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This journal provides early access to some articles. Articles Genetic analysis of synaptotagmin 2 in spontaneous and Ca2+-triggered neurotransmitter release Zhiping P Pang, Jianyuan Sun, Josep Rizo, Anton Maximov, and Thomas C Südhof PMCID: PMC1462977 An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics Debbie Willoughby, Wei Wong, Jerome Schaack, John D Scott, and Dermot M F Cooper PMCID: PMC1462982 Phospholipase Cγ/diacylglycerol-dependent activation of β2-chimaerin restricts EGF-induced Rac signaling HongBin Wang, Chengfeng Yang, Federico Coluccio Leskow, Jing Sun, Bertram Canagarajah, James H Hurley, and Marcelo G Kazanietz PMCID: PMC1462969 Regulating angiogenesis at the level of PtdIns-4,5-P2 Eunok Im and Andrius Kazlauskas PMCID: PMC1462986 Nuclear Akt associates with PKC-phosphorylated Ebp1, preventing DNA fragmentation by inhibition of caspase-activated DNase Jee-Yin Ahn, Xia Liu, Zhixue Liu, Lorena Pereira, Dongmei Cheng, Junmin Peng, Paul A Wade, Anne W Hamburger, and Keqiang Ye PMCID: PMC1462972 The length of the transcript encoded from the Kcnq1ot1 antisense promoter determines the degree of silencing Chandrasekhar Kanduri, Noopur Thakur, and Radha Raman Pandey PMCID: PMC1462980 Regulation of αA-crystallin via Pax6, c-Maf, CREB and a broad domain of lens-specific chromatin Ying Yang, Tomáš Stopka, Nady Golestaneh, Yan Wang, Kongming Wu, Anping Li, Bharesh K Chauhan, Chun Y Gao, Květa Cveklová, Melinda K Duncan, Richard G Pestell, Ana B Chepelinsky, Arthur I Skoultchi, and Aleš Cvekl PMCID: PMC1462985 The FUSE/FBP/FIR/TFIIH system is a molecular machine programming a pulse of c-myc expression Juhong Liu, Fedor Kouzine, Zuqin Nie, Hye-Jung Chung, Zichrini Elisha-Feil, Achim Weber, Keji Zhao, and David Levens PMCID: PMC1462968 pH-dependent conformational switch activates the inhibitor of transcription elongation Oleg Laptenko, Seung-Sup Kim, Jookyung Lee, Marina Starodubtseva, Fellipe Cava, Jose Berenguer, Xiang-Peng Kong, and Sergei Borukhov PMCID: PMC1462974 Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA Akiko Noma, Yohei Kirino, Yoshiho Ikeuchi, and Tsutomu Suzuki PMCID: PMC1462984 Interaction of Moloney murine leukemia virus matrix protein with IQGAP Juliana Leung, Andrew Yueh, Frank S K Appah, Jr, Bing Yuan, Kenia de los Santos, and Stephen P Goff PMCID: PMC1462987 ATM–Chk2–p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency Liu Cao, Sangsoo Kim, Cuiying Xiao, Rui-Hong Wang, Xavier Coumoul, Xiaoyan Wang, Wen Mei Li, Xiao Ling Xu, Joseph A De Soto, Hiroyuki Takai, Sabine Mai, Stephen J Elledge, Noboru Motoyama, and Chu-Xia Deng PMCID: PMC1462967 A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites Jolanta Polanowska, Julie S Martin, Tatiana Garcia-Muse, Mark I R Petalcorin, and Simon J Boulton PMCID: PMC1462971 Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA Jeanette Ringvoll, Line M Nordstrand, Cathrine B Vågbø, Vivi Talstad, Karen Reite, Per Arne Aas, Knut H Lauritzen, Nina Beate Liabakk, Alexandra Bjørk, Richard William Doughty, Pål Ø Falnes, Hans E Krokan, and Arne Klungland PMCID: PMC1462979 Primer initiation and extension by T7 DNA primase Udi Qimron, Seung-Joo Lee, Samir M Hamdan, and Charles C Richardson PMCID: PMC1462978 Communication between subunits within an archaeal clamp-loader complex Anja Seybert, Martin R Singleton, Nicola Cook, David R Hall, and Dale B Wigley PMCID: PMC1462970 Nucleotide flips determine the specificity of the Ecl18kI restriction endonuclease Matthias Bochtler, Roman H Szczepanowski, Gintautas Tamulaitis, Saulius Grazulis, Honorata Czapinska, Elena Manakova, and Virginijus Siksnys PMCID: PMC1462983 When a helicase is not a helicase: dsDNA tracking by the motor protein EcoR124I Louise K Stanley, Ralf Seidel, Carsten van der Scheer, Nynke H Dekker, Mark D Szczelkun, and Cees Dekker PMCID: PMC1462981 Opaque cells signal white cells to form biofilms in Candida albicans Karla J Daniels, Thyagarajan Srikantha, Shawn R Lockhart, Claude Pujol, and David R Soll PMCID: PMC1462973 A Drosophila model of oculopharyngeal muscular dystrophy reveals intrinsic toxicity of PABPN1 Aymeric Chartier, Béatrice Benoit, and Martine Simonelig PMCID: PMC1462976 A structural model for monastrol inhibition of dimeric kinesin Eg5 Troy C Krzysiak, Thomas Wendt, Lisa R Sproul, Peter Tittmann, Heinz Gross, Susan P Gilbert, and Andreas Hoenger PMCID: PMC1462975
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