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J Clin Pathol. 1983 October; 36(10): 1129–1135. | PMCID: PMC498488 |
Haematological features of primary myelodysplastic syndromes (PMDS) at initial presentation: a study of 118 cases. S K Juneja, M Imbert, H Jouault, J Y Scoazec, F Sigaux, and C Sultan Abstract The haematological features of 118 cases of primary myelodysplastic syndromes (PMDS) were reviewed to see how these could be related and classified according to the recent FAB proposals. A majority of the cases were elderly who presented with a macrocytic or normocytic anaemia and reticulocytopenia. Cases of acquired idiopathic sideroblastic anaemia (AISA) usually had normal leucocyte and platelet counts, erythroid hyperplasia, marked dyserythropoiesis and more than 20% ringed sideroblasts. Cases of refractory anaemia with excess of blasts (RAEB) had frequent neutropenia and thrombopenia usually with prominent dysgranulopoiesis and dysthrombopoiesis. Refractory anaemia or refractory cytopenia appeared morphologically to be a heterogeneous group. Leukaemic transformation did not occur in any of these 16 cases of AISA whereas six of the 34 cases of RAEB transformed into acute leukaemia. It appears that the cases of PMDS present with well defined haematological features which permit recognition of different groups; these latter groups appear to be morphologically and prognostically distinct. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (937K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References. These references are in PubMed. This may not be the complete list of references from this article. - DACIE JV, SMITH MD, WHITE JC, MOLLIN DL. Refractory normoblastic anaemia: a clinical and haematological study of seven cases. Br J Haematol. 1959 Jan;5(1):56–82. [PubMed]
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