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Journal List > West J Med > v.141(3); Sep 1984

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West J Med. 1984 September; 141(3): 329–334.
PMCID: PMC1021820
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Brain Infarction and Hemorrhage in Young and Middle-aged Adults
Joseph R. Lacy, MD, Christopher M. Filley, MD, Michael P. Earnest, MD, and Neill R. Graff-Radford, MB, BCh, MRCP
Abstract
Of 131 young (17 to 44 years) and middle-aged (45 to 55 years) adults who had brain infarction or hemorrhage, the most common etiologic factors were rheumatic heart disease, migraine and oral contraceptive use among the younger group. In contrast, atherosclerotic, hypertensive and diabetes-associated cerebrovascular were the most common causes in the middle-aged group. Patients who have a stroke before age 45 should have prompt, complete laboratory and radiologic testing to define a possible treatable cause.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
  • Warlow C. The young stroke. Br J Hosp Med. 1979 Sep;22(3):252–259. [PubMed]
  • Grindal AB, Cohen RJ, Saul RF, Taylor JR. Cerebral infarction in young adults. Stroke. 1978 Jan–Feb;9(1):39–42. [PubMed]
  • Hindfelt B, Nilsson O. Brain infarction in young adults (with particular reference to pathogenesis). Acta Neurol Scand. 1977 Feb;55(2):145–157. [PubMed]
  • Chopra JS, Prabhakar S. Clinical features and risk factors in stroke in young. Acta Neurol Scand. 1979;60(5):289–300. [PubMed]
  • Vignaendra V, Chong BH, Loh TG, Ang AH. Occlusive cerebrovascular disease in young adults. Eur Neurol. 1977;16(1-6):115–120. [PubMed]
  • Janaki S, Baruah JK, Jayaram SR, Saxena VK, Sharma SH, Gulati MS. Stoke in the young: a four-year study, 1968 to 1972. Stroke. 1975 May–Jun;6(3):318–320. [PubMed]
  • Louis S, McDowell F. Stroke in young adults. Ann Intern Med. 1967 May;66(5):932–938. [PubMed]
  • WELLS CE, TIMBERGER RJ. Cerebral thrombosis in patients under fifty years of age. Arch Neurol. 1961 Mar;4:268–271. [PubMed]
  • Cohen RJ, Taylor JR. Persistent neurologic sequelae of migraine: a case report. Neurology. 1979 Aug;29(8):1175–1177. [PubMed]
  • Vessey MP. Oral contraceptives and stroke. N Engl J Med. 1973 Apr 26;288(17):906–907. [PubMed]
  • Stadel BV. Oral contraceptives and cardiovascular disease (second of two parts). N Engl J Med. 1981 Sep 17;305(12):672–677. [PubMed]
  • Fogelholm R, Aho K. Ischaemic cerebrovascular disease in young adults. 1. Smoking habits, use of oral contraceptives, relative weight, blood pressure and electrocardiographic findings. Acta Neurol Scand. 1973;49(4):415–427. [PubMed]
  • Watson RT. TIA, stroke, and mitral valve prolapse. Neurology. 1979 Jun;29(6):886–889. [PubMed]
  • Hanson MR, Conomy JP, Hodgman JR. Brain events associated with mitral valve prolapse. Stroke. 1980 Sep–Oct;11(5):499–506. [PubMed]
  • Shapiro SK, Warshawsky R, Shapiro I, See CE. Neurological and ophthalmological complications of mitral valve prolapse. Minn Med. 1981 Apr;64(4):197–199. [PubMed]
  • Barnett HJ, Boughner DR, Taylor DW, Cooper PE, Kostuk WJ, Nichol PM. Further evidence relating mitral-valve prolapse to cerebral ischemic events. N Engl J Med. 1980 Jan 17;302(3):139–144. [PubMed]
  • Lee K. Alcoholism and cerebrovascular thrombosis in the young. Acta Neurol Scand. 1979 May;59(5):270–274. [PubMed]
  • Walbran BB, Nelson JS, Taylor JR. Association of cerebral infarction and chronic alcoholism: an autopsy study. Alcohol Clin Exp Res. 1981 Fall;5(4):531–535. [PubMed]
  • Hillbom M, Kaste M. Ethanol intoxication: a risk factor for ischemic brain infarction in adolescents and young adults. Stroke. 1981 Jul–Aug;12(4):422–425. [PubMed]
  • Lee K, Nielsen JD, Zeeberg I, Gormsen J. Platelet aggregation and fibrinolytic activity in young alcoholics. Acta Neurol Scand. 1980 Nov;62(5):287–292. [PubMed]
  • Kannel WB, Gordon T, Wolf PA, McNamara P. Hemoglobin and the risk of cerebral infarction: the Framingham Study. Stroke. 1972 Jul–Aug;3(4):409–420. [PubMed]
  • Tohgi H, Yamanouchi H, Murakami M, Kameyama M. Importance of the hematocrit as a risk factor in cerebral infarction. Stroke. 1978 Jul–Aug;9(4):369–374. [PubMed]
  • Nomura A, Comstock GW, Kuller L, Tonascia JA. Cigarette smoking and strokes. Stroke. 1974 Jul–Aug;5(4):483–486. [PubMed]
  • Hoogendijk EM, Jenkins CS, van Wijk EM, Vos J, ten Cate JW. Spontaneous platelet aggregation in cerebrovascular disease II. Further characterisation of the platelet defect. Thromb Haemost. 1979 May 25;41(3):512–522. [PubMed]
  • Bansal BC, Prakash C, Arya RK, Gulati SK, Mittal SC. Serum lipids, platelets, and fibrinolytic activity in cerebrovascular disease. Stroke. 1978 Mar–Apr;9(2):137–139. [PubMed]
  • Køhler O, Rasmussen K. Plasma lipids and lipoproteins in patients with cerebral infarct or transient cerebral ischemia. Acta Neurol Scand. 1979 Mar;59(2-3):55–62. [PubMed]
  • Murai A, Tanaka T, Miyahara T, Kameyama M. Lipoprotein abnormalities in the pathogenesis of cerebral infarction and transient ischemic attack. Stroke. 1981 Mar–Apr;12(2):167–172. [PubMed]
  • Hart RG, Miller VT. Cerebral infarction in young adults: a practical approach. Stroke. 1983 Jan–Feb;14(1):110–114. [PubMed]
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