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J Clin Pathol. Jul 1981; 34(7): 773–778.
PMCID: PMC493813

Diagnostic accuracy of cytology and biopsy in primary bronchial carcinoma.

Abstract

The accuracy of diagnosis in 656 patients with the four common histopathological types of primary lung cancer has been assessed by comparing the cell type diagnosis made on cytological and histological investigation with that determined by examination of the surgically resected or necroscopy specimen. The accuracy of diagnosis achieved by cytological examination of sputum and bronchial aspirate, and by bronchial biopsy histology was over 85%. The least accurate diagnostic procedure was percutaneous needle biopsy (62%). Squamous and small cell tumours were accurately diagnosed by all four investigations but errors were made in the diagnosis of large cell and adenocarcinomas. Nearly half the number of patients (43%) with large cell carcinoma were later reclassified as having squamous carcinoma and of the patients with adenocarcinoma 32% had been predicted to be squamous and 18% large cell carcinoma. We consider such quality control of pretreatment diagnosis mandatory in management of individual patients and before enrollment in clinical trials.

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Selected References

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  • Payne CR, Stovin PG, Barker V, McVittie S, Stark JE. Diagnostic accuracy of cytology and biopsy in primary bronchial carcinoma. Thorax. 1979 Jun;34(3):294–299. [PMC free article] [PubMed]
  • Feinstein AR, Gelfman NA, Yesner R. The diverse effects of histopathology on manifestations and outcome of lung cancer. Chest. 1974 Sep;66(3):225–229. [PubMed]
  • Weiss RB. Small-cell carcinoma of the lung: therapeutic management. Ann Intern Med. 1978 Apr;88(4):522–531. [PubMed]
  • Fox W, Scadding JG. Medical Research Council comparative trial of surgery and radiotherapy for primary treatment of small-celled or oat-celled carcinoma of bronchus. Ten-year follow-up. Lancet. 1973 Jul 14;2(7820):63–65. [PubMed]
  • Rubinstein I, Baum GL, Kalter Y, Pauzner Y, Lieberman Y, Bubis JJ. The influence of cell type and lymph node metastases on survival of patients with carcinoma of the lung undergoing thoracotomy. Am Rev Respir Dis. 1979 Feb;119(2):253–262. [PubMed]
  • Freise G, Gabler A, Liebig S. Bronchial carcinoma and long-term survival. Retrospective study of 433 patients who underwent resection. Thorax. 1978 Apr;33(2):228–234. [PMC free article] [PubMed]
  • YESNER R, GERSTL B, AUERBACH O. APPLICATION OF THE WORLD HEALTH ORGANIZATION CLASSIFICATION OF LUNG CARCINOMA TO BIOPSY MATERIAL. Ann Thorac Surg. 1965 Jan;10:33–49. [PubMed]
  • Feinstein AR, Gelfman NA, Yesner R. Observer variability in the histopathologic diagnosis of lung cancer. Am Rev Respir Dis. 1970 May;101(5):671–684. [PubMed]
  • WALTER JB, PRYCE DM. The histology of lung cancer. Thorax. 1955 Jun;10(2):107–116. [PMC free article] [PubMed]
  • Hinson KF, Miller AB, Tall R. An assessment of the World Health Organization classification of the histologic typing of lung tumors applied to biopsy and resected material. Cancer. 1975 Feb;35(2):399–405. [PubMed]
  • Oswald NC, Hinson KF, Canti G, Miller AB. The diagnosis of primary lung cancer with special reference to sputum cytology. Thorax. 1971 Nov;26(6):623–627. [PMC free article] [PubMed]
  • Lange E, Hoeg K. Cytologic typing of lung cancer. Acta Cytol. 1972 Jul-Aug;16(4):327–330. [PubMed]
  • Tao LC, Pearson FG, Delarue NC, Langer B, Sanders DE. Percutaneous fine-needle aspiration biopsy. I. Its value to clinical practice. Cancer. 1980 Mar 15;45(6):1480–1485. [PubMed]
  • Straus MJ. Combination chemotherapy in advanced lung cancer with increased survival. Cancer. 1976 Dec;38(6):2232–2241. [PubMed]

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