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J Virol. Sep 1977; 23(3): 811–815.
PMCID: PMC515892

Correlation of virus polypeptide structure with attenuation of poliovirus type 1.

Abstract

Several avirulent samples of poliovirus type 1 derived in the process attenuating the neurovirulent Mahoney strain show an altered virus capsid polypeptide, VP-1, on polyacrylamide gel electrophoresis of sodium dodecyl sulfate-disrupted virions.

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Selected References

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  • Beckman LD, Caliguiri LA, Lilly LS. Cleavage site alterations in poliovirus-specific precursor proteins. Virology. 1976 Aug;73(1):216–227. [PubMed]
  • HOLLAND JJ, McLAREN LC. Improved method for staining cell monolayers for virus plaque counts. J Bacteriol. 1959 Oct;78:596–597. [PMC free article] [PubMed]
  • Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970 Aug 15;227(5259):680–685. [PubMed]
  • LI CP, SCHAEFFER M. Isolation of a non-neurotropic variant of type I poliomyelitis virus. Proc Soc Exp Biol Med. 1954 Oct;87(1):148–153. [PubMed]
  • Phillips BA, Fennell R. Polypeptide composition of poliovirions, naturally occurring empty capsids, and 14S precursor particles. J Virol. 1973 Aug;12(2):291–299. [PMC free article] [PubMed]
  • Tattersall P, Cawte PJ, Shatkin AJ, Ward DC. Three structural polypeptides coded for by minite virus of mice, a parvovirus. J Virol. 1976 Oct;20(1):273–289. [PMC free article] [PubMed]

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