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Volume 126(8);  2016 Aug 1

Articles from this journal are generally available in PMC after a 3-month delay (embargo), however the delay may vary at the discretion of the publisher.
The cover of the journal

CAR T cells with intrinsic checkpoint blockade

Reviews

The bright side of dark matter: lncRNAs in cancer
Joseph R. Evans, Felix Y. Feng, Arul M. Chinnaiyan
J Clin Invest. 2016 Aug 1; 126(8): 2775–2782. Published online 2016 Aug 1. doi: 10.1172/JCI84421
PMCID:
PMC4966302
Investigating long noncoding RNAs using animal models
Michael Feyder, Loyal A. Goff
J Clin Invest. 2016 Aug 1; 126(8): 2783–2791. Published online 2016 Aug 1. doi: 10.1172/JCI84422
PMCID:
PMC4966299

Commentaries

Pravastatin to prevent obstetrical complications in women with antiphospholipid syndrome
Maged M. Costantine
J Clin Invest. 2016 Aug 1; 126(8): 2792–2794. Published online 2016 Jul 25. doi: 10.1172/JCI89137
PMCID:
PMC4966319
Driving an improved CAR for cancer immunotherapy
Xiaopei Huang, Yiping Yang
J Clin Invest. 2016 Aug 1; 126(8): 2795–2798. Published online 2016 Jul 25. doi: 10.1172/JCI88959
PMCID:
PMC4966332
RelA: a tale of a stitch in time
Murray Korc
J Clin Invest. 2016 Aug 1; 126(8): 2799–2801. Published online 2016 Jul 25. doi: 10.1172/JCI89156
PMCID:
PMC4966314
BRCA1 loses the ring but lords over resistance
Simon N. Powell
J Clin Invest. 2016 Aug 1; 126(8): 2802–2804. Published online 2016 Jul 25. doi: 10.1172/JCI89209
PMCID:
PMC4966308

Research Article

Donor dendritic cell–derived exosomes promote allograft-targeting immune response
Quan Liu, Darling M. Rojas-Canales, Sherrie J. Divito, William J. Shufesky, Donna Beer Stolz, Geza Erdos, Mara L.G. Sullivan, Gregory A. Gibson, Simon C. Watkins, Adriana T. Larregina, Adrian E. Morelli
J Clin Invest. 2016 Aug 1; 126(8): 2805–2820. Published online 2016 Jun 27. doi: 10.1172/JCI84577
PMCID:
PMC4966303

Brief Report

Pneumococcal meningitis is promoted by single cocci expressing pilus adhesin RrgA
Federico Iovino, Disa L. Hammarlöf, Genevieve Garriss, Sarah Brovall, Priyanka Nannapaneni, Birgitta Henriques-Normark
J Clin Invest. 2016 Aug 1; 126(8): 2821–2826. Published online 2016 Jun 27. doi: 10.1172/JCI84705
PMCID:
PMC4966305

