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J Clin Pathol. May 1992; 45(5): 443–444.
PMCID: PMC495311

Multinucleated stromal giant cells in adolescent gynaecomastia.


Bizzare multinucleated stromal giant cells were observed in a case of adolescent gynaecomastia. Similar cells have been described in the female breast in both benign and malignant conditions where they are thought to originate either from reactive stromal cells or from the mononuclear phagocyte system, respectively. Immunohistochemistry and electron microscopy in this case support the idea that they originate from stromal fibroblasts. Their occurrence in gynaecomastia is further evidence that these changes in stromal cells may be due to hormonal influences.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Rosen PP. Multinucleated mammary stromal giant cells: a benign lesion that simulates invasive carcinoma. Cancer. 1979 Oct;44(4):1305–1308. [PubMed]
  • Athanasou NA, Wells CA, Quinn J, Ferguson DP, Heryet A, McGee JO. The origin and nature of stromal osteoclast-like multinucleated giant cells in breast carcinoma: implications for tumour osteolysis and macrophage biology. Br J Cancer. 1989 Apr;59(4):491–498. [PMC free article] [PubMed]
  • Abdul-Karim FW, Cohen RE. Atypical stromal cells of lower female genital tract. Histopathology. 1990 Sep;17(3):249–253. [PubMed]
  • Biro FM, Lucky AW, Huster GA, Morrison JA. Hormonal studies and physical maturation in adolescent gynecomastia. J Pediatr. 1990 Mar;116(3):450–455. [PubMed]
  • Carlson HE. Gynecomastia. N Engl J Med. 1980 Oct 2;303(14):795–799. [PubMed]

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