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The Janus kinases (Jaks)
Kunihiro Yamaoka, Pipsa Saharinen, Marko Pesu, Vance ET Holt, III, Olli Silvennoinen, John J O'Shea
Genome Biol. 2004; 5(12): 253. Published online 2004 November 30. doi: 10.1186/gb-2004-5-12-253
PMCID:
PMC545791
Abstract Full Text PDF–121K Supplementary Material
 Is Cited by the Following 27 Articles in this Archive:
The JAK/STAT Pathway Is Involved in Synaptic Plasticity
Céline S. Nicolas, Stéphane Peineau, Mascia Amici, Zsolt Csaba, Assia Fafouri, Charlotte Javalet, Valerie J. Collett, Lars Hildebrandt, Gillian Seaton, Sun-Lim Choi, Su-Eon Sim, Clarrisa Bradley, Kyungmin Lee, Min Zhuo, Bong-Kiun Kaang, Pierre Gressens, Pascal Dournaud, Stephen M. Fitzjohn, Zuner A. Bortolotto, Kwangwook Cho, Graham L. Collingridge
Neuron. 2012 January; 73(2): 374–390. doi: 10.1016/j.neuron.2011.11.024
PMCID:
PMC3268861
Abstract Full Text Supplementary Material
Restoration of IFNγR Subunit Assembly, IFNγ Signaling and Parasite Clearance in Leishmania donovani Infected Macrophages: Role of Membrane Cholesterol
Subha Sen, Koushik Roy, Sandip Mukherjee, Rupkatha Mukhopadhyay, Syamal Roy
PLoS Pathog. 2011 September; 7(9): e1002229. Published online 2011 September 8. doi: 10.1371/journal.ppat.1002229
PMCID:
PMC3169561
Abstract Full Text PDF–3.4M Supplementary Material
Curcumin suppresses the production of interleukin-6 in Prevotella intermedia lipopolysaccharide-activated RAW 264.7 cells
Sung-Jo Kim
J Periodontal Implant Sci. 2011 June; 41(3): 157–163. Published online 2011 June 30. doi: 10.5051/jpis.2011.41.3.157
PMCID:
PMC3139050
Abstract Full Text PDF–427K
Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2
Brandon C. Sos, Charles Harris, Sarah M. Nordstrom, Jennifer L. Tran, Mercedesz Balázs, Patrick Caplazi, Maria Febbraio, Milana A.B. Applegate, Kay-Uwe Wagner, Ethan J. Weiss
J Clin Invest. 2011 April 1; 121(4): 1412–1423. Published online 2011 March 1. doi: 10.1172/JCI42894
Correction in:
J Clin Invest. 2011 August 1; 121(8): 3360.
PMCID:
PMC3069761
Abstract Full Text PDF–949K Supplementary Material Correction
RAF associates with phosphorylated nuclear BubR1 during endoreduplication induced by JAK inhibition
Gudrun Reiterer, Lihua Chen, Ryan Tasseff, Jeffery D Varner, Chang-Yan Chen, Andrew Yen
Cell Cycle. 2010 August 15; 9(16): 3297–3304. Published online 2010 August 15. doi: 10.4161/cc.9.16.12631
PMCID:
PMC3230478
Abstract Full Text PDF–899K
Activation of JAK2-V617F by Components of Heterodimeric Cytokine Receptors
Anuradha Pradhan, Que T. Lambert, Lori N. Griner, Gary W. Reuther
J Biol Chem. 2010 May 28; 285(22): 16651–16663. Published online 2010 April 2. doi: 10.1074/jbc.M109.071191
PMCID:
PMC2878064
Abstract Full Text Supplementary Material
Uncoupling JAK3 activation induces apoptosis in human lymphoid cancer cells via regulating critical survival pathways
Zsuzsanna S. Nagy, Jeremy A. Ross, Georgialina Rodriguez, Julia Bader, Jonathan Dimmock, Robert A. Kirken
FEBS Lett. Author manuscript; available in PMC 2011 April 16.
Published in final edited form as: FEBS Lett. 2010 April 16; 584(8): 1515–1520. Published online 2010 March 6. doi: 10.1016/j.febslet.2010.02.071
PMCID:
PMC2854231
Abstract Full Text PDF–771K
Allelic variation in the Tyk2 and EGF genes as potential genetic determinants of CNS repair
Allan J. Bieber, Kanitta Suwansrinon, Jason Kerkvliet, Weidong Zhang, Larry R. Pease, Moses Rodriguez
Proc Natl Acad Sci U S A. 2010 January 12; 107(2): 792–797. Published online 2009 December 22. doi: 10.1073/pnas.0906589107
PMCID:
PMC2818917
Abstract Full Text PDF–517K Supplementary Material
Cell cycle progression following naïve T cell activation is independent of Jak3/γc cytokine signals
Min Shi, Tsung H. Lin, Kenneth C. Appell, Leslie J. Berg
J Immunol. Author manuscript; available in PMC 2010 October 1.
