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J Clin Invest. 1996 February 15; 97(4): 1129–1133. doi: 10.1172/JCI118507. | PMCID: PMC507162 |
The effect of docosahexaenoic acid on aggression in young adults. A placebo-controlled double-blind study. T Hamazaki, S Sawazaki, M Itomura, E Asaoka, Y Nagao, N Nishimura, K Yazawa, T Kuwamori, and M Kobayashi The First Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan. 41 students took either docosahexaenoic acid (DHA)-rich oil capsules containing 1.5-1.8 grams DHA/day (17 females and 5 males) or control oil capsules containing 97% soybean oil plus 3% fish oil (12 females and 7 males) for 3 mo in a double-blind fashion. They took a psychological test (P-F Study) and Stroop and dementia-detecting tests at the start and end of the study. The present study started at the end of summer vacation and ended in the middle of mental stress such as final exams. In the control group extraggression (aggression against others) in P-F Study was significantly increased at the end of the study as compared with that measured at the start (delta = +8.9%, P = 0.0022), whereas it was not significantly changed in the DHA group (delta = -1.0%). The 95% CI of differences between the DHA and control groups were -16.8 to -3.0%. DHA supplementation did not affect the Stroop and dementia-detecting tests. Thus, DHA intake prevented extraggression from increasing at times of mental stress. This finding might help understand how fish oils prevent disease like coronary heart disease. The Full Text of this article is available as a PDF (156K). These references are in PubMed. This may not be the complete list of references from this article. - Neuringer M, Connor WE, Lin DS, Barstad L, Luck S. Biochemical and functional effects of prenatal and postnatal omega 3 fatty acid deficiency on retina and brain in rhesus monkeys. Proc Natl Acad Sci U S A. 1986 Jun;83(11):4021–4025. [PMC free article] [PubMed]
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