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Logo of jclinpathJournal of Clinical PathologyCurrent TOCInstructions for authors
J Clin Pathol. Jun 1986; 39(6): 585–589.
PMCID: PMC499954

Lymphocytic infiltration and survival in rectal cancer.

Abstract

Lymphocytic infiltration was assessed semiquantitatively in 447 specimens of rectal cancer. Corrected five year survivals for pronounced, moderate, and little lymphocytic infiltration were 92%, 65% and 36%, respectively. Grading was shown to be reproducible in an intraobserver study (observed agreement 81%, expected agreement 34%, kappa coefficient 0.72). In the multivariate survival analysis of grade and stage related variables lymphocytic infiltration was the only grade related variable to be accepted within the prognostic model. This model also included the number of lymph node metastases and the extent of tumour spread. It is suggested that the conservation of the normal interactive traffic between epithelium and mucosa associated lymphoid tissue (MALT) signals a low grade growth. This is supported by the association between lymphocytic infiltration and the expression of secretory component by malignant epithelium.

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Selected References

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  • Murray D, Hreno A, Dutton J, Hampson LG. Prognosis in colon cancer: a pathologic reassessment. Arch Surg. 1975 Aug;110(8):908–913. [PubMed]
  • Zamcheck N, Doos WG, Prudente R, Lurie BB, Gottlieb LS. Prognostic factors in colon carcinoma: correlation of serum carcinoembryonic antigen level and tumor histopathology. Hum Pathol. 1975 Jan;6(1):31–45. [PubMed]
  • Watt AG, House AK. Colonic carcinoma: a quantitative assessment of lymphocyte infiltration at the periphery of colonic tumors related to prognosis. Cancer. 1978 Jan;41(1):279–282. [PubMed]
  • Thynne GS, Weiland LH, Moertel CG, Silvers A. Correlation of histopathologic characteristics of primary tumor and uninvolved regional lymph nodes in Dukes' class C colonic carcinoma with prognosis. Mayo Clin Proc. 1980 Apr;55(4):243–245. [PubMed]
  • Zhou XG, Yu BM, Shen YX. Surgical treatment and late results in 1226 cases of colorectal cancer. Dis Colon Rectum. 1983 Apr;26(4):250–256. [PubMed]
  • Carlon CA, Fabris G, Arslan-Pagnini C, Pluchinotta AM, Chinelli E, Carniato S. Prognostic correlations of operable carcinoma of the rectum. Dis Colon Rectum. 1985 Jan;28(1):47–50. [PubMed]
  • Svennevig JL, Lunde OC, Holter J, Bjørgsvik D. Lymphoid infiltration and prognosis in colorectal carcinoma. Br J Cancer. 1984 Mar;49(3):375–377. [PMC free article] [PubMed]
  • Freedman LS, Macaskill P, Smith AN. Multivariate analysis of prognostic factors for operable rectal cancer. Lancet. 1984 Sep 29;2(8405):733–736. [PubMed]
  • Talbot IC, Ritchie S, Leighton M, Hughes AO, Bussey HJ, Morson BC. Invasion of veins by carcinoma of rectum: method of detection, histological features and significance. Histopathology. 1981 Mar;5(2):141–163. [PubMed]
  • Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics. 1977 Mar;33(1):159–174. [PubMed]
  • Jass JR, Faludy J. Immunohistochemical demonstration of IgA and secretory component in relation to epithelial cell differentiation in normal colorectal mucosa and metaplastic polyp: a semiquantitative study. Histochem J. 1985 Mar;17(3):373–380. [PubMed]
  • Csiba A, Whitwell HL, Moore M. Distribution of histocompatibility and leucocyte differentiation antigens in normal human colon and in benign and malignant colonic neoplasms. Br J Cancer. 1984 Nov;50(5):699–709. [PMC free article] [PubMed]
  • Armstrong CA, Klostergaard J, Granger GA. Isolation and initial characterization of tumoricidal monokine(s) from the human monocytic leukemia cell line THP-1. J Natl Cancer Inst. 1985 Jan;74(1):1–9. [PubMed]
  • Allen C, Hogg N. Monocytes and other infiltrating cells in human colorectal tumours identified by monoclonal antibodies. Immunology. 1985 Jun;55(2):289–299. [PMC free article] [PubMed]
  • Koch B, Giedl J, Hermanek P, Kalden JR. The analysis of mononuclear cell infiltrations in colorectal adenocarcinoma. J Cancer Res Clin Oncol. 1985;109(2):142–151. [PubMed]
  • Fink A, Shani A, Weisman Z, Wechsler U, Pfeffermann R, Harpaz N, Eitan S, Bentwich Z. Leukocyte adherence inhibition (LAI) for detecting specific tumor immunity in colorectal cancer. Immunol Lett. 1985;9(2-3):143–147. [PubMed]
  • Schwartz R, Momburg F, Moldenhauer G, Dörken B, Schirrmacher V. Induction of HLA class-II antigen expression on human carcinoma cell lines by IFN-Gamma. Int J Cancer. 1985 Feb 15;35(2):245–250. [PubMed]
  • Patt DJ, Brynes RK, Vardiman JW, Coppleson LW. Mesocolic lymph node histology is an important prognostic indicator for patients with carcinoma of the sigmoid colon: an immunomorphologic study. Cancer. 1975 May;35(5):1388–1396. [PubMed]
  • Pihl E, Nairn RC, Nind AP, Muller HK, Hughes ES, Cuthbertson AM, Rollo AJ. Correlation of regional lymph node in vitro antitumor immunoreactivity histology with colorectal carcinoma. Cancer Res. 1976 Oct;36(10):3665–3671. [PubMed]
  • Pihl E, Malahy MA, Khankhanian N, Hersh EM, Mavligit GM. Immunomorphological features of prognostic significance in Dukes' Class B colorectal carcinoma. Cancer Res. 1977 Nov;37(11):4145–4149. [PubMed]
  • Tsakraklides V, Wanebo HJ, Sternberg SS, Stearns M, Good RA. Prognostic evaluation of regional lymph node morphology colorectal cancer. Am J Surg. 1975 Feb;129(2):174–180. [PubMed]
  • Pihl E, Nairn RC, Milne BJ, Cuthbertson AM, Hughes ES, Rollo A. Lymphoid hyperplasia: a major prognostic feature in 519 cases of colorectal carcinoma. Am J Pathol. 1980 Aug;100(2):469–480. [PMC free article] [PubMed]
  • Lampert IA, Kirkland S, Farrell S, Borysiewicz LK. HLA-DR expression in a human colonic carcinoma cell line. J Pathol. 1985 Aug;146(4):337–344. [PubMed]
  • Isaacson P. Immunoperoxidase study of the secretory immunoglobulin system in colonic neoplasia. J Clin Pathol. 1982 Jan;35(1):14–25. [PMC free article] [PubMed]
  • Arends JW, Wiggers T, Thijs CT, Verstijnen C, Swaen GJ, Bosman FT. The value of secretory component (SC) immunoreactivity in diagnosis and prognosis of colorectal carcinomas. Am J Clin Pathol. 1984 Sep;82(3):267–274. [PubMed]

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