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Proc Natl Acad Sci U S A. Jan 1990; 87(1): 399–403.

Unusual molecular characteristics of a repeat sequence island within a Giemsa-positive band on the mouse X chromosome.


The mouse genome contains 50 copies of a long complex repeat unit localized as a repeat sequence island to the A3 Giemsa-positive (dark) band on the mouse X chromosome. The repeat units are not tandemly arranged but are juxtaposed and inserted by unrelated sequences of high repetition. The repeat sequence island possesses two notable features that have been suggested as diagnostic features of mammalian Giemsa-positive bands. First, the repeat sequence island encompasses a 1-megabase region devoid of CpG islands; second, it features a high concentration of L1 long interspersed repeat sequences.

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  • Bickmore WA, Sumner AT. Mammalian chromosome banding--an expression of genome organization. Trends Genet. 1989 May;5(5):144–148. [PubMed]
  • Goldman MA, Holmquist GP, Gray MC, Caston LA, Nag A. Replication timing of genes and middle repetitive sequences. Science. 1984 May 18;224(4650):686–692. [PubMed]
  • Holmquist GP. Role of replication time in the control of tissue-specific gene expression. Am J Hum Genet. 1987 Feb;40(2):151–173. [PMC free article] [PubMed]
  • Holmquist G, Gray M, Porter T, Jordan J. Characterization of Giemsa dark- and light-band DNA. Cell. 1982 Nov;31(1):121–129. [PubMed]
  • Korenberg JR, Rykowski MC. Human genome organization: Alu, lines, and the molecular structure of metaphase chromosome bands. Cell. 1988 May 6;53(3):391–400. [PubMed]
  • Lichtman JW, Taghert PH. Developmental neurobiology. Trophic factor theory matures. Nature. 326(6111):336–336. [PubMed]
  • Gardiner-Garden M, Frommer M. CpG islands in vertebrate genomes. J Mol Biol. 1987 Jul 20;196(2):261–282. [PubMed]
  • Bird AP. CpG-rich islands and the function of DNA methylation. Nature. 1986 May 15;321(6067):209–213. [PubMed]
  • Brockdorff N, Amar LC, Brown SD. Pulse-field linkage of the P3, G6pd and Cf-8 genes on the mouse X chromosome: demonstration of synteny at the physical level. Nucleic Acids Res. 1989 Feb 25;17(4):1315–1326. [PMC free article] [PubMed]
  • Burmeister M, Monaco AP, Gillard EF, van Ommen GJ, Affara NA, Ferguson-Smith MA, Kunkel LM, Lehrach H. A 10-megabase physical map of human Xp21, including the Duchenne muscular dystrophy gene. Genomics. 1988 Apr;2(3):189–202. [PubMed]
  • Disteche CM, McConnell GK, Grant SG, Stephenson DA, Chapman VM, Gandy S, Adler DA. Comparison of the physical and recombination maps of the mouse X chromosome. Genomics. 1989 Aug;5(2):177–184. [PubMed]
  • Brockdorff N, Fisher EM, Cavanna JS, Lyon MF, Brown SD. Construction of a detailed molecular map of the mouse X chromosome by microcloning and interspecific crosses. EMBO J. 1987 Nov;6(11):3291–3297. [PMC free article] [PubMed]
  • Brockdorff N, Cross GS, Cavanna JS, Fisher EM, Lyon MF, Davies KE, Brown SD. The mapping of a cDNA from the human X-linked Duchenne muscular dystrophy gene to the mouse X chromosome. Nature. 1987 Jul 9;328(6126):166–168. [PubMed]
  • Feinberg AP, Vogelstein B. "A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum. Anal Biochem. 1984 Feb;137(1):266–267. [PubMed]
  • Davis MM, Calame K, Early PW, Livant DL, Joho R, Weissman IL, Hood L. An immunoglobulin heavy-chain gene is formed by at least two recombinational events. Nature. 1980 Feb 21;283(5749):733–739. [PubMed]
  • Rackwitz HR, Zehetner G, Frischauf AM, Lehrach H. Rapid restriction mapping of DNA cloned in lambda phage vectors. Gene. 1984 Oct;30(1-3):195–200. [PubMed]
  • Herrmann BG, Barlow DP, Lehrach H. A large inverted duplication allows homologous recombination between chromosomes heterozygous for the proximal t complex inversion. Cell. 1987 Mar 13;48(5):813–825. [PubMed]
  • Fisher EM, Cavanna JS, Brown SD. Microdissection and microcloning of the mouse X chromosome. Proc Natl Acad Sci U S A. 1985 Sep;82(17):5846–5849. [PMC free article] [PubMed]
  • D'Eustachio P, Bothwell AL, Takaro TK, Baltimore D, Ruddle FH. Chromosomal location of structural genes encoding murine immunoglobulin lambda light chains. Genetics of murine lambda light chains. J Exp Med. 1981 Apr 1;153(4):793–800. [PMC free article] [PubMed]
  • Disteche CM, Tantravahi U, Gandy S, Eisenhard M, Adler D, Kunkel LM. Isolation and characterization of two repetitive DNA fragments located near the centromere of the mouse X chromosome. Cytogenet Cell Genet. 1985;39(4):262–268. [PubMed]
  • Fanning TG. Characterization of a highly repetitive family of DNA sequences in the mouse. Nucleic Acids Res. 1982 Aug 25;10(16):5003–5013. [PMC free article] [PubMed]
  • Brown SD, Piechaczyk M. Insertion sequences and tandem repetitions as sources of variation in a dispersed repeat family. J Mol Biol. 1983 Apr 5;165(2):249–256. [PubMed]
  • Lyon MF, Zenthon J, Evans EP, Burtenshaw MD, Wareham KA, Williams ED. Lack of inactivation of a mouse X-linked gene physically separated from the inactivation centre. J Embryol Exp Morphol. 1986 Sep;97:75–85. [PubMed]
  • Lyon MF, Zenthon J, Burtenshaw MD, Evans EP. Localization of the Hprt locus by in situ hybridization and distribution of loci on the mouse X-chromosome. Cytogenet Cell Genet. 1987;44(2-3):163–166. [PubMed]
  • Voliva CF, Jahn CL, Comer MB, Hutchison CA, 3rd, Edgell MH. The L1Md long interspersed repeat family in the mouse: almost all examples are truncated at one end. Nucleic Acids Res. 1983 Dec 20;11(24):8847–8859. [PMC free article] [PubMed]
  • Moyzis RK, Torney DC, Meyne J, Buckingham JM, Wu JR, Burks C, Sirotkin KM, Goad WB. The distribution of interspersed repetitive DNA sequences in the human genome. Genomics. 1989 Apr;4(3):273–289. [PubMed]

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