pmc logo image
Logo of jclinpathJournal of Clinical PathologyCurrent TOCInstructions for authors

Formats:

J Clin Pathol. 1982 June; 35(6): 606–610.
PMCID: PMC497733
Villous atrophy with crypt hyperplasia in malignant histiocytosis of the nose.
K Aozasa
Abstract
Intestinal changes, mainly in the jejunum, were investigated in 13 cases of malignant histiocytosis at necropsy and who had presented as lethal midline granuloma. Villous atrophy with crypt hyperplasia was observed in all cases, and a proliferation of atypical histiocytes was observed in seven cases. In the remaining cases, histiocytes with normal morphology increased in number. These findings showed that a prolonged abnormal proliferation of histiocytes was present in the small intestine of these cases concurrently with the nasal lesions.
Full text
Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.7M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.
Images in this article
Click on the image to see a larger version.
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
  • Isaacson P, Wright DH. Malignant histiocytosis of the intestine. Its relationship to malabsorption and ulcerative jejunitis. Hum Pathol. 1978 Nov;9(6):661–677. [PubMed]
  • Aozasa K, Watanabe Y, Ikeda H. Malignant histiocytosis presenting as lethal midline granuloma. Pathol Res Pract. 1981 May;171(3-4):314–324. [PubMed]
  • Warnke RA, Kim H, Dorfman RF. Malignant histiocytosis (histiocytic medullary reticulosis). I. Clinicopatholigic study of 29 cases. Cancer. 1975 Jan;35(1):215–230. [PubMed]
  • Chawla SK, Lopresti PA, Burdman D, Sileo A, Govoni AF, Smulewicz JJ. Diffuse small bowel involvement in malignant histiocytosis. Am J Gastroenterol. 1975 Feb;63(2):129–134. [PubMed]
  • Macgillivray JB, Duthie JS. Malignant histiocytosis (histiocytic medullary reticulosis) with spindle cell differentiation and tumour formation. J Clin Pathol. 1977 Feb;30(2):120–125. [PubMed]
  • Marshall AH, Revell PA. Malignant histiocytosis with associated "reticulum celled sarcoma". J Pathol. 1977 May;122(1):9–12. [PubMed]
  • GREENBERG E, COHEN DM, PEASE GL, KYLE RA. Histiocytic medullary reticulosis. Proc Staff Meet Mayo Clin. 1962 May 9;37:271–283. [PubMed]
  • Isaacson P, Wright DH. Intestinal lymphoma associated with malabsorption. Lancet. 1978 Jan 14;1(8055):67–70. [PubMed]
  • Kassel SH, Echevarria RA, Guzzo FP. Midline malignant reticulosis (so-called lethal midline granuloma). Cancer. 1969 Apr;23(4):920–935. [PubMed]
  • Eichel BS, Harrison EG, Jr, Devine KD, Scanlon PW, Brown HA. Primary lymphoma of the nose including a relationship to lethal midline granuloma. Am J Surg. 1966 Oct;112(4):597–605. [PubMed]
  • Fechner RE, Lamppin DW. Midline malignant reticulosis. A clinicopathologic entity. Arch Otolaryngol. 1972 May;95(5):467–476. [PubMed]
  • Fu YS, Perzin KH. Nonepithelial tumors of the nasal cavity, paranasal sinuses and nasopharynx: a clinicopathologic study. X. Malignant lymphomas. Cancer. 1979 Feb;43(2):611–621. [PubMed]
  • Zucker JM, Caillaux JM, Vanel D, Gerard-Marchant R. Malignant histiocytosis in childhood: clinical study and therapeutic results in 22 cases. Cancer. 1980 Jun 1;45(11):2821–2829. [PubMed]