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J Clin Invest. Nov 1970; 49(11): 2146–2149.
PMCID: PMC535790

The role of phosphate in the secretion of parathyroid hormone in man


In man, oral administration of 1 g of phosphorus resulted in a 60-125% increase in serum immunoassayable parathyroid hormone (PTH) concentration. Peak PTH levels were attained in 1 hr, and PTH returned to base line levels in 2 hr. This increase in PTH appeared to be initiated by a very small decrease of total and ionized calcium and was abolished by a calcium infusion. There was no correlation between serum phosphorus and PTH. The experiments show that oral phosphorus administration initiates a calcium-mediated control system for PTH secretion and that this system operates very sensitively in man.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Dale DC, Roth SI, Garcia GE. Effect of calcium on parathyroid secretion. Endocrinology. 1965 Oct;77(4):725–730. [PubMed]
  • Sherwood LM, Mayer GP, Ramberg CF, Jr, Kronfeld DS, Aurbach GD, Potts JT., Jr Regulation of parathyroid hormone secretion: proportional control by calcium, lack of effect of phosphate. Endocrinology. 1968 Nov;83(5):1043–1051. [PubMed]
  • MORRIN PA, GEDNEY WB, REISS E. Phosphate homeostasis: sensitivity of parathyroid-mediated response of renal excretion. J Lab Clin Med. 1962 Mar;59:387–395. [PubMed]
  • Moore EW. Ionized calcium in normal serum, ultrafiltrates, and whole blood determined by ion-exchange electrodes. J Clin Invest. 1970 Feb;49(2):318–334. [PMC free article] [PubMed]
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  • Reis E, Canterbury JM. A radioimmunoassay for parathyroid hormone in man. Proc Soc Exp Biol Med. 1968 Jun;128(2):501–504. [PubMed]
  • Berson SA, Yalow RS. Parathyroid hormone in plasma in adenomatous hyperparathyroidism, uremia, and bronchogenic carcinoma. Science. 1966 Nov 18;154(3751):907–909. [PubMed]
  • Berson SA, Yalow RS. Immunochemical heterogeneity of parathyroid hormone in plasma. J Clin Endocrinol Metab. 1968 Jul;28(7):1037–1047. [PubMed]
  • Reiss E, Canterbury JM, Egdahl RH. Experience with a radioimmunoassay of parathyroid hormone in human sera. Trans Assoc Am Physicians. 1968;81:104–115. [PubMed]
  • Reiss E, Canterbury JM. Application of radioimmunoassay to differentiation of adenoma and hyperplasia and to preoperative localization of hyperfunctioning parathyroid glands. N Engl J Med. 1969 Jun 19;280(25):1381–1385. [PubMed]
  • Bricker NS, Slatopolsky E, Reiss E, Avioli LV. Caclium, phosphorus, and bone in renal disease and transplantation. Arch Intern Med. 1969 May;123(5):543–553. [PubMed]

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