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J Clin Pathol. 1998 May; 51(5): 413–415. | PMCID: PMC500710 |
Raised serum hCG in a male patient caused by primary jejunal choriocarcinoma. G S Chan, W K Ng, D T Chua, and P C Wu Department of Pathology, University of Hong Kong, Queen Mary Hospital, Hong Kong. Abstract A rare case of primary choriocarcinoma of the jejunum occurred in a 45 year old Chinese man. This tumour was associated with massive melaena and a markedly raised serum human chorionic gonadotrophin (beta-hCG) concentration. Necropsy examination showed no primary lesion in other possible sites including testes, mediastinum, and pineal gland. Histologically, the tumour showed morphology typical of choriocarcinoma with no adenocarcinomatous element identified. The presence of choriocarcinoma in non-gonadal sites may be explained by retrodifferentiation or metaplasia of a conventional carcinomatous component to primitive trophoblasts. Serum beta-hCG level may represent a useful marker in earlier diagnosis and monitoring of this potentially treatable disease. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (966K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References. Images in this article Click on the image to see a larger version. These references are in PubMed. This may not be the complete list of references from this article. - Gailani S, Chu TM, Nussbaum A, Ostrander M, Christoff N. Human chorionic gonadotrophins (hCG) in non-trophoblastic neoplasms. Assessment of abnormalities of hCG and CEA in bronchogenic and digestive neoplasms. Cancer. 1976 Oct;38(4):1684–1686. [PubMed]
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