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J Clin Invest. Nov 1970; 49(11): 2146–2149.
PMCID: PMC535790

The role of phosphate in the secretion of parathyroid hormone in man

Abstract

In man, oral administration of 1 g of phosphorus resulted in a 60-125% increase in serum immunoassayable parathyroid hormone (PTH) concentration. Peak PTH levels were attained in 1 hr, and PTH returned to base line levels in 2 hr. This increase in PTH appeared to be initiated by a very small decrease of total and ionized calcium and was abolished by a calcium infusion. There was no correlation between serum phosphorus and PTH. The experiments show that oral phosphorus administration initiates a calcium-mediated control system for PTH secretion and that this system operates very sensitively in man.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Dale DC, Roth SI, Garcia GE. Effect of calcium on parathyroid secretion. Endocrinology. 1965 Oct;77(4):725–730. [PubMed]
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