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Journal List > Am J Pathol > v.134(3); Mar 1989

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Am J Pathol. 1989 March; 134(3): 627–631.
PMCID: PMC1879513
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Induction of a mixed ductal-squamous-islet cell carcinoma in a rat treated with a tobacco-specific carcinogen.
P. M. Pour and A. Rivenson
Eppley Institute, University of Nebraska Medical Center, Omaha 68105-1065.
Abstract
Treatment of rats with tobacco-specific nitrosamines resulted in the induction of pancreatic acinar cell and ductal cell neoplasms. One of these tumors had a mixed ductal-squamous-islet cell components, the electron microscopic and immunohistochemical patterns of which are described. This is the first report of such a pancreatic mixed cell neoplasm.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
  • Levison DA, Morgan RG, Brimacombe JS, Hopwood D, Coghill G, Wormsley KG. Carcinogenic effects of Di(2-hydroxypropyl)nitrosamine (DHPN) in male Wistar rats: promotion of pancreatic cancer by a raw soya flour diet. Scand J Gastroenterol. 1979;14(2):217–224. [PubMed]
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  • Kodama T, Mori W. Morphological behavior of carcinoma of the pancreas. 2. Argyrophil cells and Langerhans' islets in the carcinomatous tissues. Acta Pathol Jpn. 1983 May;33(3):483–493. [PubMed]
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