Logo of pnasPNASInfo for AuthorsSubscriptionsAboutThis Article
Proc Natl Acad Sci U S A. Oct 15, 1991; 88(20): 8880–8884.
PMCID: PMC52614

Distribution of glutamine and asparagine residues and their near neighbors in peptides and proteins.

Abstract

In a statistical study of neighboring residues in 1465 peptides and proteins comprising 450,431 residues, it was found that the preferences for residues neighboring to glutamine and asparagine residues are consistent with the hypothesis that the rates of deamidation of these residues are of biological significance. Some dipeptide and tripeptide structures have special usefulness and some are especially undesirable. More such structures exist for amide residues than for other residues, and their specific types are those most relevant to the deamidation of amide residues under biological conditions.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.0M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Robinson AB, Rudd CJ. Deamidation of glutaminyl and asparaginyl residues in peptides and proteins. Curr Top Cell Regul. 1974;8(0):247–295. [PubMed]
  • Robinson AB, Scotchler JW, McKerrow JH. Rates of nonenzymatic deamidation of glutaminyl and asparaginyl residues in pentapeptides. J Am Chem Soc. 1973 Nov 28;95(24):8156–8159. [PubMed]
  • Geiger T, Clarke S. Deamidation, isomerization, and racemization at asparaginyl and aspartyl residues in peptides. Succinimide-linked reactions that contribute to protein degradation. J Biol Chem. 1987 Jan 15;262(2):785–794. [PubMed]
  • Flatmark T, Sletten K. Multiple forms of cytochrome c in the rat. Precursor-product relationship between the main component Cy I and the minor components Cy II and Cy 3 in vivo. J Biol Chem. 1968 Apr 10;243(7):1623–1629. [PubMed]
  • Robinson AB, McKerrow JH, Legaz M. Sequence dependent deamidation rates for model peptides of cytochrome C. Int J Pept Protein Res. 1974;6(1):31–35. [PubMed]
  • Robinson AB, McKerrow JH, Cary P. Controlled deamidation of peptides and proteins: an experimental hazard and a possible biological timer. Proc Natl Acad Sci U S A. 1970 Jul;66(3):753–757. [PMC free article] [PubMed]
  • Robinson AB. Evolution and the distribution of glutaminyl and asparaginyl residues in proteins. Proc Natl Acad Sci U S A. 1974 Mar;71(3):885–888. [PMC free article] [PubMed]
  • Robinson AB. Molecular clocks, molecular profiles, and optimum diets: three approaches to the problem of aging. Mech Ageing Dev. 1979 Feb;9(3-4):225–236. [PubMed]
  • Westall FC, Robinson AB, Caccam J, Jackson J, Ylar EH. Essential chemical requirements for induction of allergic encephalomyelitis. Nature. 1971 Jan 1;229(5279):22–24. [PubMed]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • Compound
    Compound
    PubChem Compound links
  • MedGen
    MedGen
    Related information in MedGen
  • PubMed
    PubMed
    PubMed citations for these articles
  • Substance
    Substance
    PubChem Substance links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...