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J Clin Pathol. 1993 August; 46(8): 738–741. | PMCID: PMC501460 |
Benign familial hyperphosphatasaemia as a cause of unexplained increase in plasma alkaline phosphatase activity. S B Rosalki, A Y Foo, and J S Dooley Department of Chemical Pathology and Human Metabolism, Royal Free Hospital and School of Medicine, London. Abstract AIMS--To consider a possible genetic origin for the persistent unexplained increase in plasma alkaline phosphatase (ALP) in five non-related patients referred over an 18 month period. METHODS--Plasma ALP isoenzyme activities were measured in patients and their first degree relatives. RESULTS--In each patient there was a noticeable increase in intestinal plasma ALP, either alone or accompanied by an increase in bone or liver ALP. Family studies showed an unexpected increase in plasma ALP and similar isoenzyme changes in first degree relatives. The findings were consistent with autosomal dominant inheritance. CONCLUSION--Inherited raised plasma ALP activity is a reasonably common cause of persistent unexplained hyperphosphatasaemia which deserves wider recognition. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (873K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References. Images in this article Click on the image to see a larger version. These references are in PubMed. This may not be the complete list of references from this article. - De Broe ME, Bosteels V, Wieme RJ. Letter: Increased intestinal alkaline phosphatase in serum of patients on maintenance haemodialysis. Lancet. 1974 Apr 20;1(7860):753–754. [PubMed]
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