Research Articles

Natural allelic variation of the IL-21 receptor modulates ischemic stroke infarct volume
Han Kyu Lee, Sehoon Keum, Huaxin Sheng, David S. Warner, Donald C. Lo, Douglas A. Marchuk
J Clin Invest. 2016 Aug 1; 126(8): 2827–2838. Published online 2016 Jul 11. doi: 10.1172/JCI84491
PMCID:
PMC4966306
IRF3 promotes adipose inflammation and insulin resistance and represses browning
Manju Kumari, Xun Wang, Louise Lantier, Anna Lyubetskaya, Jun Eguchi, Sona Kang, Danielle Tenen, Hyun Cheol Roh, Xingxing Kong, Lawrence Kazak, Rasheed Ahmad, Evan D. Rosen
J Clin Invest. 2016 Aug 1; 126(8): 2839–2854. Published online 2016 Jul 11. doi: 10.1172/JCI86080
PMCID:
PMC4966307
ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors
Philip L.S.M. Gordts, Ryan Nock, Ni-Huiping Son, Bastian Ramms, Irene Lew, Jon C. Gonzales, Bryan E. Thacker, Debapriya Basu, Richard G. Lee, Adam E. Mullick, Mark J. Graham, Ira J. Goldberg, Rosanne M. Crooke, Joseph L. Witztum, Jeffrey D. Esko
J Clin Invest. 2016 Aug 1; 126(8): 2855–2866. Published online 2016 Jul 11. doi: 10.1172/JCI86610
PMCID:
PMC4966320
Schlafen 4–expressing myeloid-derived suppressor cells are induced during murine gastric metaplasia
Lin Ding, Michael M. Hayes, Amanda Photenhauer, Kathryn A. Eaton, Qian Li, Ramon Ocadiz-Ruiz, Juanita L. Merchant
J Clin Invest. 2016 Aug 1; 126(8): 2867–2880. Published online 2016 Jul 18. doi: 10.1172/JCI82529
PMCID:
PMC4966326
Destabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung disease
Saskia N. van der Crabben, Marije P. Hennus, Grant A. McGregor, Deborah I. Ritter, Sandesh C.S. Nagamani, Owen S. Wells, Magdalena Harakalova, Ivan K. Chinn, Aaron Alt, Lucie Vondrova, Ron Hochstenbach, Joris M. van Montfrans, Suzanne W. Terheggen-Lagro, Stef van Lieshout, Markus J. van Roosmalen, Ivo Renkens, Karen Duran, Isaac J. Nijman, Wigard P. Kloosterman, Eric Hennekam, Jordan S. Orange, Peter M. van Hasselt, David A. Wheeler, Jan J. Palecek, Alan R. Lehmann, Antony W. Oliver, Laurence H. Pearl, Sharon E. Plon, Johanne M. Murray, Gijs van Haaften
J Clin Invest. 2016 Aug 1; 126(8): 2881–2892. Published online 2016 Jul 18. doi: 10.1172/JCI82890
PMCID:
PMC4966312
Induced superficial chondrocyte death reduces catabolic cartilage damage in murine posttraumatic osteoarthritis
Minjie Zhang, Sriniwasan B. Mani, Yao He, Amber M. Hall, Lin Xu, Yefu Li, David Zurakowski, Gregory D. Jay, Matthew L. Warman
J Clin Invest. 2016 Aug 1; 126(8): 2893–2902. Published online 2016 Jul 18. doi: 10.1172/JCI83676
PMCID:
PMC4966316
BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1
Rinske Drost, Kiranjit K. Dhillon, Hanneke van der Gulden, Ingrid van der Heijden, Inger Brandsma, Cristina Cruz, Dafni Chondronasiou, Marta Castroviejo-Bermejo, Ute Boon, Eva Schut, Eline van der Burg, Ellen Wientjens, Mark Pieterse, Christiaan Klijn, Sjoerd Klarenbeek, Fabricio Loayza-Puch, Ran Elkon, Liesbeth van Deemter, Sven Rottenberg, Marieke van de Ven, Dick H.W. Dekkers, Jeroen A.A. Demmers, Dik C. van Gent, Reuven Agami, Judith Balmaña, Violeta Serra, Toshiyasu Taniguchi, Peter Bouwman, Jos Jonkers
J Clin Invest. 2016 Aug 1; 126(8): 2903–2918. Published online 2016 Jul 25. doi: 10.1172/JCI70196
PMCID:
PMC4966325
RelA regulates CXCL1/CXCR2-dependent oncogene-induced senescence in murine Kras-driven pancreatic carcinogenesis
Marina Lesina, Sonja Maria Wörmann, Jennifer Morton, Kalliope Nina Diakopoulos, Olga Korneeva, Margit Wimmer, Henrik Einwächter, Jan Sperveslage, Ihsan Ekin Demir, Timo Kehl, Dieter Saur, Bence Sipos, Mathias Heikenwälder, Jörg Manfred Steiner, Timothy Cragin Wang, Owen J. Sansom, Roland Michael Schmid, Hana Algül
J Clin Invest. 2016 Aug 1; 126(8): 2919–2932. Published online 2016 Jul 25. doi: 10.1172/JCI86477
PMCID:
PMC4966329

Clinical Medicine

Pravastatin improves pregnancy outcomes in obstetric antiphospholipid syndrome refractory to antithrombotic therapy
Eleftheria Lefkou, Apostolos Mamopoulos, Themistoklis Dagklis, Christos Vosnakis, David Rousso, Guillermina Girardi
J Clin Invest. 2016 Aug 1; 126(8): 2933–2940. Published online 2016 Jul 25. doi: 10.1172/JCI86957
PMCID:
PMC4966313

