• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of pnasPNASInfo for AuthorsSubscriptionsAboutThis Article
Proc Natl Acad Sci U S A. Mar 1, 1991; 88(5): 1621–1625.
PMCID: PMC51076

Dissociation of object and spatial visual processing pathways in human extrastriate cortex.

Abstract

The existence and neuroanatomical locations of separate extrastriate visual pathways for object recognition and spatial localization were investigated in healthy young men. Regional cerebral blood flow was measured by positron emission tomography and bolus injections of H2(15)O, while subjects performed face matching, dot-location matching, or sensorimotor control tasks. Both visual matching tasks activated lateral occipital cortex. Face discrimination alone activated a region of occipitotemporal cortex that was anterior and inferior to the occipital area activated by both tasks. The spatial location task alone activated a region of lateral superior parietal cortex. Perisylvian and anterior temporal cortices were not activated by either task. These results demonstrate the existence of three functionally dissociable regions of human visual extrastriate cortex. The ventral and dorsal locations of the regions specialized for object recognition and spatial localization, respectively, suggest some homology between human and nonhuman primate extrastriate cortex, with displacement in human brain, possibly related to the evolution of phylogenetically newer cortical areas.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.4M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Images in this article

Click on the image to see a larger version.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Ratcliff G, Davies-Jones GA. Defective visual localization in focal brain wounds. Brain. 1972;95(1):49–60. [PubMed]
  • Ratcliff G, Newcombe F. Spatial orientation in man: effects of left, right, and bilateral posterior cerebral lesions. J Neurol Neurosurg Psychiatry. 1973 Jun;36(3):448–454. [PMC free article] [PubMed]
  • Newcombe F, Ratcliff G, Damasio H. Dissociable visual and spatial impairments following right posterior cerebral lesions: clinical, neuropsychological and anatomical evidence. Neuropsychologia. 1987;25(1B):149–161. [PubMed]
  • Damasio AR, Benton AL. Impairment of hand movements under visual guidance. Neurology. 1979 Feb;29(2):170–174. [PubMed]
  • Damasio AR, Damasio H, Van Hoesen GW. Prosopagnosia: anatomic basis and behavioral mechanisms. Neurology. 1982 Apr;32(4):331–341. [PubMed]
  • Fox PT, Mintun MA, Raichle ME, Miezin FM, Allman JM, Van Essen DC. Mapping human visual cortex with positron emission tomography. Nature. 323(6091):806–809. [PubMed]
  • Fox PT, Miezin FM, Allman JM, Van Essen DC, Raichle ME. Retinotopic organization of human visual cortex mapped with positron-emission tomography. J Neurosci. 1987 Mar;7(3):913–922. [PubMed]
  • Alpert NM, Eriksson L, Chang JY, Bergstrom M, Litton JE, Correia JA, Bohm C, Ackerman RH, Taveras JM. Strategy for the measurement of regional cerebral blood flow using short-lived tracers and emission tomography. J Cereb Blood Flow Metab. 1984 Mar;4(1):28–34. [PubMed]
  • Rumsey JM, Duara R, Grady C, Rapoport JL, Margolin RA, Rapoport SI, Cutler NR. Brain metabolism in autism. Resting cerebral glucose utilization rates as measured with positron emission tomography. Arch Gen Psychiatry. 1985 May;42(5):448–455. [PubMed]
  • Friston KJ, Passingham RE, Nutt JG, Heather JD, Sawle GV, Frackowiak RS. Localisation in PET images: direct fitting of the intercommissural (AC-PC) line. J Cereb Blood Flow Metab. 1989 Oct;9(5):690–695. [PubMed]
  • Fox PT, Perlmutter JS, Raichle ME. A stereotactic method of anatomical localization for positron emission tomography. J Comput Assist Tomogr. 1985 Jan-Feb;9(1):141–153. [PubMed]
  • Fox PT, Mintun MA, Reiman EM, Raichle ME. Enhanced detection of focal brain responses using intersubject averaging and change-distribution analysis of subtracted PET images. J Cereb Blood Flow Metab. 1988 Oct;8(5):642–653. [PubMed]
  • Gattass R, Sousa AP, Gross CG. Visuotopic organization and extent of V3 and V4 of the macaque. J Neurosci. 1988 Jun;8(6):1831–1845. [PubMed]
  • Lueck CJ, Zeki S, Friston KJ, Deiber MP, Cope P, Cunningham VJ, Lammertsma AA, Kennard C, Frackowiak RS. The colour centre in the cerebral cortex of man. Nature. 1989 Aug 3;340(6232):386–389. [PubMed]
  • Corbetta M, Miezin FM, Dobmeyer S, Shulman GL, Petersen SE. Attentional modulation of neural processing of shape, color, and velocity in humans. Science. 1990 Jun 22;248(4962):1556–1559. [PubMed]
  • Cowey A, Gross CG. Effects of foveal prestriate and inferotemporal lesions on visual discrimination by rhesus monkeys. Exp Brain Res. 1970;11(2):128–144. [PubMed]
  • Petersen SE, Fox PT, Posner MI, Mintun M, Raichle ME. Positron emission tomographic studies of the cortical anatomy of single-word processing. Nature. 1988 Feb 18;331(6157):585–589. [PubMed]
  • Posner MI, Walker JA, Friedrich FJ, Rafal RD. Effects of parietal injury on covert orienting of attention. J Neurosci. 1984 Jul;4(7):1863–1874. [PubMed]
  • Roland PE, Friberg L. Localization of cortical areas activated by thinking. J Neurophysiol. 1985 May;53(5):1219–1243. [PubMed]
  • Farah MJ, Hammond KM, Levine DN, Calvanio R. Visual and spatial mental imagery: dissociable systems of representation. Cogn Psychol. 1988 Oct;20(4):439–462. [PubMed]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • MedGen
    MedGen
    Related information in MedGen
  • PubMed
    PubMed
    PubMed citations for these articles

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...