabel Lopez de Silanes, Purificación Muñoz, Gonzalo Gómez-López, Juana M. Flores, and Maria A. Blasco Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19393–19398. Published online 2009 November 3. doi: 10.1073/pnas.0909265106.PMCID: PMC2772818 Developmental Biology The receptor protein tyrosine phosphatase LAR promotes R7 photoreceptor axon targeting by a phosphatase-independent signaling mechanism Kerstin Hofmeyer and Jessica E. Treisman Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19399–19404. Published online 2009 November 4. doi: 10.1073/pnas.0903961106.PMCID: PMC2780745 | Free in PMC on 2010/05/17 | Ecology Sodium shortage as a constraint on the carbon cycle in an inland tropical rainforest Michael Kaspari, Stephen P. Yanoviak, Robert Dudley, May Yuan, and Natalie A. Clay Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19405–19409. Published online 2009 November 2. doi: 10.1073/pnas.0906448106.PMCID: PMC2780770 | Free in PMC on 2010/05/17 | Evolution Emergent gene order in a model of modular polyketide synthases Benjamin Callahan, Mukund Thattai, and Boris I. Shraiman Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19410–19415. Published online 2009 October 28. doi: 10.1073/pnas.0902364106.PMCID: PMC2780807 | Free in PMC on 2010/05/17 | How blood-derived odor influences mate-choice decisions by a mosquito-eating predator Fiona R. Cross, Robert R. Jackson, and Simon D. Pollard Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19416–19419. Published online 2009 November 3. doi: 10.1073/pnas.0904125106.PMCID: PMC2780784 | Free in PMC on 2010/05/17 | A mechanism for functional segregation of mitochondrial and cytosolic genetic codes Yaiza Español, Daniel Thut, André Schneider, and Lluís Ribas de Pouplana Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19420–19425. Published online 2009 October 30. doi: 10.1073/pnas.0909937106.PMCID: PMC2780774 | Free in PMC on 2010/05/17 | Ecologically dependent postmating isolation between sympatric host forms of Neochlamisus bebbianae leaf beetles Scott P. Egan and Daniel J. Funk Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19426–19431. Published online 2009 October 29. doi: 10.1073/pnas.0909424106.PMCID: PMC2780776 | Free in PMC on 2010/05/17 | Genetics From the Cover: Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis Shinichi Someya, Jinze Xu, Kenji Kondo, Dalian Ding, Richard J. Salvi, Tatsuya Yamasoba, Peter S. Rabinovitch, Richard Weindruch, Christiaan Leeuwenburgh, Masaru Tanokura, and Tomas A. Prolla Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19432–19437. Published online 2009 November 9. doi: 10.1073/pnas.0908786106.PMCID: PMC2780799 | Free in PMC on 2010/05/17 | Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus Helen M. McGuire, Alexis Vogelzang, Natasha Hill, Malin Flodström-Tullberg, Jonathan Sprent, and Cecile King Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19438–19443. Published online 2009 October 30. doi: 10.1073/pnas.0903561106.PMCID: PMC2780811 | Free in PMC on 2010/05/17 | Rescue and characterization of episomally replicating DNA from the moss Physcomitrella Eva Murén, Anders Nilsson, Mikael Ulfstedt, Monika Johansson, and Hans Ronne Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19444–19449. Published online 2009 November 5. doi: 10.1073/pnas.0908037106.PMCID: PMC2780769 | Free in PMC on 2010/05/17 | Immunology Adenovirus E3 MHC inhibitory genes but not TNF/Fas apoptotic inhibitory genes expressed in β cells prevent autoimmune diabetes Marshall S. Horwitz, Shimon Efrat, Urs Christen, Matthias G. von Herrath, and Michael B. A. Oldstone Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19450–19454. Published online 2009 November 3. doi: 10.1073/pnas.0910648106.PMCID: PMC2780797 | Free in PMC on 2010/05/17 | Successful immunotherapy with IL-2/anti-CD40 induces the chemokine-mediated mitigation of an immunosuppressive tumor microenvironment Jonathan M. Weiss, Timothy C. Back, Anthony J. Scarzello, Jeff J. Subleski, Veronica L. Hall, Jimmy K. Stauffer, Xin Chen, Dejan Micic, Kory Alderson, William J. Murphy, and Robert H. Wiltrout Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19455–19460. Published online 2009 November 5. doi: 