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J Clin Pathol. 1984 July; 37(7): 826–828. | PMCID: PMC498819 |
Serum placental type alkaline phosphatase in cigarette smokers. P J McLaughlin, A M Twist, C C Evans, and P M Johnson Abstract By means of enzyme immunoassays based on two monoclonal antibodies with specificities for distinct forms of placental type alkaline phosphatase (Pl-ALP), together with L-leucine inhibition studies, it has been possible to distinguish the Nagao type carcinoplacental enzyme from other placental type alkaline phosphatases. This approach has shown that it is the Nagao type (placental like) enzyme which is detectable in small amounts in the plasma of healthy individuals, particularly cigarette smokers. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (409K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References. These references are in PubMed. This may not be the complete list of references from this article. - Stigbrand T, Millán JL, Fishman WH. The genetic basis of alkaline phosphatase isozyme expression. Isozymes Curr Top Biol Med Res. 1982;6:93–117. [PubMed]
- Fishman WH. Perspectives on alkaline phosphatase isoenzymes. Am J Med. 1974 May;56(5):617–650. [PubMed]
- Fishman WH, Inglis NI, Stolbach LL, Krant MJ. A serum alkaline phosphatase isoenzyme of human neoplastic cell origin. Cancer Res. 1968 Jan;28(1):150–154. [PubMed]
- Nakayama T, Yoshida M, Kitamura M. L-leucine sensitive, heat-stable alkaline-phosphatase isoenzyme detected in a patient with pleuritis carcinomatosa. Clin Chim Acta. 1970 Nov;30(2):546–548. [PubMed]
- Millán JL, Stigbrand T, Ruoslahti E, Fishman WH. Characterization and use of an allotype-specific monoclonal antibody to placental alkaline phosphatase in the study of cancer-related phosphatase polymorphism. Cancer Res. 1982 Jun;42(6):2444–2449. [PubMed]
- McLaughlin PJ, Travers PJ, McDicken IW, Johnson PM. Demonstration of placental and placental-like alkaline phosphatase in non-malignant human tissue extracts using monoclonal antibodies in an enzyme immunoassay. Clin Chim Acta. 1984 Mar 13;137(3):341–348. [PubMed]
- Goldstein DJ, Rogers C, Harris H. A search for trace expression of placental-like alkaline phosphatase in non-malignant human tissues: demonstration of its occurrence in lung, cervix, testis and thymus. Clin Chim Acta. 1982 Oct 13;125(1):63–75. [PubMed]
- Millán JL, Eriksson A, Stigbrand T. A possible new locus of alkaline phosphatase expressed in human testis. Hum Genet. 1982;62(4):293–295. [PubMed]
- Maslow WC, Muensch HA, Azama F, Schneider AS. Sensitive fluorometry of heat-stable alkaline phosphatase (Regan enzyme) activity in serum from smokers and nonsmokers. Clin Chem. 1983 Feb;29(2):260–263. [PubMed]
- Tonik SE, Ortmeyer AE, Shindelman JE, Sussman HH. Elevation of serum placental alkaline phosphatase levels in cigarette smokers. Int J Cancer. 1983 Jan 15;31(1):51–53. [PubMed]
- McLaughlin PJ, Gee H, Johnson PM. Placental-type alkaline phosphatase in pregnancy and malignancy plasma: specific estimation using a monoclonal antibody in a solid phase enzyme immunoassay. Clin Chim Acta. 1983 May 30;130(2):199–209. [PubMed]
- McLaughlin PJ, Cheng MH, Slade MB, Johnson PM. Expression on cultured human tumour cells of placental trophoblast membrane antigens and placental alkaline phosphatase defined by monoclonal antibodies. Int J Cancer. 1982 Jul 15;30(1):21–26. [PubMed]
- Wei SC, Doellgast GJ. Immunochemical studies of human placental-type variants of alkaline phosphatase. Structural differences between the "Nagao isoenzyme" and the placental "D-variant". Eur J Biochem. 1981 Aug;118(1):39–45. [PubMed]
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