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Proc Natl Acad Sci U S A. Apr 1990; 87(7): 2496–2500.
PMCID: PMC53716

DNA "fingerprinting" reveals high levels of inbreeding in colonies of the eusocial naked mole-rat.

Abstract

Using the technique of DNA fingerprinting, we investigated the genetic structure within and among four wild-caught colonies (n = 50 individuals) of a eusocial mammal, the naked mole-rat (Heterocephalus glaber; Rodentia: Bathyergidae). We found that DNA fingerprints of colony-mates were strikingly similar and that between colonies they were much more alike than fingerprints of non-kin in other free-living vertebrates. Extreme genetic similarity within colonies is due to close genetic relationship (mean relatedness estimate +/- SE, r = 0.81 +/- 0.10), which apparently results from consanguineous mating. The inbreeding coefficient (F = 0.45 +/- 0.18) is the highest yet recorded among wild mammals. The genetic structure of naked mole-rat colonies lends support to kin selection and ecological constraints models for the evolution of cooperative breeding and eusociality.

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Selected References

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  • Jarvis JU. Eusociality in a mammal: cooperative breeding in naked mole-rat colonies. Science. 1981 May 1;212(4494):571–573. [PubMed]
  • Hamilton WD. The genetical evolution of social behaviour. II. J Theor Biol. 1964 Jul;7(1):17–52. [PubMed]
  • Michod RE. Evolution of interactions in family-structured populations: mixed mating models. Genetics. 1980 Sep;96(1):275–296. [PMC free article] [PubMed]
  • Bartz SH. Evolution of eusociality in termites. Proc Natl Acad Sci U S A. 1979 Nov;76(11):5764–5768. [PMC free article] [PubMed]
  • Jeffreys AJ, Wilson V, Thein SL. Hypervariable 'minisatellite' regions in human DNA. Nature. 1985 Mar 7;314(6006):67–73. [PubMed]
  • Jeffreys AJ, Brookfield JF, Semeonoff R. Positive identification of an immigration test-case using human DNA fingerprints. Nature. 317(6040):818–819. [PubMed]
  • Jeffreys AJ, Morton DB. DNA fingerprints of dogs and cats. Anim Genet. 1987;18(1):1–15. [PubMed]
  • Jeffreys AJ, Wilson V, Thein SL. Individual-specific 'fingerprints' of human DNA. Nature. 1985 Jul 4;316(6023):76–79. [PubMed]
  • Wetton JH, Carter RE, Parkin DT, Walters D. Demographic study of a wild house sparrow population by DNA fingerprinting. Nature. 1987 May 14;327(6118):147–149. [PubMed]
  • Burke T, Bruford MW. DNA fingerprinting in birds. Nature. 1987 May 14;327(6118):149–152. [PubMed]
  • Vassart G, Georges M, Monsieur R, Brocas H, Lequarre AS, Christophe D. A sequence in M13 phage detects hypervariable minisatellites in human and animal DNA. Science. 1987 Feb 6;235(4789):683–684. [PubMed]
  • Georges M, Lequarré AS, Castelli M, Hanset R, Vassart G. DNA fingerprinting in domestic animals using four different minisatellite probes. Cytogenet Cell Genet. 1988;47(3):127–131. [PubMed]
  • Saghai-Maroof MA, Soliman KM, Jorgensen RA, Allard RW. Ribosomal DNA spacer-length polymorphisms in barley: mendelian inheritance, chromosomal location, and population dynamics. Proc Natl Acad Sci U S A. 1984 Dec;81(24):8014–8018. [PMC free article] [PubMed]
  • Westneat DF, Noon WA, Reeve HK, Aquadro CF. Improved hybridization conditions for DNA 'fingerprints' probed with M13. Nucleic Acids Res. 1988 May 11;16(9):4161–4161. [PMC free article] [PubMed]
  • Jeffreys AJ, Wilson V, Kelly R, Taylor BA, Bulfield G. Mouse DNA 'fingerprints': analysis of chromosome localization and germ-line stability of hypervariable loci in recombinant inbred strains. Nucleic Acids Res. 1987 Apr 10;15(7):2823–2836. [PMC free article] [PubMed]
  • Jeffreys AJ, Wilson V, Thein SL, Weatherall DJ, Ponder BA. DNA "fingerprints" and segregation analysis of multiple markers in human pedigrees. Am J Hum Genet. 1986 Jul;39(1):11–24. [PMC free article] [PubMed]
  • Lynch M. Estimation of relatedness by DNA fingerprinting. Mol Biol Evol. 1988 Sep;5(5):584–599. [PubMed]
  • Evans JR, Massler M. The effective clinical teacher. J Dent Educ. 1977 Oct;41(10):613–617. [PubMed]

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