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Journal List > Proc Natl Acad Sci U S A > v.88(23); Dec 1, 1991

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Proc Natl Acad Sci U S A. 1991 December 1; 88(23): 10740–10743.
PMCID: PMC53006
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Inhibition of the activation of Hageman factor (factor XII) by human vascular endothelial cell culture supernates.
O D Ratnoff, B Everson, P Embury, N P Ziats, J M Anderson, M M Emanuelson, and C J Malemud
Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106.
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Abstract
The supernatant fluid (conditioned medium) of cultured human vascular endothelial cells inhibits activation of Hageman factor (factor XII), whether by ellagic acid, bovine brain sulfatides, or bismuth subgallate; inhibition appears to be a property of one or more proteins in the culture supernates. This phenomenon may contribute to maintaining the fluidity of circulating blood by inhibiting surface activation of the intrinsic pathway of coagulation.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
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