Research Articles

p53 coordinates decidual sestrin 2/AMPK/mTORC1 signaling to govern parturition timing
Wenbo Deng, Jeeyeon Cha, Jia Yuan, Hirofumi Haraguchi, Amanda Bartos, Emma Leishman, Benoit Viollet, Heather B. Bradshaw, Yasushi Hirota, Sudhansu K. Dey
J Clin Invest. 2016 Aug 1; 126(8): 2941–2954. Published online 2016 Jul 25. doi: 10.1172/JCI87715
PMCID:
PMC4966330
E2f8 mediates tumor suppression in postnatal liver development
Lindsey N. Kent, Jessica B. Rakijas, Shusil K. Pandit, Bart Westendorp, Hui-Zi Chen, Justin T. Huntington, Xing Tang, Sooin Bae, Arunima Srivastava, Shantibhusan Senapati, Christopher Koivisto, Chelsea K. Martin, Maria C. Cuitino, Miguel Perez, Julian M. Clouse, Veda Chokshi, Neelam Shinde, Raleigh Kladney, Daokun Sun, Antonio Perez-Castro, Ramadhan B. Matondo, Sathidpak Nantasanti, Michal Mokry, Kun Huang, Raghu Machiraju, Soledad Fernandez, Thomas J. Rosol, Vincenzo Coppola, Kamal S. Pohar, James M. Pipas, Carl R. Schmidt, Alain de Bruin, Gustavo Leone
J Clin Invest. 2016 Aug 1; 126(8): 2955–2969. Published online 2016 Jul 25. doi: 10.1172/JCI85506
PMCID:
PMC4966321
Activation of tyrosine kinase c-Abl contributes to α-synuclein–induced neurodegeneration
Saurav Brahmachari, Preston Ge, Su Hyun Lee, Donghoon Kim, Senthilkumar S. Karuppagounder, Manoj Kumar, Xiaobo Mao, Joo Ho Shin, Yunjong Lee, Olga Pletnikova, Juan C. Troncoso, Valina L. Dawson, Ted M. Dawson, Han Seok Ko
J Clin Invest. 2016 Aug 1; 126(8): 2970–2988. Published online 2016 Jun 27. doi: 10.1172/JCI85456
PMCID:
PMC4966315
Developmental SHP2 dysfunction underlies cardiac hypertrophy in Noonan syndrome with multiple lentigines
Jessica Lauriol, Janel R. Cabrera, Ashbeel Roy, Kimberly Keith, Sara M. Hough, Federico Damilano, Bonnie Wang, Gabriel C. Segarra, Meaghan E. Flessa, Lauren E. Miller, Saumya Das, Roderick Bronson, Kyu-Ho Lee, Maria I. Kontaridis
J Clin Invest. 2016 Aug 1; 126(8): 2989–3005. Published online 2016 Jun 27. doi: 10.1172/JCI80396
PMCID:
PMC4966304
Truncated netrin-1 contributes to pathological vascular permeability in diabetic retinopathy
Khalil Miloudi, François Binet, Ariel Wilson, Agustin Cerani, Malika Oubaha, Catherine Menard, Sullivan Henriques, Gaelle Mawambo, Agnieszka Dejda, Phuong Trang Nguyen, Flavio A. Rezende, Steve Bourgault, Timothy E. Kennedy, Przemyslaw Sapieha
J Clin Invest. 2016 Aug 1; 126(8): 3006–3022. Published online 2016 Jul 11. doi: 10.1172/JCI84767
PMCID:
PMC4966311
Probing chromatin landscape reveals roles of endocardial TBX20 in septation
Cornelis J. Boogerd, Ivy Aneas, Noboru Sakabe, Ralph J. Dirschinger, Quen J. Cheng, Bin Zhou, Ju Chen, Marcelo A. Nobrega, Sylvia M. Evans
J Clin Invest. 2016 Aug 1; 126(8): 3023–3035. Published online 2016 Jun 27. doi: 10.1172/JCI85350
PMCID:
PMC4966318
Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape
Meenakshi Hegde, Malini Mukherjee, Zakaria Grada, Antonella Pignata, Daniel Landi, Shoba A. Navai, Amanda Wakefield, Kristen Fousek, Kevin Bielamowicz, Kevin K.H. Chow, Vita S. Brawley, Tiara T. Byrd, Simone Krebs, Stephen Gottschalk, Winfried S. Wels, Matthew L. Baker, Gianpietro Dotti, Maksim Mamonkin, Malcolm K. Brenner, Jordan S. Orange, Nabil Ahmed
J Clin Invest. 2016 Aug 1; 126(8): 3036–3052. Published online 2016 Jul 18. doi: 10.1172/JCI83416
PMCID:
PMC4966331

Brief Reports

PKCδ-targeted intervention relieves chronic pain in a murine sickle cell disease model
Ying He, Diana J. Wilkie, Jonathan Nazari, Rui Wang, Robert O. Messing, Joseph DeSimone, Robert E. Molokie, Zaijie Jim Wang
J Clin Invest. 2016 Aug 1; 126(8): 3053–3057. Published online 2016 Jun 27. doi: 10.1172/JCI86165
PMCID:
PMC4966317
The nonsense-mediated RNA decay pathway is disrupted in inflammatory myofibroblastic tumors
JingWei Lu, Terra-Dawn Plank, Fang Su, XiuJuan Shi, Chen Liu, Yuan Ji, ShuaiJun Li, Andrew Huynh, Chao Shi, Bo Zhu, Guang Yang, YanMing Wu, Miles F. Wilkinson, YanJun Lu
J Clin Invest. 2016 Aug 1; 126(8): 3058–3062. Published online 2016 Jun 27. doi: 10.1172/JCI86508
PMCID:
PMC4966300