10.1073/pnas.0909474106.PMCID: PMC2773732 Transcriptional regulator Id2 controls survival of hepatic NKT cells Laurel A. Monticelli, Yang Yang, Jamie Knell, Louise M. D'Cruz, Michael A. Cannarile, Isaac Engel, Mitchell Kronenberg, and Ananda W. Goldrath Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19461–19466. Published online 2009 November 2. doi: 10.1073/pnas.0908249106.PMCID: PMC2780802 | Free in PMC on 2010/05/17 | Medical Sciences Prevention and treatment of cervical cancer in mice using estrogen receptor antagonists Sang-Hyuk Chung and Paul F. Lambert Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19467–19472. Published online 2009 November 9. doi: 10.1073/pnas.0911436106.PMCID: PMC2780740 | Free in PMC on 2010/05/17 | A t-butyloxycarbonyl-modified Wnt5a-derived hexapeptide functions as a potent antagonist of Wnt5a-dependent melanoma cell invasion Veronika Jenei, Victoria Sherwood, Jillian Howlin, Rickard Linnskog, Annette Säfholm, Lena Axelsson, and Tommy Andersson Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19473–19478. Published online 2009 November 9. doi: 10.1073/pnas.0909409106.PMCID: PMC2780806 | Free in PMC on 2010/05/17 | PTEN dosage is essential for neurofibroma development and malignant transformation Caroline Gregorian, Jonathan Nakashima, Sarah M. Dry, P. Leia Nghiemphu, Kate Barzan Smith, Yan Ao, Julie Dang, Gregory Lawson, Ingo K. Mellinghoff, Paul S. Mischel, Michael Phelps, Luis F. Parada, Xin Liu, Michael V. Sofroniew, Fritz C. Eilber, and Hong Wu Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19479–19484. Published online 2009 October 21. doi: 10.1073/pnas.0910398106.PMCID: PMC2765459 Hypoxia-induced pathological angiogenesis mediates tumor cell dissemination, invasion, and metastasis in a zebrafish tumor model Samantha Lin Chiou Lee, Pegah Rouhi, Lasse Dahl Jensen, Danfang Zhang, Hong Ji, Giselbert Hauptmann, Philip Ingham, and Yihai Cao Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19485–19490. Published online 2009 November 3. doi: 10.1073/pnas.0909228106.PMCID: PMC2780785 | Free in PMC on 2010/05/17 | Alpha 1,3 fucosyltransferases are master regulators of prostate cancer cell trafficking Steven R. Barthel, Georg K. Wiese, Jaehyung Cho, Matthew J. Opperman, Danielle L. Hays, Javed Siddiqui, Kenneth J. Pienta, Bruce Furie, and Charles J. Dimitroff Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19491–19496. Published online 2009 November 4. doi: 10.1073/pnas.0906074106.PMCID: PMC2780742 | Free in PMC on 2010/05/17 | Alternatively spliced tissue factor induces angiogenesis through integrin ligation Y. W. van den Berg, L. G. van den Hengel, H. R. Myers, O. Ayachi, E. Jordanova, W. Ruf, C. A. Spek, P. H. Reitsma, V. Y. Bogdanov, and H. H. Versteeg Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19497–19502. Published online 2009 October 29. doi: 10.1073/pnas.0905325106.PMCID: PMC2780792 | Free in PMC on 2010/05/17 | Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition Anthony C. Faber, Danan Li, YoungChul Song, Mei-Chih Liang, Beow Y. Yeap, Roderick T. Bronson, Eugene Lifshits, Zhao Chen, Sauveur-Michel Maira, Carlos García-Echeverría, Kwok-Kin Wong, and Jeffrey A. Engelman Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19503–19508. Published online 2009 October 22. doi: 10.1073/pnas.0905056106.PMCID: PMC2765921 Microbiology Hydrodynamic gene delivery of baboon trypanosome lytic factor eliminates both animal and human-infective African trypanosomes Russell Thomson, Pilar Molina-Portela, Helen Mott, Mark Carrington, and Jayne Raper Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19509–19514. Published online 2009 October 26. doi: 10.1073/pnas.0905669106.PMCID: PMC2780755 | Free in PMC on 2010/05/17 | Cellular stress created by intermediary metabolite imbalances Sang Jun Lee, Andrei Trostel, Phuoc Le, Rajendran Harinarayanan, Peter C. FitzGerald, and Sankar Adhya Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19515–19520. Published online 2009 November 3. doi: 10.1073/pnas.0910586106.PMCID: PMC2780772 | Free in PMC on 2010/05/17 | Nitrogen recycling and nutritional provisioning by Blattabacterium, the cockroach endosymbiont Zakee L. Sabree, Srinivas Kambhampati, and Nancy A. Moran Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19521–19526. Published online 2009 October 30. doi: 10.1073/pnas.0907504106.PMCID: PMC2780778 | Free in PMC on 2010/05/17 | Cell cycle deregulation by a poxvirus partial mimic of anaphase-promoting complex subunit 11 Min Mo, Stephen B. Fleming, and Andrew A. Mercer Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19527–19532. Published online 2009 November 3. doi: 10.1073/pnas.0905893106.PMCID: PMC2780751 | Free in PMC on 2010/05/17 | A key role for vesicles in fungal secondary metabolism Anindya Chanda, Ludmila V. Roze, Suil Kang, Katherine A. Artymovich, Glenn R. Hicks, Natasha V. Raikhel, Ana M. Calvo, and John E. Linz Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19533–19538. Published online 2009 November 4. doi: 10.1073/pnas.0907416106.PMCID: PMC2773199 HIV-1 Vif-mediated ubiquitination/degradation of APOBEC3G involves four critical lysine residues in its C-terminal domain Yasumasa Iwatani, Denise S. B. Chan, Lin Liu, Hiroaki Yoshii, Junko Shibata, Naoki Yamamoto, Judith G. Levin, Angela M. Gronenborn, and Wataru Sugiura Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19539–19544. Published online 2009 November 3. doi: 10.1073/pnas.0906652106.PMCID: PMC2772817 Recent human-to-poultry host jump, adaptation, and pandemic spread of Staphylococcus aureus Bethan V. Lowder, Caitriona M. Guinane, Nouri L. Ben Zakour, Lucy A. Weinert, Andrew Conway-Morris, Robyn A. Cartwright, A. John Simpson, Andrew Rambaut, Ulrich Nübel, and J. Ross Fitzgerald Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19545–19550. Published online 2009 November 2. doi: 10.1073/pnas.0909285106.PMCID: PMC2780746 | Free in PMC on 2010/05/17 | Neuroscience INAUGURAL ARTICLE by a Recently Elected Academy Member: Neural correlates of behavior in the moth Manduca sexta in response to complex odors Jeffrey A. Riffell, H. Lei, and John G. Hildebrand Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19219–19226. Published online 2009 November 11. doi: 10.1073/pnas.0910592106.PMCID: PMC2780752 | Free in PMC on 2010/05/17 | Evolution amplified processing with temporally dispersed slow neuronal connectivity in primates Roberto Caminiti, Hassan Ghaziri, Ralf Galuske, Patrick R. Hof, and Giorgio M. Innocenti Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19551–19556. Published online 2009 October 29. doi: 10.1073/pnas.0907655106.PMCID: PMC2770441 From the Cover: Visually evoked activity in cortical cells imaged in freely moving animals Juergen Sawinski, Damian J. Wallace, David S. Greenberg, Silvie Grossmann, Winfried Denk, and Jason N. D. Kerr Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19557–19562. Published online 2009 November 4. doi: 10.1073/pnas.0903680106.PMCID: PMC2773198 Stability of muscle synergies for voluntary actions after cortical stroke in humans Vincent C. K. Cheung, Lamberto Piron, Michela Agostini, Stefano Silvoni, Andrea Turolla, and Emilio Bizzi Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19563–19568. Published online 2009 October 30. doi: 10.1073/pnas.0910114106.PMCID: PMC2780765 | Free in PMC on 2010/05/17 | Shape-specific preparatory activity mediates attention to targets in human visual cortex Mark Stokes, Russell Thompson, Anna C. Nobre, and John Duncan Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19569–19574. Published online 2009 November 3. doi: 10.1073/pnas.0905306106.PMCID: PMC2772815 Rapid modulation of spine morphology by the 5-HT2A serotonin receptor through kalirin-7 signaling Kelly A. Jones, Deepak P. Srivastava, John A. Allen, Ryan T. Strachan, Bryan L. Roth, and Peter Penzes Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19575–19580. Published online 2009 November 4. doi: 10.1073/pnas.0905884106.PMCID: PMC2780750 | Free in PMC on 2010/05/17 | A homologous genetic basis of the murine cpfl1 mutant and human achromatopsia linked to mutations in the PDE6C gene Bo Chang, Tanja Grau, Susann Dangel, Ron Hurd, Bernhard Jurklies, E. Cumhur Sener, Sten Andreasson, Helene Dollfus, Britta Baumann, Sylvia Bolz, Nikolai Artemyev, Susanne Kohl, John Heckenlively, and Bernd Wissinger Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19581–19586. Published online 2009 November 3. doi: 10.1073/pnas.0907720106.PMCID: PMC2780790 | Free in PMC on 2010/05/17 | Oncomodulin links inflammation to optic nerve regeneration Yuqin Yin, Qi Cui, Hui-ya Gilbert, Yang Yang, Zhiyong Yang, Cynthia Berlinicke, Zhiwei Li, Camila Zaverucha-do-Valle, Huamei He, Victoria Petkova, Donald J. Zack, and Larry I. Benowitz Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19587–19592. Published online 2009 October 29. doi: 10.1073/pnas.0907085106.PMCID: PMC2780793 | Free in PMC on 2010/05/17 | Role of dysbindin in dopamine receptor trafficking and cortical GABA function Yuanyuan Ji, Feng Yang, Francesco Papaleo, Huai-Xing Wang, Wen-Jun Gao, Daniel R. Weinberger, and Bai Lu Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19593–19598. Published online 2009 November 3. doi: 10.1073/pnas.0904289106.PMCID: PMC2780743 | Free in PMC on 2010/05/17 | HDAC6 is a target for protection and regeneration following injury in the nervous system Mark A. Rivieccio, Camille Brochier, Dianna E. Willis, Breset A. Walker, Melissa A. D'Annibale, Kathryn McLaughlin, Ambreena Siddiq, Alan P. Kozikowski, Samie R. Jaffrey, Jeffery L. Twiss, Rajiv R. Ratan, and Brett Langley Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19599–19604. Published online 2009 November 2. doi: 10.1073/pnas.0907935106.PMCID: PMC2780768 | Free in PMC on 2010/05/17 | Synaptic scaffolding protein SYD-2 clusters and activates kinesin-3 UNC-104 in C. elegans Oliver I. Wagner, Alessandro Esposito, Barbara Köhler, Chih-Wei Chen, Che-Piao Shen, Gong-Her Wu, Eugenia Butkevich, Sailaja Mandalapu, Dirk Wenzel, Fred S. Wouters, and Dieter R. Klopfenstein Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19605–19610. Published online 2009 October 30. doi: 10.1073/pnas.0902949106.PMCID: PMC2780759 | Free in PMC on 2010/05/17 | Pharmacology Sulindac confers high level ischemic protection to the heart through late preconditioning mechanisms Ian Moench, Howard Prentice, Zach Rickaway, and Herbert Weissbach Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19611–19616. Published online 2009 November 2. doi: 10.1073/pnas.0911046106.PMCID: PMC2780796 | Free in PMC on 2010/05/17 | Physiology Deletion of Drosophila insulin-like peptides causes growth defects and metabolic abnormalities Hua Zhang, Jingnan Liu, Caroline R. Li, Bahram Momen, Ronald A. Kohanski, and Leslie Pick Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19617–19622. Published online 2009 November 3. doi: 10.1073/pnas.0905083106.PMCID: PMC2780814 | Free in PMC on 2010/05/17 | Plasticity in Ca2+ selectivity of Orai1/Orai3 heteromeric channel Rainer Schindl, Irene Frischauf, Judith Bergsmann, Martin Muik, Isabella Derler, Barbara Lackner, Klaus Groschner, and Christoph Romanin Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19623–19628. Published online 2009 November 3. doi: 10.1073/pnas.0907714106.PMCID: PMC2780800 | Free in PMC on 2010/05/17 | Social Sciences Anthropology Daily life of the ancient Maya recorded on murals at Calakmul, Mexico Ramón Carrasco Vargas, Verónica A. Vázquez López, and Simon Martin Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19245–19249. Published online 2009 November 9. doi: 10.1073/pnas.0904374106.PMCID: PMC2780771 | Free in PMC on 2010/05/17 | Corrections Correction for Lee et al., A robust method for searching the smallest set of smallest rings with a path-included distance matrix Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19629. Published online 2009 October 30. doi: 10.1073/pnas.0911801106.PMCID: PMC2780757 Corrects: Chang Joon Lee, et al. A robust method for searching the smallest set of smallest rings with a path-included distance matrix. Proc Natl Acad Sci U S A. 2009 October 13; 106(41): 17355–17358. Correction for Yoon et al., CIB1 functions as a Ca2+-sensitive modulator of stress-induced signaling by targeting ASK1 Proc Natl Acad Sci U S A. 2009 November 17; 106(46): 19629. Published online 2009 October 30. doi: 10.1073/pnas.0911831106.PMCID: PMC2780758 Corrects: Kyoung Wan Yoon, et al. CIB1 functions as a Ca2+-sensitive modulator of stress-induced signaling by targeting ASK1. Proc Natl Acad Sci U S A. 2009 October 13; 106(41): 17389–17394.
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