Published in final edited form as: J Immunol. 2009 October 1; 183(7): 4493–4501. Published online 2009 September 4. doi: 10.4049/jimmunol.0804339
PMCID:
PMC2768578
Abstract Full Text PDF–2.6M Supplementary Material
JAK redux: a second look at the regulation and role of JAKs in the heart
Mazen Kurdi, George W. Booz
Am J Physiol Heart Circ Physiol. 2009 November; 297(5): H1545–H1556. Published online 2009 August 28. doi: 10.1152/ajpheart.00032.2009
PMCID:
PMC2781365
Abstract Full Text
A JAK2 Interdomain Linker Relays Epo Receptor Engagement Signals to Kinase Activation
Lequn Zhao, Hongyun Dong, Cheng Cheng Zhang, Lisa Kinch, Mitsujiro Osawa, Michelina Iacovino, Nikolai V. Grishin, Michael Kyba, Lily Jun-shen Huang
J Biol Chem. 2009 September 25; 284(39): 26988–26998. Published online 2009 July 28. doi: 10.1074/jbc.M109.011387
PMCID:
PMC2785384
Abstract Full Text Supplementary Material
Ligand-independent Thrombopoietin Mutant Receptor Requires Cell Surface Localization for Endogenous Activity
Caroline Marty, Ronan Chaligné, Catherine Lacout, Stefan N. Constantinescu, William Vainchenker, Jean-Luc Villeval
J Biol Chem. 2009 May 1; 284(18): 11781–11791. doi: 10.1074/jbc.M808703200
PMCID:
PMC2673247
Abstract Full Text
Organization of F-Actin via Concerted Regulation of Kette by PTP61F and dAbl
Hsueh-Yen Ku, Chia-Lun Wu, Leonard Rabinow, Guang-Chao Chen, Tzu-Ching Meng
Mol Cell Biol. 2009 July; 29(13): 3623–3632. Published online 2009 April 27. doi: 10.1128/MCB.00229-09
PMCID:
PMC2698756
Abstract Full Text PDF–1.4M Supplementary Material
Adapter Protein SH2B1β Cross-Links Actin Filaments and Regulates Actin Cytoskeleton
Leah Rider, Jing Tao, Stacy Snyder, Brittany Brinley, Jiayun Lu, Maria Diakonova
Mol Endocrinol. 2009 July; 23(7): 1065–1076. Published online 2009 April 2. doi: 10.1210/me.2008-0428
PMCID:
PMC2703597
Abstract Full Text
Janus kinases in immune cell signaling
Kamran Ghoreschi, Arian Laurence, John J. O’Shea
Immunol Rev. Author manuscript; available in PMC 2010 March 1.
Published in final edited form as: Immunol Rev. 2009 March; 228(1): 273–287. doi: 10.1111/j.1600-065X.2008.00754.x
PMCID:
PMC2782696
Abstract Full Text PDF–187K
Examining the Chirality, Conformation and Selective Kinase Inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550)
Jian-kang Jiang, Kamran Ghoreschi, Francesca Deflorian, Zhi Chen, Melissa Perreira, Marko Pesu, Jeremy Smith, Dac-Trung Nguyen, Eric H. Liu, William Leister, Stefano Costanzi, John J. O’Shea, Craig J. Thomas
J Med Chem. Author manuscript; available in PMC 2009 March 25.
Published in final edited form as: J Med Chem. 2008 December 25; 51(24): 8012–8018. doi: 10.1021/jm801142b
PMCID:
PMC2660606
Abstract Full Text PDF–1.1M
Molecular Characterization of Human Breast Tumor Vascular Cells
Rajendra Bhati, Cam Patterson, Chad A. Livasy, Cheng Fan, David Ketelsen, Zhiyuan Hu, Evangeline Reynolds, Catherine Tanner, Dominic T. Moore, Franco Gabrielli, Charles M. Perou, Nancy Klauber-DeMore
Am J Pathol. 2008 May; 172(5): 1381–1390. doi: 10.2353/ajpath.2008.070988
PMCID:
PMC2329846
Abstract Full Text PDF–1.4M
Protein tyrosine phosphatases in the JAK/STAT pathway
Dan Xu, Cheng-Kui Qu
Front Biosci. Author manuscript; available in PMC 2008 December 9.
Published in final edited form as: Front Biosci. 2008 May 1; 13: 4925–4932.