Research Articles

Transcription factor TBX4 regulates myofibroblast accumulation and lung fibrosis
Ting Xie, Jiurong Liang, Ningshan Liu, Caijuan Huan, Yanli Zhang, Weijia Liu, Maya Kumar, Rui Xiao, Jeanine D’Armiento, Daniel Metzger, Pierre Chambon, Virginia E. Papaioannou, Barry R. Stripp, Dianhua Jiang, Paul W. Noble
J Clin Invest. 2016 Aug 1; 126(8): 3063–3079. Published online 2016 Jul 11. doi: 10.1172/JCI85328
Correction in:
J Clin Invest. 2016 Sep 1; 126(9): 3626.
PMCID:
PMC4966327
EPHB4 kinase–inactivating mutations cause autosomal dominant lymphatic-related hydrops fetalis
Silvia Martin-Almedina, Ines Martinez-Corral, Rita Holdhus, Andres Vicente, Elisavet Fotiou, Shin Lin, Kjell Petersen, Michael A. Simpson, Alexander Hoischen, Christian Gilissen, Heather Jeffery, Giles Atton, Christina Karapouliou, Glen Brice, Kristiana Gordon, John W. Wiseman, Marianne Wedin, Stanley G. Rockson, Steve Jeffery, Peter S. Mortimer, Michael P. Snyder, Siren Berland, Sahar Mansour, Taija Makinen, Pia Ostergaard
J Clin Invest. 2016 Aug 1; 126(8): 3080–3088. Published online 2016 Jul 11. doi: 10.1172/JCI85794
PMCID:
PMC4966301
p21 mediates macrophage reprogramming through regulation of p50-p50 NF-κB and IFN-β
Gorjana Rackov, Enrique Hernández-Jiménez, Rahman Shokri, Lorena Carmona-Rodríguez, Santos Mañes, Melchor Álvarez-Mon, Eduardo López-Collazo, Carlos Martínez-A, Dimitrios Balomenos
J Clin Invest. 2016 Aug 1; 126(8): 3089–3103. Published online 2016 Jul 18. doi: 10.1172/JCI83404
PMCID:
PMC4966310
Reprogramming Müller glia via in vivo cell fusion regenerates murine photoreceptors
Daniela Sanges, Giacoma Simonte, Umberto Di Vicino, Neus Romo, Isabel Pinilla, Marta Nicolás, Maria Pia Cosma
J Clin Invest. 2016 Aug 1; 126(8): 3104–3116. Published online 2016 Jul 18. doi: 10.1172/JCI85193
PMCID:
PMC4966323
Stem-loop binding protein is a multifaceted cellular regulator of HIV-1 replication
Ming Li, Lynne D. Tucker, John M. Asara, Collins K. Cheruiyot, Huafei Lu, Zhijin J. Wu, Michael C. Newstein, Mark S. Dooner, Jennifer Friedman, Michelle A. Lally, Bharat Ramratnam
J Clin Invest. 2016 Aug 1; 126(8): 3117–3129. Published online 2016 Jul 25. doi: 10.1172/JCI82360
PMCID:
PMC4966322
Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition
Leonid Cherkassky, Aurore Morello, Jonathan Villena-Vargas, Yang Feng, Dimiter S. Dimitrov, David R. Jones, Michel Sadelain, Prasad S. Adusumilli
J Clin Invest. 2016 Aug 1; 126(8): 3130–3144. Published online 2016 Jul 25. doi: 10.1172/JCI83092
PMCID:
PMC4966328
RING domain–deficient BRCA1 promotes PARP inhibitor and platinum resistance
Yifan Wang, John J. Krais, Andrea J. Bernhardy, Emmanuelle Nicolas, Kathy Q. Cai, Maria I. Harrell, Hyoung H. Kim, Erin George, Elizabeth M. Swisher, Fiona Simpkins, Neil Johnson
J Clin Invest. 2016 Aug 1; 126(8): 3145–3157. Published online 2016 Jul 25. doi: 10.1172/JCI87033
PMCID:
PMC4966309

Corrigendum

Juhyun Lee, Peng Fei, René R. Sevag Packard, Hanul Kang, Hao Xu, Kyung In Baek, Nelson Jen, Junjie Chen, Hilary Yen, C.-C. Jay Kuo, Neil C. Chi, Chih-Ming Ho, Rongsong Li, Tzung K. Hsiai
J Clin Invest. 2016 Aug 1; 126(8): 3158. Published online 2016 Aug 1. doi: 10.1172/JCI89549
PMCID:
PMC4966324

Articles from The Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation