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Proc Natl Acad Sci U S A. Apr 5, 2005; 102(14): 4936–4942.
Published online Mar 23, 2005. doi:  10.1073/pnas.0408031102
PMCID: PMC555974
Gene Regulatory Networks Special FeatureFrom the Cover
Perspective

Gene regulatory networks for development

Abstract

The genomic program for development operates primarily by the regulated expression of genes encoding transcription factors and components of cell signaling pathways. This program is executed by cis-regulatory DNAs (e.g., enhancers and silencers) that control gene expression. The regulatory inputs and functional outputs of developmental control genes constitute network-like architectures. In this PNAS Special Feature are assembled papers on developmental gene regulatory networks governing the formation of various tissues and organs in nematodes, flies, sea urchins, frogs, and mammals. Here, we survey salient points of these networks, by using as reference those governing specification of the endomesoderm in sea urchin embryos and dorsal–ventral patterning in the Drosophila embryo.


Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences
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