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J Clin Pathol. 1996 Jun; 49(6): 519–521.
PMCID: PMC500550

Carcinosarcoma arising in a dermoid cyst of the ovary.


A case of carcinosarcoma arising within an otherwise benign cystic teratoma is reported. The patient, a 78 year old nulliparous woman, presented with right sided abdominal pain of short duration and subsequently underwent a bilateral salphingo-oophorectomy. Slicing of the left ovary revealed a unilocular cyst containing hair admixed with soft yellow material with a thin wall apart from a solid area at one pole. Extensive areas of necrosis and cystic degeneration were present within this mass. Histologically, the large cyst was a typical mature cystic teratoma, containing carcinomatous and sarcomatous elements. Mature cystic teratomas have been reported in association with a variety of malignant ovarian tumours such as mucinous cystadenocarcinoma and malignant germ cell neoplasms. Secondary malignant transformation within a dermoid cyst is a much rarer occurrence, estimated as less than 2% of all such lesions. Adenocarcinomas are the second most common malignancies arising within dermoid cysts. Sarcomas alone or in combination with squamous carcinoma have been described arising in a mature cystic teratoma. To the best of our knowledge, no case of sarcoma arising in association with adenocarcinoma has been described before.

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Selected References

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  • Chang DH, Hsueh S, Soong YK. Small cell carcinoma with neurosecretory granules arising in an ovarian dermoid cyst. Gynecol Oncol. 1992 Aug;46(2):246–250. [PubMed]
  • Morimitsu Y, Nakashima O, Nakashima Y, Kojiro M, Shimokobe T. Apocrine adenocarcinoma arising in cystic teratoma of the ovary. Arch Pathol Lab Med. 1993 Jun;117(6):647–649. [PubMed]
  • Randall BJ, Ritchie C, Hutchison RS. Paget's disease and invasive undifferentiated carcinoma occurring in a mature cystic teratoma of the ovary. Histopathology. 1991 May;18(5):469–470. [PubMed]
  • Genadry R, Parmley T, Woodruff JD. Secondary malignancies in benign cystic teratomas. Gynecol Oncol. 1979 Oct;8(2):246–251. [PubMed]
  • Hanada M, Tsujimura T, Shimizu H. Multiple malignancies (squamous cell carcinoma and sarcoma) arising in a dermoid cyst of the ovary. Acta Pathol Jpn. 1981 Jul;31(4):681–688. [PubMed]
  • Ueda G, Fujita M, Ogawa H, Sawada M, Inoue M, Tanizawa O. Adenocarcinoma in a benign cystic teratoma of the ovary: report of a case with a long survival period. Gynecol Oncol. 1993 Feb;48(2):259–263. [PubMed]

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