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Journal List > J Clin Pathol > v.15(5); Sep 1962

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J Clin Pathol. 1962 September; 15(5): 456–458.
PMCID: PMC480434
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Serum vitamin B12 in renal failure
D. M. Matthews, A. Gordon Beckett, and Patricia Maxwell
Department of Chemical Pathology, Royal Free Hospital, London
Diabetic Department, Royal Free Hospital, London
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Abstract
The serum vitamin B12 level was abnormally high in 14 out of 32 cases of renal failure. This was probably due to impaired excretion of the vitamin, but the results of measurements of the rate of excretion of radioactive vitamin B12 did not provide unequivocal evidence on this point; other possible explanations are discussed. Renal failure must be added to the causes of high serum B12 levels.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
  • ADAMS JF. The urinary excretion of assayable vitamin B12 and radioactivity after parenteral 58Co B12 in man. J Clin Pathol. 1961 Jul;14:351–355. [PubMed]
  • DUNN AL, WALSH JR, HOLTHAUS JM. Radioactive cyanocobalamin (vitamin B12) in renal disease. AMA Arch Intern Med. 1958 May;101(5):927–931. [PubMed]
  • HALSTED JA, CARROLL J, RUBERT S. Serum and tissue concentration of vitamin B12 in certain pathologic states. N Engl J Med. 1959 Mar 19;260(12):575–580. [PubMed]
  • KUHLBACK B, NYBERG W, GRASBECK R. The Schilling test in renal failure. Scand J Clin Lab Invest. 1960;12:140–142. [PubMed]
  • MATTHEWS DM. Observations on the estimation of serum vitamin B12 using Lactobacillus leichmannii. Clin Sci. 1962 Feb;22:101–111. [PubMed]
  • MILLER A. The in vitro binding of cobalt 60 labeled vitamin B12 by normal and leukemic sera. J Clin Invest. 1958 Apr;37(4):556–566. [PubMed]
  • MOLLIN DL, ROSS GI. Serum vitamin B12 concentrations in leukaemia and in some other haematological conditions. Br J Haematol. 1955 Apr;1(2):155–172. [PubMed]
  • ARONOVITCH J, GROSSOWICZ N, RACHMILEWITZ M. Serum concentrations of vitamin B12 in acute and chronic liver disease. J Lab Clin Med. 1956 Sep;48(3):339–344. [PubMed]
  • DUFFY BJ, Jr, MCCURDY PR, RATH CE. Effect of renal disease on the Schilling test. N Engl J Med. 1957 Jan 17;256(3):111–114. [PubMed]
  • WATKIN DM, BARROWS CH, Jr, CHOW BF, SHOCK NW. Renal clearance of intravenously administered vitamin B12. Proc Soc Exp Biol Med. 1961 May;107:219–221. [PubMed]
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