PMCID:
PMC2599796
Abstract Full Text PDF–60K
Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia
Elisabetta Flex, Valentina Petrangeli, Lorenzo Stella, Sabina Chiaretti, Tekla Hornakova, Laurent Knoops, Cristina Ariola, Valentina Fodale, Emmanuelle Clappier, Francesca Paoloni, Simone Martinelli, Alessandra Fragale, Massimo Sanchez, Simona Tavolaro, Monica Messina, Giovanni Cazzaniga, Andrea Camera, Giovanni Pizzolo, Assunta Tornesello, Marco Vignetti, Angela Battistini, Hélène Cavé, Bruce D. Gelb, Jean-Christophe Renauld, Andrea Biondi, Stefan N. Constantinescu, Robin Foà, Marco Tartaglia
J Exp Med. 2008 April 14; 205(4): 751–758. doi: 10.1084/jem.20072182
PMCID:
PMC2292215
Abstract Full Text PDF–2.1M Supplementary Material
The Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenes
Gerlinde Wernig, Jeffrey R. Gonneville, Brian J. Crowley, Margret S. Rodrigues, Mamatha M. Reddy, Heidi E. Hudon, Christoph Walz, Andreas Reiter, Klaus Podar, Yohan Royer, Stefan N. Constantinescu, Michael H. Tomasson, James D. Griffin, D. Gary Gilliland, Martin Sattler
Blood. 2008 April 1; 111(7): 3751–3759. Prepublished online 2008 January 23. doi: 10.1182/blood-2007-07-102186
PMCID:
PMC2275031
Abstract Full Text
RNAi screening of the tyrosine kinome identifies therapeutic targets in acute myeloid leukemia
Jeffrey W. Tyner, Denise K. Walters, Stephanie G. Willis, Mary Luttropp, Jason Oost, Marc Loriaux, Heidi Erickson, Amie S. Corbin, Thomas O'Hare, Michael C. Heinrich, Michael W. Deininger, Brian J. Druker
Blood. 2008 February 15; 111(4): 2238–2245. Prepublished online 2007 November 19. doi: 10.1182/blood-2007-06-097253
PMCID:
PMC2234058
Abstract Full Text Supplementary Material
Inhibition of Jak1-Dependent Signal Transduction in Airway Epithelial Cells Infected with Adenovirus
Lei Shi, Murali Ramaswamy, Lori J. Manzel, Dwight C. Look
Am J Respir Cell Mol Biol. 2007 December; 37(6): 720–728. Published online 2007 July 19. doi: 10.1165/rcmb.2007-0158OC
PMCID:
PMC2219548
Abstract Full Text PDF–986K
Interferons induce tyrosine phosphorylation of the eIF2α kinase PKR through activation of Jak1 and Tyk2
Qiaozhu Su, Shuo Wang, Dionissios Baltzis, Li-Ke Qu, Jennifer F Raven, Suiyang Li, Andrew Hoi-Tao Wong, Antonis E Koromilas
EMBO Rep. 2007 March; 8(3): 265–270. Published online 2007 February 9. doi: 10.1038/sj.embor.7400891
PMCID:
PMC1808029
Abstract Full Text PDF–208K Supplementary Material
Expression of TEL-JAK2 in primary human hematopoietic cells drives erythropoietin-independent erythropoiesis and induces myelofibrosis in vivo
J. A. Kennedy, F. Barabé, B. J. Patterson, J. Bayani, J. A. Squire, D. L. Barber, J. E. Dick
Proc Natl Acad Sci U S A. 2006 November 7; 103(45): 16930–16935. Published online 2006 October 31. doi: 10.1073/pnas.0604902103
PMCID:
PMC1629449
Abstract Full Text PDF–892K Supplementary Material
Binding of SH2-B Family Members within a Potential Negative Regulatory Region Maintains JAK2 in an Active State
Jason H. Kurzer, Pipsa Saharinen, Olli Silvennoinen, Christin Carter-Su
Mol Cell Biol. 2006 September; 26(17): 6381–6394. doi: 10.1128/MCB.00570-06
PMCID:
PMC1592834
Abstract Full Text PDF–514K
Phosphorylation of JAK2 at Serine 523: a Negative Regulator of JAK2 That Is Stimulated by Growth Hormone and Epidermal Growth Factor
Anna M. Mazurkiewicz-Munoz, Lawrence S. Argetsinger, Jean-Louis K. Kouadio, Allan Stensballe, Ole N. Jensen, Joel M. Cline, Christin Carter-Su
Mol Cell Biol. 2006 June; 26(11): 4052–4062. doi: 10.1128/MCB.01591-05
PMCID:
PMC1489095
Abstract Full Text PDF–388K
The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation
Catriona H. M. Jamieson, Jason Gotlib, Jeffrey A. Durocher, Mark P. Chao, M. Rajan Mariappan, Marla Lay, Carol Jones, James L. Zehnder, Stan L. Lilleberg, Irving L. Weissman
Proc Natl Acad Sci U S A. 2006 April 18; 103(16): 6224–6229. Published online 2006 April 7. doi: 10.1073/pnas.0601462103
PMCID:
PMC1434515
Abstract Full Text PDF–1.6M Supplementary Material
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